Search Results - (Author, Cooperation:Spindler)
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1Printed BooksStaff View Availability
Person(s): Spindler, Detlef [Hrsg.]Type of Medium: BookPages: XXII, 154 S., graph. Darst.Series Statement: Blickpunkt Hochschuldidaktik 18Language: German -
2Printed BooksStaff View Availability
Person(s): Spindler, Herbert [Verfasser]Type of Medium: BookPages: 334 S., graph. Darst.ISBN: 3768465829Language: German -
3Printed BooksStaff View Availability
Person(s): Deutsche Forschungsgemeinschaft; Spindler, MichaelType of Medium: UnknownPages: 211 S.ISBN: 352731251XLanguage: German -
4Articles: DFG German National LicensesStaff View
ISSN: 0016-6480Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0020-1790Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0020-1790Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesLondershausen, M. ; Kammann, V. ; Spindler-Barth, M. ; Spindler, K.-D. ; Thomas, H.
Amsterdam : ElsevierStaff ViewISSN: 0020-1790Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0022-1910Keywords: Chironomus tentans cell line ; ecdysteroid ''receptor'' ; ecdysteroids ; high affinity binding proteinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesSpindler-Barth, M. ; Krahwinkel, R. ; Kanmann, V. ; Turberg, A. ; Lezzi, M. ; Spindler, K.-D.
Amsterdam : ElsevierStaff ViewISSN: 0022-4731Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesSpindler, K.-D. ; Hamann, A. ; Spindler-Barth, M. ; Ihne, A. ; Beckers, C. ; Emmerich, H.
Amsterdam : ElsevierStaff ViewISSN: 0039-128XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesFretz, A. ; Lubbert, A. ; Markmann-Mulisch, U. ; Spindler-Barth, M. ; Spindler, K.-D.
Amsterdam : ElsevierStaff ViewISSN: 0965-1748Keywords: 20-OH-ecdysone ; Cell line ; Chironomus ; Insect ; Moulting hormone ; Protein synthesis ; TranscriptionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-1904Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0003-5459Topics: Ethnic SciencesNotes: COMPTES RENDUS/BOOK REVIEWSURL: -
14Articles: DFG German National LicensesSpindler-Barth, Margarethe ; Schmidt, Heinrich ; Drews, Ulrich ; Spindler, Klaus -Dieter
Springer
Published 1988Staff ViewISSN: 1432-041XKeywords: Acetylcholinesterase ; Chironomus cell line ; EcdysteroidSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary An epithelial cell line from Chironomus tentans exhibits acetylcholinesterase activity (specific activity 0.05–0.2 nkat/mg protein), which rises 30− to 40-fold after addition of 10−6 M 20-OH-ecdysone. The first visible increase occurs after 4 days of incubation with hormone. The enzyme has an apparent K m of 2.3±0.2×10−4 M for acetylthiocholine iodide as substrate and is inhibited by eserine and BW284 C51 (50% inhibition at 5×10−7 M for both inhibitiors) as well as by high concentrations of substrate, but not by tetraisopropylpyrophosphamide. The sensitivity against inhibitors is the same in extracts from hormone-treated cells and from controls. The cholinesterase activity correlates with morphological changes (shape and cell arrangement) and is indepenent of neuronal differentiation. We therefore propose a function for this activity during morphogenesis.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-1793Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Chitinase andN-acetyl-β-D-glucosaminidase activity were quantified inPalaemon serratus (Pennant) integument and midgut gland during the moulting cycle. Studies were performed on specimens collected near Concarneau, France, in July 1989. The changes in specific activity are different in the two organs: in the midgut gland enzymatic activity is high throughout the whole moulting cycle with a weak peak at the early premoult Stage D1′, whereas in the integument the activity of both enzymes is very low throughout post- and intermoult stages and rises only after premoult Stage D1′. The highest specific activity is reached in D1‴ for chitinase and somewhat earlier (D1″) forN-acetyl-β-D-glucosaminidase. The increase in specific chitinolytic activity coincides with an increase in ecdysteroids.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-1955Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesSpindler, Klaus-Dieter ; Spindler-Barth, Margarethe ; Londershausen, Michael
Springer
Published 1990Staff ViewISSN: 1432-1955Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Chitin is an important component of the exoskeleton of arthropods and of the egg shell in nematodes, but it does not occur in vertebrates. Therefore, it represents a useful target for drugs against ectoparasitic crustaceans, insects and endoparasitic nematodes. In this review we describe the basic characteristics of chitin, chitin synthesis and degradation and the hormonal regulation of chitin metabolism. Substances interfering with chitin metabolism like benzoylphenyl-urea derivatives but also some recently detected compounds are described. The necessity for a more detailed understanding of chitin metabolism and the establishment of better model systems, like e.g. chitin producing insect cell lines, is stressed and some examples are given in this review.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesMehlhorn, H. ; Spindler, K. D. ; Spindler-Barth, M. ; Walldorf, V. ; Andrews, P. ; Thomas, H.
Springer
Published 1986Staff ViewISSN: 1432-1955Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesOn the action of RH 5849, a nonsteroidal ecdysteroid agonist, on a cell line from Chironomus tentansSpindler-Barth, Margarethe ; Turberg, Andreas ; Spindler, Klaus-Dieter
New York, NY [u.a.] : Wiley-Blackwell
Published 1991Staff ViewISSN: 0739-4462Keywords: receptor ; antibody ; chitin ; acetylcholinesterase ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyNotes: RH 5849 competes with 3H-ponasterone A for ecdysteroid binding sites in Chironomus tentans cells with an about fourfold lower relative affinity as compared to 20-OH-ecydsone. It does not interfere with glucocorticoid and estrogen binding sites in vertebrates. It is also not recognized by an ecdysteroid antibody. RH 5849 exerts typical morphological and physiological effects ascribed to the action of 20-OH-ecdysone on C. tentans cells, namely an increase in acetylcholinesterase activity and an inhibition of chitin synthesis.Additional Material: 6 Ill.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesLudwig, Monika ; Spindler-Barth, Margarethe ; Spindler, Klaus-Dieter
New York, NY [u.a.] : Wiley-Blackwell
Published 1991Staff ViewISSN: 0739-4462Keywords: chitin synthesis ; cell line ; Chironomus tentans ; insect ; proteolytic activation ; allosamidin ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyNotes: Homogenates of Chironomus cells synthesize chitin as effectively as intact cells. Chitin is produced in a dose-dependent manner, when GlcN, GlcNAc, or UDP-GlcNAc is used as precursor. Due to the lability of UDP-GlcNAc incorporation of this substrate is underestimated. No allosteric effect is observed when GlcN or GlcNAc is used as a substrate. Chitin synthesis is stimulated by Mg2+ and inhibited by uridine monophosphate (UMP), uridine diphosphate (UDP), and uridine triphosphate (UTP). The apparent temperature optimum is 30°C, the apparent pH optimum is 5.5-6. Addition of the chitinase inhibitor allosamidin does not enhance chitin synthesis significantly. The time course of chitin formation reveals a lag period of about 12 h, which can be overcome by trypsin treatment. Addition of protease inhibitors prevents chitin synthesis.Additional Material: 10 Ill.Type of Medium: Electronic ResourceURL: