Search Results - (Author, Cooperation:Spiro)
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1Staff View Availability
Person(s): Anderson, Richard C.; Spiro, R.J.; Montague, W.E.Type of Medium: UnknownPages: 448 S.ISBN: 047099293XLanguage: EnglishNote: Conference on Schooling and the Acquisition of Knowledge; (San Diego): 1975.11. -
2Staff View
ISSN: 0003-9861Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
3Staff View
ISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
4Staff View
ISSN: 0022-4731Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
5Agnew, Spiro T. 〈Vice President Spiro〉
Washington, D.C. : Periodicals Archive Online (PAO)
Published 1971Staff ViewISSN: 0018-7194Topics: Political ScienceURL: -
6Glucose entry into rat mesangial cells is mediated by both Na+-coupled and facilitative transportersStaff View
ISSN: 1432-0428Keywords: Key words Na+-coupled glucose transporter ; facilitative glucose transporters ; mesangial cells ; glomerulopathy ; phlorizin.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Since previous studies from our laboratory have demonstrated that increased glucose consumption by cultured rat mesangial cells is accompanied by an accelerated production of type IV and type VI collagen, we have now examined the manner by which glucose is transported into these cells. A progressive stimulation of glucose uptake by the mesangial cells was observed with increasing concentrations of NaCl so that at 145 mmol/l about twice as much glucose entered the cells as in its absence (substituted by choline chloride). Moreover, since phlorizin inhibited the NaCl-promoted uptake of glucose and this salt was found to increase the accumulation of α-methylglucoside in a manner which could not be duplicated by KCl or mannitol, both Na+-coupled and facilitative glucose transporters appeared to be present in the cells. Km values of 1.93 mmol/l and 1.36 mmol/l were determined for the co-transport and facilitated transport pathways, respectively, with their Vmax being 29.5 and 18.0 nmol · mg protein− 1· h− 1. Both uptake activities were found to be down-regulated by exposure of the cells to high glucose and furthermore the Na+-dependent transport could no longer be detected after about 12 passages of the cells. Hybridization of mesangial cell mRNA with cDNA probes revealed transcripts for the Na+/glucose co-transporter as well as GLUT1 and to a lesser extent GLUT4. The identification of the co-transporter in these non-polarized cells is pertinent to an understanding of the intracellular signals which can lead to the development of the diabetic glomerular lesions; in the hyperglycaemic state this carrier provides an additional route for accelerated glucose entry and furthermore by the attendant increase in Na+ flux may bring about an alteration in the ionic composition of the cell. [Diabetologia (1995) 38: 291–297]Type of Medium: Electronic ResourceURL: -
7Glucose entry into rat mesangial cells is mediated by both Na+-coupled and facilitative transportersStaff View
ISSN: 1432-0428Keywords: Na+-coupled glucose transporter ; facilitative glucose transporters ; mesangial cells ; glomerulopathy ; phlorizinSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Since previous studies from our laboratory have demonstrated that increased glucose consumption by cultured rat mesangial cells is accompanied by an accelerated production of type IV and type VI collagen, we have now examined the manner by which glucose is transported into these cells. A progressive stimulation of glucose uptake by the mesangial cells was observed with increasing concentrations of NaCl so that at 145 mmol/l about twice as much glucose entered the cells as in its absence (substituted by choline chloride). Moreover, since phlorizin inhibited the NaCl-promoted uptake of glucose and this salt was found to increase the accumulation of α-methylglucoside in a manner which could not be duplicated by KCl or mannitol, both Na+-coupled and facilitative glucose transporters appeared to be present in the cells. Km values of 1.93 mmol/l and 1.36 mmol/l were determined for the co-transport and facilitated transport pathways, respectively, with their Vmax being 29.5 and 18.0 nmol·mg protein−1· h−1. Both uptake activities were found to be down-regulated by exposure of the cells to high glucose and furthermore the Na+-dependent transport could no longer be detected after about 12 passages of the cells. Hybridization of mesangial cell mRNA with cDNA probes revealed transcripts for the Na+/glucose co-transporter as well as GLUT1 and to a lesser extent GLUT4. The identification of the co-transporter in these non-polarized cells is pertinent to an understanding of the intracellular signals which can lead to the development of the diabetic glomerular lesions; in the hyperglycaemic state this carrier provides an additional route for accelerated glucose entry and furthermore by the attendant increase in Na+ flux may bring about an alteration in the ionic composition of the cell.Type of Medium: Electronic ResourceURL: -
