Search Results - (Author, Cooperation:S. Shimada)
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1Latest Papers from Table of Contents or Articles in PressH. Yoshida ; Y. Kuwauchi ; J. R. Jinschek ; K. Sun ; S. Tanaka ; M. Kohyama ; S. Shimada ; M. Haruta ; S. Takeda
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-01-24Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Articles: DFG German National LicensesShibaki, A. ; Ohkawara, A. ; Shimada, S. ; Ra, C. ; Aiba, S. ; Cooper, K. D.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1600-0625Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract In atopic dermatitis (AD) patients, IgE molecules are demonstrated on the surface of Langerhans cells (LC). FcεRI molecules, which are present on the surface of LC in AD patients as well as normal individuals, are responsible for this binding. In this study, we have investigated phenotypic and functional characteristics of FcεRI on epidermal and dermal cell populations. Epidermal and dermal cell suspensions were prepared enzymatically with dispase followed by either trypsin or collagenase treatment, respectively. Peripheral blood basophils were negatively selected by excluding other leukocytes with surface marker staining. Consistent with previous reports, both peripheral blood basophils and epidermal LC were positively stained with anti FcεRI monoclonal antibody. In addition, an FcεRI positive population was demon-strated among dermal HLA-DR positive cells. These cells express significant amounts of HLA-DR molecules (DRHi) and co-express CD la molecules, which identifies them as LC-like dendritie APC of the dermis. No other FcεRI positive population was found in the other dermal DRMid or DR populations, except for a minor DRlo population, presumably mast cells. To analyze whether these FcεRI molecules are signal transducing for LC, intracellular calcium mobilization after crosslinking of FcεRI was measured with How cytometry. Following crosslinking, peripheral blood basophils clearly increased intracellular calcium. On the other hand, neither normal epidermal LC nor dermal DRHiCD Ia+ cells changed their intracellular calcium level after FcεRI crosslinking. These data indicate that normal epidermal and dermal LC, but not basophils, are resistant to calcium flux following FcεRI engagement.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0003-2697Keywords: Hantzsch reaction ; alditols ; anion-exchange chromatography ; automated analysis ; periodate oxidation ; photometric and fluorimetric postcolumn derivatizationSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesHAYASHI, S. ; KUBOTA, Y. ; SHIMADA, S. ; HORI, Y.
Oxford, UK : Blackwell Publishing Ltd
Published 1990Staff ViewISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We have examined the cytoplasmic distribution of actin and fibronectin in cultured neurofibroma tells (NF cells) derived from a patient with von Recklinghausen's disease by using phase contrast and indirect immunofluorescence microscopy, NF cells were larger in size and more dendritic in shape compared to normal human dermal fibroblasts. NF cells also showed abundant granular staining of actin and a decrease in the linear staining pattern of fibronectin. Furthermore, employing a colony-formation assay on the top of an agar-gel in the presence of fibroblast growth factor (FGF), normal fibroblasts showed a significant number of colonies, whereas NF cells did not demonstrate colony formation even after addition of FGF. These findings suggests that NF cells from patients with von Recklinghausen's disease may have different characteristics when compared with normal fibroblasts, and that NF cells are similar to transformed cells with regard to their actin and fibronectin distribution.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1551-2916Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: SiNx films were deposited on Si wafer and SUS steel (Fe–18Cr–8Ni) substrate from a hexamethyldisiloxane solution by N2 plasma-enhanced chemical vapor deposition equipped with a liquid injection device. The SiNx films with dense columnar structures were identified to be amorphous by means of X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. An enhancement of deposition rate, in combination with a large amount of oxygen contaminant, was obtained after modifying the nozzle position from a top injection to a side injection method by providing a greater liquid supply. The corrosion performance of SiNx film-coated SUS steel was evaluated by exposure test in KCl vapor atmosphere at 650°C, indicating that the high purity SiNx film demonstrated a significantly improved resistance, while an increased remanent oxygen content inside the films produced a deleterious effect on the anti-corrosion behavior.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesIsomoto, H. ; Inoue, K. ; Furusu, H. ; Enjoji, A. ; Fujimoto, C. ; Yamakawa, M. ; Hirakata, Y. ; Omagari, K. ; Mizuta, Y. ; Murase, K. ; Shimada, S. ; Murata, I. ; Kohno, S.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background : There is currently no optimal second-line treatment after failure of Helicobacter pylori triple therapy.Aim : To determine effective salvage therapy after failure of lansoprazole–amoxicillin–clarithromycin.Methods : After failure of lansoprazole–amoxicillin–clarithromycin 123 out-patients were randomized to receive either 2-week rabeprazole (20 mg b.d.) + amoxicillin (1000 mg b.d.) (RA group) or 1-week rabeprazole (10 mg b.d.) + amoxicillin (750 mg twice b.d.) + metronidazole (250 mg b.d.) (RAM group). Eradication was assessed by the 13C-urea breath test. We also evaluated cytochrome p450 (CYP) 2C19 genotype status, determined by polymerase chain reaction – restriction fragment length polymorphism, and susceptibility to clarithromycin and metronidazole.Results : On an intention-to-treat basis, H. pylori infection cure was achieved in 37 of 63 (59%) patients in the RA group and in 49 of 60 (82%) patients in the RAM group. Per protocol-based eradication rates in the RA and RAM groups were 66% (37/56) and 88% (49/56), respectively. In both analytic sets there were significant differences between the treatment groups (P 〈 0.01 in each). Mild adverse events were observed in eight and five patients from the RA and RAM groups, respectively. Genetic predisposition of CYP2C19 and antibiotic resistance did not influence the treatment outcome either regimen.Conclusions : The rabeprazole + amoxicillin + metronidazole therapy yielded satisfactory results. In contrast, the cure rate in high-dose rabeprazole + amoxicillin was below an acceptable level.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesSAEKI, H. ; HAYASHI, N. ; KOMINE, M. ; SOMA, Y. ; SHIMADA, S. ; WATANABE, K. ; HASHIMOTO, T.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary We describe a 31-year-old Japanese woman with generalized pustular psoriasis treated with PUVA who subsequently developed a bullous disease. Throughout the disease coures, there was no phase of psoriasis vulgaris. Although several reports describe coexistence of psoriasis vulgaris and bullous disease such as bullous periphigoid, coexistence of generalized pustular psoriasis without any phase of psoriasis vulgaris and bullous disease is rare. As for the bullous disease, direct immunofluorescence study showed lgG and C3 deposition along the basement membrane zone. Indirect immunofluorescence disclosed lgG antibasement membrane zone antibodies. Indirect immunofluorescence on 1 mol/1 sodium chloride-split skin demonstrated linear lgG staining almost exclusively on the dermal side of the split. Western immunoblot analysis revealed that the antibody was directed to neither epidermolysis bullosa acquisita antigen nor bullous pemphigoid antigens. Considering the unusual clinical course, we suspect the possibility of a novel autoimmune blistering disease.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary The number, morphology and response of Thy-1+ dendritic epidermal cells to recombinant interleukin-2 (rIL-2) were investigated in young and aged mice. The Thy-1+ dendritic cells in the aged mice continued to express T-cell receptor (TCR) γ/δ but differed morphologically from those of the young mice. The aged mice had 50% fewer cells than the young ones. In the rIL-2 treated mice all the Thy-1+ cells were expressed as TCR γ/δ and exposure to rlL-2 increased the number of these cells in a time- and dose-dependent manner when given systemically and locally. In the aged mice daily injection of rlL.-2 increased the number of Thy-1+ dendritic cells within 2 weeks to almost that of young mice. however they had a lower response in the earlier stage. Nude mice showed no response to rIL-2.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesInozume, T. ; Matsue, H. ; Furuhashi, M. ; Nakamura, Y. ; Mitsui, H. ; Ando, N. ; Mizutani, M. ; Miyahara, A. ; Kawamura, T. ; Shibagaki, N. ; Tsukamoto, K. ; Shimada, S.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1359-0197Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyEnergy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1359-0197Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyEnergy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesWatanabe, T. ; Takahashi, S. ; Toriyama, N. ; Asazuma, S. ; Kim, K.J. ; Maeda, T. ; Wada, Y. ; Shimada, S. ; Hashimoto, I.
Amsterdam : ElsevierStaff ViewISSN: 0011-2240Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesMinami, M. ; Bito, H. ; Ohishi, N. ; Tsuge, H. ; Miyano, M. ; Mori, M. ; Wada, H. ; Mutoh, H. ; Abe, K. ; Shimada, S. ; Izumi, T. ; Shimizu, T.
Amsterdam : ElsevierStaff ViewISSN: 0014-5793Keywords: Aminopeptidase ; Leukotriene ; Leukotriene A"4 hydrolase ; Site-directed mutagenesis ; Zinc-metalloproteaseSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesMushiake, S. ; Etani, Y. ; Shimada, S. ; Tohyama, M. ; Hasebe, M. ; Futai, M. ; Maeda, M.
Amsterdam : ElsevierStaff ViewISSN: 0014-5793Keywords: DNA-binding protein ; GATA factor ; Gastric specific transcription ; H^+/K^+-ATPase ; Hybridization (in situ) ; Parietal cellSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Chloroplast Photosynthesis ; Membrane protein ; O"2 evolution ; Photosystem IISource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: (Thermophilic bacterium PS3) ; Cytochrome aa"3 ; Cytochrome c oxidase ; DNA sequence ; Subunit structureSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesCrystal growth of bismuth titanates and titanium oxide from melts in the system Bi"2O"3-V"2O"5-TiO"2Staff View
ISSN: 0022-0248Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyGeosciencesPhysicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0022-0248Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyGeosciencesPhysicsType of Medium: Electronic ResourceURL: