Search Results - (Author, Cooperation:T. Honma)
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1Latest Papers from Table of Contents or Articles in PressM. Okada-Iwabu ; T. Yamauchi ; M. Iwabu ; T. Honma ; K. Hamagami ; K. Matsuda ; M. Yamaguchi ; H. Tanabe ; T. Kimura-Someya ; M. Shirouzu ; H. Ogata ; K. Tokuyama ; K. Ueki ; T. Nagano ; A. Tanaka ; S. Yokoyama ; T. Kadowaki
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenylate Kinase/metabolism ; Adiponectin/metabolism/pharmacology ; Adipose Tissue, White/drug effects/metabolism/pathology ; Administration, Oral ; Animals ; Diabetes Mellitus, Type 2/complications/*drug therapy/metabolism/prevention & ; control ; Diet, High-Fat ; Drug Evaluation, Preclinical ; Dyslipidemias/drug therapy ; Enzyme Activation/drug effects ; Glucose Intolerance/drug therapy ; Inflammation/drug therapy ; Insulin Resistance ; Liver/drug effects/metabolism/pathology ; Longevity/*drug effects ; Mice ; Mitochondria/drug effects/metabolism ; Muscle Fibers, Skeletal/cytology/drug effects ; Muscles/cytology ; Obesity/complications/drug therapy/genetics/*physiopathology ; Oxidative Stress/drug effects ; PPAR alpha/metabolism ; Piperidines/administration & dosage/metabolism/*pharmacology/therapeutic use ; Receptors, Adiponectin/*agonists/deficiency/genetics/metabolism ; Signal Transduction/drug effects ; Small Molecule Libraries/chemistry ; Transcription Factors/biosynthesis ; Triglycerides/metabolismPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: This paper describes a vectorial finite element method for the analysis of electromagnetic waves propagating in helical systems. The present method can be as easily used as the methods for guided electromagnetic waves in systems with translational and axial symmetries. The functional for the vector Helmholtz equation is minimized using twisted coordinates in which the problem becomes two-dimensional. The spurious solutions, which do not satisfy the divergence-free condition, are removed on the basis of the penalty method. Two finite element equations for the covariant and contravariant components of electromagnetic fields are derived and boundary conditions for both formulations are described. The present method is applied to the analysis of a twisted waveguide with a rectangular cross section and the numerical solutions are shown to be in good agreement with the perturbed solutions for a small helical pitch.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesHonma, T. ; Benino, Y. ; Fujiwara, T. ; Komatsu, T.
[S.l.] : American Institute of Physics (AIP)
Published 2002Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The electronic polarizability and optical basicity of La2O3 and related glasses have been determined from ultraviolet absorption spectra and calculations based on the Lorentz–Lorenz equation. The optical basicity for La2O3 oxide is found to be 1.07, being much larger compared with typical glass-forming oxides such as B2O3 (0.42) and SiO2 (0.48) but being similar to heavy element oxides such as TeO2 (0.93). The Yamashita and Kurosawa's interaction parameter of La2O3 is 0.03 Å−3, indicating that La2O3 is classified as a normal ionic (basic) oxide, i.e., an ionic bonding character in the La3+–O bond is proposed. Close correlations are confirmed among optical basicity, interaction parameter, and oxygen 1s binding energy in x-ray photoelectron (XPS) spectra for La2O3–P2O5 and other La2O3-containing glasses. It is found from XPS and Raman spectra that La3+ ions in La2O3–P2O5 glasses act as network modifiers, supporting an ionic bonding character in the La3+–O bond. The parameters related to electronic polarizability in La2O3 determined in the present study would be useful for the design of rare-earth containing optical functional glasses. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesHonma, T. ; Benino, Y. ; Komatsu, T.
College Park, Md. : American Institute of Physics (AIP)
Published 2001Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The structural relaxation kinetics in the glass transition for xSb2O3⋅(100−x)B2O3 glasses with covalent bonding character has been examined from viscosity and heat capacity measurements. These binary glasses have low glass transition temperatures, Tg=250–290 °C, but show a high thermal resistance against crystallization. The degree of fragility m estimated from the activation energy for viscous flow (Eη=290–531 kJ mol−1) is m=29–51. The activation energy for enthalpy relaxation, ΔH=297–602 kJ mol−1, is evaluated from the cooling rate dependence of the limiting fictive temperature. The ΔH values are very close to the Eη values, meaning that the decoupling between enthalpy relaxation and viscous flow is small. The values of Kovacs–Aklonis–Huchinson–Ramos (KAHR) parameter θ estimated from ΔH/RTg2 are 0.13–0.25, where R is the gas constant. The glasses with 30–60 mol % Sb2O3 have very similar Eη, m, ΔH, and θ values. It has been demonstrated that the structural relaxation kinetics of the binary antimony borate glasses is affected by the boron coordination numbers (i.e., BO3 and BO4) and the covalent bonding character of Sb–O bonds, and consequently these glasses are regarded as a highly strong glass-forming system in the fragile/strong classification concept. © 2001 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesSano, M ; Nakanishi, Y ; Yagasaki, H ; Honma, T ; Oinuma, T ; Obana, Y ; Suzuki, A ; Nemoto, N
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims: To determine the expression of Mcl-1 in testicular germ cell tumours in order to clarify the role of this anti-apoptotic factor in these tumours. Various members of the Bcl-2 family have been implicated in the apoptotic mechanisms regulating germ cell apoptosis. Mcl-1 is an anti-apoptotic Bcl-2 family member and has recently been reported to be related to the progression of malignancy; however, the involvement of Mcl-1 in the development of germ cell tumours is still unknown.Methods and results: Mcl-1 expression in testicular germ cell tumours was investigated by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). By immunohistochemistry, overexpression of Mcl-1 was present in all germ cell tumours that were studied, including embryonal carcinoma and yolk sac tumour, as well as choriocarcinoma and teratoma. In teratomas, Mcl-1 was widely distributed in the epithelial, myogenic, neural and mesenchymal components. RT-PCR analysis after microdissection revealed high levels of Mcl-1 mRNA in all tumour variants compared with non-neoplastic germ cells.Conclusion: Overexpression of anti-apoptotic Mcl-1 may function to enhance the viability of testicular germ cells, thereby leading to tumorigenesis.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0303-2647Keywords: Delay compensation ; Neural network ; Phase conjugate ; SimulationSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0005-2744Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0921-4526Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0921-4534Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0921-4534Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesYamaya, K. ; Haga, T. ; Honma, T. ; Abe, Y. ; Minami, F. ; Takekawa, S. ; Tajima, Y. ; Hidaka, Y.
Amsterdam : ElsevierStaff ViewISSN: 0921-4534Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesIgarashi, K. ; Sugawara, T. ; Honma, T. ; Tada, Y. ; Miyazaki, H. ; Nagata, H. ; Mayama, M. ; Kubota, T.
Amsterdam : ElsevierStaff ViewISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: Laurencia nipponica ; Rhodomelaceae ; bromo ethers ; enynes ; laurediols. ; precursorsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0385-6380Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: