Search Results - (Author, Cooperation:S. J. Aves)

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  1. 1
    B. A. Curtis ; G. Tanifuji ; F. Burki ; A. Gruber ; M. Irimia ; S. Maruyama ; M. C. Arias ; S. G. Ball ; G. H. Gile ; Y. Hirakawa ; J. F. Hopkins ; A. Kuo ; S. A. Rensing ; J. Schmutz ; A. Symeonidi ; M. Elias ; R. J. Eveleigh ; E. K. Herman ; M. J. Klute ; T. Nakayama ; M. Obornik ; A. Reyes-Prieto ; E. V. Armbrust ; S. J. Aves ; R. G. Beiko ; P. Coutinho ; J. B. Dacks ; D. G. Durnford ; N. M. Fast ; B. R. Green ; C. J. Grisdale ; F. Hempel ; B. Henrissat ; M. P. Hoppner ; K. Ishida ; E. Kim ; L. Koreny ; P. G. Kroth ; Y. Liu ; S. B. Malik ; U. G. Maier ; D. McRose ; T. Mock ; J. A. Neilson ; N. T. Onodera ; A. M. Poole ; E. J. Pritham ; T. A. Richards ; G. Rocap ; S. W. Roy ; C. Sarai ; S. Schaack ; S. Shirato ; C. H. Slamovits ; D. F. Spencer ; S. Suzuki ; A. Z. Worden ; S. Zauner ; K. Barry ; C. Bell ; A. K. Bharti ; J. A. Crow ; J. Grimwood ; R. Kramer ; E. Lindquist ; S. Lucas ; A. Salamov ; G. I. McFadden ; C. E. Lane ; P. J. Keeling ; M. W. Gray ; I. V. Grigoriev ; J. M. Archibald
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-12-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Algal Proteins/genetics/metabolism ; Alternative Splicing/genetics ; Cell Nucleus/*genetics ; Cercozoa/cytology/*genetics/metabolism ; Cryptophyta/cytology/*genetics/metabolism ; Cytosol/metabolism ; *Evolution, Molecular ; Gene Duplication/genetics ; Gene Transfer, Horizontal/genetics ; Genes, Essential/genetics ; Genome/*genetics ; Genome, Mitochondrial/genetics ; Genome, Plant/genetics ; Genome, Plastid/genetics ; Molecular Sequence Data ; *Mosaicism ; Phylogeny ; Protein Transport ; Proteome/genetics/metabolism ; Symbiosis/*genetics ; Transcriptome/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Smerdon, G. R. ; Walton, E. F. ; Aves, S. J.
    Springer
    Published 1998
    Staff View
    ISSN:
    1432-0614
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Process Engineering, Biotechnology, Nutrition Technology
    Notes:
    Abstract Strains of the fission yeast Schizosaccharomyces pombe have been constructed containing single or multiple chromosomally integrated copies of an expression cassette for production of human gastric lipase. Integrant strains of S. pombe secrete active lipase and are stable for lipase production over a minimum of 50 generations in non-selective media. Lipase activity levels for integrant strains containing up to three tandem copies of the expression cassette are strongly correlated with copy number of the cassette in both complete and minimal media. Lipase activity is higher in complete medium than in minimal medium. Strains carrying three chromosomally integrated expression cassette copies can be grown without selection in complete medium and are capable of significantly higher lipase activities than strains containing the expression cassette on a multicopy plasmid.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002530051135

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1432-0983
    Keywords:
    Key wordsSchizosaccharomyces pombe ; cdc23 ; DNA replication ; Cell cycle
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract The fission yeast cdc23 gene is required for correct DNA replication: cdc23 mutants show reduced rates of DNA synthesis and become elongated after cell-cycle arrest. We have cloned the Schizosaccharomyces pombe cdc23 gene by complementation of the temperature-sensitive phenotype of cdc23-M36 and confirmed the identity of the gene by integrative mapping. Analysis of the DNA sequence reveals that cdc23 can encode a protein of 593 amino acids (Mr=67 kDa) with 22% overall identity and many structural homologies with the product of the Saccharomyces cerevisiae DNA43 (MCM10) gene which is required for correct initiation of DNA synthesis at chromosomal origins of replication. Construction of a cdc23 null allele has established that the cdc23 gene is essential for viability, with cdc23 deletion mutant spores germinating but undergoing arrest with undivided nuclei in the first or second cell cycle. The S. pombe cdc23 gene on an expression plasmid is able to complement the S. cerevisiae dna43-1 mutant. These structural and functional homologies between two distantly related species suggest that cdc23 and DNA43 may represent genes for a conserved essential eukaryotic DNA replication function.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002940050382

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1617-4623
    Keywords:
    Schizosaccharomyces pombe ; Histone H2A variant ; Chromosome stability ; H2A.F/Z
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract We have isolated and characterised the pht1 gene from the fission yeast Schizosaccharomyces pombe. The sequence of the predicted translation product has revealed a striking similarity to the family of H2A.F/Z histone variant proteins, which have been found in a variety of different organisms. Cells deleted for the pht1 gene locus grow slowly, exhibit an altered colony morphology, increased resistance to heat shock and show a significant decrease in the fidelity of segregation of an S. pombe minichromosome. We propose that the histone H2A variant encoded by the pht1 gene is important for chromosomal structure and function, possibly including a role in controlling the fidelity of chromosomal segregation during mitosis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00282226

    Articles: DFG German National Licenses