Search Results - (Author, Cooperation:S. N. Birrell)
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1Latest Papers from Table of Contents or Articles in PressH. Mohammed ; I. A. Russell ; R. Stark ; O. M. Rueda ; T. E. Hickey ; G. A. Tarulli ; A. A. Serandour ; S. N. Birrell ; A. Bruna ; A. Saadi ; S. Menon ; J. Hadfield ; M. Pugh ; G. V. Raj ; G. D. Brown ; C. D'Santos ; J. L. Robinson ; G. Silva ; R. Launchbury ; C. M. Perou ; J. Stingl ; C. Caldas ; W. D. Tilley ; J. S. Carroll
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-08-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressH. Mohammed ; I. A. Russell ; R. Stark ; O. M. Rueda ; T. E. Hickey ; G. A. Tarulli ; A. A. Serandour ; S. N. Birrell ; A. Bruna ; A. Saadi ; S. Menon ; J. Hadfield ; M. Pugh ; G. V. Raj ; G. D. Brown ; C. D'Santos ; J. L. Robinson ; G. Silva ; R. Launchbury ; C. M. Perou ; J. Stingl ; C. Caldas ; W. D. Tilley ; J. S. Carroll
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-07-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Breast Neoplasms/drug therapy/*genetics/*metabolism/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromatin/drug effects/genetics/metabolism ; DNA Copy Number Variations/genetics ; Disease Progression ; Estrogen Receptor alpha/antagonists & inhibitors/*metabolism ; Estrogens/metabolism/pharmacology ; Female ; *Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Ligands ; Mice ; Progesterone/metabolism/pharmacology ; Protein Binding/drug effects ; Receptors, Progesterone/genetics/*metabolism ; Transcription, Genetic/drug effects ; Xenograft Model Antitumor AssaysPublished by: -
3Latest Papers from Table of Contents or Articles in PressRicciardelli, C., Bianco-Miotto, T., Jindal, S., Butler, L. M., Leung, S., McNeil, C. M., O'Toole, S. A., Ebrahimie, E., Millar, E. K. A., Sakko, A. J., Ruiz, A. I., Vowler, S. L., Huntsman, D. G., Birrell, S. N., Sutherland, R. L., Palmieri, C., Hickey, T. E., Tilley, W. D.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-05-16Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1573-7039Keywords: ANDROGENS ; ANDROGEN RECEPTOR ; MEDROXYPROGESTERONE ACETATE ; RECEPTOR VARIANTSSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Although the androgen receptor (AR)3is often co-expressed with the estrogen receptor (ER)and progesterone receptor (PR) in human breast tumors,its role in breast cancer is poorly understood. Specific growth stimulatory and inhibitory actions ofandrogens have been described in human breast cancercell lines. The mechanisms by which androgens exertthese contrasting growth effects are unknown. A commonly utilized second line therapy for the treatmentof advanced breast cancer is high dosemedroxyprogesterone acetate (MPA). Although MPA, asynthetic progestin, was thought to act exclusivelythrough the PR, the androgenic side-effects observed in womentaking MPA suggest that its action may also be mediatedin part by the AR. In support of this hypothesis, thelevel of AR measured by radioligand binding in primary breast tumors was correlated with theduration of response to MPA treatment following failureof tamoxifen therapy. Recent data suggest that thepresence of structurally altered AR in breast cancers may account for unresponsiveness to MPA in someof these cases. Further studies are warranted todetermine the role of AR mediated pathways in regulatingbreast tumor growth. In particular, identification of androgen-regulated genes may lead to newpossibilities for the hormonal treatment of breastcancer.Type of Medium: Electronic ResourceURL: