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1Latest Papers from Table of Contents or Articles in PressCorrigendum: In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 systemD. Maddalo ; E. Manchado ; C. P. Concepcion ; C. Bonetti ; J. A. Vidigal ; Y. C. Han ; P. Ogrodowski ; A. Crippa ; N. Rekhtman ; E. de Stanchina ; S. W. Lowe ; A. Ventura
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2012-02-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/biosynthesis/*genetics/therapeutic use ; Neoplasm Metastasis ; Neoplasms/diagnosis/drug therapy/*genetics/pathology ; Oncogenes/genetics ; Tumor Suppressor Protein p53/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressC. Scuoppo ; C. Miething ; L. Lindqvist ; J. Reyes ; C. Ruse ; I. Appelmann ; S. Yoon ; A. Krasnitz ; J. Teruya-Feldstein ; D. Pappin ; J. Pelletier ; S. W. Lowe
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-06-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Gene Deletion ; Gene Regulatory Networks ; Genetic Testing ; Humans ; Lymphoma, B-Cell/*genetics/physiopathology ; Lysine/*analogs & derivatives/chemistry ; Mice ; Mice, Inbred C57BL ; Polyamines/*chemistry ; RNA, Small Interfering/genetics/metabolism ; Reproducibility of Results ; Tumor Suppressor Proteins/*geneticsPublished by: -
4Latest Papers from Table of Contents or Articles in PressS. Cheloufi ; U. Elling ; B. Hopfgartner ; Y. L. Jung ; J. Murn ; M. Ninova ; M. Hubmann ; A. I. Badeaux ; C. Euong Ang ; D. Tenen ; D. J. Wesche ; N. Abazova ; M. Hogue ; N. Tasdemir ; J. Brumbaugh ; P. Rathert ; J. Jude ; F. Ferrari ; A. Blanco ; M. Fellner ; D. Wenzel ; M. Zinner ; S. E. Vidal ; O. Bell ; M. Stadtfeld ; H. Y. Chang ; G. Almouzni ; S. W. Lowe ; J. Rinn ; M. Wernig ; A. Aravin ; Y. Shi ; P. J. Park ; J. M. Penninger ; J. Zuber ; K. Hochedlinger
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-12-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cells, Cultured ; Cellular Reprogramming/*genetics ; Chromatin/metabolism ; Chromatin Assembly Factor-1/antagonists & inhibitors/genetics/*metabolism ; Gene Expression Regulation/genetics ; Heterochromatin/metabolism ; Mice ; Nucleosomes/metabolism ; RNA Interference ; Transduction, GeneticPublished by: -
5Latest Papers from Table of Contents or Articles in PressC. Miething ; C. Scuoppo ; B. Bosbach ; I. Appelmann ; J. Nakitandwe ; J. Ma ; G. Wu ; L. Lintault ; M. Auer ; P. K. Premsrirut ; J. Teruya-Feldstein ; J. Hicks ; H. Benveniste ; M. R. Speicher ; J. R. Downing ; S. W. Lowe
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-05-09Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Chemokines/metabolism ; Gene Knockdown Techniques ; Leukemia/*enzymology/genetics/*physiopathology ; Mice, Transgenic ; PTEN Phosphohydrolase/*genetics/*metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; RNA Interference ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Tumor Microenvironment/*physiologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressD. Maddalo ; E. Manchado ; C. P. Concepcion ; C. Bonetti ; J. A. Vidigal ; Y. C. Han ; P. Ogrodowski ; A. Crippa ; N. Rekhtman ; E. de Stanchina ; S. W. Lowe ; A. Ventura
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-10-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antineoplastic Agents/therapeutic use ; *Caspase 9 ; Cells, Cultured ; Chromosome Inversion/genetics ; *Clustered Regularly Interspaced Short Palindromic Repeats ; Disease Models, Animal ; Genetic Engineering/*methods ; Lung Neoplasms/drug therapy/enzymology/pathology ; Mice ; NIH 3T3 Cells ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles/therapeutic use ; Pyridines/therapeutic use ; Receptor Protein-Tyrosine Kinases/metabolism ; Translocation, Genetic/*geneticsPublished by: -
7Latest Papers from Table of Contents or Articles in PressD. Juric ; P. Castel ; M. Griffith ; O. L. Griffith ; H. H. Won ; H. Ellis ; S. H. Ebbesen ; B. J. Ainscough ; A. Ramu ; G. Iyer ; R. H. Shah ; T. Huynh ; M. Mino-Kenudson ; D. Sgroi ; S. Isakoff ; A. Thabet ; L. Elamine ; D. B. Solit ; S. W. Lowe ; C. Quadt ; M. Peters ; A. Derti ; R. Schegel ; A. Huang ; E. R. Mardis ; M. F. Berger ; J. Baselga ; M. Scaltriti
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Breast Neoplasms/*drug therapy/*genetics/metabolism/pathology ; Drug Resistance, Neoplasm/drug effects/*genetics ; Female ; Humans ; Loss of Heterozygosity/drug effects/genetics ; Mice ; Mice, Nude ; PTEN Phosphohydrolase/*deficiency/*genetics/metabolism ; Phosphatidylinositol 3-Kinases/*antagonists & inhibitors ; Thiazoles/*pharmacology/therapeutic use ; Xenograft Model Antitumor AssaysPublished by: -
8Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2015-09-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Chromatin/*genetics/*metabolism ; Female ; Humans ; Male ; Mutation/*genetics ; Neoplasms/*genetics/*pathology ; Tumor Suppressor Protein p53/*genetics/*metabolismPublished by: -
9Latest Papers from Table of Contents or Articles in PressY. Liu ; C. Chen ; Z. Xu ; C. Scuoppo ; C. D. Rillahan ; J. Gao ; B. Spitzer ; B. Bosbach ; E. R. Kastenhuber ; T. Baslan ; S. Ackermann ; L. Cheng ; Q. Wang ; T. Niu ; N. Schultz ; R. L. Levine ; A. A. Mills ; S. W. Lowe
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Cell Transformation, Neoplastic/genetics ; Chromosomes, Human, Pair 17/genetics ; Chromosomes, Mammalian/genetics ; Disease Models, Animal ; Disease Progression ; Female ; Genes, p53/*genetics ; Heterozygote ; Humans ; Leukemia, Myeloid, Acute/genetics/pathology ; Lymphoma/genetics/pathology ; Male ; Mice ; Neoplasms/*genetics/*pathology ; Peptide Initiation Factors/genetics/metabolism ; RNA-Binding Proteins/genetics/metabolism ; Sequence Deletion/*genetics ; Synteny/genetics ; Tumor Suppressor Protein p53/*deficiencyPublished by: -
10Latest Papers from Table of Contents or Articles in PressJ. Zuber ; J. Shi ; E. Wang ; A. R. Rappaport ; H. Herrmann ; E. A. Sison ; D. Magoon ; J. Qi ; K. Blatt ; M. Wunderlich ; M. J. Taylor ; C. Johns ; A. Chicas ; J. C. Mulloy ; S. C. Kogan ; P. Brown ; P. Valent ; J. E. Bradner ; S. W. Lowe ; C. R. Vakoc
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Acetylation ; Animals ; Azepines/pharmacology ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Chromatin/metabolism ; Disease Progression ; Epigenesis, Genetic/genetics ; Gene Expression Regulation, Neoplastic ; Genes, myc/genetics ; Histones/metabolism ; Humans ; Leukemia, Myeloid, Acute/*drug therapy/*genetics/pathology ; Mice ; Neoplasm Transplantation ; Neoplastic Stem Cells/drug effects/pathology ; Nuclear Proteins/antagonists & inhibitors/biosynthesis/genetics/*metabolism ; *RNA Interference ; RNA, Small Interfering/genetics ; Transcription Factors/antagonists & inhibitors/biosynthesis/genetics/*metabolism ; Triazoles/pharmacologyPublished by: -
11Latest Papers from Table of Contents or Articles in PressRuscetti, M., Leibold, J., Bott, M. J., Fennell, M., Kulick, A., Salgado, N. R., Chen, C.-C., Ho, Y.-j., Sanchez-Rivera, F. J., Feucht, J., Baslan, T., Tian, S., Chen, H.-A., Romesser, P. B., Poirier, J. T., Rudin, C. M., de Stanchina, E., Manchado, E., Sherr, C. J., Lowe, S. W.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-12-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Immunology, Medicine, DiseasesPublished by: -
12Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Keywords: Key words. Apoptosis; chemotherapy; prognosis; tumor suppressor; cancer genetics; clinical outcome.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. The ultimate goal of basic cancer research is to provide a theoretical foundation for rational approaches to improve cancer therapy. Our extensive insight into the biology of the p53 tumour suppressor and the clinical behaviour of tumours harbouring p53 mutations indicates that information concerning p53 will be useful in diagnosis and prognosis, and may ultimately produce new therapeutic strategies. At the same time, efforts to understand the clinical implications of p53 mutations have revealed conceptual and technical limitations in translating basic biology to the clinic. The lessons learned from p53 may lay the groundwork for future efforts to synthesize cancer gene function, cancer genetics and cancer therapy.Type of Medium: Electronic ResourceURL: