Search Results - (Author, Cooperation:S. Gururangan)
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1Latest Papers from Table of Contents or Articles in PressG. Robinson ; M. Parker ; T. A. Kranenburg ; C. Lu ; X. Chen ; L. Ding ; T. N. Phoenix ; E. Hedlund ; L. Wei ; X. Zhu ; N. Chalhoub ; S. J. Baker ; R. Huether ; R. Kriwacki ; N. Curley ; R. Thiruvenkatam ; J. Wang ; G. Wu ; M. Rusch ; X. Hong ; J. Becksfort ; P. Gupta ; J. Ma ; J. Easton ; B. Vadodaria ; A. Onar-Thomas ; T. Lin ; S. Li ; S. Pounds ; S. Paugh ; D. Zhao ; D. Kawauchi ; M. F. Roussel ; D. Finkelstein ; D. W. Ellison ; C. C. Lau ; E. Bouffet ; T. Hassall ; S. Gururangan ; R. Cohn ; R. S. Fulton ; L. L. Fulton ; D. J. Dooling ; K. Ochoa ; A. Gajjar ; E. R. Mardis ; R. K. Wilson ; J. R. Downing ; J. Zhang ; R. J. Gilbertson
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-06-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; CREB-Binding Protein/genetics ; Cadherins/genetics ; Cdh1 Proteins ; Cell Cycle Proteins/deficiency/genetics ; Cell Lineage ; Cerebellar Neoplasms/*classification/*genetics/pathology ; Child ; DEAD-box RNA Helicases/genetics ; DNA Copy Number Variations ; DNA Helicases/genetics ; DNA Mutational Analysis ; Disease Models, Animal ; Genome, Human/genetics ; Genomics ; Hedgehog Proteins/metabolism ; Histone Demethylases/genetics ; Histones/metabolism ; Humans ; Medulloblastoma/*classification/*genetics/pathology ; Methylation ; Mice ; Mutation/*genetics ; Nuclear Proteins/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Transcription Factors/genetics ; Wnt Proteins/metabolism ; beta Catenin/geneticsPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1432-1998Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Bone metastases are extremely rare in patients with classical Wilms' tumor (WT). We describe the clinical and radiologic features, treatment and outcome of three patients with WT (one with favorable histology and two with anaplasia) in whom bone metastases were detected at diagnosis or relapse. Bone metastases were documented by skeletal radiographs, computed tomography and/or bone scintigraphy. The patient with favorable histology WT had no evidence of pulmonary metastases and is now free of disease following aggressive chemotherapy and radiotherapy.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1434-0879Keywords: Bone metastasizing renal tumour of childhood (BMRTC) ; Ploidy changes ; Relapse ; Wilms' tumourSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Ploidy patterns, analysed by flow cytometry (FCM) and image analysis (IA), were investigated at relapse in a group of six children with renal tumours [five Wilms' tumour (WT) and one bone metastasizing renal tumour of childhood (BMRTC)] and results compared with diagnostic profiles. IA detected one or more aneuploid populations in five of 12 tumours which were diploid on FCM. Patterns in three of six patients [two with unfavourable histology (UH) and one with favourable histology (FH)] were aneuploid at diagnosis and relapse, two patients (one FH, one BMRTC) developed aneuploid features at relapse and one patient with a tetraploid tumour was diploid at relapse. Histology patterns were similar at diagnosis and relapse in all patients. Three of six patients (two UH, one BMRTC) have died of disease. This report highlights (1) the superiority of IA over FCM in detecting aneuploid populations and (2) changes in ploidy status which have not previously been reported in these tumours. Overinterpretation of DNA status at relapse may prove misleading.Type of Medium: Electronic ResourceURL: