Search Results - (Author, Cooperation:S. Saeki)
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1Latest Papers from Table of Contents or Articles in PressT. Nagata ; M. Koyanagi ; H. Tsukamoto ; S. Saeki ; K. Isono ; Y. Shichida ; F. Tokunaga ; M. Kinoshita ; K. Arikawa ; A. Terakita
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-01-28Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cues ; Depth Perception ; Fixation, Ocular ; Light ; Locomotion ; Opsins/analysis/physiology ; Photoreceptor Cells, Invertebrate/chemistry/*physiology ; Predatory Behavior ; Spiders/*physiology ; Vision, OcularPublished by: -
2Latest Papers from Table of Contents or Articles in PressOtsuka, Y., Watanabe, E., Shinya, E., Okura, S., Saeki, H., Geijtenbeek, T. B. H., Takahashi, H.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-11-06Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
3Articles: DFG German National LicensesObase, Y. ; Shimoda, T. ; Kawano, T. ; Saeki, S. ; Tomari, S. ; Izaki, K. ; Fukushima, C. ; Matsuse, H. ; Kohno, S.
Oxford, UK : Munksgaard International Publishers
Published 2003Staff ViewISSN: 1398-9995Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: About 70% of childhood asthmatics become free of asthma-related symptoms during adolescence. Little is known about bronchial hyperresponsiveness (BHR) and airway inflammation in young adults with “outgrown” childhood asthma.Methods: We studied 61 nonsmoking medical students (18 intermittent mild asthmatics, 23 students with outgrown childhood asthma but free of asthma-related symptoms for 10 years (asymptomatic asthmatics) and 20 healthy students). BHR and lung function were measured, and induced sputum samples analyzed for eosinophil count, eosinophilic cationic protein (ECP), granulocyte-macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α).Results: BHR was still present in most asymptomatic asthmatics, but it was milder compared with healthy students. Only three subjects with previous asthma had no BHR and no signs of airway inflammation. Percentages of eosinophil, and ECP, TNF-α and GM-CSF concentrations in induced sputum of mild asthmatics and asymptomatic asthma groups were higher than in the healthy group. In asymptomatic asthmatics group, the duration of asthma, sputum eosinophil percentage, and the level of TNF-α in sputum correlated significantly with BHR.Conclusions: Only a few subjects with longstanding asymptomatic asthma could be considered as cured; most asymptomatic asthmatics continued to exhibit BHR and signs of airway inflammation. The outcome of childhood asthma and BHR was associated with the degree of airway inflammation and the duration of childhood asthma.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: The effect of a dc electric field on the spatial evolution of an external wave in a small cold beam–plasma system is investigated numerically. The wave enhancement is strongly dependent on the sign of detuning δω(=ω−ω0) (ω is the wave frequency and ω0 is the frequency of the most unstable mode). Negative detuning, i.e., negative δω, leads to an anomalous increase in the wave power as compared with the wave enhancement for zero or positive detuning. Weak collisions also can play an important role in limiting the wave enhancement.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesCho, M. W. ; Chang, J. H. ; Bagnall, D. M. ; Koh, K. W. ; Saeki, S. ; Park, K. T. ; Zhu, Z. ; Hiraga, K. ; Yao, T.
[S.l.] : American Institute of Physics (AIP)
Published 1999Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: We report on the growth and characterization of beryllium–chalcogenide layers prepared on GaAs (100) by molecular beam epitaxy. Be- and Te-terminated BeTe surfaces show (4×1) and (2×1) reconstructions, respectively. The stability of each surface is investigated by reflection high energy electron diffraction as a function of substrate temperature. The dependence of growth rate of BeTe on growth temperature and Be cell temperature is investigated. The best full width at half maximum (FWHM) of a (400) x-ray rocking curve of BeTe is 78 arcsec. The dependence of the ZnBeSe energy gap on Be composition is obtained by four-crystal x-ray diffraction (XRD) and low temperature photoluminescence measurements. The energy gap of Zn1−xBexSe varies as Eg=0.0107x+2.790 (eV) for small Be composition (x〈0.25) at 77 K. Lattice-matched ZnBeSe (Eg=2.82 eV) and ZnMgBeSe (Eg=2.975 eV) layers show narrower XRD peaks, the FWHM values of which are 64 and 21 arcsec, respectively. The variation of FWHM of x-ray rocking curve due to lattice misfit is investigated for ZnMgBeSe quaternaries with various lattice misfits extending from compressive to tensile strain. The FWHM value under compressive strain increases more steeply with lattice misfit than that under tensile strain. © 1999 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesMachida, I. ; Matsuse, H. ; Kondo, Y. ; Kawano, T. ; Saeki, S. ; Tomari, S. ; Obase, Y. ; Fukushima, C. ; Kohno, S.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Dendritic cells (DCs) play an important role in the immune response and are critically involved in asthma. β2-agonists could potentially exacerbate type 2 T helper (Th2) cell-mediated immune response.Objectives To determine the effects of various anti-asthmatic agents on DCs function both in vitro and in vivo.Methods Murine bone marrow-derived DCs were pulsed with mite allergen in the presence of pranlukast, salbutamol, salmeterol or fluticasone. These DCs were then inoculated intranasally into naïve mice to induce allergic airway inflammation in vivo.Results Pranlukast reduced IL-10 and increased IL-12, while fluticasone reduced both IL-10 and IL-12 production by mite allergen-pulsed DCs. Allergic airway inflammation in pranlukast- and fluticasone-treated and mite allergen pulsed DCs-harbouring mice was attenuated and such response was associated with inhibition of Th2 response in the airway. Salbutamol did not alter cytokine production, while salmeterol reduced IL-12 production by mite allergen-pulsed DCs. Lung pathology in β2-agonist-harbouring mice was comparable with those of mite allergen-pulsed DCs-harbouring mice.Conclusions Our results indicate that leukotriene receptor antagonists and corticosteroids inhibit DCs-induced Th2 skewed immune response, and that short- and long-acting β2-agonists do not modify DCs-induced allergic airway inflammation.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesKondo, Y. ; Matsuse, H. ; Machida, I. ; Kawano, T. ; Saeki, S. ; Tomari, S. ; Obase, Y. ; Fukushima, C. ; Kohno, S.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Respiratory syncytial virus (RSV) infection is known to develop and exacerbate asthma in young children. In adult, RSV causes recurrent but asymptomatic infections. However, the impact of asymptomatic RSV infection on adult asthma is yet to be determined. The present study is designed to determine the effects of primary and secondary low-grade RSV infections on allergic airway inflammation in a murine model of allergic asthma.Methods A low-grade RSV (2 × 103 plaque-forming units/mouse) was inoculated, and this caused neither pulmonary inflammation nor symptoms but induced significant IFN-γ production in thoracic lymph nodes. To investigate interaction between low-grade virus and Dermatophagoides farinae (Df), airway hyper-responsiveness, lung inflammation and cytokine production from thoracic lymph nodes were compared after primary and secondary low-grade RSV infections in four groups of mice; control, Df allergen-sensitized, RSV-infected and Df-sensitized RSV-infected mice. A direct comparison between low- and high-grade RSV infections was also performed in primary infection. To investigate the role of IL-5 during secondary RSV infection, anti-IL-5 monoclonal antibody (anti-IL-5 mAb) was injected in mice and similar parameters were compared in four groups of mice.Results Primary high-grade RSV infection increased allergen-induced airway inflammation, while primary low-grade RSV infection attenuated allergen-induced airway inflammation concomitant with significant IFN-γ production in lung-draining lymph nodes. In marked contrast, secondary low-grade RSV infection increased both IFN-γ and IL-5 production, resulting in exacerbation of allergen-induced airway inflammation. Anti-IL-5 mAb treatment in secondary low-grade RSV infection and Df allergen-sensitized mice attenuated virus and allergen-induced airway inflammation.Conclusions Low-grade RSV infection per se does not cause pulmonary inflammation, whereas it induces a significant immunological response in the allergen-sensitized host. These results indicate that subclinical and recurrent RSV infection may play an important role in exacerbation and maintenance of asthma in adults, wherein IL-5 is critically involved.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0022-2852Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0022-2852Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0022-2860Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0022-2860Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0022-2852Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesSaeki, S. ; Ogihara, T. ; Yuichi, K. ; Kobayashi, Y. ; Yamamura, Y. ; Watanabe, F.
Amsterdam : ElsevierStaff ViewISSN: 0039-128XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0584-8539Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0584-8539Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0584-8539Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0584-8539Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0584-8539Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: