Search Results - (Author, Cooperation:S. Monti)
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1K. Lu ; X. Heng ; L. Garyu ; S. Monti ; E. L. Garcia ; S. Kharytonchyk ; B. Dorjsuren ; G. Kulandaivel ; S. Jones ; A. Hiremath ; S. S. Divakaruni ; C. LaCotti ; S. Barton ; D. Tummillo ; A. Hosic ; K. Edme ; S. Albrecht ; A. Telesnitsky ; M. F. Summers
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-10-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: 5' Untranslated Regions ; Base Pairing ; Binding Sites ; Codon, Initiator ; Dimerization ; Genes, gag ; *Genome, Viral ; HIV-1/*genetics/*physiology ; Human Immunodeficiency Virus Proteins/metabolism ; Mutagenesis, Site-Directed ; Nuclear Magnetic Resonance, Biomolecular ; Nucleic Acid Conformation ; Nucleocapsid Proteins/metabolism ; Protein Binding ; Protein Biosynthesis ; RNA, Viral/*chemistry/*genetics ; *Virus Assembly ; gag Gene Products, Human Immunodeficiency Virus/metabolismPublished by: -
2M. A. Chapman ; M. S. Lawrence ; J. J. Keats ; K. Cibulskis ; C. Sougnez ; A. C. Schinzel ; C. L. Harview ; J. P. Brunet ; G. J. Ahmann ; M. Adli ; K. C. Anderson ; K. G. Ardlie ; D. Auclair ; A. Baker ; P. L. Bergsagel ; B. E. Bernstein ; Y. Drier ; R. Fonseca ; S. B. Gabriel ; C. C. Hofmeister ; S. Jagannath ; A. J. Jakubowiak ; A. Krishnan ; J. Levy ; T. Liefeld ; S. Lonial ; S. Mahan ; B. Mfuko ; S. Monti ; L. M. Perkins ; R. Onofrio ; T. J. Pugh ; S. V. Rajkumar ; A. H. Ramos ; D. S. Siegel ; A. Sivachenko ; A. K. Stewart ; S. Trudel ; R. Vij ; D. Voet ; W. Winckler ; T. Zimmerman ; J. Carpten ; J. Trent ; W. C. Hahn ; L. A. Garraway ; M. Meyerson ; E. S. Lander ; G. Getz ; T. R. Golub
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-03-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Blood Coagulation/genetics ; CpG Islands/genetics ; DNA Mutational Analysis ; DNA Repair/genetics ; Exons/genetics ; Exosome Multienzyme Ribonuclease Complex ; Genome, Human/*genetics ; Genomics ; Histones/metabolism ; Homeodomain Proteins/genetics ; Homeostasis/genetics ; Humans ; Methylation ; Models, Molecular ; Molecular Sequence Data ; Multiple Myeloma/drug therapy/enzymology/*genetics/metabolism ; Mutation/*genetics ; NF-kappa B/metabolism ; Oncogenes/genetics ; Open Reading Frames/genetics ; Protein Biosynthesis/genetics ; Protein Conformation ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors/genetics/metabolism ; RNA Processing, Post-Transcriptional/genetics ; Ribonucleases/chemistry/genetics ; Signal Transduction/genetics ; Transcription, Genetic/geneticsPublished by: -
3Staff View
ISSN: 0014-5793Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
4Le Pichon, X. ; Angelier, J. ; Aubouin, J. ; Lyberis, N. ; Monti, S. ; Renard, V. ; Got, H. ; Hsu, K. ; Matthews, D. ; Mitropoulos, D. ; Chronis, G. ; Mascle, J. ; Tsoflias, P. ; Mart, Y.
Amsterdam : ElsevierStaff ViewISSN: 0012-821XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: GeosciencesPhysicsType of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 0010-8545Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 0009-2614Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
7Bortolus, P. ; Camaioni, N. ; Flamigni, L. ; Minto, F. ; Monti, S. ; Faucitano, A.
Amsterdam : ElsevierStaff ViewISSN: 1010-6030Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 0301-0104Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 0047-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 0047-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 0047-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 0301-0104Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
13Nolè, F. ; de Braud, F. ; Aapro, M. ; Minchella, I. ; De Pas, M. ; Zampino, M. G. ; Monti, S. ; Andreoni, G. ; Goldhirsch, A.
Springer
Published 1997Staff ViewISSN: 1569-8041Keywords: breast cancer ; chemotherapy ; fluorouracil ; folates ; vinorelbineSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Background: Vinorelbine, is an active drug in the treatment of metastatic breast cancer and has a favorable toxicity profile. Its combination with other effective and well-tolerated cytotoxics may thus be beneficial. We investigated the therapeutic effect of a combination of vinorelbine plus 5-fluorouracil and folinic acid as first-line treatment in patients with metastatic breast cancer. Patients and methods: Forty-five patients with advanced or metastatic breast cancer were enrolled in this phase I–II study and treated with 5-fluorouracil (350 mg/m2 i.v. on day 1 to 3), folinic acid (100 mg/m2 i.v. on day 1 to 3) and vinorelbine given on days 1 and 3 at the dose of 25 mg/m2 (dose level 1), or 30 mg/m2 (dose level 2). Therapy was given on an outpatient basis every three weeks. Results: Phase I: Dose limiting toxicity (DLT) occurred at the second dose level of vinorelbine (30 mg/m2), with two out of three patients developing severe constipation (‘ileus-like syndrome’ grade 4), and fever (grade 2). Consequently, the dose evaluated in the phase II study was 25 mg/m2. Phase II: Objective responses were observed in 24 of 39 evaluable patients (95% confidence interval (95% CI), 47% to 77%). There were seven complete responses (18%), 17 partial responses (44%), and for nine patients (23%) disease was stable. Only six patients (15%) experienced disease progression. The median response duration was 10 months (range 6 to 24+) and the median time to progression was eight months (range 2 to 24+). Granulocytopenia was the most frequently observed side effect, with a grade 4 nadir being observed in 30 patients (77%), with four hospital admissions due to febrile neutropenia. Nausea, vomiting, and anorexia were mild to moderate and reported by less than half of the patients. Alopecia was moderate and occurred in about one-third of the patients. The other side effects were mild and easily manageable. Conclusions: This effective combination chemotherapy of vinorelbine, 5-fluorouracil and folinic acid is comparable to other first-line regimens in terms of efficacy, and is subjectively well tolerated, thus deserving a test in randomized trials in the advanced and adjuvant settings.Type of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 0047-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 0047-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 0047-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 0047-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Sciarra, F. ; Monti, S. ; Adamo, M. V. ; Palma, E. ; Toscano, V. ; d'Eramo, G. ; Silverio, F.
Springer
Published 1995Staff ViewISSN: 1434-0879Keywords: Benign prostatic hyperplasia ; Epidermal growth factor ; Testosterone ; DihydrotestosteroneSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In benign prostatic hyperplasia (BPH), basic fibroblast growth factor (bFGF) is found to have a regional distribution, with concentrations in the periurethral zone (where the primitive fibrostromal nodule originates) higher than those of the peripheral subcapsular zone. The aim of the present investigation was to verify whether androgens and epidermal growth factor (EGF) are uniformly distributed from the periurethral to the peripheral zone or whether they show regional differences. Tissue samples, removed by transvesical resection from nine untreated BPH patients, sectioned in periurethral, subcapsular, and intermediate zones, were examined. In the periurethral zone, dihydrotestosterone (DHT), testosterone, and EGF, determined by radioimmunoassay (RIA) techniques after purification on Celite microcolumns and Sep-pak C18 cartridge, showed values significantly higher (mean ± SD: 1121±482 pg, 250±129 pg, and 6.89±3.28 ng/mg DNA, respectively;P〈0.01) than those of the subcapsular zone (489±190 pg, 114±70 pg, and 3.40±1.90 ng/mg DNA, respectively). A positive linear correlation between EGF, testosterone, and DHT was also observed. The regional distribution of EGF, testosterone, and DHT was similar to that found for bFGF: the highest levels of these factors in the periurethral region allow us to hypothesize on their possible involvement in the rewakening of mesenchymal tissue, leading to the formation of the primitive fibrostromal nodule and then to BPH development.Type of Medium: Electronic ResourceURL: -
19LE PICHON, X. ; AUZENDE, J. M. ; PAUTOT, G. ; MONTI, S. ; FRANCHETEAU, J.
[s.l.] : Nature Publishing Group
Published 1971Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Fig. 1 The track of the troika (heavy line). F is the fault. The photographs were taken as a troika4 was dragged along 3 km of seafloor (depth 4,800 m) in the south-eastern region of this turbidite abyssal plain which shows strong evidence of active tectonic deformation5. In all, 450 photographs ...Type of Medium: Electronic ResourceURL: -
20Köhler, G. ; Grabner, G. ; Klein, C. TH. ; Marconi, G. ; Mayer, B. ; Monti, S. ; Rechthaler, K. ; Rotkiewicz, K. ; Viernstein, H. ; Wolschann, P.
Springer
Published 1996Staff ViewISSN: 1573-1111Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract We compare spectroscopic properties of higher order complexes of organic guests (e.g. naphthalene, phenols, indole, C60 fullerene) with cyclodextrins (CDx) to results of molecular modeling investigations. Naphthalene 1:2 complexes with α-CDx show high spectral resolution and peculiar triplet properties. Molecular simulations and calculation of the experimentally measured induced circular dichroism (ICD) provide detailed structural information.Type of Medium: Electronic ResourceURL: