Search Results - (Author, Cooperation:S. Roberts)

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  1. 1
    Staff View
    Publication Date:
    2018-06-15
    Publisher:
    BMJ Publishing Group
    Print ISSN:
    1351-0711
    Electronic ISSN:
    1470-7926
    Topics:
    Medicine
    Keywords:
    Editor's choice
    Published by:
    http://www.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-03-14
    Publisher:
    American Chemical Society (ACS)
    Topics:
    Chemistry and Pharmacology
    Published by:
    http://www.acs.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-03-15
    Publisher:
    BMJ Publishing
    Electronic ISSN:
    2044-6055
    Topics:
    Medicine
    Keywords:
    Open access, Mental health
    Published by:
    http://group.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2018-01-25
    Publisher:
    National Academy of Sciences
    Print ISSN:
    0027-8424
    Electronic ISSN:
    1091-6490
    Topics:
    Biology
    Medicine
    Natural Sciences in General
    Published by:
    http://www.nasonline.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2018-02-09
    Publisher:
    BMJ Publishing
    Electronic ISSN:
    2044-6055
    Topics:
    Medicine
    Keywords:
    Open access, Radiology and imaging
    Published by:
    http://group.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2018-12-11
    Publisher:
    Nature Publishing Group (NPG)
    Electronic ISSN:
    2045-2322
    Topics:
    Natural Sciences in General
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    S. C. Mack ; H. Witt ; R. M. Piro ; L. Gu ; S. Zuyderduyn ; A. M. Stutz ; X. Wang ; M. Gallo ; L. Garzia ; K. Zayne ; X. Zhang ; V. Ramaswamy ; N. Jager ; D. T. Jones ; M. Sill ; T. J. Pugh ; M. Ryzhova ; K. M. Wani ; D. J. Shih ; R. Head ; M. Remke ; S. D. Bailey ; T. Zichner ; C. C. Faria ; M. Barszczyk ; S. Stark ; H. Seker-Cin ; S. Hutter ; P. Johann ; S. Bender ; V. Hovestadt ; T. Tzaridis ; A. M. Dubuc ; P. A. Northcott ; J. Peacock ; K. C. Bertrand ; S. Agnihotri ; F. M. Cavalli ; I. Clarke ; K. Nethery-Brokx ; C. L. Creasy ; S. K. Verma ; J. Koster ; X. Wu ; Y. Yao ; T. Milde ; P. Sin-Chan ; J. Zuccaro ; L. Lau ; S. Pereira ; P. Castelo-Branco ; M. Hirst ; M. A. Marra ; S. S. Roberts ; D. Fults ; L. Massimi ; Y. J. Cho ; T. Van Meter ; W. Grajkowska ; B. Lach ; A. E. Kulozik ; A. von Deimling ; O. Witt ; S. W. Scherer ; X. Fan ; K. M. Muraszko ; M. Kool ; S. L. Pomeroy ; N. Gupta ; J. Phillips ; A. Huang ; U. Tabori ; C. Hawkins ; D. Malkin ; P. N. Kongkham ; W. A. Weiss ; N. Jabado ; J. T. Rutka ; E. Bouffet ; J. O. Korbel ; M. Lupien ; K. D. Aldape ; G. D. Bader ; R. Eils ; P. Lichter ; P. B. Dirks ; S. M. Pfister ; A. Korshunov ; M. D. Taylor
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-02-21
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Brain Neoplasms/drug therapy/genetics ; CpG Islands/*genetics ; DNA Methylation/drug effects ; Embryonic Stem Cells/metabolism ; Ependymoma/drug therapy/*genetics ; Epigenesis, Genetic/*genetics ; Epigenomics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing/drug effects ; Histones/drug effects/metabolism ; Humans ; Infant ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation/genetics ; Phenotype ; Polycomb Repressive Complex 2/metabolism ; Prognosis ; Rhombencephalon/pathology ; Xenograft Model Antitumor Assays
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  8. 8
    S. Roberts ; H. Fuller ; B. Caterson
    Nature Publishing Group (NPG)
    Published 2013
    Staff View
    Publication Date:
    2013-04-20
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Drug Contamination/*prevention & control/statistics & numerical data ; Indicators and Reagents/*standards ; *Laboratories ; Quality Control
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  9. 9
    Staff View
    Publication Date:
    2014-01-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  10. 10
    Staff View
    Publication Date:
    2018-11-17
    Publisher:
    Nature Publishing Group (NPG)
    Electronic ISSN:
    2045-2322
    Topics:
    Natural Sciences in General
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  11. 11
    J. Zhang ; L. Ding ; L. Holmfeldt ; G. Wu ; S. L. Heatley ; D. Payne-Turner ; J. Easton ; X. Chen ; J. Wang ; M. Rusch ; C. Lu ; S. C. Chen ; L. Wei ; J. R. Collins-Underwood ; J. Ma ; K. G. Roberts ; S. B. Pounds ; A. Ulyanov ; J. Becksfort ; P. Gupta ; R. Huether ; R. W. Kriwacki ; M. Parker ; D. J. McGoldrick ; D. Zhao ; D. Alford ; S. Espy ; K. C. Bobba ; G. Song ; D. Pei ; C. Cheng ; S. Roberts ; M. I. Barbato ; D. Campana ; E. Coustan-Smith ; S. A. Shurtleff ; S. C. Raimondi ; M. Kleppe ; J. Cools ; K. A. Shimano ; M. L. Hermiston ; S. Doulatov ; K. Eppert ; E. Laurenti ; F. Notta ; J. E. Dick ; G. Basso ; S. P. Hunger ; M. L. Loh ; M. Devidas ; B. Wood ; S. Winter ; K. P. Dunsmore ; R. S. Fulton ; L. L. Fulton ; X. Hong ; C. C. Harris ; D. J. Dooling ; K. Ochoa ; K. J. Johnson ; J. C. Obenauer ; W. E. Evans ; C. H. Pui ; C. W. Naeve ; T. J. Ley ; E. R. Mardis ; R. K. Wilson ; J. R. Downing ; C. G. Mullighan
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-01-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Age of Onset ; Child ; DNA Copy Number Variations/genetics ; Genes, ras/genetics ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; Genomics ; Hematopoiesis/genetics ; Histones/metabolism ; Humans ; Janus Kinases/genetics/metabolism ; Leukemia, Myeloid, Acute/drug therapy/genetics/pathology ; Molecular Sequence Data ; Mutation/*genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/*genetics/pathology ; Receptors, Interleukin-7/genetics ; Sequence Analysis, DNA ; Signal Transduction/genetics ; Stem Cells/metabolism/pathology ; T-Lymphocytes/metabolism/pathology ; Translocation, Genetic/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  12. 12
    Roberts, S. ; Gorte, R. J.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1990
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The growth of Pt films on ZnO(0001)Zn and ZnO(0001¯)O and their adsorption properties for CO have been studied and compared to results obtained for Pt on α-Al2O3(0001). Samples were prepared by vapor deposition of Pt onto flat substrates in ultra high vacuum, and metal coverages were measured using a quartz-crystal, film thickness monitor. On both ZnO surfaces, Auger electron spectroscopy (AES) and transmission electron microscopy (TEM) indicate that Pt grows in as a 2D film at 300 K, in contrast to results for Pt on α-Al2O3(0001) where 3D particles are formed under these conditions. Furthermore, transmission electron diffraction (TED) showed that the Pt grew as an ordered overlayer on the ZnO crystals. Heating the Pt/ZnO surfaces resulted in the formation of Pt particles starting at ∼650 K, but the Pt particles were still oriented with the ZnO. On both ZnO surfaces, temperature programmed desorption (TPD) curves for CO from high Pt coverages (〉one monolayer) and from Pt particles formed by heating thinner films were identical to TPD curves for CO from Pt on α-Al2O3(0001). The main desorption features were observed at 400 and 510 K and are interpreted as being due to different site geometries on the Pt by comparison to results from Pt single crystals. However, for Pt at submonolayer coverages prior to particle formation, the TPD curves for CO from Pt on ZnO(0001)Zn were shifted down in temperature by ∼60 K compared to results for Pt on ZnO(0001¯)O. These results are interpreted as indicating a chemical interaction between Pt and the Zn+2 ions which are in direct contact.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.459653

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Direct-drive implosions on the OMEGA laser [T. R. Boehly, D. L. Brown, R. S. Craxton et al., Opt. Commun. 133, 495 (1997)] have been diagnosed using a wide range of techniques based on neutrons, charged particles, and x rays. These implosions use full single-beam smoothing (distributed phase plates, 1-THz-bandwidth smoothing by spectral dispersion and polarization smoothing). The beam-to-beam power imbalance is ≤5%. Fuel areal densities close to those in one-dimensional (1-D) simulations are inferred for implosions with calculated convergence ratios ∼15. The experimental neutron yields are ∼35% of 1-D yields. The complementary nature of the experimental observables is exploited to infer fuel shell mix in these implosions. Data suggest that this mix occurs at relatively small scales. Analysis of the experimental observables results in a picture of the core and mix region indicating that nearly 70% of the compressed fuel areal density is unmixed, and about 20% of the compressed shell areal density is in the mixed region. Comparisons of this model with inferred core conditions from argon-doped implosions are also presented. © 2002 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1459452

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The performance of gas-filled, plastic-shell implosions has significantly improved with advances in on-target uniformity on the 60-beam OMEGA laser system [T. R. Boehly, D. L. Brown, R. S. Craxton et al., Opt. Commun. 133, 495 (1997)]. Polarization smoothing (PS) with birefringent wedges and 1-THz-bandwidth smoothing by spectral dispersion (SSD) have been installed on OMEGA. The beam-to-beam power imbalance is ≤5% rms. Implosions of 20-μm-thick CH shells (15 atm fill) using full beam smoothing (1-THz SSD and PS) have primary neutron yields and fuel areal densities that are ∼70% larger than those driven with 0.35-THz SSD without PS. They also produce ∼35% of the predicted one-dimensional neutron yield. The results described here suggest that individual-beam nonuniformity is no longer the primary cause of nonideal target performance. A highly constrained model of the core conditions and fuel–shell mix has been developed. It suggests that there is a "clean" fuel region, surrounded by a mixed region, that accounts for half of the fuel areal density. © 2001 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1350964

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Initial results from direct-drive spherical cryogenic target implosions on the 60-beam OMEGA laser system [T. R. Boehly, D. L. Brown, R. S. Craxton et al., Opt. Commun. 133, 495 (1997)] are presented. These experiments are part of the scientific base leading to direct-drive ignition implosions planned for the National Ignition Facility (NIF) [W. J. Hogan, E. I. Moses, B. E. Warner et al., Nucl. Fusion 41, 567 (2001)]. Polymer shells (1-mm diam with walls 〈3 μm) are filled with up to 1000 atm of D2 to provide 100-μm-thick ice layers. The ice layers are smoothed by IR heating with 3.16-μm laser light and are characterized using shadowgraphy. The targets are imploded by a 1-ns square pulse with up to ∼24 kJ of 351-nm laser light at a beam-to-beam rms energy balance of 〈3% and full-beam smoothing. Results shown include neutron yield, secondary neutron and proton yields, the time of peak neutron emission, and both time-integrated and time-resolved x-ray images of the imploding core. The experimental values are compared with 1-D numerical simulations. The target with an ice-layer nonuniformity of σrms=9 μm showed 30% of the 1-D predicted neutron yield. These initial results are encouraging for future cryogenic implosions on OMEGA and the NIF. © 2002 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1458586

    Articles: DFG German National Licenses
  16. 16
    Attanoos, R. ; Nahar, K. ; Bigrigg, A. ; Roberts, S. ; Newcombe, R.G. ; Ismail, S.M.

    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Science Inc.
    Published 1995
    Staff View
    ISSN:
    1525-1438
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Fifty-five primary invasive adenocarcinomas of the cervix, presenting over a 20-year period, were retrospectively studied with particular reference to clinical and pathologic prognostic indicators. Mean age at presentation was 54.5 years (range 27–91), with an age distribution showing two incidence peaks of equal size in the 31–35 and 61–65 groups, respectively. Twenty-four patients died of the disease and the remaining patients were followed up for a mean of 4.9 years (range 1–17). The results were analyzed using a Cox’s proportional hazards survival model. The independent good prognostic indicators were early tumor stage (P 〈 0.001). and young patient age (P 〈 0.001) at presentation. The presence within the tumor of numerous intraepithelial lymphocytes and the concomitant occurrence of background in situ carcinoma were also good prognostic indicators, although these did not operate independently of stage and age. Histologic tumor subtype and grade of tumor differentiation were not significant prognostic factors. Treatment did not have a significant independent effect on survival. No definite conclusions could be drawn about the effect of oral contraceptives on the disease process.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1525-1438.1995.05030179.x

    Articles: DFG German National Licenses
  17. 17
    Dhawahir, F E ; Sheridan, C ; Kent, D ; Wong, D ; Grierson, I ; Roberts, S

    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Published 2004
    Staff View
    ISSN:
    1524-475X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Scarring causes the irreversible loss of vision seen in macular degeneration and retinal detachment. Treatment of both conditions is ineffective. Cells within the retina, retinal pigment epithelial cells (RPE), are pivotal in the formation of these diseases. Modifying the behavior of these cells may help in controlling the scarring process. We have shown that RPE involved in scarring, unlike normal RPE, express a cell surface sugar called the Thomsen Friedenreich (TF) antigen. Binding by a naturally occurring substance from the common mushroom, called a lectin, can inhibit key RPE functions that are crucial to scar formation. The present study investigates the potential of conjugating this lectin and/or a monoclonal antibody to the TF antigen with known anti-proliferative agents (e.g. Mitomycin) in order to evaluate if the anti-scarring effects of the agents are additive.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1067-1927.2004.0abstractcs.x

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1527-3458
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1527-3458.2000.tb00168.x

    Articles: DFG German National Licenses
  19. 19
    Cleary, R. ; Beard, R. W. ; Coles, J. ; Devlin, H. B. ; Hopkins, A. ; Roberts, S. ; Schumacher, D. ; Wickings, H. I.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1994
    Staff View
    ISSN:
    1471-0528
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Objective To assess the validity of clinical information held on a regional maternity database, the St Mary's Maternity Information System (SMMIS).Design A retrospective review of 892 maternity case notes and matched SMMIS records, by a midwife trained in clinical coding techniques.Setting Three maternity units in the North West Thames Region.Main outcome measures Percentage agreement for 17 directly recorded SMMIS data items and equivalent data abstracted from the notes. Frequencies of diagnosis codes abstracted from case notes, as compared with those generated by SMMIS on the basis of directly recorded data.Results A generally high level of agreement was observed between the abstracts of the notes and the SMMIS records. Of the 17 data items examined, 10 showed 95% agreement or better, and all but two exceeded 80% agreement. Little difference was found between the levels of agreement observed at the three sites. A greater number and range of diagnosis codes were abstracted from the notes than were generated by SMMIS.Conclusions The directly recorded clinical data held on the SMMIS regional database is largely accurate and consistently recorded across a variety of units. The database can therefore be considered a valuable resource for the comparative audit of maternity practice. The SMMIS technique for deriving, on a semi-automatic basis, diagnosis codes from the directly recorded fields, appears to work moderately well. We suggest that the direct method of data collection used in SMMIS could provide a model for other specialties in the National Health Service.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-0528.1994.tb13579.x

    Articles: DFG German National Licenses
  20. 20
    Roberts, S. M. ; Turner, N. J. ; Willetts, A. J. ; Turner, M. K.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1996
    Staff View
    ISSN:
    1550-7408
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1550-7408.1996.tb04500.x

    Articles: DFG German National Licenses