Search Results - (Author, Cooperation:S. Y. Tsai)
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1Latest Papers from Table of Contents or Articles in PressJ. Qin ; S. P. Wu ; C. J. Creighton ; F. Dai ; X. Xie ; C. M. Cheng ; A. Frolov ; G. Ayala ; X. Lin ; X. H. Feng ; M. M. Ittmann ; S. J. Tsai ; M. J. Tsai ; S. Y. Tsai
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; COUP Transcription Factor II/deficiency/genetics/*metabolism ; Cell Cycle Checkpoints ; Cell Line, Tumor ; *Cell Transformation, Neoplastic ; Disease Models, Animal ; Disease Progression ; Gene Deletion ; Humans ; Male ; Mice ; Neoplasm Metastasis ; PTEN Phosphohydrolase/deficiency/genetics ; Proportional Hazards Models ; Prostate/metabolism/pathology ; Prostatic Neoplasms/*metabolism/*pathology ; *Signal Transduction ; Smad4 Protein/deficiency/genetics/metabolism ; Transforming Growth Factor beta/*antagonists & inhibitors/metabolismPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1600-079XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: Increasing evidence of the neuroimmunomodulatory role of the pineal gland prompted the present study of pineal gland expression of the immunoregulatory cytokine, interleukin (IL)-1β. IL-1β was constitutively expressed in the adult gland, with mRNA levels higher in glands collected during the photophase than in those collected during the scotophase of the light:dark cycle. IL-1β was up-regulated in pineal cultures, after treatment with either norepinephrine (NE) or interferon (IFN)/lipopolysaccharide (LPS). Although both astrocytes and microglia expressed IL-1β, important differences were found in the cellular expression of this cytokine under in vivo and in vitro conditions. Increased IL-1β expression by NE ex vivo and the decline in IL-I expression at night, when NE levels are elevated, can be explained by immunocytochemical data showing that astrocytes are the predominant cell type expressing this cytokine in vivo, whereas IL-1β-positive cells are predominantly microglia in pineal explants and dispersed cell cultures. These results are consistent with the hypothesis that cytokines secreted by pineal glia (astrocytes and microglia) may have an important regulatory role in the pineal gland.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0891-5849Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0385-6380Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0955-2863Keywords: 1,2-dimethylhydrazine ; carcinogenesis ; diet ; lipid peroxidation ; polyunsaturated fatty acidsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract Relevant low energy data are analyzed in the framework of a generalSU(2) L ×SU(2) R ×U(1) B−L electroweak gauge model. The model is general in that it allows for a left-right asymmetric gauge coupling and introduces a most general mass term for the weak gauge bosons. It is shown that the recent μ-decay measurement, combined with neutral-current data, leads to the boundM w 2〉~180 GeV on the mass of the second charged weak boson. It is also noted that the recentB-meson life-time measurement, combined with constraints from theK L 0 −K S 0 mass difference, gives a weaker bound, i.e.M w 2≳140 GeV, independently of the structure of the leptonic sector.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Keywords: Key words. Orphan nuclear receptors; COUP-TF; embryogenesis.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are orphan members of the steroid/thyroid hormone receptor superfamily. They have been shown to negatively regulate the activation function of vitamin D, thyroid hormone, retinoic acid, the retinoid X and the peroxisome proliferator-activated receptors. COUP-TF genes have been cloned from many species and their sequences are exceptionally conserved through evolution. This suggests a critical role for the COUP-TFs in these organisms. Indeed, the Drosophila COUP-TF, seven-up and mouse COUP-TFII are essential for development and differentiation during embryogenesis. Our current understanding of COUP-TF function suggests that they serve vital physiological roles during development despite extensive overlaps of expression. This defines the COUP-TFs as important factors in regulation of development and differentiation in multiple organisms.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract Multiplicities of hadrons produced in μp scattering are analyzed with a diquark scattering model. it is assumed that a proton is composed of a quark and a scaler diquark and that both the quark and the diquark act as partons. A reasonable agreement between the experimental data and the predictions of the model is obtained. In particular, the observed large ratio of the proton to the overall positive hadron yield forx〉0.2 is successfully reproduced.Type of Medium: Electronic ResourceURL: