Search Results - (Author, Cooperation:S. Sawyer)
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1I. Lazaridis ; N. Patterson ; A. Mittnik ; G. Renaud ; S. Mallick ; K. Kirsanow ; P. H. Sudmant ; J. G. Schraiber ; S. Castellano ; M. Lipson ; B. Berger ; C. Economou ; R. Bollongino ; Q. Fu ; K. I. Bos ; S. Nordenfelt ; H. Li ; C. de Filippo ; K. Prufer ; S. Sawyer ; C. Posth ; W. Haak ; F. Hallgren ; E. Fornander ; N. Rohland ; D. Delsate ; M. Francken ; J. M. Guinet ; J. Wahl ; G. Ayodo ; H. A. Babiker ; G. Bailliet ; E. Balanovska ; O. Balanovsky ; R. Barrantes ; G. Bedoya ; H. Ben-Ami ; J. Bene ; F. Berrada ; C. M. Bravi ; F. Brisighelli ; G. B. Busby ; F. Cali ; M. Churnosov ; D. E. Cole ; D. Corach ; L. Damba ; G. van Driem ; S. Dryomov ; J. M. Dugoujon ; S. A. Fedorova ; I. Gallego Romero ; M. Gubina ; M. Hammer ; B. M. Henn ; T. Hervig ; U. Hodoglugil ; A. R. Jha ; S. Karachanak-Yankova ; R. Khusainova ; E. Khusnutdinova ; R. Kittles ; T. Kivisild ; W. Klitz ; V. Kucinskas ; A. Kushniarevich ; L. Laredj ; S. Litvinov ; T. Loukidis ; R. W. Mahley ; B. Melegh ; E. Metspalu ; J. Molina ; J. Mountain ; K. Nakkalajarvi ; D. Nesheva ; T. Nyambo ; L. Osipova ; J. Parik ; F. Platonov ; O. Posukh ; V. Romano ; F. Rothhammer ; I. Rudan ; R. Ruizbakiev ; H. Sahakyan ; A. Sajantila ; A. Salas ; E. B. Starikovskaya ; A. Tarekegn ; D. Toncheva ; S. Turdikulova ; I. Uktveryte ; O. Utevska ; R. Vasquez ; M. Villena ; M. Voevoda ; C. A. Winkler ; L. Yepiskoposyan ; P. Zalloua ; T. Zemunik ; A. Cooper ; C. Capelli ; M. G. Thomas ; A. Ruiz-Linares ; S. A. Tishkoff ; L. Singh ; K. Thangaraj ; R. Villems ; D. Comas ; R. Sukernik ; M. Metspalu ; M. Meyer ; E. E. Eichler ; J. Burger ; M. Slatkin ; S. Paabo ; J. Kelso ; D. Reich ; J. Krause
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-09-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Agriculture/history/manpower ; Asia/ethnology ; Europe ; European Continental Ancestry Group/*classification/*genetics ; Genome, Human/*genetics ; History, Ancient ; Humans ; Population Dynamics ; Principal Component AnalysisPublished by: -
2S. Benazzi ; V. Slon ; S. Talamo ; F. Negrino ; M. Peresani ; S. E. Bailey ; S. Sawyer ; D. Panetta ; G. Vicino ; E. Starnini ; M. A. Mannino ; P. A. Salvadori ; M. Meyer ; S. Paabo ; J. J. Hublin
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-04-25Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Archaeology ; Base Sequence ; DNA, Mitochondrial/analysis/genetics ; Dental Enamel/chemistry ; *Extinction, Biological ; Genome, Mitochondrial/genetics ; Humans ; Incisor/anatomy & histology/chemistry ; Molecular Sequence Data ; Neanderthals/anatomy & histology/*classification/*genetics ; *Phylogeny ; Tooth, Deciduous/anatomy & histology/chemistryPublished by: -
3K. Prufer ; F. Racimo ; N. Patterson ; F. Jay ; S. Sankararaman ; S. Sawyer ; A. Heinze ; G. Renaud ; P. H. Sudmant ; C. de Filippo ; H. Li ; S. Mallick ; M. Dannemann ; Q. Fu ; M. Kircher ; M. Kuhlwilm ; M. Lachmann ; M. Meyer ; M. Ongyerth ; M. Siebauer ; C. Theunert ; A. Tandon ; P. Moorjani ; J. Pickrell ; J. C. Mullikin ; S. H. Vohr ; R. E. Green ; I. Hellmann ; P. L. Johnson ; H. Blanche ; H. Cann ; J. O. Kitzman ; J. Shendure ; E. E. Eichler ; E. S. Lein ; T. E. Bakken ; L. V. Golovanova ; V. B. Doronichev ; M. V. Shunkov ; A. P. Derevianko ; B. Viola ; M. Slatkin ; D. Reich ; J. Kelso ; S. Paabo
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-12-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Africa ; Animals ; Caves ; DNA Copy Number Variations/genetics ; Female ; *Fossils ; Gene Flow/genetics ; Gene Frequency ; Genome/*genetics ; Heterozygote ; Humans ; Inbreeding ; Models, Genetic ; Neanderthals/classification/*genetics ; Phylogeny ; Population Density ; Siberia/ethnology ; Toe Phalanges/anatomy & histologyPublished by: -
4Staff View
ISSN: 0040-5809Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 0040-5809Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 0040-5809Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 0040-5809Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
8Sawyer, S. M. ; Davidson, P. M. ; Beasley, S. W. ; Stokes, K. B. ; Pepperell, R. J.
Springer
Published 1989Staff ViewISSN: 1437-9813Keywords: Hydrohaematometrocolpos ; Imperforate hymen ; Mayer-Rokitansky syndrome ; Renal agenesisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Hydrohaematometrocolpos may occur secondary to isolated imperforate hymen, genital tract duplications, and complex urogenital sinus or cloacal abnormalities. The presenting symptoms and relation to menarche provide clues to the diagnosis. Examination of the abdomen, introitus, and vagina may confirm the diagnosis and assist in clarification of the anatomy. In genital duplications ultrasonography further delineates the pelvic anatomy and demonstrates unilateral renal agenesis. We have reviewed our 10-year experience and present an approach for the diagnosis and investigation of these patients.Type of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 1437-9813Keywords: Meconium ileus ; Cystic fibrosis ; Ileostomy ; Gastrografin enemaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Recent reviews of meconium ileus (MI) in cystic fibrosis (CF) have documented reduced mortality when compared to earlier studies but suggest significant morbidity is still present, with feeding difficulties and prolonged hospital admission. A chart review was made of 98 infants with MI and CF born in Victoria in the 20-year period 1973–1992. Results were analysed in two consecutive 10-year cohorts. A questionnaire about infant feeding was sent to all current patients from the most recent cohort. MI was the mode of presentation in 21% of all cases of CF. Results of the 1983–1992 cohort (n = 48) showed that 27 of 48 cases (56%) were uncomplicated MI without associated pathology or complications. The remaining 44% had complicated MI. Sixteen of the 27 infants (62%) with uncomplicated MI had a gastrografin enema (GE) performed with a success rate of 50%, with no complications. Surgery was performed in 36 of 48 infants, with the majority (89%) having a stoma fashioned, most commonly an ileostomy (84%), with a mean stoma duration of 17 days (range 5–83). Breast-feeding was established in 25 of 35 cases (71%). The mean duration of hospital stay was 27 days (range 5–90). There was an early mortality of 8%, with a 6-month survival of 90%. Early and late surgical complications were present in 17% of cases. The mean length of hospital stay for cases of uncomplicated MI was 12 days for patients managed non-operatively and 33 days for those treated surgically. Comparison of the two cohorts shows that there has been no further reduction in early mortality (8% in the recent cohort vs 10% in the earlier cohort) and 6-month survival remains unchanged at 90% in both 10-year cohorts. There has been a reduction in early and late surgical morbidity (17% versus 29%). A greater proportion of cases of uncomplicated MI managed non-operatively would result in a reduction in both early and late surgical complications and a shorter hospital stay. The majority of infants with MI do not require long-term parenteral nutrition or pre-digested formula, but can be successfully breast-fed.Type of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 1741-2765Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Results of an experimental program for determining stress-intensity factors utilizing round tensile specimens are presented. Hydrogen embrittlement was utilized as a crack starter for several solid specimens. Notched hollow rounds of various geometries were tested and evaluated.Type of Medium: Electronic ResourceURL: -
11Sawada, K. ; Krantz, S. B. ; Sawyer, S. T. ; Civin, C. I.
New York, NY [u.a.] : Wiley-Blackwell
Published 1988Staff ViewISSN: 0021-9541Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyMedicineNotes: Highly purified human erythroid colony-forming cells (ECFC), which consist predominately of colony-forming units-erythroid (CFU-F), were prepared from human blood and used to study the binding and processing of erythropoietin (Ep). When radioiodinated human recombinant Ep (125I-rEp) was incubated with these cells, binding was specific and saturable. Specific binding was directly proportional to cell concentration and did not occur with other human cells. Saturation of specific binding at 3°C occurred at 1 nM (3.9/U/ml), and Scatchard analysis revealed two classes of binding sites on the cell surface. Of a total of 1,050 binding sites per ECFC, one-fifth had a Kd of 0.10 nM, while the remainder had a Kd of 0.57 nM. Specific binding was twofold greater at 37°C than at 3°C, and removal of surface-bound Ep with acid indicated that 125I-rEp was internalized into the cells after incubation at 37°C. Further incubation at this temperature showed a decline of cellular radioactivity, with a release of small molecular weight degradation fragments into the medium. These studies demonstrate two classes of receptors for Ep on normal human ECFC. Internalization and degradation of EP occur, and the biologic effect of the hormone is produced by a small number of Ep molecules, as demonstrated in murine erythroid progenitor cells.Additional Material: 7 Ill.Type of Medium: Electronic ResourceURL: -
12Koury, M. J. ; Sawyer, S. T. ; Bondurant, M. C.
New York, NY [u.a.] : Wiley-Blackwell
Published 1984Staff ViewISSN: 0021-9541Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyMedicineNotes: Splenic erythroblasts obtained from mice during the acute disease caused by either the polycythemia-inducing (FVP) or anemia-inducing (FVA) strain of Friend virus were examined for their degree of terminal differentiation. Morphology, benzidine staining, and heme synthesis kinetics showed that many erythroblasts from FVP-infected mice were undergoing terminal differentiation, while few erythroblasts from FVA-infected mice showed evidence of terminal differentiation. When cultured in methylcellulose medium, splenic erythroblasts from FVP-infected mice completed differentiation without the addition of erythropoietin (EP) to the medium. However, splenic erythroblasts from FVA-infected mice underwent terminal differentiation in vitro only when EP was added to the medium. From spleens of FVA-infected mice, a population of large, immature-appearing erythroblasts was obtained by separation with velocity sedimentation at unit gravity. Serial studies of the separated erythroblasts which were cultured with EP showed that despite some heterogeneity in their proliferative capacity, they were relatively homogeneous in their degree of differentiation in that they had not begun to synthesize heme or globin. Morphological changes and syntheses of heme and globins were monitored during terminal differentiation induced in vitro by EP. The accumulation of immature erythroblasts in vivo, their responsiveness in vitro to EP, and availability of large numbers of cells (108 or more) make the splenic erythroblasts of FVA-infected mice an ideal population of cells with which to study EP-mediated terminal differentiation. This erythroblast population should permit the biochemical and molecular studies in erythroid differentiation which heretofore had to be done with chemically induced erythroid differentiation in continuous cell lines.Additional Material: 5 Ill.Type of Medium: Electronic ResourceURL: