Search Results - (Author, Cooperation:S. Jounier)

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  1. 1
    Staff View
    Publication Date:
    2016-01-28
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Chromatin Assembly and Disassembly ; DNA Helicases/metabolism ; DNA-Binding Proteins/*metabolism ; *Gene Expression Regulation ; Genome/*genetics ; Histones/metabolism ; Mice ; Micrococcal Nuclease/metabolism ; Mouse Embryonic Stem Cells/cytology/*metabolism ; Nuclear Proteins/metabolism ; Nucleosomes/*genetics/*metabolism ; Promoter Regions, Genetic/genetics ; RNA Polymerase II/metabolism ; Substrate Specificity ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; Transcription Initiation Site
    Published by:
    http://www.nature.com/

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  2. 2
    Staff View
    ISSN:
    1432-2013
    Keywords:
    Cortical thick ascending limb Low-Mg2+ diet Mg2+ transport Microperfusion
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract. Mice aged 4 or 8 weeks were fed with a low-Mg2+ diet for 1, 2, 3 or 4 days. After 1 day of diet, the urinary excretion of Mg2+ and Ca2+ was strongly reduced in both animal groups (4 and 8 weeks), accompanied by a significant fall in plasma Mg2+ concentration and an increase in urinary volume. This profile persisted after 2, 3 or 4 days of dietary Mg2+ restriction. After 1 day of diet, transepithelial ion net fluxes of Na+, Cl–, Ca2+ and Mg2+ (J Na, J Cl, J Ca, J Mg) measured in vitro from isolated perfused cortical thick ascending limbs (CTALs) of these animals remained unchanged. After 2 days of diet, measurements of J Ca and J Mg in isolated perfused CTALs showed that transepithelial Mg2+ and Ca2+ reabsorption were enhanced in CTALs from Mg2+-depleted, 8-week-old animals, whereas transepithelial Mg2+ and Ca2+ transport were not altered in 4-week-old mice. J Na and J Cl and the transepithelial potential (PDte) were not modified in CTALs from either animal group. Our results suggest that a low-Mg2+ diet leads to urinary retention of Mg2+ and Ca2+ which is most likely due to increased Mg2+ and Ca2+ transport in the CTAL. Furthermore, in response to dietary Mg2+ restriction, the reabsorption of divalent cations in the CTAL of adult, but not of young, mice undergoes cellular adaptation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004249900197

    Articles: DFG German National Licenses