Search Results - (Author, Cooperation:S. G. Hilsenbeck)
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1Latest Papers from Table of Contents or Articles in PressJ. D. Kessler ; K. T. Kahle ; T. Sun ; K. L. Meerbrey ; M. R. Schlabach ; E. M. Schmitt ; S. O. Skinner ; Q. Xu ; M. Z. Li ; Z. C. Hartman ; M. Rao ; P. Yu ; R. Dominguez-Vidana ; A. C. Liang ; N. L. Solimini ; R. J. Bernardi ; B. Yu ; T. Hsu ; I. Golding ; J. Luo ; C. K. Osborne ; C. J. Creighton ; S. G. Hilsenbeck ; R. Schiff ; C. A. Shaw ; S. J. Elledge ; T. F. Westbrook
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-12-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Breast Neoplasms/*genetics/metabolism/mortality/pathology ; Cell Cycle ; Cell Line, Tumor ; *Cell Transformation, Neoplastic ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; *Genes, myc ; Humans ; Mammary Neoplasms, Experimental/genetics/metabolism/mortality/pathology ; Mice ; Mice, Nude ; Mitosis ; Neoplasm Transplantation ; Proto-Oncogene Proteins c-myc/*metabolism ; RNA Interference ; RNA, Small Interfering ; Spindle Apparatus/physiology ; Sumoylation ; *Transcription, Genetic ; Transplantation, Heterologous ; Ubiquitin-Activating Enzymes/antagonists & inhibitors/*genetics/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressChiang, A. C. A., Fowler, S. W., Savjani, R. R., Hilsenbeck, S. G., Wallace, C. E., Cirrito, J. R., Das, P., Jankowsky, J. L.
Rockefeller University Press
Published 2018Staff ViewPublication Date: 2018-05-08Publisher: Rockefeller University PressPrint ISSN: 0022-1007Electronic ISSN: 1540-9538Topics: MedicineKeywords: NeurosciencePublished by: -
3Articles: DFG German National LicensesSchneider, B. G. ; Pekkel, V. ; Shelton, C. H. ; Pulitzer, D. R. ; Allred, D. C. ; Hilsenbeck, S. G. ; Hensel, C. H. ; Rodríguez-Martínez, H. A. ; Gutiérrez-Díaz C., M. E.
Springer
Published 1994Staff ViewISSN: 1432-2307Keywords: Adenocarcinoma ; Immunohistochemistry ; Tumour suppressor gene ; EthnicitySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Gastric cancer is more than twice as common in Hispanics as in Anglos in Texas, while colorectal cancer is almost twice as common in Anglos as Hispanics. To test the hypothesis that mutations in the p53 tumour suppressor gene are involved in these differences, we examined 131 gastric and 138 colorectal cancers from Hispanic and Anglo patients from South Texas and Mexico using immunohistochemistry (IHC) as a screening assay for p53 mutations. The fraction of p53 positive cases was not significantly different in gastric cancers from Hispanics compared to Anglos (43% versus 61%, respectively, p=0.13) or in colorectal cancer (57% versus 58%, respectively, p=1.0), suggesting that p53 mutations are not involved in causing the different incidences of these cancers in these populations. In addition, the types of p53 mutations arising in gastric tumours from Hispanic patients were consistent with those reported in gastric tumours in other populations. Sequencing of mutations in five gastric cancers revealed two G: C to A: T transitions, two A: T to G: C transitions and one complex deletion. In contrast with findings in studies in other tumour types, neither stage nor survival was associated with p53 positive staining by IHC in either gastric or colorectal tumours in this study. Positive p53 immunostaining was associated with the diffuse histological subtype in gastric carcinoma (p=0.05) and high histological grade in colorectal carcinoma (p=0.04).Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesSharma, S. ; Raymond, E. ; Soda, H. ; Sun, D. ; Hilsenbeck, S. G. ; Sharma, A. ; Izbicka, E. ; Windle, B. ; Von Hoff, D. D.
Springer
Published 1997Staff ViewISSN: 1569-8041Keywords: cancer ; chemotherapy ; telomerase ; telomeresSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Background: Telomerase is an important enzyme whose activity has been convincingly demonstrated in humans recently. It is required for maintenance of ends of chromosomes (telomeres) during cell division. Since its presence has been selectively demonstrated in dividing cells including tumor cells, it has generated considerable excitement as a potential anti-cancer strategy. Design: In this article, we review the current relevant biology of the enzyme, the challenges encountered in the preclinical phase of target development and the current efforts that focus on telomeres and telomerase as therapeutic targets. We also speculate on the potential toxicities and mechanisms of resistance that may be encountered during use of such therapies.Type of Medium: Electronic ResourceURL: