Search Results - (Author, Cooperation:S. Zimmer)

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  1. 1
    Staff View
    Publication Date:
    2018-07-11
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    0556-2821
    Electronic ISSN:
    1089-4918
    Topics:
    Physics
    Keywords:
    Experiments in gravity, cosmology, cosmic rays
    Published by:
    http://www.aps.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    H. J. Pletsch ; L. Guillemot ; H. Fehrmann ; B. Allen ; M. Kramer ; C. Aulbert ; M. Ackermann ; M. Ajello ; A. de Angelis ; W. B. Atwood ; L. Baldini ; J. Ballet ; G. Barbiellini ; D. Bastieri ; K. Bechtol ; R. Bellazzini ; A. W. Borgland ; E. Bottacini ; T. J. Brandt ; J. Bregeon ; M. Brigida ; P. Bruel ; R. Buehler ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; P. A. Caraveo ; J. M. Casandjian ; C. Cecchi ; O. Celik ; E. Charles ; R. C. Chaves ; C. C. Cheung ; J. Chiang ; S. Ciprini ; R. Claus ; J. Cohen-Tanugi ; J. Conrad ; S. Cutini ; F. D'Ammando ; C. D. Dermer ; S. W. Digel ; P. S. Drell ; A. Drlica-Wagner ; R. Dubois ; D. Dumora ; C. Favuzzi ; E. C. Ferrara ; A. Franckowiak ; Y. Fukazawa ; P. Fusco ; F. Gargano ; N. Gehrels ; S. Germani ; N. Giglietto ; F. Giordano ; M. Giroletti ; G. Godfrey ; I. A. Grenier ; M. H. Grondin ; J. E. Grove ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; P. R. den Hartog ; M. Hayashida ; E. Hays ; A. B. Hill ; X. Hou ; R. E. Hughes ; G. Johannesson ; M. S. Jackson ; T. Jogler ; A. S. Johnson ; W. N. Johnson ; J. Kataoka ; M. Kerr ; J. Knodlseder ; M. Kuss ; J. Lande ; S. Larsson ; L. Latronico ; M. Lemoine-Goumard ; F. Longo ; F. Loparco ; M. N. Lovellette ; P. Lubrano ; F. Massaro ; M. Mayer ; M. N. Mazziotta ; J. E. McEnery ; J. Mehault ; P. F. Michelson ; W. Mitthumsiri ; T. Mizuno ; M. E. Monzani ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; T. Nakamori ; R. Nemmen ; E. Nuss ; M. Ohno ; T. Ohsugi ; N. Omodei ; M. Orienti ; E. Orlando ; F. de Palma ; D. Paneque ; J. S. Perkins ; F. Piron ; G. Pivato ; T. A. Porter ; S. Raino ; R. Rando ; P. S. Ray ; M. Razzano ; A. Reimer ; O. Reimer ; T. Reposeur ; S. Ritz ; R. W. Romani ; C. Romoli ; D. A. Sanchez ; P. M. Saz Parkinson ; A. Schulz ; C. Sgro ; E. do Couto e Silva ; E. J. Siskind ; D. A. Smith ; G. Spandre ; P. Spinelli ; D. J. Suson ; H. Takahashi ; T. Tanaka ; J. B. Thayer ; J. G. Thayer ; D. J. Thompson ; L. Tibaldo ; M. Tinivella ; E. Troja ; T. L. Usher ; J. Vandenbroucke ; V. Vasileiou ; G. Vianello ; V. Vitale ; A. P. Waite ; B. L. Winer ; K. S. Wood ; M. Wood ; Z. Yang ; S. Zimmer
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-11-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    M. Ackermann ; M. Ajello ; A. Allafort ; L. Baldini ; J. Ballet ; G. Barbiellini ; M. G. Baring ; D. Bastieri ; K. Bechtol ; R. Bellazzini ; R. D. Blandford ; E. D. Bloom ; E. Bonamente ; A. W. Borgland ; E. Bottacini ; T. J. Brandt ; J. Bregeon ; M. Brigida ; P. Bruel ; R. Buehler ; G. Busetto ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; P. A. Caraveo ; J. M. Casandjian ; C. Cecchi ; O. Celik ; E. Charles ; S. Chaty ; R. C. Chaves ; A. Chekhtman ; C. C. Cheung ; J. Chiang ; G. Chiaro ; A. N. Cillis ; S. Ciprini ; R. Claus ; J. Cohen-Tanugi ; L. R. Cominsky ; J. Conrad ; S. Corbel ; S. Cutini ; F. D'Ammando ; A. de Angelis ; F. de Palma ; C. D. Dermer ; E. do Couto e Silva ; P. S. Drell ; A. Drlica-Wagner ; L. Falletti ; C. Favuzzi ; E. C. Ferrara ; A. Franckowiak ; Y. Fukazawa ; S. Funk ; P. Fusco ; F. Gargano ; S. Germani ; N. Giglietto ; P. Giommi ; F. Giordano ; M. Giroletti ; T. Glanzman ; G. Godfrey ; I. A. Grenier ; M. H. Grondin ; J. E. Grove ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; M. Hayashida ; K. Hayashi ; E. Hays ; J. W. Hewitt ; A. B. Hill ; R. E. Hughes ; M. S. Jackson ; T. Jogler ; G. Johannesson ; A. S. Johnson ; T. Kamae ; J. Kataoka ; J. Katsuta ; J. Knodlseder ; M. Kuss ; J. Lande ; S. Larsson ; L. Latronico ; M. Lemoine-Goumard ; F. Longo ; F. Loparco ; M. N. Lovellette ; P. Lubrano ; G. M. Madejski ; F. Massaro ; M. Mayer ; M. N. Mazziotta ; J. E. McEnery ; J. Mehault ; P. F. Michelson ; R. P. Mignani ; W. Mitthumsiri ; T. Mizuno ; A. A. Moiseev ; M. E. Monzani ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; T. Nakamori ; R. Nemmen ; E. Nuss ; M. Ohno ; T. Ohsugi ; N. Omodei ; M. Orienti ; E. Orlando ; J. F. Ormes ; D. Paneque ; J. S. Perkins ; M. Pesce-Rollins ; F. Piron ; G. Pivato ; S. Raino ; R. Rando ; M. Razzano ; S. Razzaque ; A. Reimer ; O. Reimer ; S. Ritz ; C. Romoli ; M. Sanchez-Conde ; A. Schulz ; C. Sgro ; P. E. Simeon ; E. J. Siskind ; D. A. Smith ; G. Spandre ; P. Spinelli ; F. W. Stecker ; A. W. Strong ; D. J. Suson ; H. Tajima ; H. Takahashi ; T. Takahashi ; T. Tanaka ; J. G. Thayer ; J. B. Thayer ; D. J. Thompson ; S. E. Thorsett ; L. Tibaldo ; O. Tibolla ; M. Tinivella ; E. Troja ; Y. Uchiyama ; T. L. Usher ; J. Vandenbroucke ; V. Vasileiou ; G. Vianello ; V. Vitale ; A. P. Waite ; M. Werner ; B. L. Winer ; K. S. Wood ; M. Wood ; R. Yamazaki ; Z. Yang ; S. Zimmer
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-02-16
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    L. A. T. C. Fermi ; M. Ackermann ; M. Ajello ; J. Ballet ; G. Barbiellini ; D. Bastieri ; A. Belfiore ; R. Bellazzini ; B. Berenji ; R. D. Blandford ; E. D. Bloom ; E. Bonamente ; A. W. Borgland ; J. Bregeon ; M. Brigida ; P. Bruel ; R. Buehler ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; P. A. Caraveo ; E. Cavazzuti ; C. Cecchi ; O. Celik ; E. Charles ; S. Chaty ; A. Chekhtman ; C. C. Cheung ; J. Chiang ; S. Ciprini ; R. Claus ; J. Cohen-Tanugi ; S. Corbel ; R. H. Corbet ; S. Cutini ; A. de Luca ; P. R. den Hartog ; F. de Palma ; C. D. Dermer ; S. W. Digel ; E. do Couto e Silva ; D. Donato ; P. S. Drell ; A. Drlica-Wagner ; R. Dubois ; G. Dubus ; C. Favuzzi ; S. J. Fegan ; E. C. Ferrara ; W. B. Focke ; P. Fortin ; Y. Fukazawa ; S. Funk ; P. Fusco ; F. Gargano ; D. Gasparrini ; N. Gehrels ; S. Germani ; N. Giglietto ; F. Giordano ; M. Giroletti ; T. Glanzman ; G. Godfrey ; I. A. Grenier ; J. E. Grove ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; M. Hayashida ; E. Hays ; A. B. Hill ; R. E. Hughes ; G. Johannesson ; A. S. Johnson ; T. J. Johnson ; T. Kamae ; H. Katagiri ; J. Kataoka ; M. Kerr ; J. Knodlseder ; M. Kuss ; J. Lande ; F. Longo ; F. Loparco ; M. N. Lovellette ; P. Lubrano ; M. N. Mazziotta ; J. E. McEnery ; P. F. Michelson ; W. Mitthumsiri ; T. Mizuno ; C. Monte ; M. E. Monzani ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; T. Nakamori ; M. Naumann-Godo ; J. P. Norris ; E. Nuss ; M. Ohno ; T. Ohsugi ; A. Okumura ; N. Omodei ; E. Orlando ; M. Ozaki ; D. Paneque ; D. Parent ; M. Pesce-Rollins ; M. Pierbattista ; F. Piron ; G. Pivato ; T. A. Porter ; S. Raino ; R. Rando ; M. Razzano ; A. Reimer ; O. Reimer ; S. Ritz ; R. W. Romani ; M. Roth ; P. M. Saz Parkinson ; C. Sgro ; E. J. Siskind ; G. Spandre ; P. Spinelli ; D. J. Suson ; H. Takahashi ; T. Tanaka ; J. G. Thayer ; J. B. Thayer ; D. J. Thompson ; L. Tibaldo ; M. Tinivella ; D. F. Torres ; G. Tosti ; E. Troja ; Y. Uchiyama ; T. L. Usher ; J. Vandenbroucke ; G. Vianello ; V. Vitale ; A. P. Waite ; B. L. Winer ; K. S. Wood ; M. Wood ; Z. Yang ; S. Zimmer ; M. J. Coe ; F. Di Mille ; P. G. Edwards ; M. D. Filipovic ; J. L. Payne ; J. Stevens ; M. A. Torres
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-01-17
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    M. Ackermann ; M. Ajello ; A. Allafort ; L. Baldini ; J. Ballet ; G. Barbiellini ; D. Bastieri ; A. Belfiore ; R. Bellazzini ; B. Berenji ; R. D. Blandford ; E. D. Bloom ; E. Bonamente ; A. W. Borgland ; E. Bottacini ; M. Brigida ; P. Bruel ; R. Buehler ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; P. A. Caraveo ; J. M. Casandjian ; C. Cecchi ; A. Chekhtman ; C. C. Cheung ; J. Chiang ; S. Ciprini ; R. Claus ; J. Cohen-Tanugi ; A. de Angelis ; F. de Palma ; C. D. Dermer ; E. S. E. do Couto ; P. S. Drell ; D. Dumora ; C. Favuzzi ; S. J. Fegan ; W. B. Focke ; P. Fortin ; Y. Fukazawa ; P. Fusco ; F. Gargano ; S. Germani ; N. Giglietto ; F. Giordano ; M. Giroletti ; T. Glanzman ; G. Godfrey ; I. A. Grenier ; L. Guillemot ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; M. Hayashida ; K. Hayashi ; E. Hays ; G. Johannesson ; A. S. Johnson ; T. Kamae ; H. Katagiri ; J. Kataoka ; M. Kerr ; J. Knodlseder ; M. Kuss ; J. Lande ; L. Latronico ; S. H. Lee ; F. Longo ; F. Loparco ; B. Lott ; M. N. Lovellette ; P. Lubrano ; P. Martin ; M. N. Mazziotta ; J. E. McEnery ; J. Mehault ; P. F. Michelson ; W. Mitthumsiri ; T. Mizuno ; C. Monte ; M. E. Monzani ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; M. Naumann-Godo ; P. L. Nolan ; J. P. Norris ; E. Nuss ; T. Ohsugi ; A. Okumura ; E. Orlando ; J. F. Ormes ; M. Ozaki ; D. Paneque ; D. Parent ; M. Pesce-Rollins ; M. Pierbattista ; F. Piron ; M. Pohl ; D. Prokhorov ; S. Raino ; R. Rando ; M. Razzano ; T. Reposeur ; S. Ritz ; P. M. Parkinson ; C. Sgro ; E. J. Siskind ; P. D. Smith ; P. Spinelli ; A. W. Strong ; H. Takahashi ; T. Tanaka ; J. G. Thayer ; J. B. Thayer ; D. J. Thompson ; L. Tibaldo ; D. F. Torres ; G. Tosti ; A. Tramacere ; E. Troja ; Y. Uchiyama ; J. Vandenbroucke ; V. Vasileiou ; G. Vianello ; V. Vitale ; A. P. Waite ; P. Wang ; B. L. Winer ; K. S. Wood ; Z. Yang ; S. Zimmer ; S. Bontemps
    American Association for the Advancement of Science (AAAS)
    Published 2011
    Staff View
    Publication Date:
    2011-11-26
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Zimmer, S. ; Maule, B.H.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1978
    Staff View
    ISSN:
    1365-2044
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2044.1978.tb08352.x

    Articles: DFG German National Licenses
  7. 7
    Davidson, I. ; Zimmer, S.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1989
    Staff View
    ISSN:
    1365-2044
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2044.1989.tb09179.x

    Articles: DFG German National Licenses
  8. 8
    Barthel, C. R. ; Zimmer, S. ; West, G. ; Roulet, J.-F.

    Copenhagen : Munksgaard International Publishers
    Published 2000
    Staff View
    ISSN:
    1600-0595
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract – The aim of this study was to examine whether intracanal medication prior to root canal obturation has an inhibitory effect on corono-apical penetration of bacteria. 93 single rooted teeth were instrumented and sterilized with ethylene oxide. They were assigned to three control groups and four test groups with n=20 each. For one week, they were dressed with different medicaments: The first group with a 5% chlorhexidine gel, the second with Ledermix, the third with a fresh mix of calcium hydroxide and water and the fourth without any medication. After obturation (lateral condensation, AH26) the roots were fixed between a top and a bottom chamber. The top chamber contained 3 mL trypticase soy broth with 108Staphylococcus epidermidis CFU's/mL, whereas the bottom chamber contained sterile trypticase soy broth. For one year, the mounts were incubated at 37°C. They were checked on a regular basis for turbidity in their bottom chambers indicating bacterial growth. None of the test samples leaked for three months. After one year, the calcium hydroxide group had only 6 leaking samples whereas the chlorhexidine group had 14, the Ledermix group 15, and the unmedicated group had 13 leaking samples. It may be concluded that under the conditions of this study, calcium hydroxide was the medicament of choice to avoid bacterial penetration of the root canal. Ledermix did not perform better than no pre-medication. Chlorhexidine was superior to Ledermix in the second third of the observation period.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1034/j.1600-9657.2000.016006282.x

    Articles: DFG German National Licenses
  9. 9
    Zimmer, S.

    Berlin : Periodicals Archive Online (PAO)
    Published 1983
    Staff View
    ISSN:
    0030-5383
    Topics:
    Linguistics and Literary Studies
    Ethnic Sciences
    History
    Notes:
    Besprechungen
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4148-1983-078-04-000012

    Articles: DFG German National Licenses
  10. 10
    Zimmer, S. ; Barthel, C. R. ; Coffman, L. ; Raab, W. H.-M. ; Hefferren, J. J.

    Oxford, UK : Munksgaard International Publishers
    Published 2005
    Staff View
    ISSN:
    1600-051X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Objectives: Professional tooth cleaning (PTC) may lead to loss of exposed dentin. The aim of the present study was to determine the absolute loss of dentin during PTC using various product combinations with an in vitro model.Material and Methods: Dentin specimens (72) were randomly assigned to nine groups. In four groups each, prophy brushes and prophy cups were used in combination with four different abrasives (calcium pyrophosphate, pumice, Hawe cleanic, Nupro coarse). In the ninth group, a rubber cup with embedded fluoride and abrasives was used (pasteless prophy cup). The treatment time was 37 s. Surface loss was determined by profilometry.Results: The surface loss in the nine groups was as following: (1) brush/calcium pyrophosphate: 6.18 μm (a); (2) brush/pumice: 5.51 μm; (3) brush/Nupro coarse: 10.10 μm (b); (4) brush/Hawe cleanic: 1.88 (a, b); (5) prophy cup/calcium pyrophosphate 2.07 (c); (6) prophy cup/pumice: 6.07 μm; (7) prophy cup/Nupro coarse: 5.93 μm (c); (8) prophy cup/Hawe cleanic: 4.93 μm (c); (9) pasteless prophy cup: 11.86 μm (c). Groups with the same letter in parentheses are statistically significant different at p〈0.05. In a pooled analysis, no statistically significant difference between brushes and prophy cups was found.Conclusion: In the present study, the surface loss of about eight PTC procedures was simulated. Hence, the dentin loss ranged between 0.24 and 1.48 μm per PTC. Therefore, PTC does not seem to be a main factor in dentin loss.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-051X.2005.00764.x

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1987.tb32910.x

    Articles: DFG German National Licenses
  12. 12
    Griebel, M. ; Zenger, C. ; Zimmer, S.
    Springer
    Published 1993
    Staff View
    ISSN:
    1436-5057
    Keywords:
    65F10 ; 65N20 ; 65N30 ; Anisotropic problems ; block-Gauss-Seidel iteration ; Gauss-Seidel iteration ; hierarchical basis ; multigrid methods ; partial differential equations ; point-oriented methods ; semidefinite system ; sparse grids
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Computer Science
    Description / Table of Contents:
    Zasammenfassung Wir stellen gitterorientierte und neu entwickelte punktorientierte robuste Multilevelverfahren für Voll- und Dünngitterdiskretisierungen vor. Besonders die punktorientierten Multilevelmethoden sind sehr gut zu parallelisieren und erweisen sich als robust für anisotrope Modellprobleme. Sie erlauben eine einfache Erweiterung auf gebietsorientierte Multilevelmethoden mit denselben Eigenschaften. Wir berichten die Ergebnisse numerischer Experimente für die Reduktionszahlen dieser neuen Algorithmen.
    Notes:
    Abstract We present grid-oriented and newly developed point-oriented robust multilevel methods for full and sparse grid discretizations. Especially the point-oriented multilevel methods are very well suited for parallelization and behave robust for anisotropic model problems. They can be generalized easily to domain-oriented multilevel methods with the same properties.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02238610

    Articles: DFG German National Licenses
  13. 13
    Zimmer, S. ; Biltonen, R.
    Springer
    Published 1972
    Staff View
    ISSN:
    1572-8927
    Keywords:
    Adenine ; nucleic acid ; ionization ; enthalpy ; heat capacity ; calorimetry
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Notes:
    Abstract The thermodynamic quantities associated with ionization of the N1 and N9 protons of adenine have been calorimetrically determined as a function of temperature. The ΔH values for proton dissociation of these groups, with pK values of 4.19 and 9.92, were found to be 5.1 and 9.1 kcal/mole, respectively, at 25°C, μ=0.025. The ΔC p values for proton dissociation of these groups were estimated to be −11 and −17 cal/mole-deg. These results indicate that the large heat capacity changes observed during conformational transitions of polynucleotides are not the result of ionization of the bases.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00715988

    Articles: DFG German National Licenses
  14. 14
    Faist, E. ; Schinkel, C. ; Zimmer, S.
    Springer
    Published 1996
    Staff View
    ISSN:
    1432-2323
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract. Major trauma results in massive impairment of immunologic reactivity, the clinical consequence of which consists in the high susceptibility of the traumatized individual toward serious infection. Whereas parts of the immune system are stimulated within a systemic, nondiscriminant, excessive whole-body inflammation, other functions within the complex of cell-mediated immunity (CMI) are dramatically paralyzed. Immune abnormalities in the aftermath of trauma occur in a sequence of states of cellular activation and within a complex order of events that is not yet well understood. Traumatic stress is causing disintegration of the intact monocyte (Mφ)–T cell interaction, which is associated with profound changes in Mφ forward-regulatory capacities and substantial depression of T cell function. Extensive tissue destruction results in the generation of numerous stimuli, such as phagocytosis, immune complexes, complement split products, and endo- and exotoxins, all of which contribute to excessive Mφ activation. Mφ then rapidly produce and release prostaglandin E2 (PGE2), a powerful endogenous immune suppressant. PGE2 is an inhibitor of T cell mitogenesis, interleukin 2 (IL-2) production, and IL-2 receptor expression; and it has a massive impact on the quality of B cell antibody synthesis. Most importantly, PGE2 represents an important cofactor for the induction of T-helper lymphocyte (TH) activity toward the TH2 direction. TH2 cells are associated with the synthesis of immunosuppressive cytokines, such as IL-4 and IL-10. Although immunosuppressive substrates are inhibitory for TH1 cells—the functional carriers of CMI—they support TH2 activity, which predisposes the host to develop infection. The endogenous ability of the organism to survive overwhelming trauma is insufficient and requires major exogenous support. Immune modulatory interventions, depending on the immune abnormalities seen in the traumatized host, should be started as early as possible after trauma in a preventive fashion to protect against organ tissue destruction. Ideally, it should protect all cellular host defense compartments from hyperactivation as well as from exhaustion. We do believe that only a combination of drugs can effectively control the posttraumatic dyshomeostasis of the various cell systems.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002689900071

    Articles: DFG German National Licenses
  15. 15
    Gerken, M. ; Zimmer, S. ; Petersen, J.
    Springer
    Published 1988
    Staff View
    ISSN:
    1432-2242
    Keywords:
    Japanese quail ; Diallel cross ; Heterosis ; Gonad development ; Sexual dimorphism
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Summary The influence of growth on the extent of heterosis for juvenile body weight and gonad development was studied in a diallel cross among two lines of Japanese quail differing in adult body size. A total of 1,096 birds (563 males and 533 females) was slaughtered between 25 and 49 days of age. Reciprocal cross differences were non-significant. Heterosis showed a curvilinear course with age peaking during early growth (body weight) and during sexual maturity (gonad percentage). Overall advanced physiological development of the crossbreds probably begins as early as during the embryonic stages and results in earlier sexual maturity. In females, heterosis for percentage gonads was biased strongly by the presence of a hard-shelled egg in the uterus.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00303525

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1573-7373
    Keywords:
    collagenolytic activity ; CxT24neo3 tumors
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The function of proteases in brain tumor invasion is currently not well established. For tumors of epithelial and fibromatous origin collagenase production can enhance the invasive capacity of cells to penetrate basement membranes. We showed previously that a c-Ha-ras transformed glial cell line (CxT24neo3) invaded hamster brain tissuein vivo. These cells were also capable of invading reconstituted basement membrane and embryonic chick heartsin vitro. Since the histopathology of CxT24neo3 tumors mimics that of glioblastoma multiforme in humans, CxT24neo3 was used as the modelin vitro for this type of brain tumor. Presently, we detected by zymogram analysis a gelatinase that was secreted by CxT24neo3 and that had an apparent molecular mass of 62 kD. To verify whether gelatinase affected invasionin vitro of these glial cells we determined the efficacy of a substrate specific collagenase inhibitor on invasionin vitro. GM6001 is a synthetic polypeptide that specifically occupies the substrate binding sites of metalloprotease. Since this drug did not show cytotoxicity, its specificity for metalloprotease is a valuable tool to evaluate the physiological function of these enzymes on invasion. We found that treatment of CxT24neo3 with GM6001 reduced the fraction of invading CxT24neo3 cells through reconstituted basement membrane. These data suggest that metalloproteases can stimulate brain tumor invasion.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01052898

    Articles: DFG German National Licenses
  17. 17
    Boghaert, E. R. ; Austin, V. ; Zimmer, S. G.
    Springer
    Published 1991
    Staff View
    ISSN:
    1573-7276
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract We compared the pathology of two groups of tumors following implantation of cells enmeshed in alginate beads into the syngeneic rat. The first group of tumors was generated by implanting alginate beads containing cloned embryonic fibroblasts (CREF) that were transfected with activated c-Ha-ras (T24) and v-ras (pH1) (CREF tumors). The second group was created by implantation of CREF cells that were transfected with E1a and E1b of wild type adenovirus type 5 prior to transfection with T24 and pH1 (Wt tumors). Alginate beads were implanted at three different sites in the rat, i.e. subcutaneous in the flank, subcutaneous in the tail and under the renal capsule. Tumorigenicity, invasiveness and metastatic capacity of the transfectant cell lines were determined. The tumor latency period (TLP), the doubling time of the tumors and the metastatic capacity of the cell lines depended on the site of implantation. Invasion was not influenced by site-dependency. Wt tumors were invasive and generally had longer TLP than the CREF tumors. Wt tumors did not metastasize to the lungs as opposed to CREF tumors. We concluded that the genetic background of Wt cells modulated the effect ofras transfection by stretching the TLP and by limiting the metastatic potential to the draining lymph nodes. Malignancyper se was not repressed since no differences in invasive capacity were noticed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01753727

    Articles: DFG German National Licenses
  18. 18
    Schmieder, P. ; Zimmer, S. ; Kessler, H.

    Chichester : Wiley-Blackwell
    Published 1991
    Staff View
    ISSN:
    0749-1581
    Keywords:
    Resolution enhancement by folding ; Folding in the hetero-dimension ; Proton detected heteronuclear NMR ; HMQC resolution in the hetero-dimension ; HMBC resolution in the hetero-dimension ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Chemistry and Pharmacology
    Notes:
    Limited resolution in indirect detected frequency dimensions (evolution periods) in multi-dimensional spectroscopy is a common problem, especially in the carbon dimension of heteronuclear experiments. Folding of signals in empty regions can overcome these problems. To record the spectra in a pure phase certain conditions have to be fulfilled to account for unavoidable deviations from zero time of the zero increment. A new slight variation of inverse heteronuclear correlation pulse sequences is proposed to allow pure phase spectra. Practical applications are given.
    Additional Material:
    6 Ill.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/mrc.1260290415

    Articles: DFG German National Licenses