8Dong, Zhizhong ; Zuber, Christian ; Spiro, Mary Jane ; Spiro, Robert G. ; Roth, Jürgen
Springer
Published 2000Staff ViewISSN: 1432-119XKeywords: Endomannosidase Immunohistochemistry Endothelia RatSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. Asparagine-linked oligosaccharides of glycoproteins are subject to a series of trimming reactions by glucosidases and mannosidases in the endoplasmic reticulum which result in the removal of all three glucose residues and several of the nine mannose residues. At present, endomannosidase represents the only processing enzyme which cleaves internally and provides an alternate deglucosylation pathway. However, in contrast to the endoplasmic reticulum residential proteins glucosidase I and II, endomannosidase is primarily situated in the Golgi apparatus of rat liver hepatocytes and hepatocyte cell lines. We have performed a confocal immunohistochemical study to investigate endomannosidase in various rat tissues and used a monoclonal antibody against Golgi mannosidase II as a marker for the Golgi apparatus. Although immunofluorescence for both endomannosidase and Golgi mannosidase II was detectable in the epithelia of many tissues, renal proximal tubular cells, cortex and medulla of adrenal gland, gastric mucosa, and Leydig cells of testis were unreactive for endomannosidase. Furthermore, the endothelia in all studied tissues were unreactive for endomannosidase but positive for Golgi mannosidase II. It is concluded that by immunohistochemistry endomannosidase exhibits a cell type-specific expression in rat tissues.Type of Medium: Electronic ResourceURL: -
9Staff View
Type of Medium: articlePublication Date: 2003Keywords: Globalisierung ; Bologna-Prozess ; Albanien ; AuslandIn: Higher education in Europe, Bd. 38 (2003) H. 3, S. 311-313, 0379-7724Language: English -
10Staff View
Type of Medium: bookPublication Date: 2011Keywords: Planung ; SchulentwicklungLanguage: English -
11Staff View
Type of Medium: articlePublication Date: 2005Keywords: Frühbeginn ; Grundschule ; Unterrichtsstunde ; Gedicht ; Schreibübung ; Fremdsprachenunterricht ; Englischunterricht ; SchreibenIn: Primary English, Bd. 3 (2005) H. 1, S. 23-, 1610-6784Language: EnglishNote: Anmerkungen -
12Staff View
Type of Medium: bookPublication Date: 2006Keywords: Kommunikation ; Lehrer ; Lehrerhandbuch ; Kommunikative KompetenzLanguage: English -
13Staff View
Type of Medium: articlePublication Date: 1982Keywords: Motivation ; Sozialplanung ; Sozialpolitik ; Sozialpädagogik ; SozialpädagogeIn: Unsere Jugend, Bd. 34 (1982) H. 1, S. 6-11, 0342-5258Language: German -
14Staff View
Type of Medium: OnlinePublication Date: 2022Keywords: Lehrmittel ; Schulbuch ; Sprachunterricht ; FremdsprachenunterrichtIn: The Routledge handbook of materials development for language teaching., Abingdon, Oxon: Routledge, Taylor & Francis Group (2022), S. 475-487, 978-0-8153-8257-7978-1-000-53973-8978-1-000-53978-3978-1-003-26247-3978-1-032-20152-8Language: EnglishNote: Literaturangaben S. 486-487 -
15Staff View
Type of Medium: articlePublication Date: 2014Keywords: Internationalität ; StudentenschaftIn: Higher education quarterly, Bd. 68 (2014) H. 1, S. 65-84, 0263-97690951-52241468-2273Language: English -
16Staff View
Type of Medium: bookPublication Date: 2005Keywords: Personal Computer ; Lernen ; Motivation ; Computer ; Hochschulschrift ; Nutzung ; Alter Mensch ; Rentner ; DeutschlandLanguage: GermanNote: Tabellen 31, Zugl. Bremen, Univ., Diss., 2005. -
17Morgan B. Vaughn, Jianyu Zhang, Thomas G. Spiro, R. Brian Dyer and Judith P. Klinman
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-01-12Publisher: American Chemical Society (ACS)Print ISSN: 0002-7863Electronic ISSN: 1520-5126Topics: Chemistry and PharmacologyPublished by: -
18Tovy, A., Spiro, A., McCarthy, R., Shipony, Z., Aylon, Y., Allton, K., Ainbinder, E., Furth, N., Tanay, A., Barton, M., Oren, M.
Cold Spring Harbor Laboratory Press
Published 2018Staff ViewPublication Date: 2018-10-02Publisher: Cold Spring Harbor Laboratory PressPrint ISSN: 0890-9369Topics: BiologyPublished by: -
19Rajendran, S., Benna, C., Monticelli, H., Spiro, G., Menin, C., Mocellin, S.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-03-09Publisher: BMJ Publishing GroupPrint ISSN: 0017-5749Electronic ISSN: 1468-3288Topics: MedicineKeywords: GutPublished by: -
20J. M. Berg ; N. Bhalla ; P. E. Bourne ; M. Chalfie ; D. G. Drubin ; J. S. Fraser ; C. W. Greider ; M. Hendricks ; C. Jones ; R. Kiley ; S. King ; M. W. Kirschner ; H. M. Krumholz ; R. Lehmann ; M. Leptin ; B. Pulverer ; B. Rosenzweig ; J. E. Spiro ; M. Stebbins ; C. Strasser ; S. Swaminathan ; P. Turner ; R. D. Vale ; K. VijayRaghavan ; C. Wolberger
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-05-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: