Search Results - (Author, Cooperation:S. H. Lim)
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1Latest Papers from Table of Contents or Articles in PressTseng, S.-H., Lim, C. P., Chen, Q., Tang, C. C., Kong, S. T., Ho, P. C.-L.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-03-28Publisher: The American Society for Microbiology (ASM)Print ISSN: 0066-4804Electronic ISSN: 1098-6596Topics: BiologyMedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressC. W. McNamara ; M. C. Lee ; C. S. Lim ; S. H. Lim ; J. Roland ; A. Nagle ; O. Simon ; B. K. Yeung ; A. K. Chatterjee ; S. L. McCormack ; M. J. Manary ; A. M. Zeeman ; K. J. Dechering ; T. R. Kumar ; P. P. Henrich ; K. Gagaring ; M. Ibanez ; N. Kato ; K. L. Kuhen ; C. Fischli ; M. Rottmann ; D. M. Plouffe ; B. Bursulaya ; S. Meister ; L. Rameh ; J. Trappe ; D. Haasen ; M. Timmerman ; R. W. Sauerwein ; R. Suwanarusk ; B. Russell ; L. Renia ; F. Nosten ; D. C. Tully ; C. H. Kocken ; R. J. Glynne ; C. Bodenreider ; D. A. Fidock ; T. T. Diagana ; E. A. Winzeler
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: 1-Phosphatidylinositol 4-Kinase/*antagonists & ; inhibitors/chemistry/genetics/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Binding Sites ; Cytokinesis/drug effects ; Drug Resistance/drug effects/genetics ; Fatty Acids/metabolism ; Female ; Hepatocytes/parasitology ; Humans ; Imidazoles/metabolism/pharmacology ; Life Cycle Stages/drug effects ; Macaca mulatta ; Malaria/*drug therapy/*parasitology ; Male ; Models, Biological ; Models, Molecular ; Phosphatidylinositol Phosphates/metabolism ; Plasmodium/classification/*drug effects/*enzymology/growth & development ; Pyrazoles/metabolism/pharmacology ; Quinoxalines/metabolism/pharmacology ; Reproducibility of Results ; Schizonts/cytology/drug effects ; rab GTP-Binding Proteins/genetics/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressK. N. Jo ; K. S. Woo ; S. Yi ; D. Y. Yang ; H. S. Lim ; Y. Wang ; H. Cheng ; R. L. Edwards
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-10-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressK. N. Jo ; K. S. Woo ; S. Yi ; D. Y. Yang ; H. S. Lim ; Y. Wang ; H. Cheng ; R. L. Edwards
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-04-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Climate ; History, Ancient ; *Hydrology ; Ice Cover ; Korea ; Pacific Ocean ; Rain ; Time Factors ; Tropical ClimatePublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-04-13Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Free Research Articles, Lymphoid Neoplasia, Review Articles, Review Series, Clinical Trials and ObservationsPublished by: -
6Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-01-23Publisher: BMJ Publishing GroupPrint ISSN: 0021-9746Electronic ISSN: 1472-4146Topics: MedicinePublished by: -
7Articles: DFG German National LicensesLim, S. H. ; Pi, W. K. ; Noh, T. H. ; Kim, H. J. ; Kang, I. K.
[S.l.] : American Institute of Physics (AIP)
Published 1993Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The magnetic properties of an Fe73.5Cu1Nb3Si13.5B9 alloy with nanoscale crystalline structure have been investigated as a function of the melt temperature. In the temperature range of 1240 to 1380 °C investigated in the present study, the permeability increases with the melt temperature. This result may be explained in terms of the reduction in the magnetic anisotropy as a function of the melt temperature. This is supported by the results for the remanence ratio, which also increases with melt temperature in a similar manner to the permeability. In the latter part of the work described in this paper, the relationships between the permeability and the coercivity, and the permeability and the remanence ratio have been investigated for the nanocrystalline alloy. It was found that the permeability is correlated more closely to the remanence ratio than the coercivity.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesLim, S. H. ; Pi, W. K. ; Noh, T. H. ; Kim, H. J. ; Kang, I. K.
[S.l.] : American Institute of Physics (AIP)
Published 1993Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The effects of Al on the soft magnetic properties of nanocrystalline Fe73.5−xAlxCu1Nb3Si13.5B9 alloy ribbons are investigated in the composition range of 0≤x≤1.0. The relative initial permeability at 1 kHz is found to increase by the addition of Al, and reaches the peak value at x=0.1. The coercivity decreases, rather significantly, with the Al content in the whole composition range investigated in the present work, the values of the coercivity being 12.5 mOe at x=0 and 9.3 mOe at x=1.0. The magnetic induction at an applied field of 10 Oe, however, decreases moderately by the introduction of Al, possibly due to the dilution effect. The improvement in the soft magnetic properties is considered to result from the reduction in the grain size of the α Fe-Si solid solution phase of the Al-added alloy ribbons, which has been observed by transmission electron microscopy. Another factor may be due to the decrease in the intrinsic magnetocrystalline anisotropy K1 as Al is added to the alloy.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: ZnO films were grown on a (011¯2) r-plane LiTaO3 substrate by electron cyclotron resonance-assisted molecular-beam epitaxy. The detailed structures of the interface and defects are investigated by high-resolution electron microscopy and image simulation. The epitaxial relationship was found to be [0001]ZnO(parallel)[01¯11]LiTaO3 and (112¯0)ZnO(parallel)(011¯2)LiTaO3. This epitaxial relationship corresponds to the c axis of ZnO parallel to the piezoelectric r-plane LiTaO3, which results in the enhanced electromechanical coupling factor. The interfaces were very smooth and structurally semicoherent with a comparative regular array of misfit dislocations at the interface accommodating a lattice mismatch of 9.49% when the incident electron beam is parallel to the [0001]ZnO(parallel)[01¯11]LiTaO3 direction. A high efficiency of transfer of acoustic energy across the interface is expected for surface acoustic wave devices with such an interface. The dominant defects commonly observed in ZnO films were found to be the type-I1 intrinsic stacking fault. The formation of stacking faults was shown to be growth kinetics on particular crystallographic planes during the initial stage of film growth. The effects of these defects and interfaces on electrical and optical properties for device applications are discussed. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Induced anisotropy with a large energy of 6×104 J/m3 is formed in an amorphous Sm–Fe based thin film by sputtering under an applied magnetic field of 500–600 Oe. The induced anisotropy results in a large anisotropy in magnetostriction, a strain anisotropy ratio reaching as high as 35, although intrinsic magnetostriction is affected only slightly. The large strain anisotropy allows one to realize a large strain in a particular direction and, hence, it is of significant practical importance. Induced anisotropy is also found to be formed by postannealing under applied magnetic field, but the magnitude of anisotropy energy formed is very small. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesLim, S.-H. ; Swider, W. ; Washburn, J. ; Liliental-Weber, Z.
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Detailed structure of the interfacial layers of Ti/Ta/Al ohmic contacts to n-type AlGaN/GaN/sapphire are investigated by means of transmission electron microscopy. High-resolution electron microscopy (HREM), optical diffractograms, and computer simulations confirmed that TiN (∼10.0 nm) and Ti3AlN (∼1.4 nm) interfacial layers form at the interface between the Ti layer and the Al0.35Ga0.65N substrate by a solid state reaction during annealing for 3 min in N2 at 950 °C. The orientation relationship between Ti3AlN and Al0.35Ga0.65N was found to be: [011]Ti3AlN(parallel)[21¯1¯0]Al0.35Ga0.65N and (11¯1)Ti3AlN(parallel)(0001)Al0.35Ga0.65N. The cubic Ti3AlN interfacial layer has a lattice parameter of 0.411±0.003 nm with the space group Pm3m matching that of Al0.35Ga0.65N. A model of the atomic configurations of the Ti3AlN/Al0.35Ga0.65N interface is proposed. This model is supported by a good match between the simulated and the experimental HREM image of the Ti3AlN/Al0.35Ga0.65N interface. The formation of TiN and Ti3AlN interfacial layers appears to be responsible for the onset of the ohmic contact behavior in Ti/Ta/Al contacts. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Effects of Sm on the magnetic and magnetostrictive properties of Tb–Fe thin films are investigated. Four alloy systems, RxFe100−x (R=Tb+Sm) with x=39.8, 41.9, 43.7, and 45.8, are examined with Sm content varied from 0 (Sm free) to 2.2 at. %. In-plane anisotropy is found to be enhanced by the addition of Sm and the strongest in-plane anisotropy occurs in the Sm content range of 1 to 2 at. % depending on R content. At low magnetic fields of 1000 Oe and below, magnetostriction increases significantly with increasing Sm content, and reaches a maximum at an intermediate Sm content where well-developed in-plane anisotropy is observed. At higher magnetic fields of 3000–5000 Oe, however, no substantial improvement of magnetostriction occurs with the addition of Sm. The Sm content dependences of magnetization and coercive force are also examined. © 1999 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesLim, S. H. ; Noh, T. H. ; Kang, I. K. ; Kim, S. R. ; Lee, S. R.
[S.l.] : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The magnetostriction of melt-spun ribbons of Dyx(Fe1−yBy)1−x (x=0.2, 0.25, 0.3; 0≤y≤0.2) alloys is systematically investigated as a function of the wheel speed during melt quenching. As the wheel speed increases from 10 to 50 m/s, the magnetic softness improves with the wheel speed rather continuously for the alloys with the Dy content x=0.2 and 0.25 but it exhibits a maximum at the wheel speed of 30 or 40 m/s for the alloys with the highest B content (x=0.3). The softness also improves with the B content for a fixed wheel speed. Homogeneous and ultrafine grain structure is observed for the first time even in the as-spun state when the ribbons of the alloy Dy0.3(Fe0.8B0.2)0.7 are fabricated at the wheel speed of 30 m/s. The ribbon having the ultrafine grain structure exhibits good magnetic softness together with a high strain.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesCraven, M. D. ; Lim, S. H. ; Wu, F. ; Speck, J. S. ; DenBaars, S. P.
Woodbury, NY : American Institute of Physics (AIP)
Published 2002Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Threading dislocation density reduction of nonpolar (112¯0) a-plane GaN films was achieved by lateral epitaxial overgrowth (LEO). We report on the dependence of morphology and defect reduction on crystallographic stripe orientation. Stripes aligned along [0001] and [1¯100], the most favorable a-plane GaN LEO stripe orientations, possessed well-behaved, symmetric morphologies. Threading dislocation reduction via mask blocking was observed by transmission electron microscopy for [1¯100] stripes which had optimal rectangular cross-sections. Cathodoluminescence studies showed increased light emission for the overgrown regions in comparison to the window regions. The extent of lateral overgrowth of these stripes was asymmetric due to the opposing polarities of the vertical c-plane sidewalls. Conversely, threading dislocations propagated into the symmetric overgrown regions of [0001] stripes which possessed coexisting inclined and vertical {101¯0} facets. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesCraven, M. D. ; Lim, S. H. ; Wu, F. ; Speck, J. S. ; DenBaars, S. P.
Woodbury, NY : American Institute of Physics (AIP)
Published 2002Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: In this letter we describe the structural characteristics of nonpolar (112¯0) a-plane GaN thin films grown on (11¯02) r-plane sapphire substrates via metalorganic chemical vapor deposition. Planar growth surfaces have been achieved and the potential for device-quality layers realized by depositing a low temperature nucleation layer prior to high temperature epitaxial growth. The in-plane orientation of the GaN with respect to the r-plane sapphire substrate was confirmed to be [0001]GaN||[1¯101]sapphire and [1¯100]GaN||[112¯0]sapphire. This relationship is explicitly defined since the polarity of the a-GaN films was determined using convergent beam electron diffraction. Threading dislocations and stacking faults, observed in plan-view and cross-sectional transmission electron microscope images, dominated the a-GaN microstructure with densities of 2.6×1010 cm−2 and 3.8×105 cm−1, respectively. Submicron pits and crystallographic terraces were observed on the optically specular a-GaN surface with atomic force microscopy. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesLim, S.-H. ; Washburn, J. ; Liliental-Weber, Z.
Woodbury, NY : American Institute of Physics (AIP)
Published 2001Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Electrical properties and microstructures of Ta/Ti/Al and Ti/Ta/Al contacts to n-AlGaN/GaN heterostructure field-effect transistor structures were investigated using the transmission line method and transmission electron microscopy. The specific resistivity (5.3×10−7 Ω cm2) of Ta/Ti/Al contacts is much lower than that (5.1×10−4 Ω cm2) of Ti/Ta/Al contacts, for the same heterostructure and similar metallization. The contact resistivity was found to depend on the thickness of the AlGaN layer, interfacial phase, and interface roughness. The formation of interfacial phases by solid-state reactions with the metal layer during annealing appears to be essential for ohmic behavior on n-III-nitrides suggesting a tunneling contact mechanism. © 2001 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesHansen, M. ; Chen, L. F. ; Lim, S. H. ; DenBaars, S. P. ; Speck, J. S.
Woodbury, NY : American Institute of Physics (AIP)
Published 2002Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Uniformly distributed precipitates have been observed by transmission electron microscopy in the p-type layers of laser structures. The precipitate density decreases with decreasing flow of biscyclopentadienyl-magnesium (Cp2Mg), and the hole concentration in the laser structure was higher for a lower precipitate density. The higher hole concentration reduces the threshold current density and improves the internal quantum efficiency of the laser because of the higher number of holes available for radiative recombination. The lasers with higher precipitate density also exhibit a higher resistance. The threshold voltage was reduced 30% from 20.8 V for lasers with a high precipitate density to 14.3 V for lasers with a lower precipitate density due to the lower resistance. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesKim, N.-S. ; Lee, I.-O. ; Lee, M.-K. ; Lim, S.-H. ; Choi, Y.-S. ; Kong, M.-H.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We investigated whether human β2 adrenoceptor (β2AR) gene polymorphisms are associated with the pressor response to laryngoscopy and tracheal intubation. Ninety-two patients undergoing elective surgery under general anaesthesia were enrolled into this study. Arterial systolic pressure, heart rate and rate pressure product were measured before induction of anaesthesia and 1 min following laryngoscopy and tracheal intubation. Genomic DNA was then used to identify the β2AR-16 and β2AR-27 genes using an allele-specific polymerase chain reaction method. Using multiple linear regression models, controlling for age, sex, weight, baseline blood pressure, heart rate and rate pressure product, we found that patients who possessed the glutamic acid homozygote of β2AR-27 produced significantly greater changes in mean arterial pressure and rate pressure products than patients with the glutamine homozygote of β2AR-27 (β coefficient for mean blood pressure = 11.81, β coefficient for pulse−pressure product = 8.76, both p-values = 0.023). These findings suggest that genetic variability in the human β2AR gene polymorphisms may be associated with the pressor response to laryngoscopy and tracheal intubation.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesLim, S. H. ; Choi, Y. S. ; Noh, T. H. ; Kang, I. K.
[S.l.] : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: How the ac effective permeability (μe) correlates with dc magnetic properties over a wide frequency range of 1 to 1000 kHz was studied, in an effort to understand the magnetization behavior of the Co-based amorphous alloy of Metglas 2714A subject to an ac magnetic field. In the low-frequency range up to 50 kHz, the correlations between μe and the dc initial permeability, and between μe and the coercivity are found to be good, the correlation coefficient being positive and negative, respectively. No definite correlation is observed with the dc maximum permeability. At high frequencies ranging from about 200 to 1000 kHz, the correlations between μe and the dc maximum permeability, and between μe and the coercivity are observed to be good, the correlation coefficient being negative and positive, respectively. The correlation of μe with the dc initial permeability is poor in this high-frequency range. The correlation with the remanence ratio is found to be rather different from the other three; the ac permeability exhibits a maximum at the value of remanence ratio of 0.5–0.6 at frequencies up to 200 kHz but, at frequencies higher than 500 kHz, it decreases linearly with the remanence ratio. From the correlation results it is considered that the dominant magnetization mechanism is the domain wall motion at frequencies up to 50 kHz and it is spin rotation at frequencies higher than 500 kHz.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesCHIRIVA-INTERNATI, M. ; WANG, Z. ; SALATI, E. ; WROBLEWSKI, D. ; LIM, S. H.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Sperm protein 17 (Sp17) is a highly immunogenic cancer-testis antigen expressed by tumour cells from up to 30% of patients with multiple myeloma (MM). We recently successfully generated Sp17-specific human leucocyte antigen (HLA)-A1 and B27-restricted cytotoxic T lymphocytes (CTLs) from the peripheral blood of a healthy donor. Because CTLs were able to kill HLA-matched fresh myeloma cells, it may be possible to generate and administer myeloma-specific donor T cells to MM patients following allogeneic stem cell transplantation to enhance graft-versus-myeloma (GVM) without inducing graft-versus-host disease (GVHD). To determine how widely applicable this approach is, we have determined the ability to generate Sp17-specific CTLs from four consecutive healthy donors with other HLA class I phenotypes. We found that Sp17-specific HLA class I-restricted CTLs could be easily generated from all four donors. Sp17-specific CTLs were primarily CD8 in phenotype and produced interferon-γ and very little interleukin-4. These T cells killed target cells primarily via the perforin-mediated route. These results therefore suggest that myeloma-specific donor T-cell infusion that targets Sp17 to selectively enhance GVM could be applicable to patients with Sp17+ MM.Type of Medium: Electronic ResourceURL: