Search Results - (Author, Cooperation:S. Wolfram)

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  1. 1
    M. Roffet-Salque ; M. Regert ; R. P. Evershed ; A. K. Outram ; L. J. Cramp ; O. Decavallas ; J. Dunne ; P. Gerbault ; S. Mileto ; S. Mirabaud ; M. Paakkonen ; J. Smyth ; L. Soberl ; H. L. Whelton ; A. Alday-Ruiz ; H. Asplund ; M. Bartkowiak ; E. Bayer-Niemeier ; L. Belhouchet ; F. Bernardini ; M. Budja ; G. Cooney ; M. Cubas ; E. M. Danaher ; M. Diniz ; L. Domboroczki ; C. Fabbri ; J. E. Gonzalez-Urquijo ; J. Guilaine ; S. Hachi ; B. N. Hartwell ; D. Hofmann ; I. Hohle ; J. J. Ibanez ; N. Karul ; F. Kherbouche ; J. Kiely ; K. Kotsakis ; F. Lueth ; J. P. Mallory ; C. Manen ; A. Marciniak ; B. Maurice-Chabard ; M. A. Mc Gonigle ; S. Mulazzani ; M. Ozdogan ; O. S. Peric ; S. R. Peric ; J. Petrasch ; A. M. Petrequin ; P. Petrequin ; U. Poensgen ; C. J. Pollard ; F. Poplin ; G. Radi ; P. Stadler ; H. Stauble ; N. Tasic ; D. Urem-Kotsou ; J. B. Vukovic ; F. Walsh ; A. Whittle ; S. Wolfram ; L. Zapata-Pena ; J. Zoughlami
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-11-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Africa, Northern ; Animals ; Archaeology ; Beekeeping/*history ; *Bees ; Ceramics/chemistry/history ; Europe ; Farmers/history ; Geographic Mapping ; History, Ancient ; Lipids/analysis/chemistry ; Middle East ; Spatio-Temporal Analysis ; Waxes/*analysis/chemistry/*history
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Type of Medium:
    article
    Publication Date:
    1988
    Keywords:
    Empirische Untersuchung ; Förderung ; Grundschule ; Primarbereich ; Schüler ; Lernbehinderung ; Anfangsunterricht ; Deutsch ; Lesekompetenz ; Lesenlernen ; Lesetechnik ; Leseschwaches Kind
    In:
    Heilpädagogische Forschung, Bd. 14 (1988) H. 1, S. 36-43, 0017-9647
    Language:
    German
    Note:
    Literaturangaben, Tabellen

    FIS Bildung Literaturdatenbank
  3. 3
    Staff View
    Type of Medium:
    article
    Publication Date:
    1988
    Keywords:
    Empirische Untersuchung ; Schulanfang ; Grundschule ; Primarbereich ; Schüler ; Deutsch ; Lesekompetenz ; Lesen ; Lesenlernen ; Lesetechnik ; Sonderschule ; Österreich
    In:
    Heilpädagogische Forschung, Bd. 14 (1988) H. 1, S. 27-35, 0017-9647
    Language:
    German
    Note:
    Literaturangaben, Tabellen

    FIS Bildung Literaturdatenbank
  4. 4
    Staff View
    Publication Date:
    2018-01-11
    Publisher:
    Royal Society
    Electronic ISSN:
    2054-5703
    Topics:
    Natural Sciences in General
    Keywords:
    biomechanics
    Published by:
    http://royalsocietypublishing.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2018-05-01
    Publisher:
    Nature Publishing Group (NPG)
    Electronic ISSN:
    2041-1723
    Topics:
    Biology
    Chemistry and Pharmacology
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Kunz, Wolfram S. ; Kuznetsov, Andrey V. ; Clark, Joseph F. ; Tracey, Irene ; Elger, Christian E.

    Oxford UK : Blackwell Science Ltd
    Published 1999
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: Biochemical micromethods were used for the investigation of changes in mitochondrial oxidative phosphorylation associated with cytochrome c oxidase deficiency in brain cortex from Movbr (mottled viable brindled) mice, an animal model of Menkes’ copper deficiency syndrome. Enzymatic analysis of cortex homogenates from Movbr mice showed an approximately twofold decrease in cytochrome c oxidase and a 1.4-fold decrease in NADH:cytochrome c reductase activities as compared with controls. Assessment of mitochondrial respiratory function was performed using digitonin-treated homogenates of the cortex, which exhibited the main characteristics of isolated brain mitochondria. Despite the substantial changes in respiratory chain enzyme activities, no significant differences were found in maximal pyruvate or succinate oxidation rates of brain cortex homogenates from Movbr and control mice. Inhibitor titrations were used to determine flux control coefficients of NADH:CoQ oxidoreductase and cytochrome c oxidase on the rate of mitochondrial respiration. Application of amobarbital to titrate the activity of NADH:CoQ oxidoreductase showed very similar flux control coefficients for control and mutant animals. Alternately, titration of respiration with azide revealed for Movbr mice significantly sharper inhibition curves than for controls, indicating a more than twofold elevated flux control coefficient of cytochrome c oxidase. Owing to the reserve capacity of respiratory chain enzymes, the reported changes in activities do not seem to affect whole-brain high-energy phosphates, as observed in a previous study using 31P NMR.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1471-4159.1999.721580.x

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    For neuroprotective therapy of neurodegenerative diseases creatine treatment has gained special interest because creatine has been shown to cross the blood–brain barrier, accumulate in the human brain in vivo and cause delayed neuronal cell death in a large number of animal models. Here, we used the pilocarpine model of temporal lobe epilepsy to determine whether creatine administration is able to attenuate the epilepsy-associated decrease in hippocampal N-acetyl aspartate (NAA) concentrations, impairment of mitochondrial function and neuronal cell loss. In vivo1H-NMR spectroscopy showed, in epileptic rats after creatine administration, higher hippocampal NAA concentrations, suggesting improved neuronal survival. However, in vitro observation of hippocampal slices from creatine-treated epileptic rats revealed a more pronounced loss of pyramidal neurons and decrease in activity of mitochondrial enzymes in hippocampal subfields. This indicates that NAA concentrations measured by in vivo1H-NMR spectroscopy reflect alterations of metabolism rather than neuronal cell densities. Our data indicate an adverse effect of creatine on neuronal survival under conditions of enhanced neuronal activity.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1460-9568.2003.02954.x

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Mitochondrial function is a key determinant of both excitability and viability of neurons. Here, we demonstrate seizure-dependent changes in mitochondrial oxidative phosphorylation in the epileptic rat hippocampus. The intense pathological neuronal activity in pilocarpine-treated rats exhibiting spontaneous seizures resulted in a selective decline of the activities of NADH–CoQ oxidoreductase (complex I of the respiratory chain) and cytochrome c oxidase (complex IV of respiratory chain) in the CA3 and CA1 hippocampal pyramidal subfields. In line with these findings, high-resolution respirometry revealed an increased flux control of complex I on respiration in the CA1 and CA3 subfields and decreased maximal respiration rates in the more severely affected CA3 subfield. Imaging of mitochondrial membrane potential using rhodamine 123 showed a lowered mitochondrial membrane potential in both pyramidal subfields. In contrast to the CA1 and CA3 subfields, mitochondrial oxidative phosphorylation was unaltered in the dentate gyrus and the parahippocampal gyrus. The changes of oxidative phosphorylation in the epileptic rat hippocampus cannot be attributed to oxidative enzyme modifications but are very likely related to a decrease in mitochondrial DNA copy number as shown in the more severely affected CA3 subfield and in cultured PC12 cells partially depleted of mitochondrial DNA. Thus, our results demonstrate that seizure activity downregulates the expression of mitochondrial-encoded enzymes of oxidative phosphorylation. This mechanism could be invoked during diverse forms of pathological neuronal activity and could severely affect both excitability and viability of hippocampal pyramidal neurons.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1460-9568.2002.01947.x

    Articles: DFG German National Licenses
  9. 9
    FOX, J. D. ; WOLFRAM, S. A. ; KEMP, J. D. ; LANGLOIS, B. E.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1980
    Staff View
    ISSN:
    1750-3841
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Process Engineering, Biotechnology, Nutrition Technology
    Notes:
    Pale, soft, exudative (PSE) and normal pork loins were cut into chops, prepackaged, and stored up to 8 days under simulated retail display at −1°C. At 0, 2, 4, 6, and 8 days of display, packages of each type were removed for physical, chemical, organoleptic, and microbiological analysis. Chops were evaluated for color, aroma, and general appearance prior to cooking and for tenderness, flavor, juiciness, cooked aroma, and shear value after being cooked to 76° C. Thiamin and TBA values were determined to evaluate changes in nutritional and chemical quality. Myoglobin content and pH of the muscle were used to verify PSE and normal classification of the loins. PSE chops scored lower (P 〈 0.01) for general appearance, raw color, raw aroma, flavor, cooked aroma, juiciness, and overall satisfaction than normal chops. Normal chops scored slightly less tender and had higher (P 〈 0.02) shear values than PSE chops. Weight loss was greater (P 〈 0.01) for PSE chops during display and during cooking than for normal chops. Myoglobin, thiamin, and pH values were higher (P 〈 0.01) in the normal chops than PSE chops, while TBA values were higher (P 〈 0.01) in the PSE chops. Color and general appearance scores decreased and TBA values increased more rapidly in the PSE chops than in normal chops as display time increased. Microbiological determinations included total count (25°C and 37°C), lactobacilli, enterococci, coliforms and staphylococci according to standard microbiological procedures. Total bacterial counts (37°C) were higher (P 〈 0.01) for the normal chops, but there were no significant differences in total bacterial counts at 25°C. Total bacterial counts at 37°C decreased between 0 and 2 days' display and then slowly increased but never reached the original population numbers by the eighth day of display. Numbers of lactobacilli, enterococci, coliforms, and staphylococci were too few to statistically evaluate.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2621.1980.tb07449.x

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1546-1718
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Medicine
    Notes:
    [Auszug] Experimental evidence for human mitochondrial DNA (mtDNA) recombination was recently obtained in an individual with paternal inheritance of mtDNA and in an in vitro cell culture system. Whether mtDNA recombination is a common event in humans remained to be determined. To detect mtDNA recombination ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/ng1606

    Articles: DFG German National Licenses
  11. 11
    Ambjorn, J. ; Wolfram, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-4916
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-4916(83)90065-9

    Articles: DFG German National Licenses
  12. 12
    Ambjorn, J. ; Wolfram, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-4916
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-4916(83)90066-0

    Articles: DFG German National Licenses
  13. 13
    Fox, G.C. ; Wolfram, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0550-3213
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0550-3213(79)90003-8

    Articles: DFG German National Licenses
  14. 14
    Field, R.D. ; Wolfram, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0550-3213
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0550-3213(83)90175-X

    Articles: DFG German National Licenses
  15. 15
    Kolb, E.W. ; Wolfram, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0550-3213
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0550-3213(80)90167-4

    Articles: DFG German National Licenses
  16. 16
    Harvey, J.A. ; Kolb, E.W. ; Reiss, D.B. ; Wolfram, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0550-3213
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0550-3213(81)90180-2

    Articles: DFG German National Licenses
  17. 17
    Llewellyn Smith, C.H. ; Wolfram, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0550-3213
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0550-3213(78)90250-X

    Articles: DFG German National Licenses
  18. 18
    Fox, G.C. ; Wolfram, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0550-3213
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0550-3213(80)90111-X

    Articles: DFG German National Licenses
  19. 19
    Harvey, J.A. ; Kolb, E.W. ; Reiss, D.B. ; Wolfram, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0550-3213
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0550-3213(82)90375-3

    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    0550-3213
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0550-3213(77)90339-X

    Articles: DFG German National Licenses