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1Latest Papers from Table of Contents or Articles in PressA. V. Biankin ; N. Waddell ; K. S. Kassahn ; M. C. Gingras ; L. B. Muthuswamy ; A. L. Johns ; D. K. Miller ; P. J. Wilson ; A. M. Patch ; J. Wu ; D. K. Chang ; M. J. Cowley ; B. B. Gardiner ; S. Song ; I. Harliwong ; S. Idrisoglu ; C. Nourse ; E. Nourbakhsh ; S. Manning ; S. Wani ; M. Gongora ; M. Pajic ; C. J. Scarlett ; A. J. Gill ; A. V. Pinho ; I. Rooman ; M. Anderson ; O. Holmes ; C. Leonard ; D. Taylor ; S. Wood ; Q. Xu ; K. Nones ; J. L. Fink ; A. Christ ; T. Bruxner ; N. Cloonan ; G. Kolle ; F. Newell ; M. Pinese ; R. S. Mead ; J. L. Humphris ; W. Kaplan ; M. D. Jones ; E. K. Colvin ; A. M. Nagrial ; E. S. Humphrey ; A. Chou ; V. T. Chin ; L. A. Chantrill ; A. Mawson ; J. S. Samra ; J. G. Kench ; J. A. Lovell ; R. J. Daly ; N. D. Merrett ; C. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; N. Kakkar ; F. Zhao ; Y. Q. Wu ; M. Wang ; D. M. Muzny ; W. E. Fisher ; F. C. Brunicardi ; S. E. Hodges ; J. G. Reid ; J. Drummond ; K. Chang ; Y. Han ; L. R. Lewis ; H. Dinh ; C. J. Buhay ; T. Beck ; L. Timms ; M. Sam ; K. Begley ; A. Brown ; D. Pai ; A. Panchal ; N. Buchner ; R. De Borja ; R. E. Denroche ; C. K. Yung ; S. Serra ; N. Onetto ; D. Mukhopadhyay ; M. S. Tsao ; P. A. Shaw ; G. M. Petersen ; S. Gallinger ; R. H. Hruban ; A. Maitra ; C. A. Iacobuzio-Donahue ; R. D. Schulick ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; P. Capelli ; V. Corbo ; M. Scardoni ; G. Tortora ; M. A. Tempero ; K. M. Mann ; N. A. Jenkins ; P. A. Perez-Mancera ; D. J. Adams ; D. A. Largaespada ; L. F. Wessels ; A. G. Rust ; L. D. Stein ; D. A. Tuveson ; N. G. Copeland ; E. A. Musgrove ; A. Scarpa ; J. R. Eshleman ; T. J. Hudson ; R. L. Sutherland ; D. A. Wheeler ; J. V. Pearson ; J. D. McPherson ; R. A. Gibbs ; S. M. Grimmond
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-10-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Axons/*metabolism ; Carcinoma, Pancreatic Ductal/*genetics/*pathology ; Gene Dosage ; Gene Expression Regulation, Neoplastic ; Genome/*genetics ; Humans ; Kaplan-Meier Estimate ; Mice ; Mutation ; Pancreatic Neoplasms/*genetics/*pathology ; Proteins/genetics ; Signal TransductionPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-23Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
3Articles: DFG German National LicensesSerra, S. ; Sanguinetti, S. ; Colombo, L.
College Park, Md. : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We present a study of the thermodynamical properties of C60 in the microcanonical ensemble. Solidlike and metastable liquidlike form can be identified in the low energy and in the high energy range, respectively. The transition between the two phases is characterized by a finite energy range, in agreement with general theories of cluster melting. In particular, we have observed that the melting is preceded by a highly isomerized transition region where a sizeable atomic mobility is achieved via hopping between different isomer structures. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesBenedek, G. ; Colombo, L. ; Gaito, S. ; Galvani, E. ; Serra, S.
College Park, Md. : American Institute of Physics (AIP)
Published 1997Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Among the hypothetical forms of fully covalent carbon lattices with either graphite-like sp2 or mixed sp2/sp3 bonding we investigated the possibility of monocrystals with a hollow structure. We have calculated the structural, elastic and electronic properties of two prototypical face–centered cubic lattices C20 and C22, respectively, making also a critical comparison to diamond and graphite. The first of these lattices belongs to a new class of sp2–bonded periodic solids which we call hollow graphites. We give a topological classification of such solids along with the algorithm to generate them. Both crystals, having a nanoporous lattice made of periodic sequence of adjacent cavities, rather than the tubular structure of schwarzites, are characterized by a large internal specific area and should be suitable to form reversible high capacity lithium insertion compounds. © 1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesBoglione, C. ; Bronzi, P. ; Cataldi, E. ; Serra, S. ; Gagliardi, F. ; Cataudella, S.
Oxford, UK : Blackwell Publishing Ltd
Published 1999Staff ViewISSN: 1439-0426Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyAgriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: This study investigates the development of the sensory-cutaneous apparatus and digestive tract of Adriatic sturgeon (Acipenser naccarii). Light and electron microscopy observations were carried out on various developmental stages, from hatching to 180 days old.At hatching, sturgeon pre-larvae exhibit differentiation of olfactory sensory cells. By day 4 taste buds are differentiated on lips and barbels. At 12 days after hatching, the larvae are equipped with an extensive ventral cephalic sensory apparatus. Electrosensory organs are arranged in regular lines in the rostral ventral region, and taste receptors are organised in parallel rows on and inside the lips as well as on the external side of the barbel. Ventral free neuromasts are positioned in rostral grooves. The retina is completely differentiated in each stratum. At this stage, larvae show canine-like teeth on lips and pharynx, and the specific mucosae of the different digestive regions are differentiated. By day 36 the canine-like teeth are located exclusively on the tongue and roof of the buccal cavity, and the mouth is protrusible. At 180 days differentiation is still not completed, and although teeth have disappeared from the palate, they still persist along a central line on the tongue.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0009-2614Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1572-9125Keywords: Bernstein polynomials ; extrapolation ; Chebyshev interpolationSource: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Abstract Given a real functionf εC 2k [0,1],k ≥ 1 and the corresponding Bernstein polynomials {B n (f)} n we derive an asymptotic expansion formula forB n (f). Then, by applying well-known extrapolation algorithms, we obtain new sequences of polynomials which have a faster convergence thanB n (f). As a subclass of these sequences we recognize the linear combinations of Bernstein polynomials considered by Butzer, Frentiu, and May [2, 6, 9]. In addition we prove approximation theorems which extend previous results of Butzer and May. Finally we consider some applications to numerical differentiation and quadrature and we perform numerical experiments showing the effectiveness of the considered technique.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1572-9125Keywords: Toeplitz matrix ; generating function ; ergodic theorem ; preconditioning ; conjugate gradient methodSource: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Abstract It is well known that the generating function f ∈ L 1([−π, π], ℜ) of a class of Hermitian Toeplitz matrices A n(f) n describes very precisely the spectrum of each matrix of the class. In this paper we consider n × n Hermitian block Toeplitz matrices with m × m blocks generated by a Hermitian matrix-valued generating function f ∈ L 1([−π, π], C m×m ). We extend to this case some classical results by Grenander and Szegö holding when m = 1 and we generalize the Toeplitz preconditioning technique introduced in the scalar case by R. H. Chan and F. Di Benedetto, G. Fiorentino and S. Serra. Finally, concerning the spectra of the preconditioned matrices, some asymptotic distribution properties are demonstrated and, in particular, a Szegö-style theorem is proved. A few numerical experiments performed at the end of the paper confirm the correctness of the theoretical analysis.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-1920Keywords: Acanthocytosis ; Amyotrophy ; Dyskinesias ; Computerized tomographySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary CT has been performed in five patients affected by amyotrophic choreo-acanthocytosis (ACA) and bicaudate diameter, bicaudate index and frontal horn/bicaudate ratio (FH/CC) have been evaluated. Findings have been confirmatory of caudate nuclei atrophy as shown by previous ACA autopsy reports, but did not differ from Huntington's chorea CT picture. There was no correlation between CT measurements and age, illness duration or degree of hyperkinesia in contradistinction to that reported for Huntington's chorea.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1590-3478Keywords: Amiotrophy choreoacanthocytosis ; hyperkinesia ; acanthocytosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Sommario La coreo-acantocitosi amiotrofica (ACA) è una malattia ereditaria caratterizzata da atrofia muscolare neurogena, ipercinesie (con morsicature della lingua e/o delle labbra), acantocitosi, normalità del quadro lipoproteico ed insorgenza in età adulta. In questo articolo vengono descritti otto casi appartenenti a tre famiglie. Viene messa in discussione la presunta rarità della malattia.Notes: Abstract Amyotrophic choreoacanthocytosis (ACA) is a hereditary disease characterized by adult onset, hyperkinesias (with tongue and/or lip biting), neurogenic muscular atrophies, acanthocytosis and normal blood lipoprotein pattern. In this paper we cite 8 patients belonging to three families, describing 6 patients of two of the families. We query the supposed rarity of the disease.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesGalatioto, S. ; Serra, S. ; Perri, R. ; Cavallari, V. ; Villari, D. ; Musolino, R.
Springer
Published 1985Staff ViewISSN: 1590-3478Keywords: Neuronal lipofuscinosis ; Kufs disease ; Hallervorden Spatz syndromeSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Sommario Descrizione clinica, neuropatologica ed ultrastrutturale di un caso di malattia di Kufs (“Forma dei nuclei della base” di Meyer). Nel caso studiato, oltre ai tipici reperti della Ceroido-lipofuscinosi neuronale, è stato rilevato un incremento della reazione per il ferro a livello pallido-nigrico. Viene discusso in particolare il significato di quest'ultimo reperto.Notes: Abstract The clinical, neuropathological and ultrastructural features of a case of Kufs disease (Meyer basal ganglia form) are, reported. In the present case, besides the typical lesions of Neuronal Ceroid-Lipofuscinosis, and increased iron reaction at pallidonigral level was detected histochemically. The significance of the last finding is discussed.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1590-3478Keywords: Amyotrophic choreo-acanthocytosis ; degenerative disease ; neuropathology ; immunohistochemistrySource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Sommario Un paziente di 47 anni, membro di una fratria affetta da Coreo-Acantocitosi Amiotrofica, è stato oggetto di studio neuropatologico, dopo alcuni anni di osservazione clinica. Oltre ai già noti reperti di microscopia ottica (perdita neuronale, gliosi astrocitaria e “status spongiosus” a livello dei nuclei della base, soprattutto del nucleo caudato), immunocitochimicamente furono evidenziati alcuni neuroni striatali MEnk+ e NPY+. A livello del midollo spinale non era riconoscibile perdita neuronale, invece si osservavano modesta demielinizzazione e iperplasia astrocitaria interfascicolare a carico dei tratti lunghi. I reperti presenti a livello del muscolo striato e del tronco nervoso periferico corrispondevano a quelli già descritti su materiale bioptico dello stesso paziente, prelevato alcuni anni prima. I diversi dati neuropatologici e immunocitochimici del caso osservato sono discussi particolarmente in riferimento alla diagnosi differenziale tra Coreo-Acantocitosi Amiotrofica e Corea di Huntington.Notes: Abstract A 47 year old man, one of a sibship affected by amyotrophic choreo-acanthocytosis was studied neuropathologically after some years of clinical observation. Besides the classic optical findings (neuronal loss, astrocytic gliosis and “status spongiosus” in the basal ganglia, namely in the caudate nucleus) a few MEnk+ and NPY+ neurons were observed immunocytochemically in the striatum. In the spinal cord also, while no neuronal loss was perceivable, both mild demyelination and interfibrillary astrocytic hyperplasia of the long tracts were present. On the other hand, microscopic findings of muscle and peripheral nerve showed no differences from what was previously intra-vitam appreciated in the same patient. The neuropathological and immunocytochemical findings of this case are discussed in relation to the differential diagnosis between amyotrophic choreoacanthocytosis and Huntington's disease.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesGallitto, G. ; Musolino, R. ; Bonanzinga, M. ; Domenico, P. ; Distefano, G. ; Serra, S. ; Perri, R.
Springer
Published 1986Staff ViewISSN: 1590-3478Keywords: Rabbit penicillin epilepsy ; spikes ; spindlesSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Sommario Sono stati studiati gli effetti della penicillina G-sodica (1.000.000 I.U./Kg.i.v.) in 28 conigli impiantati con elettrodi di superficie e con elettrodi profondi nel corno di Ammone dorsale (CAd) e nei nuclei talamici laterali (lT) e mediali (mT). In particolare sono stati esaminati l'attività di “spiking” intercritico, l'attività corticale di “spindling” e le relazioni spikes-spindles. In 20 animali la penicillina ha indotto un pattern EEG intercritico multifocale con spikes presenti a livello corticale e talamico. A livello corticale le spikes erano quasi sempre associate a spindles. Inoltre le spindles, dopo penicillina, presentavano un significativo aumento della durata media, senza modificazioni della frequenza. Il pattern EEG da somministrazione sistemica di penicillina nel coniglio appare più simile al pattern descritto nel ratto che a quello del gatto. Le variazioni della attività di “spindles” e l'attività parossistica di “spikes” potrebbero essere due fenomeni indipendenti indotti dalla penicillina e presenti durante periodi di aumentata eccitabilità corticale.Notes: Abstract The effects of Na-penicillin G (1,000,000 I.U./kg i.v.) were studied in 28 rabbits implanted with surface and deep electrodes in the medial (mT) and lateral (lT) nuclei of the thalamus and in the cornu Ammonis dorsalis (CAd). Attention was focused on interictal spike activity, cortical spindle activity and spikes-spindles relationship. A multifocal interictal EEG pattern, represented by cortical and thalamic spikes, was observed in 20 animals. A clear association between cortical spikes and spindles occurred almost constantly. Moreover a statistically significant increase in the average duration of spindles without changes in the average frequency was noticed. Seizure discharges had always a focal start and secondary generalization. The EEG features of parenteral penicillin epilepsy in the rabbit appeared to be more similar to those of the rat than to those of the cat. The spindle activity changes and the paroxysmal spike activity can be interpreted as two independent penicillin induced features appearing during raised cortical excitability periods.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesDomenico, P. ; Musolino, R. ; Rosa, A. E. ; Serra, S. ; Bonanzinga, M. M. ; Gallitto, G. ; Silvestri, R. ; Perri, R.
Springer
Published 1988Staff ViewISSN: 1590-3478Keywords: Tuberculosis ; tuberculous meningitis ; clinical and biological findings ; prognosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Sommario È stato effettuato uno studio retrospettivo su 22 casi di meningite tubercolare al fine di valutare i parametri clinico-biologici possibilmente implicati nella prognosi. Particolare attenzione è stata rivolta all'associazione tra quadro clinico al momento dell'osservazione, reperti liquorali (proteine, glucosio) ed evoluzione della malattia. Al momento del ricovero 16 pazienti presentavano alterazione della coscienza, 11 emiparesi, 7 paralisi del VI nervo cranico. In 7 è stata riscontrata positività liquorale per Mycobacterium Tuberculosis. Al momento dell'indagine 9 soggetti erano guariti completamente, 7 avevano esiti neurologici importanti, 6 erano deceduti. Correlazioni statisticamente significative sono state riscontrate tra obiettività neurologica all'ingresso ed esito di malattia.Notes: Abstract Clinical and biological findings likely to constitute prognostic factors were analyzed in a retrospective survey of 22 cases of tuberculous meningitis. In particular, associations between clinical and biological findings (clinical grade on admission, normal and abnormal CSF protein and glucose values) and outcome of illness were sought. On admission 16 patients had altered consciousness, 11 hemiparesis and 7 sixth cranial nerve paresis. Meningeal signs were present in all subjects. 7 had a positive culture for Mycobacterium tuberculosis. 9 patients recovered completely, 7 had serious late sequelae, 6 died. Prognosis appeared to be correlated to neurological status at admissionType of Medium: Electronic ResourceURL: