Search Results - (Author, Cooperation:T. A. Rando)
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1Latest Papers from Table of Contents or Articles in PressJ. T. Rodgers ; K. Y. King ; J. O. Brett ; M. J. Cromie ; G. W. Charville ; K. K. Maguire ; C. Brunson ; N. Mastey ; L. Liu ; C. R. Tsai ; M. A. Goodell ; T. A. Rando
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-05-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Cycle/genetics/*physiology ; Cells, Cultured ; G0 Phase/genetics/*physiology ; Gene Expression Profiling ; Gene Expression Regulation ; Male ; Mice ; Mice, Inbred C57BL ; Multiprotein Complexes/genetics/*metabolism ; Muscle, Skeletal/*cytology/injuries/metabolism ; Regeneration/physiology ; Satellite Cells, Skeletal Muscle/*cytology/metabolism ; TOR Serine-Threonine Kinases/genetics/*metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressS. A. Villeda ; J. Luo ; K. I. Mosher ; B. Zou ; M. Britschgi ; G. Bieri ; T. M. Stan ; N. Fainberg ; Z. Ding ; A. Eggel ; K. M. Lucin ; E. Czirr ; J. S. Park ; S. Couillard-Despres ; L. Aigner ; G. Li ; E. R. Peskind ; J. A. Kaye ; J. F. Quinn ; D. R. Galasko ; X. S. Xie ; T. A. Rando ; T. Wyss-Coray
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-09-03Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging ; Animals ; Chemokine CCL11/blood/cerebrospinal fluid/metabolism/pharmacology ; Chemokines/*blood/cerebrospinal fluid/*metabolism ; Female ; Learning/drug effects/*physiology ; Learning Disorders/blood/cerebrospinal fluid/physiopathology ; Male ; Memory Disorders/blood/cerebrospinal fluid/physiopathology ; Mice ; Mice, Inbred C57BL ; Neurogenesis/drug effects/*physiology ; Parabiosis ; Plasma/chemistry ; Time FactorsPublished by: -
3Latest Papers from Table of Contents or Articles in PressM. A. Goodell ; T. A. Rando
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-01-20Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adult Stem Cells/*physiology ; Aging/*physiology ; Animals ; Cell Aging ; Epigenesis, Genetic ; Genetic Drift ; *Health ; Humans ; Mice ; Mutation ; Organ Specificity ; Selection, GeneticPublished by: -
4Latest Papers from Table of Contents or Articles in PressT. H. Cheung ; N. L. Quach ; G. W. Charville ; L. Liu ; L. Park ; A. Edalati ; B. Yoo ; P. Hoang ; T. A. Rando
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-02-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Cycle/drug effects/*genetics ; Cell Differentiation/drug effects ; Cell Lineage/drug effects ; Cell Survival/drug effects/genetics ; DEAD-box RNA Helicases/genetics/metabolism ; DNA-Binding Proteins/genetics ; *Gene Expression Regulation/drug effects ; Gene Knockdown Techniques ; Mice ; Mice, Inbred C57BL ; MicroRNAs/*genetics ; Myoblasts/*cytology/drug effects/*metabolism ; Oligonucleotide Array Sequence Analysis ; Oncogene Proteins/genetics ; Ribonuclease III/genetics/metabolism ; Satellite Cells, Skeletal Muscle/cytology/drug effects/metabolism ; Tamoxifen/pharmacology ; Transcription, Genetic/drug effectsPublished by: -
5Latest Papers from Table of Contents or Articles in PressLeeman, D. S., Hebestreit, K., Ruetz, T., Webb, A. E., McKay, A., Pollina, E. A., Dulken, B. W., Zhao, X., Yeo, R. W., Ho, T. T., Mahmoudi, S., Devarajan, K., Passegue, E., Rando, T. A., Frydman, J., Brunet, A.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-03-16Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Cell BiologyPublished by: -
6Articles: DFG German National LicensesDhawan, J. ; Rando, T. A. ; Elson, S. E. ; Lee, F. ; Stanley, E. R. ; Blau, H. M.
Springer
Published 1996Staff ViewISSN: 1572-9931Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The osteopetrotic (op/op) mouse lacks colony stimulating factor-1 (CSF-1) due to an inactivating mutation in the CSF-1 gene. Intramuscular transplantation of engineered myoblasts was used to introduce CSF-1 into the circulation ofop/op mice. The CSF-1 cDNA was introduced into C2C12 mouse myoblasts in culture using retroviral mediated gene transfer. Upon transplantation into the skeletal muscle of mutant mice, physiological levels of the cytokine were achieved systemically and elicited a biological response: circulating monocytes were induced. However, both circulating CSF-1 levels and the induction of monocytes were transient. Analysis of the site of cell transplantation revealed local changes that may account for the transience of serum cytokine levels. Macrophage markers were induced in muscle tissue implanted with CSF-1 expressing myoblasts:c-fms, the CSF-1 receptor as well as the lineage-restricted antigen F4/80. We propose that in addition to CSF-1 clearance by Kupffer cells of the liver, macrophages that accumulated at the site of cell transplantation bound the CSF-1 produced by the muscle cell transplants, precluding the sustained release of this cytokine into the systemic circulation. Our studies also revealed that damage to muscle caused during cell transplantation or by freeze injury resulted in the accumulation of macrophages inop/op mouse muscle tissue. Indeed,op/op mice were fully capable of regenerating injured muscle suggesting the presence of as yet unidentified CSF-1-independent factors capable of generating macrophages that presumably participate in tissue remodeling in this cytokine-deficient mouse.Type of Medium: Electronic ResourceURL: