Search Results - (Author, Cooperation:T. Ando)

2018-06-08

American Society of Hematology (ASH)

0006-4971

1528-0020

Biology

Medicine

Immunobiology and Immunotherapy, Lymphoid Neoplasia

2011-08-06

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Adenosine Triphosphate/metabolism ; Bacillus/enzymology ; Bacterial Proton-Translocating ATPases/*chemistry/*metabolism ; Biocatalysis ; Catalytic Domain ; Hydrolysis ; *Microscopy, Atomic Force ; Protein Conformation ; Protein Structure, Quaternary ; Protein Subunits/chemistry/metabolism ; Rotation

2011-07-19

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Adherens Junctions ; Animals ; Body Patterning ; Cadherins/*metabolism ; Cell Polarity ; *Cell Shape ; Computer Simulation ; Drosophila/cytology/*embryology/genetics ; Drosophila Proteins/genetics/*metabolism ; Epithelial Cells/*cytology ; Intestines/cytology/embryology ; Models, Biological ; Morphogenesis ; Myosin Type I/genetics/*metabolism ; Rotation

2011-09-03

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Adsorption ; Biomass ; Cellobiose/metabolism ; Cellulose/chemistry/*metabolism ; Cellulose 1,4-beta-Cellobiosidase/*metabolism ; Crystallization ; Hydrolysis ; Kinetics ; Microscopy, Atomic Force ; Trichoderma/enzymology

2018-10-14

Institute of Physics (IOP)

1757-8981

1757-899X

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

2018-10-16

The American Association for Cancer Research (AACR)

1078-0432

1557-3265

Medicine

2018-06-30

American Physical Society (APS)

0556-2813

1089-490X

Physics

Nuclear Structure

2018-04-26

American Association for the Advancement of Science (AAAS)

2375-2548

Natural Sciences in General

2018-02-09

Genetics Society of America (GSA)

2160-1836

Biology

1089-7674

AIP Digital Archive

Physics

It is found that a reversed-field pinch (RFP) dynamo uniformly generates most of the toroidal flux in a RFP plasma with a high magnetic Reynolds (S) number. Hereafter, this is referred to as the global dynamo. The toroidal flux generated by the global dynamo is proportional to the plasma current. The effective inductance in a RFP plasma increases with S number and remains constant against the changing plasma current. This means that the pinch parameter aitch-theta is held constant, that is, the global dynamo has a self-organizing effect sustaining a particular RFP configuration. By comparing simulation results and analysis of magnetic fluctuations, it is confirmed that a global dynamo is generated by the nonlinear evolution of the single-helicity of the m=1 mode alone.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

Pressure measurements made by an ac bridge technique with a precision of 0.001 ppm in magnetic fields at low temperatures using a Straty–Adams type gauge are described. In order to improve the sensitivity and the long-term stability of the bridge system, coaxial cables without dielectric insulator were developed, with a small cable capacitance temperature coefficient of the impedance. This pressure measurement system has a sensitivity of dP/P∼5×10−10 and a long-term stability of dP/P∼2.4×10−9 over 18 h. This is especially useful for measurements such as electric and magnetic susceptibility measurements in magnetic fields at low temperatures requiring a high precision.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

A metallic glass, Fe43Cr25Ni20B12, which is paramagnetic at room temperature, becomes ferromagnetic under annealing near the crystallization temperature, then loses its magnetization with further annealing. This unique behavior is closely related to the precipitation of a very fine metastable body-centered-cubic phase in a nonmagnetic matrix. Since the magnetism of the annealed samples arises from very small magnetic particles, superparamagnetic behavior is observed. From the characteristic magnetization curves of superparamagnetism, the average moment and the density of the magnetic particles were estimated and found to be in good agreement with observations made by transmission electron microscopy. The tentative analyses for the sample annealed at 666 K indicate that both nucleation and growth take place in the early stage (3.5–20 h) and that nucleation ceases in the later stage (20–145 h) of the crystallization process.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

Defect structures in a homoepitaxial diamond film grown by chemical vapor deposition have been studied by cross-sectional transmission electron microscopy. Many interstitial dislocation loops are discerned in the (001) interface. The internal region grown on the (11¯1) facet comprises stacking faults and twins, while that on the (001) face contains mainly interstitial dislocation loops aligned in rows along ∼〈112〉 directions. Fe and Si impurities were detected only at the interface by analytical electron microscopy. The origin of the defects is briefly discussed. © 1996 American Institute of Physics.

Electronic Resource

1089-7666

AIP Digital Archive

Physics

The magnetohydrodynamic (MHD) activity and the discrete dynamo in high-aitch-theta reversed-field pinch (RFP) discharges are studied through comparisons with those in normal-aitch-theta RFP discharges, where aitch-theta=Bθ(a)/〈Bz〉 is the pinch parameter. In high-aitch-theta RFP discharges, the mode coupling of m=1 is enhanced by the high magnetic shear configuration, and the MHD activity is more turbulent as compared with that in normal-aitch-theta RFP discharges. Furthermore, the discrete increase of the toroidal magnetic flux is obviously observable. The increase of the toroidal magnetic flux generated by the discrete dynamo, which has an asymmetric structure in the toroidal direction, is only 1%–2% of the whole toroidal magnetic flux. The experimental results indicate that the discrete dynamo does not play an essential role in the RFP dynamo.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background ATP-sensitive K+ (KATP) channel activators produce relaxation of smooth muscle in many tissues. However, this wide range of effects restricts their clinical usefulness in bronchial asthma because of a reduction in systemic blood pressure.Methods We have now examined the effects of JTV-506, a new benzopyran derivative, on airway smooth muscle contraction and systemic blood pressure and have compared this compound with cromakalim. We measured isometric tension records from guinea-pig isolated trachea, as well as the respiratory resistance (Rrs) and systemic blood pressure in anesthetized guinea-pigs.Results JTV-506 caused a concentration-dependent inhibition of histamine-induced contraction in guinea-pig isolated tracheal smooth muscle, and was antagonized by glibenclamide. JTV-506 was 7.6-fold more potent than cromakalim. In anesthetized animals the intravenous injection of JTV-506 reduced the increase in Rrs induced by intravenous application of 5 μg/kg of histamine in a dose-dependent manner, 10μ/kg of JTV-506 resulted in 57.0 17.9% inhibition of the increase in Rrs at 10 min. The inhibitory action on Rrs disappeared after 60 min. 10μg/kg of cromakalim caused 25.4 ± 5.8% inhibition of the increase in Rrs induced by histamine at 1 min. The ED50 values for JTV-506 and cromakalim were 6.7 ± 3.5μg/kg and 60.1 ± 15.8μg/kg, respectively (P〈0.05). Cromakalim was ± 9-fold less potent in inhibiting the increased Rrs by histamine. and the inhibitory action lasted less than 10 min. The reduction of systemic blood pressure by JTV-506 and cromakalim (each at a dose of 10μg/kg iv) was 11.3% and 21.5%, respectivelyConclusion JTV-506 inhibits histamine-induced contraction of tracheal smooth muscle by activation of KATP channels. This compound is more potent and longer-lasting in the suppression of histamine-induced increases in Rrs, and is less hypotensive than cromakalim. Our results suggest that this compound merits further investigation for utility as a bronchodilator in the clinic.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

A serine protease from mite faecal extract, Dermatophagoides farinae, was purified using DEAE-Sephacel anion exchange chromatography and Supcrdex 75 pg gel chromato-graphy. The molecular weight of this protease was 34 kD on SDS-PAGE under reducing conditions. The optimal pH and temperature of the protease were 8-0 and 47 C, respectively. In addition, this protease cleaved arginyl or lysyl residue containing substrates selectively and was only inhibited by aprotinin, PUT-175, tind soy bean trypsin inhibitor and not by chymostatin, E-64 and iodoacetic acid. These results show that our purified serine protease belongs to the trypsin-type. Purified trypsin-like protease was shown to be allergenic by enzyme-linked immunosorbent assay. Antigeni-city of trypsin-like protease was completely different from those of Der f I and Der f II. Both, 20 N-terminal amino acid sequence and amino acid compositions of the purified protease were very similar to those of Der f III. Good similarities were found between trypsin-like protease and Der f III concerning physicochemical properties such as molecular weight on SDS-PAGE and ammonium sulphate solubility. Summarizing the above data, it can be concluded that a trypsin-like protease from mite faecal extract is actually the Der f III allergen and that it may be involved in the digestive process of the mite as it was found not in mite body but in mite faeces.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

A new set of allergens from Dermatophagoides pteronyssinus and D. farinae (provisionally named DPS and DF5, respectively) was isolated from the whole culture of mites. The apparent molecular weights of both allergens were shown to be 25000 on SDS-PAGE under a reducing condition and 27000 on Sephadex G-75 gel nitration chromatography. Both DP5 and DF5, as well as Der f III, possessed proteolytic activity. The results of substrate specificity and susceptibility to various protease inhibitors of DP5 and DF5 strongly suggested that they belonged to the chymotrypsin-like serine protease family. In sera from 88 mite-allergic patients, specific IgE antibodies to DP5 and/or DF5 were detected in only 41% of the sera by radio-allergosorbent test, while 90% and 93% had specific IgE antibodies to Der p I and/or Der f I and Der p II and/or Der f II, respecti vely.

Electronic Resource

1350-4177

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

1350-4177

lead tetraacetate ; sonochemical switching ; trans-β-methylstyrene

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

0003-2697

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource