Search Results - (Author, Cooperation:S. Marks)
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1Latest Papers from Table of Contents or Articles in PressRuzo, A., Croft, G. F., Metzger, J. J., Galgoczi, S., Gerber, L. J., Pellegrini, C., Wang, H., Fenner, M., Tse, S., Marks, A., Nchako, C., Brivanlou, A. H.
The Company of Biologists
Published 2018Staff ViewPublication Date: 2018-01-30Publisher: The Company of BiologistsPrint ISSN: 0950-1991Electronic ISSN: 1477-9129Topics: BiologyKeywords: Stem cells & regeneration, Neural development, Human developmentPublished by: -
2Latest Papers from Table of Contents or Articles in PressSanduo Zheng, Lok-To Sham, Frederick A. Rubino, Kelly P. Brock, William P. Robins, John J. Mekalanos, Debora S. Marks, Thomas G. Bernhardt, Andrew C. Kruse
National Academy of Sciences
Published 2018Staff ViewPublication Date: 2018-06-27Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
3Latest Papers from Table of Contents or Articles in PressJ. M. Schmiedel ; S. L. Klemm ; Y. Zheng ; A. Sahay ; N. Bluthgen ; D. S. Marks ; A. van Oudenaarden
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-04-04Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: 3' Untranslated Regions/genetics/physiology ; Animals ; Embryonic Stem Cells/metabolism ; *Gene Expression Regulation ; Mice ; MicroRNAs/genetics/*physiology ; Models, Genetic ; Protein Biosynthesis/*genetics ; RNA, Messenger/biosynthesis ; Single-Cell Analysis ; Transcription, GeneticPublished by: -
4Latest Papers from Table of Contents or Articles in PressI. Iossifov ; B. J. O'Roak ; S. J. Sanders ; M. Ronemus ; N. Krumm ; D. Levy ; H. A. Stessman ; K. T. Witherspoon ; L. Vives ; K. E. Patterson ; J. D. Smith ; B. Paeper ; D. A. Nickerson ; J. Dea ; S. Dong ; L. E. Gonzalez ; J. D. Mandell ; S. M. Mane ; M. T. Murtha ; C. A. Sullivan ; M. F. Walker ; Z. Waqar ; L. Wei ; A. J. Willsey ; B. Yamrom ; Y. H. Lee ; E. Grabowska ; E. Dalkic ; Z. Wang ; S. Marks ; P. Andrews ; A. Leotta ; J. Kendall ; I. Hakker ; J. Rosenbaum ; B. Ma ; L. Rodgers ; J. Troge ; G. Narzisi ; S. Yoon ; M. C. Schatz ; K. Ye ; W. R. McCombie ; J. Shendure ; E. E. Eichler ; M. W. State ; M. Wigler
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Child ; Child Development Disorders, Pervasive/*genetics ; Cluster Analysis ; Exome/genetics ; Female ; Genes ; Genetic Predisposition to Disease/*genetics ; Humans ; Intelligence Tests ; Male ; Mutation/*genetics ; Open Reading Frames/*genetics ; Reproducibility of ResultsPublished by: -
5Articles: DFG German National LicensesYoung, A. T. ; Hoyer, E. ; Marks, S. ; Martynov, V. ; Padmore, H.A. ; Plate, D. ; Schlueter, R.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: Circular polarization insertion devices and beamlines at the Advanced Light Source are described. The facility will consist of multiple undulators feeding two independent beamlines, one optimized for microscopy and the other for spectroscopy. The energy range of the beamlines will go from below 100 eV to 1800 eV, enabling studies of the magnetically important L2,3 edges of transition metals and the M4,5 edges of rare earths. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesHoyer, E. ; Akre, J. ; Humphries, D. ; Marks, S. ; Minamihara, Y. ; Pipersky, P. ; Plate, D. ; Schlueter, R.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: A 3.5-m-long elliptical wiggler, optimized to produce elliptically polarized light in the 50 eV to 10 keV range, is currently under design and construction at the Advanced Light Source at Lawrence Berkeley Laboratory. Calculations of spectral performance show that the flux of circularly polarized photons exceeds 1013 photons/s over the 50 eV to 10 keV operating range for current of 0.4 A and 1.5 GeV electron energy. This device features vertical and horizontal magnetic structures of 14 and 141/2 periods, respectively. The period length is 20.0 cm. The vertical structure is a hybrid permanent magnet design with tapered pole tips that produce a peak field of 2.0 T. The horizontal structure is an iron core electromagnetic design, shifted longitudinally 1/4 period, that is tucked between the upper and lower vertical magnetic structure sections. A maximum peak oscillating field of 0.095 T at a frequency up to 1 Hz will be achieved by excitation of the horizontal poles with a trapezoidal current waveform. The vacuum chamber is an unconventional design that is removable from the magnetic structure, after magnetic measurements, for UHV processing. The chamber is fabricated from non-magnetic stainless steel to minimize the effects of eddy currents. Device design is presented. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesHumphries, D. ; Goetz, F. ; Kownacki, P. ; Marks, S. ; Schlueter, R.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: Insertion devices for the Advanced Light Source (ALS) incorporate large numbers of permanent magnets which have a variety of magnetization orientation errors. These orientation errors can produce field errors which affect both the spectral brightness of the insertion devices and the storage ring electron beam dynamics. A perturbation study was carried out to quantify the effects of orientation errors acting in a hybrid magnetic structure. The results of this study were used to develop a multiple stage sorting algorithm which minimizes undesirable integrated field errors and essentially eliminates pole excitation errors. When applied to a measured magnet population for an existing insertion device, an order of magnitude reduction in integrated field errors was achieved while maintaining near zero pole excitation errors. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: A protein crystallography facility is being constructed for the Advanced Light Source (ALS) wiggler beamline 5.0. The radiation source is a 38 pole, 2.0 T wiggler. Calculations have been performed to determine the source phase space characteristics and the power loading on and transmission of various beamline elements. A set of computer codes have been developed for this purpose. The wiggler horizontal and vertical phase space flux density is calculated by phasex and phasey, respectively. WrFlux calculates the spectral flux density along the principal ray of the optical system. WrPwr calculates the power impinging on a target. If a filter function is specified, the transmitted, or reflected, power is calculated. The theory and operation of the codes will be presented as well as several results of calculations. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesHeimann, P. ; Mossessian, D. ; Warwick, A. ; Wang, C. ; Marks, S. ; Padmore, H. ; Kincaid, B. ; Gullikson, E. M.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: The radiation from the 5 cm period undulator at the Advanced Light Source (ALS) has been characterized using a transmission grating spectrometer. Spectral and angular distributions of radiation were measured for deflection parameter K values between 0.45 and 2.12 at low storage ring current (0.1–0.5 mA). From the calibration of the spectrometer, the absolute flux density of the undulator harmonics has been determined together with the spectral linewidth. The electron-beam emittance was determined by analyzing the angular distribution of the redshifted fundamental. Comparison has been made with radiation calculations based upon the measured magnetic-field data of the undulator. Including field errors, electron-beam emittance, and energy spread, good agreement is found between theoretically and experimentally determined harmonic widths and peak brightness. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesHoyer, E. ; Marks, S. ; Pipersky, P. ; Schlueter, R.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: Multiple trim magnets (MTMs), also known as "magic fingers,'' are an arrangement of magnets for reducing integrated magnetic-field errors in insertion devices. The idea is to use transverse arrays of permanent magnets, hence the name "multiple trim magnets,'' above and below the midplane, to correct both normal and skew longitudinal magnetic-field integral errors in a device. MTMs are typically installed at the ends of an ID. Adjustments are made by changing either the size, position, or orientation of each trim magnet. Application of the MTMs to the ALS undulators reduced both the normal and skew longitudinal field integral errors, over the entire 20 mm×60 mm "good field region,'' of the beam aperture by as much as an order of magnitude. The requirements included corrections of field and gradients outside the multipole convergence radius. Additionally, these trim magnet arrays provided correction of the linear component of the integrated field gradients for particles with trajectories not parallel to the nominal beam axis. The MTM concept, design, construction, tests that demonstrated feasibility, and magnetic-field integral reduction of ALS undulators are presented. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesHoyer, E. ; Akre, J. ; Chin, J. ; Gath, W. ; Hassenzahl, W. V. ; Humphries, D. ; Kincaid, B. ; Marks, S. ; Pipersky, P. ; Plate, D. ; Portmann, G. ; Schlueter, R.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: At Lawrence Berkeley Laboratory's Advanced Light Source, three 4.6 m long undulators have been completed, tested, and installed. A fourth is under construction. The completed undulators include two 5.0 cm period length, 89 period devices (U5.0s) which achieve a 0.85 T effective field at a 14 mm minimum gap and a 8.0 cm period length, 55 period device (U8.0) that reaches a 1.2 T effective field at a 14 mm minimum gap. The undulator under construction is a 10.0 cm period length, 43 period device (U10.0) that is designed to achieve 0.98 T at a 23 mm gap. Undulator magnetic gap variation (rms) is within 25 μm over the periodic structure length. Reproducibility of the adjustable magnetic gap has been measured to be within ±5 μm. Gap adjusting range is from 14 to 210 mm, which can be scanned in 1 min. The 5.1 m long vacuum chambers are flat in the vertical direction to within 0.74 mm and straight in the horizontal direction to within 0.08 mm over the 4.6 m magnetic structure sections. Vacuum chamber base pressures after UHV beam conditioning are in the mid-10−11 Torr range and storage ring operating pressures with full current are in the low 10−10 Torr range. Measurements show that the uncorrelated magnetic field errors are 0.23% and 0.20% for the two U5.0s and the U8.0, respectively, and that the field integrals are small over the 1 cm×6 cm beam aperture. Device description, fabrication, and measurements are presented. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesMarks, S. ; McKinney, W. ; Padmore, H. ; Young, A.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: This paper describes a design study with the objective of optimizing spectral performance of an elliptical wiggler to be installed at the Lawrence Berkeley Laboratory Advanced Light Source (ALS). This device is to produce circularly polarized radiation in the energy range of 50 eV–10 keV. A figure of merit, which is a function of flux density and degree of circular polarization, is introduced as the objective function for optimization. An optimum set point for a particular photon energy is characterized by values of peak vertical field, horizontal deflection parameter, and vertical aperture. Optimum performance is evaluated for the nominal ALS operating energy of 1.5 GeV. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesKarpenko, V. ; Kinney, J. H. ; Kulkarni, S. ; Neufeld, K. ; Poppe, C. ; Tirsell, K. G. ; Wong, J. ; Cerino, J. ; Troxel, T. ; Yang, J. ; Hoyer, E. ; Green, M. ; Humphries, D. ; Marks, S. ; Plate, D.
[S.l.] : American Institute of Physics (AIP)
Published 1989Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: A beamline has been constructed at Stanford Synchrotron Radiation Laboratory (SSRL) whose radiation source is a multipole permanent magnet wiggler installed in a straight section of the SPEAR 3–3.5 GeV electron storage ring. The wiggler is a hybrid design that utilizes Nd–Fe alloy magnet material combined with Vanadium Permendur poles. It is approximately 2 m long and has 15 full wiggler periods. Its field is regulated by varying its gap height. It has a peak operating field, limited by the electron beam vacuum chamber vertical aperture, of 1.4 T. The beamline consists of vacuum, safety, and optical components capable of transporting photons to one hard x-ray (3–30 keV) end station, with provisions for implementing up to two additional branch lines. The existing hard x-ray branch can be focused by a Pt-coated toroidal mirror with a cutoff energy of approximately 22 keV. The experimental end station is serviced by a Hower–Brown type double crystal monochromator. The wiggler and beamline construction was completed in the fall of 1987 and was operated for a brief period for characterization and experimental use. We present design details and results of the initial characterization studies.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesHULTENBY, K. ; REINHOLT, F. P. ; HEINEGÅRD, D. ; ANDERSSON, G. ; MARKS, S. C.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Osteopetrosis is a metabolic bone disease characterized by reduced bone resorption of heterogenous cause. The rabbit mutation is lethal and exhibits ultrastructural aberrations in osteoclasts and osteoblasts together with hypocalcemia, hypophosphatemia and failure to be cured by bone marrow transplantation. We have studied dental abnormalities in mutants from birth to 3 wk using radiographic, cytologic and autoradiographic methods. Radiographs show hypoplasia of most teeth in mutants. The maxillary incisor is smaller and more curved and the mandibular incisor thin and straight compared to normal littermates. The first 3 molars in both arches are unerupted and of distorted shape while the last 2 are less affected. Microscopically areas of ankylosis of mutant incisors and the first 3 molars were commonly encountered even at birth. Osteoclasts were numerous. Autoradiograms of 3H-proline incorporation showed strong periosteal and weak endosteal labeling of bone in both mutants and normal littermates. Dentin labeling in mutant incisors and molars was not less than that in normal rabbits and sites of ankylosis in mutants exhibited labeling. These data indicate that osteopetrotic rabbits exhibit major aberrations in shape and eruption of incisors and most molars and that these effects are not due to lack of dentin formation. Early ankylosis, perhaps secondary to congenital reduction of bone resorption, appears to be the major cause of the dental abnormalities which are less severe in the youngest (posterior) teeth.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The dental follicle is a loose connective tissue layer that surrounds the developing and erupting tooth. The follicle is necessary for tooth eruption in dogs and specific cellular changes occur in the follicle at the onset of tooth eruption, in particular, within the coronal region of the follicle next to areas of subsequent bone resorption there is an increase in mononuclear cells which have the ultrastructure features of monocytes and contain specific granules characteristic of preosteoclasts. The follicle has an extensive microvasculature and monocytes are often seen adjacent to capillaries and venules. Monocytes increase in number in direct proportion to the increase in osteoclasts that form the eruption pathway and decrease in number as soon as this activity is completed. It is postulated that monocytes enter the follicle from the microvasculature and then migrate to the walls of the bony crypt to participate in the formation of the eruption pathway.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The maintenance of alveolar bone is a major clinical objective in dentistry. This is particularly difficult following such local inflammatory episodes as those of periodontitis or the loss of dentition (residual ridge resorption). We present evidence from beagle dogs that local infusion of prostaglandin E1 (PGE) for 3 weeks at doses of 500 to 2000μg per week produces a dramatic, localized formation of alveolar bone in the mandible which exhibits a normal lamellar architecture and mineralization pattern when evaluated by fluorescence microscopy and microradiography. Whether this newly formed bone becomes functionally integrated into the skeleton and can replace bone lost from surgical resections or trauma remains to be established. Nevertheless, these data indicate that predictable local osteogenesis may eventually be produced by infusions of PGE.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Recent evidence for an extraskeletal origin of osteoclasts and the historical record of the genesis of osteoclasts are examined critically. Reviews of the structure, function and development of osteoclasts from mononuclear precursors, the local regulation of bone resorption and the coupling of bone formation to preceding resorption are presented as a background for discussing the clinical implications for management of osteolytic bone diseases. The roles of osteoclasts and macrophages as phagocytes are compared and contrasted, and recent evidence for macrophage heterogeneity resulting from site-specific monoblastic precursors is reviewed. The implications of these recent developments in macrophage biology are extrapolated to osteoclasts and the existence of site-specific, extraskeletal tsteoclast precursors is proposed. Finally, the investigative challenges inherent in these perspectives are discussed.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Formation of cementum, alveolar bone and periodontal ligament was produced in 18 sites on buccal surfaces of mandibular premolars and molars of 11 adult dogs near to sites of local delivery of prostaglandin E1 (PGE) for three weeks. Mineralizing bone and cementum were labelled with fluorescent dyes and polarizing microscopy showed periodontal ligament fibers between these new mineralized tissues. These observations extend recent demonstrations that local application of PGE causes formation of new bone on the mandible and suggest the potential for predictable, site-directed periodontal regeneration.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0169-4758Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: