Search Results - (Author, Cooperation:S. J. Jones)

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  1. 1
    A. S. Morrissy ; L. Garzia ; D. J. Shih ; S. Zuyderduyn ; X. Huang ; P. Skowron ; M. Remke ; F. M. Cavalli ; V. Ramaswamy ; P. E. Lindsay ; S. Jelveh ; L. K. Donovan ; X. Wang ; B. Luu ; K. Zayne ; Y. Li ; C. Mayoh ; N. Thiessen ; E. Mercier ; K. L. Mungall ; Y. Ma ; K. Tse ; T. Zeng ; K. Shumansky ; A. J. Roth ; S. Shah ; H. Farooq ; N. Kijima ; B. L. Holgado ; J. J. Lee ; S. Matan-Lithwick ; J. Liu ; S. C. Mack ; A. Manno ; K. A. Michealraj ; C. Nor ; J. Peacock ; L. Qin ; J. Reimand ; A. Rolider ; Y. Y. Thompson ; X. Wu ; T. Pugh ; A. Ally ; M. Bilenky ; Y. S. Butterfield ; R. Carlsen ; Y. Cheng ; E. Chuah ; R. D. Corbett ; N. Dhalla ; A. He ; D. Lee ; H. I. Li ; W. Long ; M. Mayo ; P. Plettner ; J. Q. Qian ; J. E. Schein ; A. Tam ; T. Wong ; I. Birol ; Y. Zhao ; C. C. Faria ; J. Pimentel ; S. Nunes ; T. Shalaby ; M. Grotzer ; I. F. Pollack ; R. L. Hamilton ; X. N. Li ; A. E. Bendel ; D. W. Fults ; A. W. Walter ; T. Kumabe ; T. Tominaga ; V. P. Collins ; Y. J. Cho ; C. Hoffman ; D. Lyden ; J. H. Wisoff ; J. H. Garvin, Jr. ; D. S. Stearns ; L. Massimi ; U. Schuller ; J. Sterba ; K. Zitterbart ; S. Puget ; O. Ayrault ; S. E. Dunn ; D. P. Tirapelli ; C. G. Carlotti ; H. Wheeler ; A. R. Hallahan ; W. Ingram ; T. J. MacDonald ; J. J. Olson ; E. G. Van Meir ; J. Y. Lee ; K. C. Wang ; S. K. Kim ; B. K. Cho ; T. Pietsch ; G. Fleischhack ; S. Tippelt ; Y. S. Ra ; S. Bailey ; J. C. Lindsey ; S. C. Clifford ; C. G. Eberhart ; M. K. Cooper ; R. J. Packer ; M. Massimino ; M. L. Garre ; U. Bartels ; U. Tabori ; C. E. Hawkins ; P. Dirks ; E. Bouffet ; J. T. Rutka ; R. J. Wechsler-Reya ; W. A. Weiss ; L. S. Collier ; A. J. Dupuy ; A. Korshunov ; D. T. Jones ; M. Kool ; P. A. Northcott ; S. M. Pfister ; D. A. Largaespada ; A. J. Mungall ; R. A. Moore ; N. Jabado ; G. D. Bader ; S. J. Jones ; D. Malkin ; M. A. Marra ; M. D. Taylor
    Nature Publishing Group (NPG)
    Published 2016
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    Publication Date:
    2016-01-14
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    A. Kundaje ; W. Meuleman ; J. Ernst ; M. Bilenky ; A. Yen ; A. Heravi-Moussavi ; P. Kheradpour ; Z. Zhang ; J. Wang ; M. J. Ziller ; V. Amin ; J. W. Whitaker ; M. D. Schultz ; L. D. Ward ; A. Sarkar ; G. Quon ; R. S. Sandstrom ; M. L. Eaton ; Y. C. Wu ; A. R. Pfenning ; X. Wang ; M. Claussnitzer ; Y. Liu ; C. Coarfa ; R. A. Harris ; N. Shoresh ; C. B. Epstein ; E. Gjoneska ; D. Leung ; W. Xie ; R. D. Hawkins ; R. Lister ; C. Hong ; P. Gascard ; A. J. Mungall ; R. Moore ; E. Chuah ; A. Tam ; T. K. Canfield ; R. S. Hansen ; R. Kaul ; P. J. Sabo ; M. S. Bansal ; A. Carles ; J. R. Dixon ; K. H. Farh ; S. Feizi ; R. Karlic ; A. R. Kim ; A. Kulkarni ; D. Li ; R. Lowdon ; G. Elliott ; T. R. Mercer ; S. J. Neph ; V. Onuchic ; P. Polak ; N. Rajagopal ; P. Ray ; R. C. Sallari ; K. T. Siebenthall ; N. A. Sinnott-Armstrong ; M. Stevens ; R. E. Thurman ; J. Wu ; B. Zhang ; X. Zhou ; A. E. Beaudet ; L. A. Boyer ; P. L. De Jager ; P. J. Farnham ; S. J. Fisher ; D. Haussler ; S. J. Jones ; W. Li ; M. A. Marra ; M. T. McManus ; S. Sunyaev ; J. A. Thomson ; T. D. Tlsty ; L. H. Tsai ; W. Wang ; R. A. Waterland ; M. Q. Zhang ; L. H. Chadwick ; B. E. Bernstein ; J. F. Costello ; J. R. Ecker ; M. Hirst ; A. Meissner ; A. Milosavljevic ; B. Ren ; J. A. Stamatoyannopoulos ; T. Wang ; M. Kellis
    Nature Publishing Group (NPG)
    Published 2015
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    Publication Date:
    2015-02-20
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Base Sequence ; Cell Lineage/genetics ; Cells, Cultured ; Chromatin/chemistry/genetics/metabolism ; Chromosomes, Human/chemistry/genetics/metabolism ; DNA/chemistry/genetics/metabolism ; DNA Methylation ; Datasets as Topic ; Enhancer Elements, Genetic/genetics ; Epigenesis, Genetic/*genetics ; *Epigenomics ; Genetic Variation/genetics ; Genome, Human/*genetics ; Genome-Wide Association Study ; Histones/metabolism ; Humans ; Organ Specificity/genetics ; RNA/genetics ; Reference Values
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  3. 3
    Staff View
    Publication Date:
    2016-04-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2011-03-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Antigens, CD/genetics/metabolism ; Antigens, CD274 ; Antigens, CD80/genetics/metabolism ; Base Sequence ; Cell Line, Tumor ; Chromosome Breakpoints ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Hodgkin Disease/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Jurkat Cells ; Lymphocyte Activation ; Lymphoma, B-Cell/*genetics ; Molecular Sequence Data ; Nuclear Proteins/*genetics ; Oncogene Proteins, Fusion/*genetics ; Programmed Cell Death 1 Ligand 2 Protein ; RNA, Neoplasm/genetics ; T-Lymphocytes/immunology/metabolism/pathology ; Tissue Array Analysis ; Trans-Activators/*genetics ; Translocation, Genetic/*genetics ; Tumor Microenvironment
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  5. 5
    P. A. Northcott ; D. J. Shih ; J. Peacock ; L. Garzia ; A. S. Morrissy ; T. Zichner ; A. M. Stutz ; A. Korshunov ; J. Reimand ; S. E. Schumacher ; R. Beroukhim ; D. W. Ellison ; C. R. Marshall ; A. C. Lionel ; S. Mack ; A. Dubuc ; Y. Yao ; V. Ramaswamy ; B. Luu ; A. Rolider ; F. M. Cavalli ; X. Wang ; M. Remke ; X. Wu ; R. Y. Chiu ; A. Chu ; E. Chuah ; R. D. Corbett ; G. R. Hoad ; S. D. Jackman ; Y. Li ; A. Lo ; K. L. Mungall ; K. M. Nip ; J. Q. Qian ; A. G. Raymond ; N. T. Thiessen ; R. J. Varhol ; I. Birol ; R. A. Moore ; A. J. Mungall ; R. Holt ; D. Kawauchi ; M. F. Roussel ; M. Kool ; D. T. Jones ; H. Witt ; L. A. Fernandez ; A. M. Kenney ; R. J. Wechsler-Reya ; P. Dirks ; T. Aviv ; W. A. Grajkowska ; M. Perek-Polnik ; C. C. Haberler ; O. Delattre ; S. S. Reynaud ; F. F. Doz ; S. S. Pernet-Fattet ; B. K. Cho ; S. K. Kim ; K. C. Wang ; W. Scheurlen ; C. G. Eberhart ; M. Fevre-Montange ; A. Jouvet ; I. F. Pollack ; X. Fan ; K. M. Muraszko ; G. Y. Gillespie ; C. Di Rocco ; L. Massimi ; E. M. Michiels ; N. K. Kloosterhof ; P. J. French ; J. M. Kros ; J. M. Olson ; R. G. Ellenbogen ; K. Zitterbart ; L. Kren ; R. C. Thompson ; M. K. Cooper ; B. Lach ; R. E. McLendon ; D. D. Bigner ; A. Fontebasso ; S. Albrecht ; N. Jabado ; J. C. Lindsey ; S. Bailey ; N. Gupta ; W. A. Weiss ; L. Bognar ; A. Klekner ; T. E. Van Meter ; T. Kumabe ; T. Tominaga ; S. K. Elbabaa ; J. R. Leonard ; J. B. Rubin ; L. M. Liau ; E. G. Van Meir ; M. Fouladi ; H. Nakamura ; G. Cinalli ; M. Garami ; P. Hauser ; A. G. Saad ; A. Iolascon ; S. Jung ; C. G. Carlotti ; R. Vibhakar ; Y. S. Ra ; S. Robinson ; M. Zollo ; C. C. Faria ; J. A. Chan ; M. L. Levy ; P. H. Sorensen ; M. Meyerson ; S. L. Pomeroy ; Y. J. Cho ; G. D. Bader ; U. Tabori ; C. E. Hawkins ; E. Bouffet ; S. W. Scherer ; J. T. Rutka ; D. Malkin ; S. C. Clifford ; S. J. Jones ; J. O. Korbel ; S. M. Pfister ; M. A. Marra ; M. D. Taylor
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-07-27
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Carrier Proteins/genetics ; Cerebellar Neoplasms/*classification/*genetics/metabolism ; Child ; DNA Copy Number Variations/genetics ; Gene Duplication/genetics ; Genes, myc/genetics ; Genome, Human/*genetics ; Genomic Structural Variation/*genetics ; Genomics ; Hedgehog Proteins/metabolism ; Humans ; Medulloblastoma/*classification/*genetics/metabolism ; NF-kappa B/metabolism ; Nerve Tissue Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Proteins/genetics ; RNA, Long Noncoding ; Signal Transduction ; Transforming Growth Factor beta/metabolism ; Translocation, Genetic/genetics
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  6. 6
    Staff View
    Publication Date:
    2013-12-18
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Antineoplastic Agents, Alkylating/*adverse effects/therapeutic use ; Brain/drug effects/pathology ; Brain Neoplasms/*drug therapy/genetics/*pathology ; DNA Helicases/genetics ; DNA Mutational Analysis ; Dacarbazine/adverse effects/*analogs & derivatives/therapeutic use ; Glioma/*drug therapy/genetics/*pathology ; Humans ; Mutagenesis/drug effects ; Neoplasm Grading ; Neoplasm Recurrence, Local/*chemically induced/drug therapy/*genetics ; Nuclear Proteins/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins c-akt/genetics ; TOR Serine-Threonine Kinases/genetics ; Transcription Factors/genetics ; Tumor Suppressor Protein p53/genetics
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    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Staff View
    Publication Date:
    2011-07-29
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Chromatin/genetics/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Genome, Human/genetics ; Histone Acetyltransferases/genetics/metabolism ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Histones/*metabolism ; Humans ; Loss of Heterozygosity/genetics ; Lymphoma, Follicular/enzymology/genetics ; Lymphoma, Large B-Cell, Diffuse/enzymology/genetics ; Lymphoma, Non-Hodgkin/enzymology/*genetics ; MADS Domain Proteins/genetics/metabolism ; MEF2 Transcription Factors ; Mutation/*genetics ; Myogenic Regulatory Factors/genetics/metabolism ; Neoplasm Proteins/genetics/metabolism
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    Latest Papers from Table of Contents or Articles in Press
  8. 8
    Middya, A. R. ; Ray, Swati ; Jones, S. J. ; Williamson, D. L.

    [S.l.] : American Institute of Physics (AIP)
    Published 1995
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The microstructures of two sets of hydrogenated amorphous silicon–germanium (a-Si1−xGex:H) alloys prepared by the plasma-enhanced, chemical-vapor-deposition technique with and without hydrogen dilution of the source gases (silane and germane) have been analyzed by small-angle x-ray scattering (SAXS), infrared vibrational spectroscopy, and flotation density measurements. Optoelectronic properties of codeposited films have also been characterized. Hydrogen dilution suppresses dihydride/polyhydride formation, reduces bonded H content, and reduces the SAXS-detected microstructure for x(approximately-greater-than)0. Studies of anisotropy in the SAXS intensity indicate an increased amount of oriented microstructure as Ge is added, consistent with a trend toward columnarlike growth in both undiluted and hydrogen-diluted films, but the diluted films have a significantly reduced degree of such oriented microstructure. The improvement in the microstructure of a-Si1−xGex:H films by H2 dilution correlates with concomitant improvement of optoelectronic properties. The modification of microstructure due to H2 dilution of the source gases is discussed in terms of growth mechanisms of alloy films. © 1995 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Mogro-Campero, A. ; Love, R. P. ; Jones, S. J.

    [S.l.] : American Institute of Physics (AIP)
    Published 1986
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Generation lifetime and surface generation velocity were measured by capacitance transient analysis of metal-oxide-semiconductor capacitors to study the effect of high-energy neutron irradiation in the fluence range 1012–1014 cm−2. Thirty-minute isochronal anneals show that the generation lifetime and surface generation velocity recover their preirradiation values at 470 °C, which is close to the temperature for annealing of recombination lifetime decreases produced by electron irradiation. The relatively low value of annealing temperature for the recovery of lifetime after neutron irradiation is in sharp contrast with the improved thermal stability of lifetime effects produced by ion implantation into silicon when compared to the case of electron irradiation.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Jones, S. J. ; Chen, Y. ; Williamson, D. L. ; Zedlitz, R. ; Bauer, G.

    Woodbury, NY : American Institute of Physics (AIP)
    Published 1993
    Staff View
    ISSN:
    1077-3118
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The microstructure of amorphous Si1−xGex:H films with x〈0.40 was studied using small-angle x-ray scattering (SAXS) and the results compared with those from opto-electronic and density measurements. The SAXS, the sub-band-gap absorption determined from photothermal deflection spectroscopy, and the photo/dark conductivity ratio all show relatively sharp changes above x=0.2. A corresponding sharp change in the anisotropic character of the SAXS is consistent with a transition to a columnar-like microstructure above x=0.2. The correlated results provide strong evidence for a direct link between degraded opto-electronic properties and the increased heterogeneity associated with the microstructural transition.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Johari, G. P. ; Pascheto, W. ; Jones, S. J.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1994
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    That the equilibrium state of impurity-free polycrystalline ice contains water has been expressed in terms of free-energy changes, and further developed to show that liquid in cavities formed at grain junctions in a microcrystalline solid containing no impurities affects its electrical properties and increases its heat capacity. General formulas for the volume of a liquid contained in the pockets formed at four-grain junctions and veins formed at three-grain junctions in equilibrium in an impurity-free polycrystalline mass are given. The variation of the volume fraction of intergranular water in impurity-free ice and the ice's total free energy have been calculated for different grain sizes and temperatures. Calculations also confirm that intergranular water or premelting contributes significantly to the pure ice's heat capacity.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Boyde, A. ; Jones, S. J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1477-9730
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Architecture, Civil Engineering, Surveying
    Notes:
    The authors discuss systems for the three dimensional measurement of microscopic features, in particular the pits made by isolated bone resorbing cells (osteoclasts) in test substrates with flat surfaces; such measurements may be used to assay the work done by these cells. Confocal light microscopy, with its very shallow depth of field, seems to be replacing scanning electron microscopic stereophotogrammetry as the preferred method for such measurement. 〈section xml:id="abs1-2"〉〈title type="main"〉Résumé Les auteurs examinent les systèmes de mesures tri-dimensionelles ďobjets microscopiques tels que, en particulier, les cavités creusies dans des substrats expérimentaux, déposés sur des surfaces plates, par des cellules isolées résorbant les os (ostéoclastes). On peut recourir à de telles mesures pour évaluer le travail effectué par ces cellules. Il semble que dans ces mesures, on tende à remplacer la stéréophotogrammétrie au microscope électronique à balayage par la microscopie à lumière confocale qui possède une très faible profondeur de champ et emporte la préférence. 〈section xml:id="abs1-3"〉〈title type="main"〉Zusammenfassung Die Autoren diskutieren Systeme zur dreidimensionalen Ausmessung von Mikroskopabbildungen, insbesondere der Vertiefungen, die durch isolierte, Knochen resorbierende Zellen (Osteoklaster) in Testsubstraten mit ebenen Oberflächen verursacht wurden. Solche Messungen konnen zur Prüfung der von diesen Zellen geleisteten Arbeit genutzt werden. Die Mikroskopie mit konfokalem Licht und einer sehr geringen Gesichtsfeldtiefe scheint die Stereophotogrammetrie mittels Rasterelektronen-mikroskop als der bevorzugten Methode für solche Messungen zu ersetzen.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Jones, S. J. ; Cohen, A. M.

    Oxford, UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1365-2044
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    GILOIS, C. ; WIERZBICKI, A. S. ; HIRANI, N. ; NORMAN, P. M. ; JONES, S. J. ; PONSFORD, S. ; ALANI, S. M. ; KRISS, A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    High-quality amorphous hydrogenated germanium has been deposited using the diode rf glow discharge method out of a gas plasma of GeH4 and H2. The optical, electrical, and structural properties of this material have been extensively characterized. The optical and electrical properties are all consistent with material containing a low density of defect related states in the energy gap. In particular, this material has an ημτ=3.2×10−7 cm2/V, ratio of photocurrent to dark current of 1.3×10−1, and flux dependence of the photocurrent with γ=0.79 at 1.25 eV measured using photoconductivity, a μτ=4×10−8 cm2/V measured using time of flight, an Urbach energy of 51 meV and α at 0.7 eV of 8.3 cm−1 measured using photothermal deflection spectroscopy, a dangling bond spin density of 5×1016 cm−3 measured using electron spin resonance, photoluminescence with a peak energy position of 0.81 eV and full width at half maximum of 0.19 eV, an activation energy of 0.52 eV and σ0 of 6.1×103 (Ω cm)−1 measured using dark conductivity, and an E04 band gap of 1.24 eV measured by optical absorption. The structural measurements indicate a homogeneous material lacking any island/tissue and columnar structure when investigated using transmission and scanning electron microscopy, respectively. Hydrogen concentrations calculated from infrared and gas evolution measurements can only by reconciled by postulating a large quantity of unbonded hydrogen whose presence is confirmed using deuteron magnetic resonance. The bonded deuterium component, as seen in this film using DMR, has a spin-lattice relaxation time of the order of 4000 s. The differential scanning calorimetry measurement shows crystallization occurring at 421 °C and the presence of large compressive stresses has been confirmed using a bending-beam method. The experimental details necessary to interpret the quantities quoted here are set out in the text which follows. It is considered that the very good optical and electrical properties of this as yet unoptimized material are directly related to the structural properties detailed above.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    JOHARI, G. P. ; JONES, S. J.

    [s.l.] : Nature Publishing Group
    Published 1976
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] For an isotropically polarisable material, a is given by the Clausius-Mossotti relationship 4/3 pNa=V (e ?1/e +1) (1) where N is Avogadro's number, V the molar volume and ??, the limiting high frequency relative permittivity of the orientation polarisation. V for H2O ice was calculated for a ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Jones, S. J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1982
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Jones, S. J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1980
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Jones, S. J.
    Springer
    Published 1993
    Staff View
    ISSN:
    1432-1459
    Keywords:
    Optic neuritis ; Multiple sclerosis ; Visual evoked potential
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Visual evoked potentials (VEPs) were compared among six groups of patients tested at various times after an episode of acute unilateral optic neuritis (ON). The incidence of abnormalities ranged from above 90% in patients tested during the first 6 months to about 70% when more than 2 years had elapsed. Compared with the acute stage (1–8 weeks), latency prolongation was almost 50% less in patients tested after 2–19 years. In the latter group, latencies were significantly correlated with the patients' age at the time of the attack. The findings confirm and extend the evidence of serial studies which shows that the shortening of VEP latency is a general phenomenon which proceeds for up to 2 years and possibly for longer in younger patients. When the patients with clinically isolated ON were compared with those who had a history of additional neurological episodes suggestive of multiple sclerosis (MS), up to 4 weeks after ON latencies were more prolonged in the MS group but between 4 and 8 weeks amplitudes were larger and between 8 weeks and 2 years latencies were significantly shorter. No significant differences were found in patients tested after more than 2 years. It is suggested that the electrophysiological deficit may initially be more severe in patients with disseminated disease, but that recovery may occur faster.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Jones, S. J. ; Glorieux, F. H. ; Travers, R. ; Boyde, A.
    Springer
    Published 1999
    Staff View
    ISSN:
    1432-0827
    Keywords:
    Key words: Osteogenesis imperfecta — Normal bone — Children — Backscattered electron imaging scanning electron microscopy.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Physics
    Notes:
    Abstract. The microstructure of iliac crest biopsies from normal children or from those afflicted with osteogenesis imperfecta (OI) has not previously been studied to determine the tissue histology in the context of the degree of mineralization. The material in this study comprised 112 iliac crest biopsies from children aged 1.9–22.9 years. Fifty-eight were reference biopsies taken from children with no bone disease and the remainder were biopsies from children diagnosed as having OI (23 were Type I, 8 Type III, 18 Type IV, and 5 Type V). The specimens, which had been embedded in polymethylmethacrylate (PMMA), were micromilled and carbon coated to permit backscattered electron imaging. Reference biopsies from very young children often contained densely mineralized cartilage, and evidence of rapid cortical drift. Circumferential lamellae became a prominent feature after the toddler stage, and active remodeling and slower cortical drift continued through childhood. The biopsies from older teenagers and young adults were indistinguishable. Occasional mineralized osteocyte lacunae were detected in even the youngest children. Bone from children with OI Type I often appeared normal in microstructure and amount, but in some there was a dearth of bone and an abundance of osteocytes. Compared with age-matched controls, cortical and trabecular bone from children with OI Types III and IV were markedly sparse and very cellular, and primary osteonal systems continued to be formed later than expected. A distinguishing feature of the bone from OI Type V patients was the failure of patches of bone to mineralize, especially adjoining a reversal line. Packets of bone tissue exhibiting either considerably higher than normal or deficient mineralization would contribute to the characteristic trait of mechanical weakness.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses