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1Latest Papers from Table of Contents or Articles in PressC. Curtis ; S. P. Shah ; S. F. Chin ; G. Turashvili ; O. M. Rueda ; M. J. Dunning ; D. Speed ; A. G. Lynch ; S. Samarajiwa ; Y. Yuan ; S. Graf ; G. Ha ; G. Haffari ; A. Bashashati ; R. Russell ; S. McKinney ; A. Langerod ; A. Green ; E. Provenzano ; G. Wishart ; S. Pinder ; P. Watson ; F. Markowetz ; L. Murphy ; I. Ellis ; A. Purushotham ; A. L. Borresen-Dale ; J. D. Brenton ; S. Tavare ; C. Caldas ; S. Aparicio
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-04-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Breast Neoplasms/classification/diagnosis/*genetics/*pathology ; DNA Copy Number Variations/*genetics ; Female ; *Gene Expression Profiling ; *Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks/genetics ; Genes, Neoplasm/genetics ; Genome, Human/*genetics ; Genomics ; Humans ; Kaplan-Meier Estimate ; MAP Kinase Kinase 4/genetics ; Polymorphism, Single Nucleotide/genetics ; Prognosis ; Protein Phosphatase 2/genetics ; Treatment OutcomePublished by: -
2Latest Papers from Table of Contents or Articles in PressC. Steidl ; S. P. Shah ; B. W. Woolcock ; L. Rui ; M. Kawahara ; P. Farinha ; N. A. Johnson ; Y. Zhao ; A. Telenius ; S. B. Neriah ; A. McPherson ; B. Meissner ; U. C. Okoye ; A. Diepstra ; A. van den Berg ; M. Sun ; G. Leung ; S. J. Jones ; J. M. Connors ; D. G. Huntsman ; K. J. Savage ; L. M. Rimsza ; D. E. Horsman ; L. M. Staudt ; U. Steidl ; M. A. Marra ; R. D. Gascoyne
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-03-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antigens, CD/genetics/metabolism ; Antigens, CD274 ; Antigens, CD80/genetics/metabolism ; Base Sequence ; Cell Line, Tumor ; Chromosome Breakpoints ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Hodgkin Disease/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Jurkat Cells ; Lymphocyte Activation ; Lymphoma, B-Cell/*genetics ; Molecular Sequence Data ; Nuclear Proteins/*genetics ; Oncogene Proteins, Fusion/*genetics ; Programmed Cell Death 1 Ligand 2 Protein ; RNA, Neoplasm/genetics ; T-Lymphocytes/immunology/metabolism/pathology ; Tissue Array Analysis ; Trans-Activators/*genetics ; Translocation, Genetic/*genetics ; Tumor MicroenvironmentPublished by: -
3Latest Papers from Table of Contents or Articles in PressS. P. Shah ; A. Roth ; R. Goya ; A. Oloumi ; G. Ha ; Y. Zhao ; G. Turashvili ; J. Ding ; K. Tse ; G. Haffari ; A. Bashashati ; L. M. Prentice ; J. Khattra ; A. Burleigh ; D. Yap ; V. Bernard ; A. McPherson ; K. Shumansky ; A. Crisan ; R. Giuliany ; A. Heravi-Moussavi ; J. Rosner ; D. Lai ; I. Birol ; R. Varhol ; A. Tam ; N. Dhalla ; T. Zeng ; K. Ma ; S. K. Chan ; M. Griffith ; A. Moradian ; S. W. Cheng ; G. B. Morin ; P. Watson ; K. Gelmon ; S. Chia ; S. F. Chin ; C. Curtis ; O. M. Rueda ; P. D. Pharoah ; S. Damaraju ; J. Mackey ; K. Hoon ; T. Harkins ; V. Tadigotla ; M. Sigaroudinia ; P. Gascard ; T. Tlsty ; J. F. Costello ; I. M. Meyer ; C. J. Eaves ; W. W. Wasserman ; S. Jones ; D. Huntsman ; M. Hirst ; C. Caldas ; M. A. Marra ; S. Aparicio
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-04-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Breast Neoplasms/diagnosis/*genetics/*pathology ; Clone Cells/metabolism/pathology ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; Disease Progression ; *Evolution, Molecular ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; INDEL Mutation/genetics ; Mutation/*genetics ; Point Mutation/genetics ; Precision Medicine ; Reproducibility of Results ; Sequence Analysis, RNAPublished by: -
4Latest Papers from Table of Contents or Articles in PressP. Eirew ; A. Steif ; J. Khattra ; G. Ha ; D. Yap ; H. Farahani ; K. Gelmon ; S. Chia ; C. Mar ; A. Wan ; E. Laks ; J. Biele ; K. Shumansky ; J. Rosner ; A. McPherson ; C. Nielsen ; A. J. Roth ; C. Lefebvre ; A. Bashashati ; C. de Souza ; C. Siu ; R. Aniba ; J. Brimhall ; A. Oloumi ; T. Osako ; A. Bruna ; J. L. Sandoval ; T. Algara ; W. Greenwood ; K. Leung ; H. Cheng ; H. Xue ; Y. Wang ; D. Lin ; A. J. Mungall ; R. Moore ; Y. Zhao ; J. Lorette ; L. Nguyen ; D. Huntsman ; C. J. Eaves ; C. Hansen ; M. A. Marra ; C. Caldas ; S. P. Shah ; S. Aparicio
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-12-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Breast Neoplasms/*genetics/*pathology/secondary ; Clone Cells/*metabolism/*pathology ; DNA Mutational Analysis ; Genome, Human/*genetics ; Genomics ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Mice ; Neoplasm Transplantation ; *Single-Cell Analysis ; Time Factors ; Transplantation, Heterologous ; *Xenograft Model Antitumor Assays/methodsPublished by: -
5Articles: DFG German National LicensesStaff View
ISSN: 1359-5997Source: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingDescription / Table of Contents: Résumé On suggère une équation d'évolution non linéaire de la détérioration en vue de prédire la résistance ultime en fatigue du béton non armé soumis à un chargement séquentiel d'amplitude constante. Cette approche paraît éliminer l'aspect dissipatif de la loi linéaire de dététérioration (hypothèse de Miner) et elle repose sur la forme observée de la relation de croissance de la détérioration. Aux fins de calcul en relation avec l'aptitude au service des structures de béton armé, on a développé une simple relation non linéaire qui relie les augmentations de flèche et les largeurs de fissures avec le taux de sollicitation cyclique. Les résultats se rapprochent des données expérimentales.Notes: Abstract Nonlinear damage evolution equation is suggested to predict fatigue life of plain concrete subjected to sequential, constant amplitude loading. This approach seems to eliminate the nonconservative aspect of the linear damage law (the Miner hypothesis) and is based on the observed shape of the damage growth relationship. For serviceability based design of reinforced concrete structures, a simple nonlinear relationship is developed to relate the increases in deflection and crack width with the cycle-ratio. The results compare favorably with experimental data.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1359-5997Source: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingDescription / Table of Contents: Resume On a étudié l'effet d'arrachement, à différentes vitesses de glissement, de fibres scellées dans une matrice de ciment. On a établi un système de mesure pour le ‘pendule Charpy’, qui permet d'utiliser deux méthodes indépendantes pour évaluer l'arrachement des fibres du ciment. On a essayé deux séries d'éprouvettes de 16 et 8 fibres, et on a examiné l'effet de la vitesse de glissement et du nombre de fibres. On propose un modèle théorique basé sur la mécanique de la rupture, qui prédit l'effet de la vitesse de glissement sur l'arrachement des fibres. Le modèle proposé, qui s'appuie sur la force maximale d'arrachement des fibres d'un modéle de référence à faible vitesse, peut prédire les forces maximales d'arrachement ainsi que les déplacements correspondant à des vitesses de glissement supérieures.Notes: Abstract A study on steel fibres pulled out from a cementitious matrix at different slip rates was conducted. A measurement system, which allows one to use two independent methods to evaluate pull-out load, was developed for the Charpy pendulum. Two series of specimens, with 16 and 8 fibres, respectively, were tested. Effects of the rate of slip and of numbers of fibres on interfacial behaviour have been examined. A theoretical model to predict the slip-rate effect on fibre pull-out has been proposed based on fracture mechanics. Based on the peak fibre pull-out load of a reference specimen with a static slip-rate, the proposed model can predict peak pull-out loads and corresponding slips at faster slip-rates.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1359-5997Source: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1359-5997Source: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1359-5997Source: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1573-4803Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Confocal microscopy provides a convenient means of acquiring three-dimensional descriptions of objects. A new technique exploits the capability of confocal microscopy to quantify rough surfaces. The microscope “optically” sections the surface, and a computer transforms a series of sections into digital images and a topographic map. Using a straightforward algorithm, the computer analyses the topographic map to derive a roughness parameter that characterizes the texture of the surface.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1573-4803Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Notched concrete beams containing varying amounts of pea gravel aggregate were tested under three-point bend, and their fracture toughness determined. The roughness of the region near the interface between the cement paste and the aggregate was evaluated by digitizing images from a confocal tandem scanning microscope. The average roughness of the paste was found to be related to the fracture parametersK IC (critical stress intensity factor) and Δa c (critical crack extension), as determined by the two-parameter fracture model. The roughness in the proximity of the paste-aggregate interface was generally higher than that of the paste far from the aggregate, and it decreased with the distance from the aggregate. This study indicates that aggregate particles increase the toughness of the cement paste portion of concrete, and that this is an important mechanism for toughening concrete.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1434-453XSource: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingGeosciencesType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1573-4803Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract A simple model is proposed to predict the ultimate tensile strength of fibre-reinforced composites when the failure is governed by fibre debonding. The theoretical analysis is based on the concept of fracture mechanics where the debonded zone is considered as an interfacial crack. The analysis is first applied to the classical pull-out test in order to determine the specific work of interfacial cracking. Using this value, the uniaxial tensile strength of the composites can be predicted from an approximate, closed-form equation proposed here. The theoretically predicted results seem to compare favourably with experimental values for fibrere-inforced cement based composite.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1741-2765Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Micromechanisms of matrix fracture in Portland cement-based fiber composites were studied by means of reflection holographic interferometry and quantitative image analysis. An experimental investigation was conducted with different volume concentrations of polypropylene fibers. Uniaxial tensile specimens were loaded within a strain range of up to three percent. The deformation history was recorded as interference holograms. The holograms were acquired in an image-analysis system. After enhancement, they were analyzed for crack density, length, opening profile, and spacing. The evolution of microcracks, their propagation, distributed microcracking and the material response beyond the characteristic damage state are also discussed.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1741-2765Keywords: Concrete ; feedback signal ; fracture ; digital image cross correlation ; nondestructive evaluationSource: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Because the nature of failure in concrete is complicated due to the material heterogeneity, a robust measuring method is essential to obtain reliable deformation data. A nondestructive displacement evaluation system using a digital image cross-correlation scheme, often called computer vision, is developed to make microscopic examinations of the fracture processes in concrete. This is a full-field measuring method that gives an accuracy within the micron range for a 100 mm × 75 mm viewing area. A feedback signal that combines the lateral and axial deformations provides a well-balanced imaging rate both before and after the peak load. Displacement vector diagrams or displacement contour maps of concrete reveal highly nonuniform deformations even in the elastic range. The processes of fracture in concrete are well defined at different deformation levels.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1741-2765Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Electronic-speckle-pattern interferometry (ESPI) is an optical nondestructive testing technique. A two-dimensional in-plane displacement sensitive interferometer was designed to observe progressive development of microcracking of carbon-fiber-reinforced concrete specimens subjected to tension. By using the two-dimensional ESPI system, the fracture processes, crack initiation and crack propagation of concrete specimens were monitored qualitatively and in real time. The displacement and strain fields were analyzed quantitatively by using digital image processing techniques.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1573-2673Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsDescription / Table of Contents: Résumé On présente un modèle de mécanique de rupture linéaire et élastique pour une rupture par arrachement causée par un ancrage rigide noyé dans un matériau fragile. L'ancrage est représenté par une plaque rigide chargée verticalement et partiellement solidaire d'un demi espace élastique. On suppose que la rupture prend naissance d'une fissuration émanant du bord de la plaque. On réduit le problème d'élasticité bidimensionnelle à la résolution numérique d'un système d'intégrales singulières couplées. On présente les facteurs d'intensité de constraintes pour diverses combinaisons de géométries de mise en charge, de longueurs de fissure, d'angle de fissuration et de profondeur de fixation. On utilise les facteurs d'intensité de contrainte pour tracer les parcours possibles pour la fissure, et pour déterminer sa stabilité de propagation.Notes: Abstract A linear elastic fracture mechanics model is presented for the pull-out failure caused by a rigid anchor embedded in a brittle material. The anchor is modeled as a vertically loaded, partly bonded rigid plate in an elastic half-space, and failure is assumed to arise from cracking which emanates from the edges of the plate. The two-dimensional elasticity problem is reduced to solving numerically a system of coupled singular integral equations. Stress intensity factors are presented for several combinations of load geometry, crack length, crack extension angle, and embedment depth. The stress intensity factors are used to construct crack paths and to determine the stability of crack propagation.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1573-2673Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsDescription / Table of Contents: Résumé Dans la construction en béton, on rencontre fréquemment des ruptures de mode mixte. Pour analyser et concevoir de manière sûr une structure en béton, il est essentiel de comprendre les méchanismes de ruine du béton sous des types de sollicitation de mode mixte. On procède à l'extension d'un modèle proposé à l'origine pour les ruptures de mode I dans le béton, pour caractériser une propagation de fissure selon un mode mixte. On discute les angles d'amorçage de la fissure, le parcours final de la rupture et l'instabilité d'une fissure dans des éprouvettes et dans des structures en béton. On a procédé à une série d'essai de sollicitation selon un mode mixte de poutres entaillées en vue de vérifier le modèle proposé. On trouve que les prédictions théoriques sont en bon accord avec les résultats expérimentaux.Notes: Abstract Mixed-mode fracture of concrete is encountered frequently in design of concrete structures. To accurately analyzed and design a concrete structure, it is essential to understand the failure mechanisms of concrete under mixed-mode types of loading. A model, which was originally proposed for mode I failure of concrete, is extended to characterized mixed-mode crack propagation. Crack initiation angles, final failure path, and crack instability of concrete specimens/structures are discussed. A series of mixed-mode notched beam tests were performed to verify the proposed model. The theoretical predictions were found to be in good agreement with the experimental results.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1573-2673Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract This paper presents the theoretical formulation describing the role of fibers in enhancing the fracture toughness of quasi-brittle cement based materials. The formulation is based on the well known R-curve approach which correlates the increase of the apparent fracture toughness of a material with the existence of a pre-critical stable crack growth region. By assuming that the critical crack length in plain matrix is a function of an initial crack length a 0, a formulation for the R-curves has recently been derived and applied to predict the response of positive and negative geometry specimens of various sizes and materials. This approach is further applied to uniaxial tensile specimens containing various fiber types. Fiber reinforcement is modeled by means of applying closing pressure on crack surfaces resulting in closure of the crack faces and a decrease in the stress intensity factor at the tip of the propagating crack. Incorporation of these two factors in the energy balance equations for crack growth results in increases in both the slope and the plateau value of the R-curve representing matrix response. Enhancement in material response is shown to occur only if precritical crack growth exists, causing fibers to convert the stable cracking process into an increase in load carrying capacity of the material. Fracture response of fiber reinforced composites can be predicted up to the bend-over-point. The theoretical predictions are compared with the experimental results of cement-based composites containing unidirectional, continuous glass, steel or polypropylene fibers.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1741-2765Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract A description is given of a modified instrumented Charpy test that is designed to enable impact-testing of cement-based composites. Problems encountered in instrumented impact testing of such composites and solutions to overcome them are discussed. Results of tests on concrete specimens at four different impact velocities are reported and are used to evaluate the performance of the test setup. A simple spring-mass model is used to verify the test results. This model is capable of providing suitable guidelines for the apriori selection of the basic test parameters with a view to minimize parasitic effects of inertial loading.Type of Medium: Electronic ResourceURL: