Search Results - (Author, Cooperation:T. A. Waldmann)
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1Latest Papers from Table of Contents or Articles in PressR. W. DePaolo ; V. Abadie ; F. Tang ; H. Fehlner-Peach ; J. A. Hall ; W. Wang ; E. V. Marietta ; D. D. Kasarda ; T. A. Waldmann ; J. A. Murray ; C. Semrad ; S. S. Kupfer ; Y. Belkaid ; S. Guandalini ; B. Jabri
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-02-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adjuvants, Immunologic/*pharmacology ; Administration, Oral ; Adolescent ; Adult ; Animals ; Celiac Disease/chemically induced/etiology/*immunology ; Cells, Cultured ; Child ; Child, Preschool ; Coculture Techniques ; Dendritic Cells/drug effects/enzymology/immunology/metabolism ; Diet ; Forkhead Transcription Factors/metabolism ; Gliadin/administration & dosage/immunology ; Glutens/administration & dosage/*immunology ; HLA-DQ Antigens/genetics/immunology ; Humans ; Immune Tolerance/drug effects ; Inflammation/immunology ; Interleukin-12/biosynthesis/immunology/secretion ; Interleukin-15/genetics/*immunology ; Interleukin-23/immunology/secretion ; Intestinal Mucosa/cytology/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; Mitogen-Activated Protein Kinase 8/metabolism ; Phosphorylation/drug effects ; Receptors, Interleukin-12/deficiency ; T-Lymphocytes, Regulatory/cytology/drug effects/immunology/metabolism ; Tretinoin/immunology/*pharmacology ; Young AdultPublished by: -
2Latest Papers from Table of Contents or Articles in PressR. Schmitz ; R. M. Young ; M. Ceribelli ; S. Jhavar ; W. Xiao ; M. Zhang ; G. Wright ; A. L. Shaffer ; D. J. Hodson ; E. Buras ; X. Liu ; J. Powell ; Y. Yang ; W. Xu ; H. Zhao ; H. Kohlhammer ; A. Rosenwald ; P. Kluin ; H. K. Muller-Hermelink ; G. Ott ; R. D. Gascoyne ; J. M. Connors ; L. M. Rimsza ; E. Campo ; E. S. Jaffe ; J. Delabie ; E. B. Smeland ; M. D. Ogwang ; S. J. Reynolds ; R. I. Fisher ; R. M. Braziel ; R. R. Tubbs ; J. R. Cook ; D. D. Weisenburger ; W. C. Chan ; S. Pittaluga ; W. Wilson ; T. A. Waldmann ; M. Rowe ; S. M. Mbulaiteye ; A. B. Rickinson ; L. M. Staudt
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-08-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Basic Helix-Loop-Helix Transcription Factors/antagonists & ; inhibitors/genetics/metabolism ; Burkitt Lymphoma/*drug therapy/*genetics/metabolism/pathology ; Cell Cycle ; Cyclin D3/genetics/metabolism ; Cyclin-Dependent Kinase 6/metabolism ; Genes, myc/genetics ; *Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Inhibitor of Differentiation Proteins/genetics/metabolism ; *Molecular Targeted Therapy ; Neoplasm Proteins/genetics/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; RNA Interference ; Receptors, Antigen, B-Cell/metabolism ; Signal TransductionPublished by: -
3Latest Papers from Table of Contents or Articles in PressMiller, J. S., Morishima, C., McNeel, D. G., Patel, M. R., Kohrt, H. E. K., Thompson, J. A., Sondel, P. M., Wakelee, H. A., Disis, M. L., Kaiser, J. C., Cheever, M. A., Streicher, H., Creekmore, S. P., Waldmann, T. A., Conlon, K. C.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-04-04Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
4Articles: DFG German National LicensesOWEN-SCHAUB, L. ; YAGITA, M. ; TSUDO, M. ; WALDMANN, T. A. ; GRIMM, E. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesKURMAN, R. J. ; SCARDINO, P. T. ; McINTIRE, K. R. ; WALDMANN, T. A. ; JAVADPOUR, N. ; NORRIS, H. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1978Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: An immunohistologic study of AFP and HCG in malignant germ cell tumors of the testis and ovary was undertaken to correlate the type of neoplasm with the presence of the markers. Twenty-one patients with testis tumors and measured serum levels of AFP and HCG and 48 patients with ovarian tumors with no availability of serum were studied utilizing an immunoperoxidase technique. AFP was demonstrated in mononuclear embryonal carcinoma cells and in endodermal sinus tumors. HCG was identified in the syncytiotrophoblastic component of choriocarcinoma and also within syncytiotrophoblastic giant cells in embryonal carcinoma frequently and in endodermal sinus tumor and seminoma rarely. In the testis tumors there was tissue localization of HCG in 13 of 14 patients (93%) with elevated serum HCG while AFP was identified in the tumor of 10 of 14 patients (71%) with elevated AFP. Based on these findings a tentative immunohistologic classification of malignant germ cell tumors utilizing AFP and HCG was proposed. Thus, embryonal carcinoma is frequently associated with both AFP and HCG, endodermal sinus tumor with AFP and choriocarcinoma with HCG, whereas pure seminoma, dysgerminoma and teratoma are unlikely to be associated with either marker.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesKORTRIGHT, K. H. ; KAPADIA, G. G. ; LEE, S. Y. ; McINTIRE, K. R. ; WALDMANN, T. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1978Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Human alpha-fetoprotein (HuAFP) was isolated from cord blood and ascites fluid of individuals with hepatocellular carcinoma. The purification procedures employed antibody-affinity chromatography and preparative polyacrylamide gel electrophoresis (Prep PAGE). Final yields of HuAFP averaged 40% and demonstrated 99.8% purity.Physicochemical studies of HuAFP from cord blood showed a molecular weight of 70.000, pl = 4.85, Stokes radius of 2.699 nm, and valence of (H*/mol) of 11.0. Similar studies of HuAFP from ascites fluid from individuals with hepatocellular carcinoma showed a molecular weight of 69.000, pl = 4.80, Stokes radius of 2.798 nm. and valence of (H*/mol) of 12.2. These AFP molecules isolated from separate origins demonstrated no significant physicochemical or antigenic differences. Assessment of potency and purity of these preparations were made by Lowry protein analyses, radioimmunoassay (RIA) to AFP and albumin. PAGE, SDS-PAGE, and isoelectric focusing patterns on polyacrylamide gel electrophoresis.The sensitivity of the RIA for human AFP was increased by the use of high affinity goat anti-AFP. To minimize non-specific serum effects, human serum, from which AFP had been specifically removed by affinity chromatography was added to each tube in the standard dose response curve. The sensitivity of the assay was 0.7 ng/ml.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1569-8041Keywords: adult T-cell leukemia ; anti-Tac mAb ; cytokine ; HTLV-I ; interleukin-2 ; interleukin-15Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Background:Cytokine receptors are exceptionally valuable targetsfor immunotherapy. For example, the high affinity IL-2 receptor is expressedby abnormal T cells in patients with certain lymphoid malignancies orautoimmune disorders and in individuals rejecting allografts whereas it is notexpressed by normal resting cells. Design:To exploit this difference in receptor expression innormal resting cells and leukemic cells we have introduced different forms ofIL-2 receptor directed therapy including an unmodified murine antibody to theα subunit of the IL-2 receptor (anti-Tac), humanized anti-Tac as well asthis antibody armed with truncated Pseudomonasexotoxin or α- andβ-emitting radionuclides (e.g., 211At and 90Y). Inparticular, unmodified murine anti-Tac was used in the therapy ofHTLV-I-associated adult T-cell leukemia (ATL). Results:Six of nineteen patients treated with this antibodyunderwent a partial (four) or complete (two) remission. In a subsequentclinical trial involving anti-Tac armed with 90Y over 50%of the patients with ATL treated underwent a partial or complete remission. Conclusions:New agents under development include humanizedantibodies directed toward shared cytokine receptors such as IL-2/15Rβused by both IL-2 and IL-15 as well as to a shared signal transduction elementJak3 utilized by the T-cell stimulatory cytokines IL-2, IL-4, IL-7, IL-9 andIL-15. Thus our emerging understanding of cytokine receptors and theirsignaling pathways taken in conjunction with the ability to produce humanizedantibodies armed with radionuclides or toxins are providing novel perspectivesfor the treatment of leukemia and lymphoma.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesMingari, M. C. ; Gerosa, F. ; Carra, G. ; Accolla, R. S. ; Moretta, A. ; Zubler, R. H. ; Waldmann, T. A. ; Moretta, L.
[s.l.] : Nature Publishing Group
Published 1984Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Fig. I B-cell growth factor activity of human IL-2. BCGF activity was measured using the assay system described by Muraguchi and Fauci9, with minor modifications10. This system is based on cultur-ing B cells for 72 h with formaldehyde-killed S. aureus Cowan strain I before addition of tested growth ...Type of Medium: Electronic ResourceURL: