Search Results - (Author, Cooperation:T. C. Mettenleiter)
-
1Latest Papers from Table of Contents or Articles in PressR. A. Fouchier ; A. Garcia-Sastre ; Y. Kawaoka ; W. S. Barclay ; N. M. Bouvier ; I. H. Brown ; I. Capua ; H. Chen ; R. W. Compans ; R. B. Couch ; N. J. Cox ; P. C. Doherty ; R. O. Donis ; H. Feldmann ; Y. Guan ; J. M. Katz ; O. I. Kiselev ; H. D. Klenk ; G. Kobinger ; J. Liu ; X. Liu ; A. Lowen ; T. C. Mettenleiter ; A. D. Osterhaus ; P. Palese ; J. S. Peiris ; D. R. Perez ; J. A. Richt ; S. Schultz-Cherry ; J. Steel ; K. Subbarao ; D. E. Swayne ; T. Takimoto ; M. Tashiro ; J. K. Taubenberger ; P. G. Thomas ; R. A. Tripp ; T. M. Tumpey ; R. J. Webby ; R. G. Webster
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-01-25Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Biomedical Research/*trends ; Birds ; Humans ; *Influenza A Virus, H5N1 Subtype ; Influenza in Birds/*transmission/*virology ; Influenza, Human/*transmission/*virologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressR. A. Fouchier ; A. Garcia-Sastre ; Y. Kawaoka ; W. S. Barclay ; N. M. Bouvier ; I. H. Brown ; I. Capua ; H. Chen ; R. W. Compans ; R. B. Couch ; N. J. Cox ; P. C. Doherty ; R. O. Donis ; H. Feldmann ; Y. Guan ; J. Katz ; H. D. Klenk ; G. Kobinger ; J. Liu ; X. Liu ; A. Lowen ; T. C. Mettenleiter ; A. D. Osterhaus ; P. Palese ; J. S. Peiris ; D. R. Perez ; J. A. Richt ; S. Schultz-Cherry ; J. Steel ; K. Subbarao ; D. E. Swayne ; T. Takimoto ; M. Tashiro ; J. K. Taubenberger ; P. G. Thomas ; R. A. Tripp ; T. M. Tumpey ; R. J. Webby ; R. G. Webster
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-01-28Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Biomedical Research ; Disease Models, Animal ; Ferrets ; Humans ; *Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza, Human/transmission/virology ; Orthomyxoviridae Infections/*transmission/virologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressVallbracht, M., Rehwaldt, S., Klupp, B. G., Mettenleiter, T. C., Fuchs, W.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-04-14Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
4Latest Papers from Table of Contents or Articles in PressKlupp, B. G., Hellberg, T., Rönfeldt, S., Franzke, K., Fuchs, W., Mettenleiter, T. C.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-07-18Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
5Articles: DFG German National LicensesStaff View
ISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Pseudorabies virus (PrV) infected cells in suspension are able to adhere to a monolayer of uninfected cells by means of PrV glycoproteins expressed at the outer cell membrane, with gB and gC playing a major role as ligands and a heparinlike substance as receptor. In order to investigate the role of gD in this process and subsequent transmission of infectivity to contact cells, experiments with a gD deletion mutant, heparin and a monoclonal antibody (Mab) against gD were performed. The first indication that gD is active during cell adhesion was found by the observation that the binding of gD− PrV infected cells was five times weaker than that of wild type (WT) PrV infected cells. Further evidence was given by the use of a Mab against gD. Preincubation of WT PrV infected cells with this Mab led to a reduction of the percentage adhering cells from 69% to 49%. The same Mab inhibited the heparin independent and heparin resistant binding of WT PrV infected cells indicating that gD is important during both processes. Furthermore, it was demonstrated in a plaque assay that, after contact with a monolayer, gD− PrV infected cells in suspension were able to induce plaques with an efficiency of 1%. In conclusion, we can state that beside the interaction of the ligands gB and gC with a heparinlike receptor also the interaction of gD with a receptor which differs from a heparinlike substance mediates the binding of WT PrV infected cells to uninfected cells and that gD is not essential for the subsequent cell-to-cell spread of the virus.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary. We determined the nucleotide sequence of an 11 059 bp fragment of the pseudorabies virus genome located in the right part of genomic BamHI fragment 3 and the adjacent part of BamHI fragment 6. Within this region eight open reading frames were identified whose deduced amino acid sequences exhibited homology to the UL6, UL7, UL8, UL8.5, UL9, UL10, UL11, and UL12 protein products of herpes simplex virus type 1. Transcriptional analyses indicated presence of 3′-coterminal mRNAs for genes UL8, UL8.5, and UL9 as well as for genes UL6 and UL7, respectively, while UL10 was represented by a very abundant unique transcript. Both gene arrangement and transcriptional organization within this region of the pseudorabies virus genome thus parallels the situation found in other alphaherpesviruses.Type of Medium: Electronic ResourceURL: