Search Results - (Author, Cooperation:S. W. Miller)
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1Latest Papers from Table of Contents or Articles in PressN. Negre ; C. D. Brown ; L. Ma ; C. A. Bristow ; S. W. Miller ; U. Wagner ; P. Kheradpour ; M. L. Eaton ; P. Loriaux ; R. Sealfon ; Z. Li ; H. Ishii ; R. F. Spokony ; J. Chen ; L. Hwang ; C. Cheng ; R. P. Auburn ; M. B. Davis ; M. Domanus ; P. K. Shah ; C. A. Morrison ; J. Zieba ; S. Suchy ; L. Senderowicz ; A. Victorsen ; N. A. Bild ; A. J. Grundstad ; D. Hanley ; D. M. MacAlpine ; M. Mannervik ; K. Venken ; H. Bellen ; R. White ; M. Gerstein ; S. Russell ; R. L. Grossman ; B. Ren ; J. W. Posakony ; M. Kellis ; K. P. White
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-03-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Chromatin Immunoprecipitation ; Drosophila melanogaster/*genetics ; Enhancer Elements, Genetic/genetics ; Genome, Insect/*genetics ; Histone Deacetylases/metabolism ; Insulator Elements/genetics ; *Molecular Sequence Annotation ; Promoter Regions, Genetic/genetics ; Regulatory Sequences, Nucleic Acid/*genetics ; Reproducibility of Results ; Silencer Elements, Transcriptional/genetics ; Transcription Factors/metabolismPublished by: -
2Articles: DFG German National LicensesSheehan, J. P. ; Swerdlow, R. H. ; Parker, W. D. ; Miller, S. W. ; Davis, R. E. ; Tuttle, J. B.
Oxford, UK : Blackwell Science Ltd
Published 1997Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: Parkinson's disease may be linked to defects in mitochondrial function. Mitochondrially transformed cells (cybrids) were created from Parkinson's disease patients or disease-free controls. Parkinson's disease cybrids had 26% less complex I activity, but maintained comparable basal calcium and energy levels. Parkinson's disease cybrids recovered from a carbachol-induced increase in cytosolic calcium 53% more slowly than controls even with lanthanum and thapsigargin blockade. Inhibition of complex I with the Parkinson's disease-inducing metabolite 1-methyl-4-phenylpyridinium (MPP+) similarly reduced the rate of recovery after carbachol. This MPP+-induced reduction in recovery rates was much more pronounced in control cybrids than in Parkinson's disease cybrids. Parkinson's disease cybrids had less carbonyl cyanide m-chlorophenylhydrazone-releasable calcium. Bypassing complex I with succinate partially restored Parkinson's disease cybrid, and MPP+ suppressed control cybrid recovery rates. The subtle alteration in calcium homeostasis of Parkinson's disease cybrids may reflect an increased susceptibility to cell death under circumstances not ordinarily toxic.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1432-1106Keywords: Visual vestibular interaction ; onflicting sensory stimulation ; Vestibular nuclei activity ; RatsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Sixty-two of 95 units within the vestibular nuclei of 24 hooded, Long-Evans rats were found to respond to both linear accelerations on a parallel swing and to linear movements of the visual field. The addition of visual clues during periods of linear accelerations produced a phase shift in the majority of the units towards the maximal acceleration of the animal, and an increase in the peak activity during the periods of maximal acceleration. Conflicting visual-vestibular stimulation resulted in reduced directional sensitivity and lower rates of firing in visually sensitive units.Type of Medium: Electronic ResourceURL: