Search Results - (Author, Cooperation:S. Koskinen)
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1Latest Papers from Table of Contents or Articles in PressA. Okbay ; J. P. Beauchamp ; M. A. Fontana ; J. J. Lee ; T. H. Pers ; C. A. Rietveld ; P. Turley ; G. B. Chen ; V. Emilsson ; S. F. Meddens ; S. Oskarsson ; J. K. Pickrell ; K. Thom ; P. Timshel ; R. de Vlaming ; A. Abdellaoui ; T. S. Ahluwalia ; J. Bacelis ; C. Baumbach ; G. Bjornsdottir ; J. H. Brandsma ; M. Pina Concas ; J. Derringer ; N. A. Furlotte ; T. E. Galesloot ; G. Girotto ; R. Gupta ; L. M. Hall ; S. E. Harris ; E. Hofer ; M. Horikoshi ; J. E. Huffman ; K. Kaasik ; I. P. Kalafati ; R. Karlsson ; A. Kong ; J. Lahti ; S. J. van der Lee ; C. deLeeuw ; P. A. Lind ; K. O. Lindgren ; T. Liu ; M. Mangino ; J. Marten ; E. Mihailov ; M. B. Miller ; P. J. van der Most ; C. Oldmeadow ; A. Payton ; N. Pervjakova ; W. J. Peyrot ; Y. Qian ; O. Raitakari ; R. Rueedi ; E. Salvi ; B. Schmidt ; K. E. Schraut ; J. Shi ; A. V. Smith ; R. A. Poot ; B. St Pourcain ; A. Teumer ; G. Thorleifsson ; N. Verweij ; D. Vuckovic ; J. Wellmann ; H. J. Westra ; J. Yang ; W. Zhao ; Z. Zhu ; B. Z. Alizadeh ; N. Amin ; A. Bakshi ; S. E. Baumeister ; G. Biino ; K. Bonnelykke ; P. A. Boyle ; H. Campbell ; F. P. Cappuccio ; G. Davies ; J. E. De Neve ; P. Deloukas ; I. Demuth ; J. Ding ; P. Eibich ; L. Eisele ; N. Eklund ; D. M. Evans ; J. D. Faul ; M. F. Feitosa ; A. J. Forstner ; I. Gandin ; B. Gunnarsson ; B. V. Halldorsson ; T. B. Harris ; A. C. Heath ; L. J. Hocking ; E. G. Holliday ; G. Homuth ; M. A. Horan ; J. J. Hottenga ; P. L. de Jager ; P. K. Joshi ; A. Jugessur ; M. A. Kaakinen ; M. Kahonen ; S. Kanoni ; L. Keltigangas-Jarvinen ; L. A. Kiemeney ; I. Kolcic ; S. Koskinen ; A. T. Kraja ; M. Kroh ; Z. Kutalik ; A. Latvala ; L. J. Launer ; M. P. Lebreton ; D. F. Levinson ; P. Lichtenstein ; P. Lichtner ; D. C. Liewald ; A. Loukola ; P. A. Madden ; R. Magi ; T. Maki-Opas ; R. E. Marioni ; P. Marques-Vidal ; G. A. Meddens ; G. McMahon ; C. Meisinger ; T. Meitinger ; Y. Milaneschi ; L. Milani ; G. W. Montgomery ; R. Myhre ; C. P. Nelson ; D. R. Nyholt ; W. E. Ollier ; A. Palotie ; L. Paternoster ; N. L. Pedersen ; K. E. Petrovic ; D. J. Porteous ; K. Raikkonen ; S. M. Ring ; A. Robino ; O. Rostapshova ; I. Rudan ; A. Rustichini ; V. Salomaa ; A. R. Sanders ; A. P. Sarin ; H. Schmidt ; R. J. Scott ; B. H. Smith ; J. A. Smith ; J. A. Staessen ; E. Steinhagen-Thiessen ; K. Strauch ; A. Terracciano ; M. D. Tobin ; S. Ulivi ; S. Vaccargiu ; L. Quaye ; F. J. van Rooij ; C. Venturini ; A. A. Vinkhuyzen ; U. Volker ; H. Volzke ; J. M. Vonk ; D. Vozzi ; J. Waage ; E. B. Ware ; G. Willemsen ; J. R. Attia ; D. A. Bennett ; K. Berger ; L. Bertram ; H. Bisgaard ; D. I. Boomsma ; I. B. Borecki ; U. Bultmann ; C. F. Chabris ; F. Cucca ; D. Cusi ; I. J. Deary ; G. V. Dedoussis ; C. M. van Duijn ; J. G. Eriksson ; B. Franke ; L. Franke ; P. Gasparini ; P. V. Gejman ; C. Gieger ; H. J. Grabe ; J. Gratten ; P. J. Groenen ; V. Gudnason ; P. van der Harst ; C. Hayward ; D. A. Hinds ; W. Hoffmann ; E. Hypponen ; W. G. Iacono ; B. Jacobsson ; M. R. Jarvelin ; K. H. Jockel ; J. Kaprio ; S. L. Kardia ; T. Lehtimaki ; S. F. Lehrer ; P. K. Magnusson ; N. G. Martin ; M. McGue ; A. Metspalu ; N. Pendleton ; B. W. Penninx ; M. Perola ; N. Pirastu ; M. Pirastu ; O. Polasek ; D. Posthuma ; C. Power ; M. A. Province ; N. J. Samani ; D. Schlessinger ; R. Schmidt ; T. I. Sorensen ; T. D. Spector ; K. Stefansson ; U. Thorsteinsdottir ; A. R. Thurik ; N. J. Timpson ; H. Tiemeier ; J. Y. Tung ; A. G. Uitterlinden ; V. Vitart ; P. Vollenweider ; D. R. Weir ; J. F. Wilson ; A. F. Wright ; D. C. Conley ; R. F. Krueger ; G. Davey Smith ; A. Hofman ; D. I. Laibson ; S. E. Medland ; M. N. Meyer ; M. Johannesson ; P. M. Visscher ; T. Esko ; P. D. Koellinger ; D. Cesarini ; D. J. Benjamin
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-05-27Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1600-0838Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineSports ScienceNotes: The effect of patellar brace on patellofemoral relationships was analyzed using magnetic resonance imaging in 17 knees with patellar subluxation or dislocation. Images were produced in 0° and 20° knee flexions without the patellar brace, with patellar brace and with patellar brace after 1 h of walking. In knee extension, the patellar brace had an unfavorable effect on lateral patellar tilt, but decreased the tilt in 20° knee flexion. The excessive lateral patellar displacement was alleviated in both knee flexion angles. The corrected position was still apparent after physical exercise. Isometric quadriceps muscle contraction increased the displacement. These results suggest a positive stabilizing effect of the brace in patients with patellar instability.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesKyröläinen, H. ; Avela, J. ; McBride, J. M. ; Koskinen, S. ; Andersen, J. L. ; Sipilä, S. ; Takala, T. E. S. ; Komi, P. V.
Oxford, UK : Blackwell Publishing
Published 2005Staff ViewISSN: 1600-0838Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineSports ScienceNotes: The present study examines changes in muscle structure and neuromuscular performance induced by 15 weeks of power training with explosive muscle actions. Twenty-three subjects, including 10 controls, volunteered for the study. Muscle biopsies were obtained from the gastrocnemius muscle before and after the training period, while maximal voluntary isometric contractions (MVC) and drop jump tests were performed once every fifth week. No statistically significant improvements in MVC of the knee extensor (KE) and plantarflexor muscles were observed during the training period. However, the maximal rate of force development (RFD) of KE increased from 18 836±4282 to 25 443±8897 N (P〈0.05) during the first 10 weeks of training. In addition, vertical jump height (vertical rise of the center of body mass) in the drop jump test increased significantly (P〈0.01). Simultaneously, explosive force production of KE muscles measured as knee moment and power increased significantly; however, there was no significant change (P〉0.05) in muscle activity (electromyography) of KE. The mean percentage for myosin heavy chain and titin isoforms, muscle fiber-type distributions and areas were unchanged. The enhanced performance in jumping as a result of power training can be explained, in part, by some modification in the joint control strategy and/or increased RFD capabilities of the KE.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesKoskinen, S. O. A. ; Höyhtyä, M. ; Turpeenniemi-Hujanen, T. ; Martikkala, V. ; Mäkinen, T. T. ; Oksa, J. ; Rintamäki, H. ; Löfberg, M. ; Somer, H. ; Takala, T. E. S.
Copenhagen : Munksgaard International Publishers
Published 2001Staff ViewISSN: 1600-0838Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineSports ScienceNotes: In the present study the release of proteins degrading extracellular matrix compounds to circulation was measured after damaging exercise in humans. Muscle damage was induced by downhill running; furthermore, the exercise was performed at both cold temperature (5 °C) and room temperature (22 °C) to study also the possible effect of environmental temperature on serum concentrations of matrix metalloproteinases MMP-2 and MMP-9, tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2, and MMP-2/TIMP-2 complex, and muscle damage monitored by serum creatine kinase measurements. Results were compared with those obtained from patients having rhabdomyolysis, myositis and Becker muscular dystrophy. The present study demonstrates an acute increase in serum concentrations of MMP-9, TIMP-1, and MMP-2/TIMP-2 complex, but no changes in serum MMP-2 concentrations in response to eccentric exercise. Serum creatine kinase activity data suggest greater muscle damage after downhill running in a cold environment than at room temperature. The present observations about at most slight changes in serum MMP and TIMP concentrations and lack of their correlation to increased serum creatine kinase after exercise indicate that serum measurements of MMPs and TIMPs do not sensitively respond to exercise induced skeletal muscle damage and extracellular matrix regeneration. On the other hand, severe skeletal muscle damage, such as rhabdomyolysis, myositis and Becker muscular dystrophy, seemed to have an effect on serum MMP and TIMP concentrations.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1434-3916Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Twenty patients with a chronic anterior cruciate ligament tear were studied. First they were interviewed on the preoperative history of unexpected giving way (pivot shift), then they were tested for clinical pivot shift sign, and last, the configuration of the lateral tibial plateau was studied using magnetic resonance imaging. A connection could be noticed between the history of instability symptoms and the pivot shift sign at clinical examination (P 〈 0.001). Interestingly, there was also a link between the instability history and the configuration of the lateral tibial plateau (P = 0.0021), and, further, between the clinical pivot shift sign and the configuration of the lateral tibial plateau (P = 0.0002). The variation in the shape of the convexity of the lateral tibial plateau seems to be associated with the symptoms and prognosis of the patients with rupture of the anterior cruciate ligament.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesKoskinen, S. K. ; Parkkola, R. K. ; Karhu, J. ; Komu, M. E. S. ; Kormano, M. J.
Springer
Published 1997Staff ViewISSN: 1432-2102Keywords: Key words MRI • Kinematic MRI • Joint • Interventional ; Schlüsselwörter MRT • Kinematische MRT • Gelenk • InterventionSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Die kürzlich eingeführten bildgebenden Systeme mit horizontal offener Konfiguration ermöglichen die Darstellung von Knie, Hüfte oder Schulter über den gesamten Bewegungsbereich, war bisher mit konventionellen MR-Systemen nicht möglich. Für genauere und reproduzierbare Untersuchungen können spezielle Gelenkbewegungsgeräte verwendet werden. Bei der Halswirbelsäule kann die funktionelle NMR-Darstellung im Hinblick auf die Beurteilung der Stabilität der Ligamenta alaria bei Patienten mit Spätfolgen eines Schleudertraumas und bei Patienten mit rheumatoider Arthritis von Nutzen sein, wenn klinisch eine zervikale Myelopathie oder superiore migration des Dens axis vermutet wird. Bei der Schulter kann eine Abduktionsstudie des vollen Bewegungsbereichs bei der Beurteilung eines Auftreffens des Tendo supraspinatus von Nutzen sein. Zur Beurteilung einer patellofemoralen Fehlstellung sollte der Quadrizeps belastet werden, da auf diese Weise die damit verbundene kontrahierende Muskulatur und verbundene Weichteilstrukturen beurteilt werden können. Die Lage des Caput femoris im Verhältnis zum Azetabulum in verschiedenen Stellungen kann beurteilt werden. Scanner mit offener Konfiguration ermöglichen während des Scannens Zugang zum Patienten und gestatten somit eine Überwachung von Interventionsverfahren durch MRT. Diese Interventionen umfassen die Aspirationszytologie/-biopsie sowie verschiedene Drainageverfahren.Notes: Summary The recently introduced horizontally open configuration imagers allow imaging of knee, hip or shoulder during whole range of motion, which is not possile in conventional MR imagers. Special joint motion devices can be used to provide accurate and reproducible studies. In cervical spine, functional MR imaging may be useful in evaluating alarligament stability in patients with late sequelae of a whiplash injury, and in patients with rheumatoid arthritis who are clinically suspected of having a cervical myelopathy or superior migration of the odontoid process. In shoulder, full range of motion abduction study may be helpful in assessing the supraspinatus tendon impingement. To evaluate patellofemoral malalignment, quadriceps loading is recommended since associated contracting muscles and related soft tissue structures can be evaluated. The position of the femoral head relative to the acetabulum during different positions can be assessed. Open-configuration scanners provide an access to patients during scanning procedure, and therefore permit interventional procedures to be monitored with MRI. Such interventions include aspiration cytology/biopsy and different drainage procedures.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesKettenbach, J. ; Silverman, S. G. ; Schwartz, R. B. ; Hsu, L. ; Koskinen, S. K. ; Kikinis, R. ; Black, P. McL. ; Jolesz, F. A.
Springer
Published 1997Staff ViewISSN: 1432-2102Keywords: Key words Minimally invasive surgery • Magnetic resonance imaging • Minimally invasive therapy • Interventional magnetic resonance imaging ; Schlüsselwörter Magnetresonanztomographie • Interventionelles MRI • Minimal invasive Therapie • Minimal invasive Chirurgie • LasertherapieSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Die Magnetresonanztomographie (MRT) eignet sich als nichtinvasives Verfahren mit hoher Auflösung besonders gut zur Bildgebung für minimal invasive, chirurgische oder interventionelle Eingriffe. Eine wesentliche Voraussetzung ist jedoch die Entwicklung offener MR-Systeme. Das hier beschriebene, offene MR-System mit supraleitendem 0,5-T-Magneten (SIGNA SP,GE) erlaubt den Zugang zum Patienten auch während der Bildaquisition und die interaktive Kontrolle der Bildebene durch den Benutzer. Die kontinuierliche Bildunterstützung ermöglicht neue Techniken zur Führung interventioneller oder chirurgischer Eingriffe, eine genauere Lokalisation von Instrumenten und die unmittelbare Verlaufskontrolle nahezu in Echtzeit. Klinische Anwendungen dieser Technologie werden dargestellt. Durch schnelle Rechentechniken für das Bildmanagement und intraoperative Bildgebung, ermöglicht das offene MR-System die Entwicklung neuer, besonders effizienter interventioneller und minimal invasiv chirurgischer Verfahren.Notes: Purpose: To develop a superconducting magnetic resonance (MR) imager that provides direct access to the patient and permits interactive MR-guided interventional procedures. Materials and methods: A 0.5-T superconducting magnet that allows a region of vertical access to the patient was designed and constructed. This magnet was integrated with newly designed shielded gradient coils, flexible surface coils, nonmagnetic displays, position-monitoring probes and device-tracking instrumentation. Results: The magnet homogeneity was 12.3 ppm or better, and the gradient field was linear to within 1 % over an imaging region of 30 cm in diameter. The signal-to-noise ratio was 10 % higher than in a comparable 0.5-T superconducting imager. Images were obtained in several anatomic regions with use of routine pulse sequences. Interactive image plane selection and near real-time imaging, with use of fast gradient-recalled echo sequences were demonstrated at a rate of one image every 1.5 s. More than 240 procedures (including open brain surgery) have been successfully performed within this environment. Conclusions: MR-guided interventional and surgical procedures can be performed with full patient access using an open-configuration, superconducting MR magnet with near real-time imaging and interactive image plane control.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesKoskinen, S. K. ; Niemi, P. T. ; Ekfors, T. O. ; Sipilä, J. ; Valavaara, R. ; Dean, P. B.
Springer
Published 1998Staff ViewISSN: 1432-1084Keywords: Key words: Glomus tumor ; Glomangioma ; Trachea ; CTSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. We report a case of a glomus tumor in the trachea which was an incidental finding in a 66-year-old man. The histological picture and immunohistochemical profile were typical for this tumor. The glomus tumor is an exceedingly rare mass lesion in the trachea, but it is useful to keep it among differential diagnostic alternatives when a tracheal tumor is seen on radiographs or endoscopy.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1573-2592Keywords: Anti-IgA antibodies ; IgA deficiency ; immunodeficiency ; IgA content ; follow-up studiesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract A follow-up study of anti-IgA antibodies in 159 healthy blood donors with severe deficiency of serum IgA (〈0.05 mg/L) and in 45 donors with decreased serum IgA levels (0.05–799 mg/L), identified in 1971–1980, was carried out. Initially anti-IgA antibodies were determined by a hemagglutination (HA) method and two reexaminations were done in 1990–1992 by an enzyme immunoassay. The median follow-up period was 19 years, during which anti-IgA level was changed considerably in only four persons, increased in two, and high level antibodies (〉1/1000 by HA) appeared in two. In reexaminations anti-IgA antibodies were found in 30 (19%) subjects with severe IgA deficiency and the antibody levels remained relatively constant in those who had high and medium antibody levels. Anti-IgA antibodies were not found in subjects with decreased, but detectable serum IgA. Thus it seems that only those healthy adults who have severe IgA deficiency develop anti-IgA antibodies and their anti-IgA levels remain fairly constant Of the 159 subjects with severe IgA deficiency, 66 had a history of IgA exposure, but no correlation to anti-IgA development was noted.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-5195Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Résumé Dans 12 genoux présentant une subluxation ou une luxation de la rotule, la situation de celle-ci a été analysée en utilisant la technique de l'imagerie par résonance magnétique. Les images ont été réalisées, avant et après l'opération, le genou à 0, 10, 20 et 30 degrés de flexion. La position préopératoire anormale de la rotule était parfaitement visible sue le genou étendu ou fléchi à 20°. La libération externe associée à la transposition de la tubérosité tibiale antérieure corrigeait cette déviation, surtout par rapport à l'angle fémoro-patellaire externe, avec et sans contraction du quadriceps. La correction du déplacement externe de la rotule n'était pas complète lorsque la déviation externe préopératoire était particulièrement importante.Notes: Abstract Twelve knees in eleven patients with subluxation or dislocation of the patella were assessed by MRI at 0, 10, 20 and 30 degrees of knee flexion, before and after vastus lateralis release and medial transplant of the tibial tuberosity. The preoperative position of the patella deviated the greatest from normal in 0–20 degrees of knee flexion. The operations were found to correct the lateral patellofemoral angle and the lateral patella tilt with or without quadriceps muscle contraction, but did not completely correct the marked preoperative lateral patellar displacement and tracking.Type of Medium: Electronic ResourceURL: