Search Results - (Author, Cooperation:S. Hutchinson)
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1Latest Papers from Table of Contents or Articles in PressL. Kruidenier ; C. W. Chung ; Z. Cheng ; J. Liddle ; K. Che ; G. Joberty ; M. Bantscheff ; C. Bountra ; A. Bridges ; H. Diallo ; D. Eberhard ; S. Hutchinson ; E. Jones ; R. Katso ; M. Leveridge ; P. K. Mander ; J. Mosley ; C. Ramirez-Molina ; P. Rowland ; C. J. Schofield ; R. J. Sheppard ; J. E. Smith ; C. Swales ; R. Tanner ; P. Thomas ; A. Tumber ; G. Drewes ; U. Oppermann ; D. J. Patel ; K. Lee ; D. M. Wilson
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-10-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Enzyme Inhibitors/*pharmacology ; Humans ; Jumonji Domain-Containing Histone Demethylases/*antagonists & inhibitors ; Macrophages/*drug effects/*immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressL. Kruidenier ; C. W. Chung ; Z. Cheng ; J. Liddle ; K. Che ; G. Joberty ; M. Bantscheff ; C. Bountra ; A. Bridges ; H. Diallo ; D. Eberhard ; S. Hutchinson ; E. Jones ; R. Katso ; M. Leveridge ; P. K. Mander ; J. Mosley ; C. Ramirez-Molina ; P. Rowland ; C. J. Schofield ; R. J. Sheppard ; J. E. Smith ; C. Swales ; R. Tanner ; P. Thomas ; A. Tumber ; G. Drewes ; U. Oppermann ; D. J. Patel ; K. Lee ; D. M. Wilson
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Biocatalysis/drug effects ; Catalytic Domain ; Cells, Cultured ; Enzyme Inhibitors/metabolism/*pharmacology ; Evolution, Molecular ; Histones/chemistry/metabolism ; Humans ; Inhibitory Concentration 50 ; Jumonji Domain-Containing Histone Demethylases/*antagonists & ; inhibitors/chemistry/classification/metabolism ; Lysine/metabolism ; Macrophages/*drug effects/enzymology/*immunology/metabolism ; Methylation/drug effects ; Mice ; Models, Molecular ; Substrate Specificity ; Tumor Necrosis Factor-alpha/biosynthesisPublished by: -
3Articles: DFG German National LicensesGoldberg, D. ; McIntyre, P.G. ; Smith, R. ; Appleyard, K. ; Dunlop, J. ; Taylor, A. ; Hutchinson, S.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Objective To determine the prevalence of the hepatitis C virus among pregnant women, to gauge the non-injecting, particularly sexual, risk of them being hepatitis C virus infected and to assess the potential impact of selective antenatal screening.Population Antenatal clinic attenders and women undergoing termination of pregnancy in 1997.Setting Ninewells Hospital, Dundee.Design Unlinked anonymous hepatitis C virus antibody testing of residual sera from specimens sent to the virus laboratory for routine serological testing. The results were linked to non-identifying risk information.Results Overall anti-hepatitis C virus prevalence was 0.6% (23/3548). Prevalences among injecting drug users, non-injectors who had a sexual partner who injected, and those with neither risk respectively were 41% (7/17), 15% (5/33) and 0.3% (11/3498). Relative risks for being an injector and a sexual partner of an injector respectively were 131 (95% CI 58-297) and 48 (95% CI 5-32). It is estimated that one of the 18 antenatal clinic attenders gave birth to an infected child.Conclusion Findings suggest that non-injecting partners of injectors may be at considerable risk of acquiring hepatitis C virus sexually. Efforts to promote the use of condoms among injectors and their sexual partners should be increased. Selective anti-hepatitis C virus screening of women who reported high risk behaviour would have failed to detect half the cases. Research to gauge the views of women of childbearing age on anti-hepatitis C virus testing is required.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesTurnbull, D. ; Farid, A. ; Hutchinson, S. ; Shorthouse, A. ; Mills, G. H.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary Lower limb compartment syndrome is a rare consequence of surgery where the lithotomy position is maintained for several hours. The aim of this study was to observe the effect of the lithotomy position on lower limb compartment pressure and blood flow to the lower limb in surgical patients having colorectal procedures. We prospectively studied 23 patients undergoing colorectal surgery requiring the lithotomy position and recorded lower limb compartment pressure, and the blood pressure in the upper and lower limbs. The lithotomy position led to a significant (p 〈 0.001) fall in blood pressure to the lower limb from 87 (SD 16) mmHg to 67.9 (SD 12) mmHg and a significant (p 〈 0.001) rise in lower limb compartment pressure from 13 (SD 7) mmHg to 31 (SD 12) mmHg. These two effects compromise blood flow to the lower limb in long surgical procedures where the lithotomy position is required. Intermittently lowering the legs and restoring blood flow may prevent compartment syndrome developing.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesMcGill, A. ; Hutchinson, S. P. ; Andrzejowski, J. C. ; Francis, G. A.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The ‘New Deal’ restrictions on junior doctors' hours have major implications for the staffing of anaesthetic departments and the provision of adequate training. The results of a national postal survey demonstrate a decline in traditional on-call arrangements, especially in hard-pressed work sectors such as intensive care. A substantial number of anaesthetic departments have still completely to satisfy the hours restrictions in many work sectors. Many departments experience recruitment difficulties and express concern about both service and training issues.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The effect of powdered ginger root was compared with metoclopramide and placebo. In a prospective, randomised, double-blind trial the incidence of postoperative nausea and vomiting was measured in 120 women presenting for elective laparoscopic gynaecological surgery on a day stay basis. The incidence of nausea and vomiting was similar in patients given metoclopramide and ginger (27% and 21%) and less than in those who received placebo (41%). The requirement for postoperative antiemetics was lower in those patients receiving ginger. The requirements for postoperative analgesia, recovery time and time until discharge were the same in all groups. There was no difference in the incidence of possible side effects such as sedation, abnormal movement, itch and visual disturbance between the three groups. Zingiber officinale is an effective and promising prophylactic antiemetic, which may be especially useful for day case surgeryType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The effect of the powdered rhizome of Zingiber officinale (ginger root) on the gastric emptying rate was investigated. In a double-blind crossover trial, 16 healthy volunteers were randomly allocated to receive either 1 g of ginger or placebo. Gastric emptying was measured using the oral paracetamol absorption model. Ingestion of ginger did not effect gastric emptying. The antiemetic effect of ginger is not associated with an effect on gastric emptying. No adverse effects were noted.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Post-larval flounders have been found to migrate into the mixohaline region of the River Itchen, southern England, in mid April. These fish were 7-9 mm total length and at the point of metamorphosis. The mean length and growth rate of O-group flounders at this site was measured at monthly intervals.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: The water balance of 0-group flounders was investigated in a range of static [0–100% sea water (SW), 100%≡ 34%‰] and cycling salinities (2–98% SW, 12 h 25 min period). The permeability coefficients of these juvenile fish were found to be higher than those quoted for adults. The permeability of juveniles in fixed salinities decreased with increased salinity whereas animals in the tidally cycling regime showed permeability changes that were directly proportional to the ambient salinity. However, comparison of the two groups showed that animals in a cycling salinity regime were less permeable to water than animals acclimated to fixed salinities. Drinking and urine production rates fluctuated within a tidal salinity regime, and 0-group flounders were found to modify their water permeability, urine production and drinking rates simultaneously, so maintaining their blood osmotic concentration and total water content within narrow limits throughout the range of salinities.The relevance of measurements made in fixed and tidally cycling salinities to water regulation under natural estuarine conditions is considered.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesHartl, M. G. J. ; Hutchinson, S. ; Hawkins, L. E. ; Eledjam, M.
Oxford, UK : Blackwell Publishing Ltd
Published 2000Staff ViewISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: The gill surface area of 0-group, post-metamorphic Pleuronectes flesus L. was examined using digital image analysis software and expressed in relation to body mass according to the equation log Y=loga+c logW (a=239·02; c=0·723). The components that constitute gill area, total filament length, interlamellar space and unilateral lamellar area were measured. The measurement of the length of every filament on all eight arches showed that commonly used methods of calculation can lead to an under-estimation of up to 24% of total filament length. Direct measurements of unilateral lamellar area with digital image analysis showed that previously reported gill area data for the same species was over-estimated by as much as 58%. In addition, in this species the neglect of gill pouch asymmetry after metamorphosis, can bring about a 14% over-estimation of total gill area.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Laboratory observations of live animals were used to describe the developmental sequence of the flounder Pleuronectes flesus. Developmental state was related to age and total length (LT) from hatching, through metamorphosis, to the juvenile form. By following animals at 7, 11 and 15° C it was found that, whilst the LT at metamorphosis was the same for all the temperature regimes and was not temperature-dependant, the time taken to reach this stage was related to rearing temperature. It was also observed that animals could be induced to metamorphose by transfer to reduced salinity but only if they were close to the critical length for metamorphosis.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The material consists of sections of seventeen spherical fructifications 275-400 jx in diameter with single central cavities 125-250 [x in diameter. The wall structure is similar to that of an ascocarp, being made up of four to eight layers of thick-walled closely packed hyphse 5-20 {i in diameter. ...Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] In these conditions the gases from forty-one of the sixty-two species had a significant effect on the rate of increase of colony diameter of at least one of the assay species. Table 1 summarizes these observations. The relatively crude measurements have not revealed any interactions affecting rate ...Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Recent experiments here have shown that a volatile metabolite secreted by the mycelium is a stimulating factor. This was first demonstrated by showing that spores held on a nutrient medium in the air above actively growing cultures of the fungus, or above medium taken from such cultures, germinated ...Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesHutchinson, S. ; Kearney, G.A. ; Horne, E. ; Lynch, B. ; Glennon, J.D. ; Anthony McKervey, M. ; Harris, S.J.
Amsterdam : ElsevierStaff ViewISSN: 0003-2670Keywords: Calixarene ; Hydroxamic acid ; Metal complexation ; Solid phase extractionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0300-9629Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: