Search Results - (Author, Cooperation:S. Tucci)
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1Latest Papers from Table of Contents or Articles in PressB. Vernot ; S. Tucci ; J. Kelso ; J. G. Schraiber ; A. B. Wolf ; R. M. Gittelman ; M. Dannemann ; S. Grote ; R. C. McCoy ; H. Norton ; L. B. Scheinfeldt ; D. A. Merriwether ; G. Koki ; J. S. Friedlaender ; J. Wakefield ; S. Paabo ; J. M. Akey
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-03-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; DNA/*genetics ; Genetic Variation ; Genome, Human/*genetics ; Humans ; Melanesia ; Neanderthals/*genetics ; Oceanic Ancestry Group/*genetics ; Sequence Analysis, DNAPublished by: -
2Latest Papers from Table of Contents or Articles in PressTucci, S., Vohr, S. H., McCoy, R. C., Vernot, B., Robinson, M. R., Barbieri, C., Nelson, B. J., Fu, W., Purnomo, G. A., Sudoyo, H., Eichler, E. E., Barbujani, G., Visscher, P. M., Akey, J. M., Green, R. E.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-08-03Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Evolution, GeneticsPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Cells obtained from 10-day mouse embryos were cultured for 3 h in medium containing colcemid. Chromosome preparations were subjected to G-banding in either calcium-magnesium free Hank's solution or the ASG method. From one to several occurrences of lateral asymmetry (unequal banding of sister chromatids) were observed in the majority of karyotypes analyzed.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1432-1157Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesNotes: Abstract High variability of suspensates in the surface water of the Ligurian Sea, an area of limited fluvial sources, sampled at a time of low terrestrial influx raises serious questions regarding conclusions about fluxes or budgets drawn from samples taken during a single cruise. The probability that concentrations found during a single cruise represent a long-term average is very small. On four cruises we found that concentrations of suspended material in the surface waters of the Ligurian Sea were highly variable, even at repeated stations. Variability is largely the result of changes in location of divergences and localized upwelling.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-0738Keywords: Sister chromatid exchanges ; Beta-aminopropionitrile ; Teratogenicity ; Fetal mutagensSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The effects of the teratogenic drug betaaminopropionitrile (BAPN) on the induction of sister chromatid exchanges (SCEs) in utero was evaluated. The frequency of sister chromatid exchanges increased with increasing doses of BAPN in the day 10 mouse embryo. The present study warns of the possible clastogenic activity of BAPN.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-0738Keywords: Saccharin ; Teratogenesis ; Chromosomes ; Mouse ; In uteroSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract For teratogenesis studies, pregnant ICR albino mice were administered saccharin by three routes and at three different doses by each route as follows: Intraperitoneal injection of 500, 1,000, or 2,000 mg/kg saccharin on day 10 of gestation; intragastric tube delivery of 5,10, or 25 mg/kg/day of saccharin on days 5–15 of gestation; and as drinking water containing a 5, 10, or 20% solution of saccharin from day 0 through day 17. Appropriate controls were used for each set. No increase in either resorptions or malformations was found in mouse embryos whose dams had received saccharin by any of the three routes. For chromosome studies, saccharin was administered IP to pregnant ICR albino mice on day 10 of gestation as either a 1,000 mg/kg or 2,000 mg/kg dose. To demonstrate sister chromatid exchanges (SCE), bromodeoxyuridine was administered as 16 consecutive half-hourly doses of 25 mg/kg during the 8 h prior to saccharin injection. In addition, one group received two doses of BrdU and 2,000 mg/kg saccharin 8 h apart to demonstrate SCE frequency following exposure to saccharin for two cell cycles. The mice were given colchicine (4 mg/kg) 6 h after the final injection and killed 2 h later. Embryonic cell suspensions and metaphase spreads were prepared by routine methods. Metaphase spreads were examined for breaks or gaps (after Giemsa staining), for G-banding (using the ASG technique), for C-banding (using Giemsa staining after exposure to 0.07 N NaOH and incubation in 2x SSC at 60° C), and for SCE by the Hoechst-Giemsa method. Fifty metaphase spreads were counted for each experimental condition. There were no increases in gaps or breaks, in sister chromatid exchanges, or in either G-band or C-band lateral asymmetries in the cells of mouse embryos exposed to saccharin in utero. The chromosomes of the 10-day mouse embryo have been shown to be a very sensitive system for evaluation of mutagenic and putative teratogenic agents. The absence of a mutagenic effect of saccharin in this system is consistent with the absence of any teratogenic effect.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1573-5117Keywords: coastal ; sediments ; transport ; particulate matterSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract A study of the granulometric, mineralogical and chemical composition of surface sediments and suspended particulate matter in the coastal area between Varazze and Cape Noli (Ligurian Sea), provided useful information on transport and sedimentation processes in the area. Sediments samples from the shelf were highly heterogeneous, ranging from pelites to sands. Minerals typical of individual river basins were found close to river mouths, indicating a limited sediment transport along the coast. Chemical and textural characteristics of the suspended particulate matter indicated that the longshore sediment transport is influenced by the presence of a submarine canyon; material coming from the east, following the Ligurian current, is partially diverted offshore along the canyon axis. The coastline pattern, some harbor artifacts, and the peculiar morphology of the shelf are all factors controlling the direction of sediment transport.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-0525Source: Springer Online Journal Archives 1860-2000Topics: Computer ScienceDescription / Table of Contents: Summary We have investigated a transaction oriented computer system operating in the presence of intermittent failures. The system integrity is maintained by a built-in checkpoint and roll-back recovery schema. The analytical results, concerning system availability and stability, are compared with those of Gelenbe [10] and validated through simulation.Notes: Resumé Le sujet de cet article est l'étude d'un système de gestion de données qui opère en présence de pannes intermittentes et dans lequel des points de reprise (PR) sont établis pour permettre la reprise après une défaillance du système. Un PR est établi après le traitement de N transactions, N étant un nombre entier fixe. Nous proposons un modèle mathématique qui nous permet de calculer la disponibilité du système. Des simulations sont également faites pour valider ces résultats. Nous comparons nos résultats à ceux de Gelenbe [10] qui suppose qu'un PR est établi après un temps fixe de fonctionnement normal du système et nous montrons que, sous certaines conditions, les deux approches sont équivalentes aussi bien du point de vue de la disponibilité du système que des valeurs optimales du temps entre PR successifs.Type of Medium: Electronic ResourceURL: