Search Results - (Author, Cooperation:S. J. Shin)
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1Latest Papers from Table of Contents or Articles in PressX. Chen ; D. Iliopoulos ; Q. Zhang ; Q. Tang ; M. B. Greenblatt ; M. Hatziapostolou ; E. Lim ; W. L. Tam ; M. Ni ; Y. Chen ; J. Mai ; H. Shen ; D. Z. Hu ; S. Adoro ; B. Hu ; M. Song ; C. Tan ; M. D. Landis ; M. Ferrari ; S. J. Shin ; M. Brown ; J. C. Chang ; X. S. Liu ; L. H. Glimcher
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antigens, CD24/metabolism ; Antigens, CD44/metabolism ; Cell Hypoxia/genetics ; Cell Line, Tumor ; Cell Proliferation ; DNA-Binding Proteins/deficiency/genetics/*metabolism ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Gene Silencing ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism ; Mice ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; Prognosis ; RNA Polymerase II/metabolism ; Transcription Factors/deficiency/genetics/*metabolism ; Transcription, Genetic ; Triple Negative Breast Neoplasms/blood supply/genetics/*metabolism/*pathology ; Unfolded Protein ResponsePublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. M. Mosquera ; S. Varma ; C. Pauli ; T. Y. MacDonald ; J. J. Yashinskie ; Z. Varga ; A. Sboner ; H. Moch ; M. A. Rubin ; S. J. Shin
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-04-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Breast Neoplasms/*classification/*genetics ; Female ; Humans ; Mutation/*genetics ; Translocation, Genetic/*geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressJhun, B. W., Yang, B., Moon, S. M., Lee, H., Park, H. Y., Jeon, K., Kwon, O. J., Ahn, J., Moon, I. J., Shin, S. J., Daley, C. L., Koh, W.-J.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-06-27Publisher: The American Society for Microbiology (ASM)Print ISSN: 0066-4804Electronic ISSN: 1098-6596Topics: BiologyMedicinePublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We report a case of mammary carcinoma with striking cytoplasmic pigmentation in a 60-year-old Japanese woman who presented with a self-evident nodular lesion in the left breast.Methods and results:After a fine needle aspiration revealing atypical clusters of cells, an excisional biopsy was performed. Histologically, a partially cystic 18 mm lesion containing a 5-mm mural nodule was present. The mural nodule and adjacent thickened epithelium were comprised of atypical cells focally invading into the cyst wall. Striking abundant granular brown pigment resembling melanin was present in some of the neoplastic cells. The differential diagnosis included metastatic melanoma and mammary carcinoma with melanocytic differentiation. After a series of special stains and immunohistochemical studies, the diagnosis of mammary carcinoma with extensive cytoplasmic lipofuscin pigment was rendered.Conclusion: Mammary carcinoma with lipofuscin pigment to the degree seen in this case which mimics melanocytic differentiation has not, to our knowledge, previously been documented.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesShin, S. J. ; Lai, F. J. ; Wen, J. D. ; Hsiao, P. J. ; Hsieh, M. C. ; Tzeng, T. F. ; Chen, H. C. ; Guh, J. Y. ; Tsai, J. H.
Springer
Published 2000Staff ViewISSN: 1432-0428Keywords: Keywords Nitric oxide ; neuronal nitric oxide synthase ; endothelial nitric oxide synthase ; diabetic kidney ; outer medulla ; renin ; angiotensinogen.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Aims/hypothesis. Several investigations have shown that the renal medulla has a greater capacity to generate nitric oxide than the renal cortex. To further evaluate the changes of nitric oxide synthesis in the kidney, particularly in the outer medulla, in disorders involving fluid and electrolyte imbalances, we sought to determine renal nitric oxide synthase expression in the diabetic rats. Methods. We determined renal nitric oxide synthase mRNA and urinary nitrite/nitrate excretion in 12 normal and 12 streptozotocin-induced diabetic rats by reverse transcription-polymerase chain reaction with Southern blot hybridization and with Griess reaction, respectively. Nitric oxide synthase immunoreactivity was detected by immunohistochemistry in four normal and four diabetic rats. Results. Neuronal and endothelial nitric oxide synthase mRNA were 3.5-fold and 1.8-fold increased in the outer medulla of 12 diabetic rats with no difference found in the cortex and inner medulla when compared with 12 normal rats. Urinary nitrite/nitrate excretion was significantly increased from the first week after diabetic induction. In normal rats, immunohistochemical studies showed positive neuronal and endothelial nitric oxide synthase immunostaining in almost all segments of renal tubules. Diabetic rats had the greatest enhancement of immunostaining for neuronal and endothelial nitric oxide synthase in the proximal straight tubule and medullary thick ascending limb. Conclusion/interpretation. Our results indicate that increases in neuronal and endothelial nitric oxide synthase synthesis in the kidney, particularly in the outer medulla, possibly play an important part in the adaptation of renal function to hyperglycaemia and hyperosmolality in diabetes. [Diabetologia (2000) 43: 649–659]Type of Medium: Electronic ResourceURL: