Search Results - (Author, Cooperation:S. Stretton)
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1Latest Papers from Table of Contents or Articles in PressM. Gallego Llorente ; E. R. Jones ; A. Eriksson ; V. Siska ; K. W. Arthur ; J. W. Arthur ; M. C. Curtis ; J. T. Stock ; M. Coltorti ; P. Pieruccini ; S. Stretton ; F. Brock ; T. Higham ; Y. Park ; M. Hofreiter ; D. G. Bradley ; J. Bhak ; R. Pinhasi ; A. Manica
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-10-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: African Continental Ancestry Group/*genetics ; Asia ; Biological Evolution ; Ethiopia ; Europe ; Genetic Variation ; *Genome, Human ; *Human Migration ; Humans ; MalePublished by: -
2Articles: DFG German National LicensesFrancis, G. ; Brennan, L. ; Stretton, S. ; Ferenci, T.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1365-2958Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Cysteine mutagenesis was used to test the proximity of 16 residues to protein-ligand interaction sites in maltoporin (LamB protein). LamB protein with additional cysteines was incorporated into the outer membrane of Escherichia coli except with a Ser-30→ Cys substitution. Phage Lambda and starch binding was assayed before and after incubation of mutants with six thiol-specific reagents. Four categories of mutation were recognized on the basis of phenotype and modification for each of the Lambda- and starch binding sites. The thiol modification experiments helped to clarify whether the phenotype of a mutation was due to a substitution at the binding site or an indirect perturbation of the structure. This study suggests that the cysteine mutagenesis/thiol modification approach may be usefully applied to the operational mapping of surface-accessible binding sites or epitopes.Type of Medium: Electronic ResourceURL: