Search Results - (Author, Cooperation:S. Lucas)
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1Latest Papers from Table of Contents or Articles in PressHurt, L., Paranjothy, S., Lucas, P. J., Watson, D., Mann, M., Griffiths, L. J., Ginja, S., Paljarvi, T., Williams, J., Bellis, M. A., Lingam, R.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-02-09Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Evidence based practicePublished by: -
2Latest Papers from Table of Contents or Articles in PressF. C. Yang, O. Hellman, M. S. Lucas, H. L. Smith, C. N. Saunders, Yuming Xiao, Paul Chow, and B. Fultz
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-07-04Publisher: American Physical Society (APS)Print ISSN: 1098-0121Electronic ISSN: 1095-3795Topics: PhysicsKeywords: Dynamics, dynamical systems, lattice effectsPublished by: -
3Latest Papers from Table of Contents or Articles in PressD. Floudas ; M. Binder ; R. Riley ; K. Barry ; R. A. Blanchette ; B. Henrissat ; A. T. Martinez ; R. Otillar ; J. W. Spatafora ; J. S. Yadav ; A. Aerts ; I. Benoit ; A. Boyd ; A. Carlson ; A. Copeland ; P. M. Coutinho ; R. P. de Vries ; P. Ferreira ; K. Findley ; B. Foster ; J. Gaskell ; D. Glotzer ; P. Gorecki ; J. Heitman ; C. Hesse ; C. Hori ; K. Igarashi ; J. A. Jurgens ; N. Kallen ; P. Kersten ; A. Kohler ; U. Kues ; T. K. Kumar ; A. Kuo ; K. LaButti ; L. F. Larrondo ; E. Lindquist ; A. Ling ; V. Lombard ; S. Lucas ; T. Lundell ; R. Martin ; D. J. McLaughlin ; I. Morgenstern ; E. Morin ; C. Murat ; L. G. Nagy ; M. Nolan ; R. A. Ohm ; A. Patyshakuliyeva ; A. Rokas ; F. J. Ruiz-Duenas ; G. Sabat ; A. Salamov ; M. Samejima ; J. Schmutz ; J. C. Slot ; F. St John ; J. Stenlid ; H. Sun ; S. Sun ; K. Syed ; A. Tsang ; A. Wiebenga ; D. Young ; A. Pisabarro ; D. C. Eastwood ; F. Martin ; D. Cullen ; I. V. Grigoriev ; D. S. Hibbett
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-06-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Basidiomycota/classification/*enzymology/*genetics ; Bayes Theorem ; *Evolution, Molecular ; *Genome, Fungal ; Indoles ; Lignin/*metabolism ; Peroxidases/*genetics/metabolism ; Wood/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressJ. A. Banks ; T. Nishiyama ; M. Hasebe ; J. L. Bowman ; M. Gribskov ; C. dePamphilis ; V. A. Albert ; N. Aono ; T. Aoyama ; B. A. Ambrose ; N. W. Ashton ; M. J. Axtell ; E. Barker ; M. S. Barker ; J. L. Bennetzen ; N. D. Bonawitz ; C. Chapple ; C. Cheng ; L. G. Correa ; M. Dacre ; J. DeBarry ; I. Dreyer ; M. Elias ; E. M. Engstrom ; M. Estelle ; L. Feng ; C. Finet ; S. K. Floyd ; W. B. Frommer ; T. Fujita ; L. Gramzow ; M. Gutensohn ; J. Harholt ; M. Hattori ; A. Heyl ; T. Hirai ; Y. Hiwatashi ; M. Ishikawa ; M. Iwata ; K. G. Karol ; B. Koehler ; U. Kolukisaoglu ; M. Kubo ; T. Kurata ; S. Lalonde ; K. Li ; Y. Li ; A. Litt ; E. Lyons ; G. Manning ; T. Maruyama ; T. P. Michael ; K. Mikami ; S. Miyazaki ; S. Morinaga ; T. Murata ; B. Mueller-Roeber ; D. R. Nelson ; M. Obara ; Y. Oguri ; R. G. Olmstead ; N. Onodera ; B. L. Petersen ; B. Pils ; M. Prigge ; S. A. Rensing ; D. M. Riano-Pachon ; A. W. Roberts ; Y. Sato ; H. V. Scheller ; B. Schulz ; C. Schulz ; E. V. Shakirov ; N. Shibagaki ; N. Shinohara ; D. E. Shippen ; I. Sorensen ; R. Sotooka ; N. Sugimoto ; M. Sugita ; N. Sumikawa ; M. Tanurdzic ; G. Theissen ; P. Ulvskov ; S. Wakazuki ; J. K. Weng ; W. W. Willats ; D. Wipf ; P. G. Wolf ; L. Yang ; A. D. Zimmer ; Q. Zhu ; T. Mitros ; U. Hellsten ; D. Loque ; R. Otillar ; A. Salamov ; J. Schmutz ; H. Shapiro ; E. Lindquist ; S. Lucas ; D. Rokhsar ; I. V. Grigoriev
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-05-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Angiosperms/chemistry/genetics ; *Biological Evolution ; Bryopsida/genetics ; Chlamydomonas/chemistry/genetics ; DNA Transposable Elements ; Evolution, Molecular ; Gene Expression Regulation, Plant ; Genes, Plant ; *Genome, Plant ; MicroRNAs/genetics ; Molecular Sequence Data ; Phylogeny ; Plant Proteins/genetics/metabolism ; Proteome/analysis ; RNA Editing ; RNA, Plant/genetics ; Repetitive Sequences, Nucleic Acid ; Selaginellaceae/*genetics/growth & development/metabolism ; Sequence Analysis, DNAPublished by: -
5Latest Papers from Table of Contents or Articles in PressD. C. Eastwood ; D. Floudas ; M. Binder ; A. Majcherczyk ; P. Schneider ; A. Aerts ; F. O. Asiegbu ; S. E. Baker ; K. Barry ; M. Bendiksby ; M. Blumentritt ; P. M. Coutinho ; D. Cullen ; R. P. de Vries ; A. Gathman ; B. Goodell ; B. Henrissat ; K. Ihrmark ; H. Kauserud ; A. Kohler ; K. LaButti ; A. Lapidus ; J. L. Lavin ; Y. H. Lee ; E. Lindquist ; W. Lilly ; S. Lucas ; E. Morin ; C. Murat ; J. A. Oguiza ; J. Park ; A. G. Pisabarro ; R. Riley ; A. Rosling ; A. Salamov ; O. Schmidt ; J. Schmutz ; I. Skrede ; J. Stenlid ; A. Wiebenga ; X. Xie ; U. Kues ; D. S. Hibbett ; D. Hoffmeister ; N. Hogberg ; F. Martin ; I. V. Grigoriev ; S. C. Watkinson
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-07-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Angiosperms/microbiology ; Basidiomycota/classification/enzymology/*genetics/physiology ; *Biodiversity ; Biological Evolution ; Biota ; Cell Wall/*metabolism ; Coniferophyta/microbiology ; Coriolaceae/enzymology/genetics/physiology ; Gene Expression Profiling ; Genes, Fungal ; Genomics ; Lignin/metabolism ; Mycorrhizae/enzymology/*genetics/physiology ; Oxidoreductases/genetics/metabolism ; Peroxidases/genetics/metabolism ; Phylogeny ; Proteome ; Symbiosis ; Trees/*microbiology ; Wood/metabolism/*microbiologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressB. A. Curtis ; G. Tanifuji ; F. Burki ; A. Gruber ; M. Irimia ; S. Maruyama ; M. C. Arias ; S. G. Ball ; G. H. Gile ; Y. Hirakawa ; J. F. Hopkins ; A. Kuo ; S. A. Rensing ; J. Schmutz ; A. Symeonidi ; M. Elias ; R. J. Eveleigh ; E. K. Herman ; M. J. Klute ; T. Nakayama ; M. Obornik ; A. Reyes-Prieto ; E. V. Armbrust ; S. J. Aves ; R. G. Beiko ; P. Coutinho ; J. B. Dacks ; D. G. Durnford ; N. M. Fast ; B. R. Green ; C. J. Grisdale ; F. Hempel ; B. Henrissat ; M. P. Hoppner ; K. Ishida ; E. Kim ; L. Koreny ; P. G. Kroth ; Y. Liu ; S. B. Malik ; U. G. Maier ; D. McRose ; T. Mock ; J. A. Neilson ; N. T. Onodera ; A. M. Poole ; E. J. Pritham ; T. A. Richards ; G. Rocap ; S. W. Roy ; C. Sarai ; S. Schaack ; S. Shirato ; C. H. Slamovits ; D. F. Spencer ; S. Suzuki ; A. Z. Worden ; S. Zauner ; K. Barry ; C. Bell ; A. K. Bharti ; J. A. Crow ; J. Grimwood ; R. Kramer ; E. Lindquist ; S. Lucas ; A. Salamov ; G. I. McFadden ; C. E. Lane ; P. J. Keeling ; M. W. Gray ; I. V. Grigoriev ; J. M. Archibald
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Algal Proteins/genetics/metabolism ; Alternative Splicing/genetics ; Cell Nucleus/*genetics ; Cercozoa/cytology/*genetics/metabolism ; Cryptophyta/cytology/*genetics/metabolism ; Cytosol/metabolism ; *Evolution, Molecular ; Gene Duplication/genetics ; Gene Transfer, Horizontal/genetics ; Genes, Essential/genetics ; Genome/*genetics ; Genome, Mitochondrial/genetics ; Genome, Plant/genetics ; Genome, Plastid/genetics ; Molecular Sequence Data ; *Mosaicism ; Phylogeny ; Protein Transport ; Proteome/genetics/metabolism ; Symbiosis/*genetics ; Transcriptome/geneticsPublished by: -
7Articles: DFG German National LicensesMortimer, S. Lucas ; Kodl, Christopher T. ; Reiling, Cristine R. ; Van Wylen, David G.L.
Springer
Published 2000Staff ViewISSN: 1435-1803Keywords: Key words Cardiac microdialysis – ischemic preconditioning – adenosine – myocardial ischemia – rabbitSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Brief myocardial ischemia (ISC) is known to attenuate purine metabolite accumulation in the interstitial fluid (ISF) during subsequent ISC. We determined how this attenuated purine accululation was altered by 1) extended reperfusion (REP) and 2) multiple cycles of brief ISC. Microdialysis probes were used to assess ISF levels of the purine metabolites adenosine, inosine, and hypoxynthine in anesthetized rabbits. In one series of experiments, two 10 min periods of regional ISC were separated by 10 (n=6), 60 (n=6), or 180 (n=6) min of REP. In the 10, 60, and 180 min REP groups the increase in ISF purine metabolites during the second ISC was 47%, 55%, and 53% of that seen during the first ISC, respectively. In a second series of experiments, hearts were exposed to 120 min of ISC with (n=6) or without (n=6) five preceding cycles of transient ISC (10 min ISC; 10 min of REP). The increase in ISF purine metabolites during the multiple cycles of ISC was progressively attenuated, and there was a delay but eventual increase in ISF purine metabolites during the 120 min ISC. These data demonstrate that attenuated purine metabolite accumulation 1) is progressively greater with multiple cycles of brief ISC, 2) has a memory time of at least 180 min, and 3) is not due to high energy phosphate depletion.Type of Medium: Electronic ResourceURL: -
8FIS Bildung LiteraturdatenbankStaff View
Type of Medium: articlePublication Date: 1983Keywords: Empirische Untersuchung ; Kind ; Behinderung ; Lippenlesen ; Sprachbehinderter ; Sprachbehinderung ; Sonderpädagogik ; Hilfe ; Maßnahme ; GroßbritannienIn: International journal of rehabilitation research, Bd. 6 (1983) H. 3, S. 342-343, 0342-5282Language: German -
9Latest Papers from Table of Contents or Articles in PressIsabel O. L. Bacellar, Maria Cecilia Oliveira, Lucas S. Dantas, Elierge B. Costa, Helena C. Junqueira, Waleska K. Martins, Andrés M. Durantini, Gonzalo Cosa, Paolo Di Mascio, Mark Wainwright, Ronei Miotto, Rodrigo M. Cordeiro, Sayuri Miyamoto, Mauricio S. Baptista
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-07-24Publisher: American Chemical Society (ACS)Print ISSN: 0002-7863Electronic ISSN: 1520-5126Topics: Chemistry and PharmacologyPublished by: -
10Latest Papers from Table of Contents or Articles in PressLienart, S., Merceron, R., Vanderaa, C., Lambert, F., Colau, D., Stockis, J., van der Woning, B., De Haard, H., Saunders, M., Coulie, P. G., Savvides, S. N., Lucas, S.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-11-23Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Immunology, Molecular BiologyPublished by: -
11Articles: DFG German National LicensesStaff View
ISSN: 1525-1314Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: Abstract The metamorphic history of the Archaean Superior Province crystalline basement in the Palaeoproterozoic Ungava Orogen attests to the importance of structural and geohydrological controls on a retrograde amphibolite-granulite transition. Two distinct metamorphic suites, separated in age by nearly one billion years, are recognized in extensively exposed tonalitic to dioritic metaplutonic gneisses. The older suite comprises c. 2.7-Ga granulite facies assemblages (orthopyroxene-clinopyroxene-hornblende-plagioclase-ilmenite ± biotite ± quartz) that record moderate pressures (±5 kbar) and high temperatures (±800° C). A younger, c. 1.8-Ga suite resulted from amphibolitization of the granulites and is characterized by regionally extensive amphibolite facies mineral zones that broadly parallel the basal décollement of the overlying Proterozoic Cape Smith Thrust Belt. Deformation/mineral growth relationships in the amphibolitized basement indicate that extensive hydration and re-equilibration of the Archaean granulites occurred during thrust belt deformation. The transition from granulite facies to amphibolite facies assemblages is characterized by the growth of garnet-hornblende-quartz ° Cummingtonite coronas between plagioclase and orthopyroxene-clinopyroxene, as well as titanite coronas on ilmenite. Multi-equilibrium thermobarometry on the coronitic assemblages documents re-equilibration of the granulitic gneiss to 7.7 kbar at 644° C in the south and 9.8 kbar at 700° C in the north. The variably deformed, amphibolite facies domain sandwiched between the coronitic garnet zone and the basal décollement is marked by significant metasomatic changes in major element concentrations within tonalite. These changes are compatible with equilibrium flow of an aqueous-chloride fluid down a temperature gradient. The source of fluids for basement hydration/metasomatism is interpreted to be dehydrating clastic rocks in the overlying thrust belt, with fluid flow probably focused along the basal décollement.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1525-1314Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: Abstract Syn-metamorphic re-imbrication of the internal part of thrust belts can result in distinct pressure–temperature–time–deformation (P–T–t–d) pathways for different structural–metamorphic domains. In the early Proterozoic Cape Smith Thrust Belt (Canada), an external (piggyback-sequence thrusting) domain is characterized by thermal peak metamorphism occurring after deformation. In contrast, thermal peak metamorphism in an internal domain occurred during re-imbrication by out-of-sequence thrusting. The interactions of tectonic and thermal processes have been studied using three methods: (i) qualitative evaluation of the timing between mineral growth and deformation; (ii) analytical P–T paths from growth-zoned garnet porphyroblasts; and (iii) numerical modelling of vertical heat conduction. Derived P–T–t–d pathways suggest that uplift in the external domain resulted in part from erosion and isostatic unloading. In contrast, paths for the internal domain indicate that the out-of-sequence portion of the thrust belt may have experienced faster unroofing relative to the external domain. This is attributed to thickening by out-of-sequence thrusting and possibly to extensional faulting at (now eroded) higher structural levels. Observations on the timing of metamorphism, coupled with numerical modelling, suggest that the thermal peak metamorphism documented in the external domain is a consequence of the emplacement of the out-of-sequence thrusts stack in the internal portion of the thrust belt.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: The study of capillary wave scattering by a circular region with different interfacial properties from the rest of an otherwise homogeneous interface is motivated by experiments on wave attenuation at a monolayer-covered air–water interface where domains of one surface phase are dispersed in a second surface phase. Here the scattering function is calculated for an incident wave of frequency ω (wavevector k0) scattering from an isolated circular domain of radius a with surface tension σ1 which is imbedded in an otherwise infinite interface of surface tension σ0. The underlying fluid is treated as irrotational and the three-dimensional flow problem coupling the heterogeneous surface to the underlying liquid is reduced to a set of dual integral equations, which are solved numerically. With this solution the scattering amplitudes and the total scattering cross sections are calculated as a function of the surface tension ratio σ0/σ1 and incident wavenumber k0a. The analogous problem of a discontinuous change in bending rigidity is also considered and the solution to the complete viscous problem is outlined in the Appendix. Experimental implications of these results are discussed. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: Often in oil reservoirs a layer of water lies under the layer of oil. The suction pressure due to a distribution of oil wells will cause the oil-water interface to rise up towards the wells. A three-dimensional boundary integral formulation is presented for calculating the steady interface shape when the oil wells are represented by point sinks. Sophisticated integration techniques are implemented in an effort to obtain accurate results. In particular, the efficiency of various integration methods are compared for this problem, including QUADPACK routines, adaptive methods based on the IMT rule, the Kronrod rule, the method of degenerate quadrilaterals, and the Gauss-Rational rule for infinite integrals. Numerical results for various general multi-sink distributions are discussed, as are some further results for the axisymmetric single well problem. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesPECORELLA, I. ; McCARTNEY, A.C.E. ; LUCAS, S. ; MICHAELS, L. ; CIARDI, A. ; TONDO, U. DI ; GARNER, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Review of a series of 98 eyes removed at autopsy from 86 AIDS patients identified 12 cases (14%) showing varying degrees of microscopic calcium oxalate deposition. The oxalate crystals were birefringent using polarisation microscopy and were stained histochemically by the silver nitrate-rubeanic acid method (Yasue), a stain considered to be specific for calcium oxalate. In two cases, the deposition was extensive and involved the surface of the ciliary processes, ciliary body and pars plana of the retina, the retinal and optic nerve blood vessel wall, a few retinal pigment cells, and the anterior inner sclera. A lesser degree of intraocular involvement was observed in the remaining 10 cases. In all but two eyes, where a peripheral active area of cytomegalovirus retinitis was present, no other significant microscopical abnormality was found. Clinically, these patients were asymptomatic. At autopsy, oxalate deposits were found in the kidney and/or thyroid in seven of the patients.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesDooms-Goossens, A. ; Beck, M. ; Dooms, M. ; Edman, B. ; Lucas, S. ; Wilkinson, J.
Oxford, UK : Blackwell Publishing Ltd
Published 1983Staff ViewISSN: 1600-0536Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesVerdejo-Lucas, S. ; Sorribas, F. J. ; Ornat, C. ; Galeano, M.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-3059Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: The effect of Pochonia chlamydosporia, a facultative fungal parasite of nematode eggs, alone or in combination with oxamyl was evaluated in a double-cropping system of lettuce and tomato in unheated plastic houses infested with Meloidogyne javanica at two sites for two consecutive growing seasons. An additional treatment of methyl bromide fumigation was included to compare crop yield in nematode-free vs. nematode-infested soil. Final population densities, reproductive rate, root gall rating, and egg production were determined after each crop. Pochonia chlamydosporia was isolated from nematode eggs up to nine months after application to soil. The fungus survived in the rhizosphere for the entire growing season at one site, but only at low densities. Final population densities of M. javanica decreased after cultivation of lettuce and increased after tomato, and this pattern of population fluctuation was unaffected by treatment, experiment or site. The reproductive rate on lettuce was equal to or below 1, and it was similar among treatments in both experiments at both sites. Eggs were not found on lettuce roots. On tomato, the reproductive rate in the fungus + oxamyl treatment was significantly lower (P 〈 0·05) than other treatments in experiment 1 at both sites. Fungus + oxamyl consistently reduced root gall ratings on tomato in all cases, but numbers of eggs per g root varied depending on treatment. Methyl bromide-treated plots remained free of M. javanica at the end of the 2-year study.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesWilkins, B S ; Davis, Z ; Lucas, S B ; Delsol, G ; Jones, D B
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims: Progressive changes have been reported in lymph nodes in HIV infection, but few accounts describe altered splenic histology at different stages of the disease. Investigation of splenic changes accompanying the progressive CD4+ T-cell depletion that occurs in HIV infection could shed light on normal immunological interactions in this organ. Therefore, we assessed the amount and distribution of lymphoid tissue in spleens from adults with documented early or advanced HIV disease.Methods and results: Immunohistochemistry was used to study splenic tissue collected in an extensive autopsy survey of HIV+ adults in West Africa. Compared with post-mortem spleens from HIV– West African adults and control UK spleens, those from HIV-infected patients showed severe atrophy of white pulp B- and T-cell compartments. In early and advanced HIV disease, marginal zone atrophy was significant. Peri-arteriolar lymphoid sheaths contained increased numbers of CD8+/CD45RO+ T-cells in advanced HIV disease. In red pulp, early and advanced cases showed a lymphocytosis of CD8+/CD45RO– T-lymphocytes.Conclusions: Atrophic changes were more extreme in advanced than early HIV infection. Reduced marginal zone function possibly explains the known predisposition of HIV+ patients to infection by encapsulated bacteria. Possible immunological consequences of these CD8+/CD45RO+ (peri-arteriolar lymphoid sheaths) and CD8+/CD45RO– (red pulp) responses deserve further study. Comparison of West African and UK control spleens indicated that there were no major ethnic differences in spleen structure to prevent extrapolation of our results to European adults.Type of Medium: Electronic ResourceURL: