Search Results - (Author, Cooperation:S. Dye)

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  1. 1
    M. J. Page ; M. Symeonidis ; J. D. Vieira ; B. Altieri ; A. Amblard ; V. Arumugam ; H. Aussel ; T. Babbedge ; A. Blain ; J. Bock ; A. Boselli ; V. Buat ; N. Castro-Rodriguez ; A. Cava ; P. Chanial ; D. L. Clements ; A. Conley ; L. Conversi ; A. Cooray ; C. D. Dowell ; E. N. Dubois ; J. S. Dunlop ; E. Dwek ; S. Dye ; S. Eales ; D. Elbaz ; D. Farrah ; M. Fox ; A. Franceschini ; W. Gear ; J. Glenn ; M. Griffin ; M. Halpern ; E. Hatziminaoglou ; E. Ibar ; K. Isaak ; R. J. Ivison ; G. Lagache ; L. Levenson ; N. Lu ; S. Madden ; B. Maffei ; G. Mainetti ; L. Marchetti ; H. T. Nguyen ; B. O'Halloran ; S. J. Oliver ; A. Omont ; P. Panuzzo ; A. Papageorgiou ; C. P. Pearson ; I. Perez-Fournon ; M. Pohlen ; J. I. Rawlings ; D. Rigopoulou ; L. Riguccini ; D. Rizzo ; G. Rodighiero ; I. G. Roseboom ; M. Rowan-Robinson ; M. Sanchez Portal ; B. Schulz ; D. Scott ; N. Seymour ; D. L. Shupe ; A. J. Smith ; J. A. Stevens ; M. Trichas ; K. E. Tugwell ; M. Vaccari ; I. Valtchanov ; M. Viero ; L. Vigroux ; L. Wang ; R. Ward ; G. Wright ; C. K. Xu ; M. Zemcov
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-05-12
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2011-07-02
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Luckman, S. M. ; Antonijevic, I. ; Leng, G. ; Dye, S. ; Douglas, A. J. ; Russell, J. A. ; Bicknell, R. J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1365-2826
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The neuropeptide oxytocin has long been known as a potent contractor of the uterus. However, it has remained difficult to attribute a definite role for neurohypophysial oxytocin in either the initiation or continuation of labour (1). Most recently, Lefebvre and colleagues (2) have suggested that oxytocin produced in the uterus, rather than in the hypothalamus, may be more important in parturition since at term the uterus of the rat contains 70-fold more mRNA for oxytocin than the hypothalamus, and this disappears at about the time of parturition. Despite the high levels of mRNA the uterus contains only nanogram quantities of immunoreactive oxytocin per gram wet weight at term (2), compared to microgram quantities present in the pituitary (3,4). Here we show that activation of the neurohypophysial oxytocin system occurs, as reflected by expression of immunoreactivity for Fos in the hypothalamic supraoptic nucleus, and that this activation is indeed critical for normal parturition, since its inhibition results in a significant prolongation of parturition. In addition, we present evidence that pulsatile delivery of oxytocin into the circulation is important for the efficient progress of parturition, indicating that a major role of the neuronal circuits regulating oxytocin secretion for parturition, as is already known for suckling, is to produce an appropriately patterned hormonal output for efficient biological action.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2826.1993.tb00358.x

    Articles: DFG German National Licenses
  4. 4
    Douglas, A. J. ; Dye, S. ; Leng, G. ; Russell, J. A. ; Bicknell, R. J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1365-2826
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We have investigated the influence of endogenous opioids on oxytocin secretion during pregnancy. In blood-sampled consciousrats on days 18 and 21 of pregnancy plasma oxytocin concentration, measured by radioimmunoassay, was significantly increased compared to non-pregnant or post-partum rats. On days 15, 18 and 21 of pregnancy, but not in non-pregnant, early pregnant or post-partum rats, the opioid antagonist naloxone caused a significant increase in plasma oxytocin compared to vehicle injection, indicating activation of an endogenous opioid restraint over oxytocin secretion.Electrically stimulated neural lobes isolated from 16- and 21-day pregnant rats released more oxytocin than those from non-pregnant rats. However, naloxone (10−5 M) was less effective at potentiating, and the k-opioid agonist U50,488 (10−5 M) was less effective at inhibiting, stimulated release at the end of pregnancy than in non-pregnant rats suggesting desensitization of oxytocin nerve terminals to actions of endogenous opioids. Neural lobes from male rats drinking 2% saline for 4 days also showed desensitization of oxytocin nerve endings to naloxone.Neither neural lobe content of dynorphin A(1–8), an endogenous k-opioid, nor prodynorphin mRNA expression, measured by in situ hybridization histochemistry in the supraoptic nucleus altered during pregnancy. However, neural lobe content of Met5enkephalin significantly decreased by day 21 of gestation suggesting enhanced release. We conclude that an endogenous opioid, possibly a product of proenkephalin A in oxytocin cells may be responsible for auto-inhibition of oxytocin release during gestation, and that this mechanism desensitizes in late pregnancy at a time when other opioid inputs to the oxytocin neurons become activated to provide an overall increase in opioid restraint of the system. The changes in opioid input through pregnancy may be involved in initiation and regulation of oxytocin secretion at parturition. A similar opioid mechanism, but possibly involving dynorphin, could explain desensitization in saline drinking rats and indicates that desensitization may be a consequence of chronic activation of secretion from the oxytocin nerve terminals rather than a phenomenon peculiar to pregnancy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2826.1993.tb00487.x

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    0920-5632
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0920-5632(90)90413-O

    Articles: DFG German National Licenses
  6. 6
    Dye, S. ; Phillips, D. ; Woodford, D. ; Barrow, I.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0039-9140
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0039-9140(93)80050-2

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0168-583X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0168-583X(91)95068-O

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0167-0115
    Keywords:
    Cholecystokinin ; Noradrenergic pathway ; Oxytocin ; Vasopressin ; c-fos
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0167-0115(93)90190-J

    Articles: DFG German National Licenses