Search Results - (Author, Cooperation:S. Louie)
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1Staff View
Publication Date: 2018-10-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Medicine, Diseases, Online OnlyPublished by: -
2N. Kayagaki ; S. Warming ; M. Lamkanfi ; L. Vande Walle ; S. Louie ; J. Dong ; K. Newton ; Y. Qu ; J. Liu ; S. Heldens ; J. Zhang ; W. P. Lee ; M. Roose-Girma ; V. M. Dixit
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-10-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Caspase 1/metabolism ; Caspases/genetics/*metabolism ; Citrobacter rodentium/immunology ; Enzyme Activation ; Escherichia coli/immunology ; Immunity, Innate/immunology ; Inflammasomes/*metabolism ; Interleukin-1beta/biosynthesis/secretion ; Lipopolysaccharides/adverse effects/immunology ; Macrophages/immunology/secretion ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Vibrio cholerae/immunologyPublished by: -
3Y. Qu ; S. Misaghi ; A. Izrael-Tomasevic ; K. Newton ; L. L. Gilmour ; M. Lamkanfi ; S. Louie ; N. Kayagaki ; J. Liu ; L. Komuves ; J. E. Cupp ; D. Arnott ; D. Monack ; V. M. Dixit
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-08-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; CARD Signaling Adaptor Proteins/chemistry/deficiency/genetics/*metabolism ; Calcium-Binding Proteins/chemistry/deficiency/genetics/*metabolism ; Caspase 1/metabolism ; Enzyme Activation ; Gene Knock-In Techniques ; Humans ; Immunity, Innate/immunology ; Inflammasomes/*metabolism ; Interleukin-1beta/immunology/secretion ; Macrophages/immunology ; Mice ; Molecular Sequence Data ; Phosphorylation ; Protein Conformation ; Protein Kinase C-delta/deficiency/genetics/metabolism ; Salmonella typhimurium/immunology ; Sequence AlignmentPublished by: -
4LOUIE, S. ; KRZANOWSKI, J. J. ; BUKANTZ, S. C ; LOCKF.Y, R. F.
Oxford, UK : Blackwell Publishing Ltd
Published 1985Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A 26-year-old asthmatic female developed severe asthma within a few hours of receiving three oral doses of 0.4 mg ergometrine maleate for the control of postpartum haemorrhaging. This experience and two previous reports of bronchospasm in asthmatic subjects following ergometrine suggested that ergometrine altered airway smooth muscle tone.In the present investigation the effect of ergometrine was studied on canine tracheal smooth muscle strips. Ergometrine (10−9m 10 −8m) induced contraction of canine tracheal smooth muscle. The concentration causing 50% of maximal contraction (EC50) was 4.73 × 10−8M. The acetylcholine EC50 was not altered by ergometrine (10−9M or 10−8M); however, acetylcholine (10 −4m and 10−3m) induced contractions were enhanced by ergometrine (10−8m). The data suggest that ergometrine maleate may cause broncho-constriction in some patients with asthma.Type of Medium: Electronic ResourceURL: -
5Halliwell, B. ; Hu, M.-L. ; Louie, S. ; Duvall, T.R. ; Tarkington, B.K. ; Motchnik, P. ; Cross, C.E.
Amsterdam : ElsevierStaff ViewISSN: 0014-5793Keywords: Antioxidant ; Lipid peroxidation, Ascorbic acid ; Nitric oxide ; Nitrogen dioxide ; Uric acidSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 1432-1254Source: Springer Online Journal Archives 1860-2000Topics: GeographyPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 1432-0630Keywords: 61.70.Tm ; 61.70.Wp ; 66.30.JtSource: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: Abstract The redistribution of boron profiles in bulk silicon and SOS (silicon-on-sapphire) type structures is investigated in this paper. Experimental data on thermally redistributed profiles are correlated with predictions based on a computer program whose numerical algorithm was described in an earlier paper. Three cases were considered which involved the thermal redistribution of 1) a high dose (2×1015 and 5×1014 cm−2) 80keV boron implant in (111) bulk silicon, in an oxidizing ambient of steam at 1000°, 1100°, and 1200°C, respectively; 2) a high dose (2.3×1015 cm−2) 25 keV boron implant in (100) silicon-on-sapphire, in a nonoxidizing ambient of nitrogen at 1000 °C; and 3) a low dose (3.2×1012 cm−2) 150 keV boron implant in (100) bulk silicon, in oxidizing and nonoxidizing ambients that make up the fabrication schedule of an-channel enhancement mode device. For all three cases the overall correlation of computer predictions with experimental data was excellent. Correlations with experimental data based on SUPREM predictions are also included.Type of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 1432-1254Source: Springer Online Journal Archives 1860-2000Topics: GeographyPhysicsDescription / Table of Contents: Zusammenfassung Die meisten Pflanzenumrisse, speziell Bäume, ähneln einer Kombination geometrischer Formen. Die Bäume sind nicht-undurchsichtige Körper für einkommende Strahlung, die durch die Blätter teilweise absorbiert wird. Nach der Hypothese ist es möglich, den Energiehaushalt für die gesamte Pflanze zu quantifizieren. Dieser erste Bericht befasst sich nur mit den Ergebnissen der direkten und diffusen Sonnenstrahlung vom Himmel bei klaren Bedingungen vor Reflexion und Absorption bei einer Anzahl simulierter geometrischer Formen, die auf allgemeinen Pflanzenumrissen basieren. Eine ganzjährige Simulation der potentiellen Besonnung dieser Formen wurde für alle Breiten von 0° bis 90° berechnet. Jede Form, Breite und Jahreszeit zeigt ihre eigenen charakteristischen Verläufe der verschiedenen Energiezyklen. Die abgeleiteten Werte unterscheiden sich von den Werten, die auf horizontale Oberflächen anwendbar sind. Die simulierten Pflanzenkörper neigten zur Vermeidung von Energieaufnahme in niedrigen Breiten, während bei höheren Breiten das Umgekehrte auftrat.Abstract: Resume Les formes extérieures des plantes et plus spécialement celles des arbres peuvent se ramener à des combinaisons de formes géométriques. Les arbres ne constituent pas des corps opaques pour le rayonnement, mais celuici n'est que partiellement absorbé par la couronne. Selon l'hypothèse présentée ici, il est possible de déterminer quantitativement le bilan énergétique de la plante entière. Ce premier mémoire se restreint à l'étude de l'absorption du rayonnement direct et diffus, c'est-à-dire du soleil et d'un ciel serein. Ces résultats sont calculés avant toute réflexion ou absorption par d'autres corps et se rapportent à un certain nombre de formes géométriques simulant des profils typiques d'arbres. On a ainsi calculé le gain énergétique de ces formes pour toute l'année et pour toutes les latitudes de 0° à 90°. Chaque profil, chaque latitude et chaque saison présente des caractéristiques propres quant à l'évolution des différents cycles d'énergie. Les valeurs ainsi obtenues se distinguent nettement de valeurs correspondantes se rapportant à des surfaces horizontales. Les profils de plantes examinés tendent à absorber aussi peu d'énergie que possible dans les basses latitudes, alors que c'est le contraire qui se produit au voisinage des pôles.Notes: Abstract The thesis is presented that most plant-shapes, especially trees, resemble a combination of geometrical shapes which present their non-opaque bodies to incoming radiation, which is partially absorbed by the foliage. Such a hypothesis makes possible the quantification of the budget of energy of the entire plant. This first report presents only the findings in regard to the receipt of direct and diffuse solar radiation from the sky (clear conditions), before reflection and absorption, on a variety of geometries which simulate common plant-shapes. An all-year simulation of potential insolation for such shapes was conducted for latitudes 0° to 90°. Each shape, latitude and each season exhibited its own characteristic patterns of the various energy cycles. Derived data differed materially from data applicable to horizontal surfaces. The simulated plant-shapes tended to avoid receipt of energy in the low latitudes, whereas the opposite occurred toward higher latitudes.Type of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 1573-5052Keywords: Crop Energy Budget Model ; Phytosynthesis Productivity ; World PopulationSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary In order to provide an initial estimate of the probable potential (no lack of soil water, fertilizer, pest and disease controls, advanced cultivation techniques, etc.) agricultural and primary productive ceilings of this planet, a series of deductive models of optimum net photosynthesis is constructed. The concern is with the generalized global trends of productivities representing many types of plants. Because a worldwide treatment of productivity is preferred at this time, a relatively simple, basic model had to be utilized in order to stay within reasonable limits of financial contraints. The findings presented in the body of the text thus represent a tentative ‘economic answer’ to a pressing question of mankind. Four models have been developed: 1 for a high-efficiency C4 plant, 2 for a C3 type agricultural crop, 3 for a broadleaf woody species and 4 for a needleleaf species. The prediction of the leaf temperature is considered the crux of the testing of the energy budget portion of the models. The four models are applied to 1 650 worldwide climatological stations. The results are discussed. Some considerations are given on the estimation of theoretical maximum crop yields. From these maximum human population figures are estimated on a high-protein diet basis, with a prediction of 4.5×109 people for the world as a whole.Type of Medium: Electronic ResourceURL: