Search Results - (Author, Cooperation:S. Kuan)

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  1. 1
    Y. Shen ; F. Yue ; D. F. McCleary ; Z. Ye ; L. Edsall ; S. Kuan ; U. Wagner ; J. Dixon ; L. Lee ; V. V. Lobanenkov ; B. Ren
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-07-06
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Acetylation ; Animals ; Chromatin/metabolism ; Chromatin Immunoprecipitation ; Conserved Sequence ; Enhancer Elements, Genetic/genetics ; Evolution, Molecular ; Gene Expression Regulation/*genetics ; Genome/*genetics ; Male ; Methylation ; Mice/*genetics ; Mice, Inbred C57BL ; Molecular Sequence Annotation ; Nucleotide Motifs ; Organ Specificity ; *Physical Chromosome Mapping ; Promoter Regions, Genetic/genetics ; Regulatory Sequences, Nucleic Acid/*genetics ; Sequence Analysis, DNA ; Transcription Factors/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    F. Yue ; Y. Cheng ; A. Breschi ; J. Vierstra ; W. Wu ; T. Ryba ; R. Sandstrom ; Z. Ma ; C. Davis ; B. D. Pope ; Y. Shen ; D. D. Pervouchine ; S. Djebali ; R. E. Thurman ; R. Kaul ; E. Rynes ; A. Kirilusha ; G. K. Marinov ; B. A. Williams ; D. Trout ; H. Amrhein ; K. Fisher-Aylor ; I. Antoshechkin ; G. DeSalvo ; L. H. See ; M. Fastuca ; J. Drenkow ; C. Zaleski ; A. Dobin ; P. Prieto ; J. Lagarde ; G. Bussotti ; A. Tanzer ; O. Denas ; K. Li ; M. A. Bender ; M. Zhang ; R. Byron ; M. T. Groudine ; D. McCleary ; L. Pham ; Z. Ye ; S. Kuan ; L. Edsall ; Y. C. Wu ; M. D. Rasmussen ; M. S. Bansal ; M. Kellis ; C. A. Keller ; C. S. Morrissey ; T. Mishra ; D. Jain ; N. Dogan ; R. S. Harris ; P. Cayting ; T. Kawli ; A. P. Boyle ; G. Euskirchen ; A. Kundaje ; S. Lin ; Y. Lin ; C. Jansen ; V. S. Malladi ; M. S. Cline ; D. T. Erickson ; V. M. Kirkup ; K. Learned ; C. A. Sloan ; K. R. Rosenbloom ; B. Lacerda de Sousa ; K. Beal ; M. Pignatelli ; P. Flicek ; J. Lian ; T. Kahveci ; D. Lee ; W. J. Kent ; M. Ramalho Santos ; J. Herrero ; C. Notredame ; A. Johnson ; S. Vong ; K. Lee ; D. Bates ; F. Neri ; M. Diegel ; T. Canfield ; P. J. Sabo ; M. S. Wilken ; T. A. Reh ; E. Giste ; A. Shafer ; T. Kutyavin ; E. Haugen ; D. Dunn ; A. P. Reynolds ; S. Neph ; R. Humbert ; R. S. Hansen ; M. De Bruijn ; L. Selleri ; A. Rudensky ; S. Josefowicz ; R. Samstein ; E. E. Eichler ; S. H. Orkin ; D. Levasseur ; T. Papayannopoulou ; K. H. Chang ; A. Skoultchi ; S. Gosh ; C. Disteche ; P. Treuting ; Y. Wang ; M. J. Weiss ; G. A. Blobel ; X. Cao ; S. Zhong ; T. Wang ; P. J. Good ; R. F. Lowdon ; L. B. Adams ; X. Q. Zhou ; M. J. Pazin ; E. A. Feingold ; B. Wold ; J. Taylor ; A. Mortazavi ; S. M. Weissman ; J. A. Stamatoyannopoulos ; M. P. Snyder ; R. Guigo ; T. R. Gingeras ; D. M. Gilbert ; R. C. Hardison ; M. A. Beer ; B. Ren
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-11-21
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Cell Lineage/genetics ; Chromatin/genetics/metabolism ; Conserved Sequence/genetics ; DNA Replication/genetics ; Deoxyribonuclease I/metabolism ; Gene Expression Regulation/genetics ; Gene Regulatory Networks/genetics ; Genome/*genetics ; Genome-Wide Association Study ; *Genomics ; Humans ; Mice/*genetics ; *Molecular Sequence Annotation ; RNA/genetics ; Regulatory Sequences, Nucleic Acid/genetics ; Species Specificity ; Transcription Factors/metabolism ; Transcriptome/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2015-02-20
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Acetylation ; *Alleles ; Chromatin/genetics/metabolism ; Chromosomes, Human/genetics ; Datasets as Topic ; Enhancer Elements, Genetic/genetics ; Epigenesis, Genetic/*genetics ; *Epigenomics ; Genetic Variation/genetics ; Haplotypes/*genetics ; Histones/metabolism ; Humans ; Nucleotide Motifs ; Organ Specificity/genetics ; Transcription, Genetic/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Shin, Kuan S. ; Michael, J. V.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1991
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    Rate constants for the reactions (1) H+O2→OH+O and (2) D+O2→OD+O have been measured over the temperature ranges 1103–2055 K and 1085–2278 K, respectively. The experimental method that has been used is the laser-photolysis–shock-tube technique. This technique utilizes atomic resonance absorption spectrophotometry (ARAS) to monitor H- or D-atom depletion in the presence of a large excess of reactant, O2. The results can be well represented by the Arrhenius expressions k1(T)=(1.15±0.16)×10−10 exp(−6917±193 K/T) cm3 molecule−1 s−1, and k2(T)=(1.09±0.20)×10−10 exp(−6937±247 K/T) cm3 molecule−1 s−1. Over the experimental temperature range, the present results show that the isotope effect is unity within experimental uncertainty. The Arrhenius equations, k−1(T)=(8.75±1.24) ×10−12 exp(1121±193 K/T) cm3 molecule−1 s−1 and k−2 (T)=(9.73±1.79)×10−12 exp(526±247 K/T) cm3 molecule−1 s−1, for the rate constants of the reverse reactions were calculated from the experimentally measured forward rate constants and expressions for the equilibrium constants that have been derived from the JANAF thermochemical database. The theoretical implications of the present results are also discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.461483

    Articles: DFG German National Licenses
  5. 5
    Albrecht, T. R. ; Dovek, M. M. ; Lang, C. A. ; Grütter, P. ; Quate, C. F. ; Kuan, S. W. J. ; Frank, C. W. ; Pease, R. F. W.

    [S.l.] : American Institute of Physics (AIP)
    Published 1988
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Direct imaging of ultrathin organic films on solid surfaces is important for a variety of reasons; in particular, the use of such films as ultrathin resists for nanometer scale fabrication and information recording requires that we understand their microstrucure. We have used the Langmuir–Blodgett technique to prepare monolayer and submonolayer films of poly(octadecylacrylate) (PODA) and poly(methylmethacrylate) (PMMA) on graphite substrates. Atomic scale images obtained with the scanning tunneling microscope (STM) and the atomic force microscope of the PODA films showed a variety of structures, including isolated narrow fibrils, parallel groups of fibrils, and an ordered structure consistent with the side chain crystallization expected with that material. The fibrils observed are interpreted as individual polymer chains or small bundles of parallel chains. Images of the PMMA samples show no ordered regions. By applying voltage pulses on the STM tip, we were able to locally modify and apparently cut through the PODA fibrils.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.341881

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0303-7207
    Keywords:
    17β-Estradiol ; Calcium, intracellular ; Inositol phosphate ; MMQ cell ; Prolactin ; Secretagogue
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0303-7207(89)90045-2

    Articles: DFG German National Licenses
  7. 7
    Guilbault, G.G. ; Sadar, M.H. ; Kuan, S. ; Casey, D.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-2670
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(01)81835-3

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1573-2665
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Children with Alagille syndrome show high serum cholesterol (15–20 mmol/L). To establish correlation of this unusual level of cholesterol with the regulation of cholesterol metabolism, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity and synthesis of cholesterol, fatty acids and acidic steroids from [14C]acetate were determined in cultured skin fibroblasts from 2–3-year old children. Prostaglandin E2 (PGE2) synthesis and nucleic acid synthesis were determined in cells when they were growing in medium containing normal, Alagille or fetal bovine serum. These values were similar to values of controls. HMGR activity was found to be similar in cells of control and children with the syndrome, whether the cells were incubated in lipoprotein-deficient or normal medium. Incorporation of acetate into cholesterol was inhibited to a greater extent by lipoprotein-containing medium in control than in children with the syndrome. Fatty acid synthesis was similar in all conditions. 1–7% of the recovered lipid radioactivity in cells and medium separated as acidic steroids. Serum from a donor patient, when included in the medium, did not affect PGE2 or nucleic acid synthesis compared with normal human or fetal bovine serum. The data suggest that cells of children with Alagille syndrome may have a membrane defect of transfer of cholesterol (LDL receptor defect) leading to excessive cholesterol synthesis. Also, synthesis of acidic steroids (bile acid-like material) and their secretion into the medium occurs in normal fibroblasts and those from children with the syndrome.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01802039

    Articles: DFG German National Licenses
  9. 9
    Rühe, J. ; Blackman, G. ; Novotny, V. J. ; Clarke, T. ; Street, G. B. ; Kuan, S.

    New York, NY [u.a.] : Wiley-Blackwell
    Published 1994
    Staff View
    ISSN:
    0021-8995
    Keywords:
    Chemistry ; Polymer and Materials Science
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Chemistry and Pharmacology
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Physics
    Notes:
    Physisorption and chemisorption of perfluoropolyethers on solid surfaces is investigated using infrared spectroscopy, microcalorimetry, ellipsometry, X-ray photoelectron spectroscopy, and atomic force microscopy. Physisorbed polymers show shifts of vibrational modes to lower frequencies in a few nanometers thick films, indicating interactions with the solid surfaces. Hydroxyl-terminated polymers are thermally attached to solid surfaces, and their thicknesses increase to saturated values with increasing heating time. The thermally attached thin polymer film consists of strongly physisorbed material as well as chemisorbed material. Strongly physisorbed polymer is slowly displaced from the surface by polar, low-molecular-weight compounds such as water or alcohols. This is to be expected on the basis of microcalorimetric results, which yield higher heats of immersion with water than with reactive perfluoropolyethers. Atomic force microscopy experiments show that the mobility of the polymer remaining on the surface decreases substantially as the amount of the physisorbed material decreases. © 1994 John Wiley & Sons, Inc.
    Additional Material:
    9 Ill.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/app.1994.070530611

    Articles: DFG German National Licenses