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1S. Nik-Zainal ; H. Davies ; J. Staaf ; M. Ramakrishna ; D. Glodzik ; X. Zou ; I. Martincorena ; L. B. Alexandrov ; S. Martin ; D. C. Wedge ; P. Van Loo ; Y. S. Ju ; M. Smid ; A. B. Brinkman ; S. Morganella ; M. R. Aure ; O. C. Lingjaerde ; A. Langerod ; M. Ringner ; S. M. Ahn ; S. Boyault ; J. E. Brock ; A. Broeks ; A. Butler ; C. Desmedt ; L. Dirix ; S. Dronov ; A. Fatima ; J. A. Foekens ; M. Gerstung ; G. K. Hooijer ; S. J. Jang ; D. R. Jones ; H. Y. Kim ; T. A. King ; S. Krishnamurthy ; H. J. Lee ; J. Y. Lee ; Y. Li ; S. McLaren ; A. Menzies ; V. Mustonen ; S. O'Meara ; I. Pauporte ; X. Pivot ; C. A. Purdie ; K. Raine ; K. Ramakrishnan ; F. G. Rodriguez-Gonzalez ; G. Romieu ; A. M. Sieuwerts ; P. T. Simpson ; R. Shepherd ; L. Stebbings ; O. A. Stefansson ; J. Teague ; S. Tommasi ; I. Treilleux ; G. G. Van den Eynden ; P. Vermeulen ; A. Vincent-Salomon ; L. Yates ; C. Caldas ; L. V. Veer ; A. Tutt ; S. Knappskog ; B. K. Tan ; J. Jonkers ; A. Borg ; N. T. Ueno ; C. Sotiriou ; A. Viari ; P. A. Futreal ; P. J. Campbell ; P. N. Span ; S. Van Laere ; S. R. Lakhani ; J. E. Eyfjord ; A. M. Thompson ; E. Birney ; H. G. Stunnenberg ; M. J. van de Vijver ; J. W. Martens ; A. L. Borresen-Dale ; A. L. Richardson ; G. Kong ; G. Thomas ; M. R. Stratton
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-05-03Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Staff View
Publication Date: 2018-01-09Publisher: Wiley-BlackwellPrint ISSN: 0094-8276Electronic ISSN: 1944-8007Topics: GeosciencesPhysicsPublished by: -
3Staff View
ISSN: 1432-0770Source: Springer Online Journal Archives 1860-2000Topics: BiologyComputer SciencePhysicsNotes: Abstract A study is made of the dynamical properties of mammalian olfactory bulb which is represented by a set of nonlinear differential equations. It is shown that when the system of the periglomerular population receives a stationary independent stochastic input from the primary olfactory nerves, the level of ongoing mean pulse rate depends only on the expected value of the input. It is also shown that if the mitral-tufted and granule population receives stationary independent stochastic inputs both from the primary olfactory nerves and centrifugal axons, then there exists a limit cycle detectable in the EEG and the phase of the limit cycle depends only on the expected values of the inputs.Type of Medium: Electronic ResourceURL: -
4Staff View
ISSN: 1432-0770Source: Springer Online Journal Archives 1860-2000Topics: BiologyComputer SciencePhysicsNotes: Abstract The neurons in the mammalian olfactory bulb sustain two types of synaptic feedback. The periglomerular cells excite each other and form a positive feedback loop. The mitral-tufted cells are excited by periglomerular neurons, and they excite granule cells and are inhibited by them. The last two neural populations form a negative feedback loop. This work contains mathematical proofs for the existence of steady state unvarying activity in periglomerular neurons, and of steady state oscillatory activity of mitral-tufted and granule cells, which is manifested in the EEG. The following predictions are made. 1) The level of mean ongoing pulse activity of the periglomerular population is determined by peripheral sensory and centrifugal input. 2) The interaction of mitral and granule populations determines a limit cycle detectable in the EEG. 3) The frequency of the limit cycle is determined by periglomerular and centrifugal input. 4) The steady and oscillatory pulse rates are stable, and if they are perturbed, they return to the levels preceding perturbation.Type of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 1432-0770Source: Springer Online Journal Archives 1860-2000Topics: BiologyComputer SciencePhysicsNotes: Abstract It is shown that there exist spatial distributions of nonzero steady state mean pulse rates of the periglomerular and mitraltufted neuron populations and of nonzero EEG in the mammalian olfactory bulb. Such distributions are stable, i.e., if there are small perturbations, the population state variables return to the equilibrium states. It is predicted that the sensory and centrifugal inputs to the neuron populations in the bulb determine existence of such active states.Type of Medium: Electronic ResourceURL: