Search Results - (Author, Cooperation:S. Cusack)

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  1. 1
    Staff View
    Publication Date:
    2015-10-28
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Apoenzymes/chemistry/metabolism ; Binding Sites ; Crystallography, X-Ray ; Endonucleases/chemistry/metabolism ; Enzyme Activation ; Influenzavirus C/*enzymology ; Models, Molecular ; Peptide Chain Initiation, Translational ; Promoter Regions, Genetic/genetics ; Protein Binding ; Protein Structure, Tertiary ; Protein Subunits/chemistry/metabolism ; RNA Caps/metabolism ; RNA Replicase/*chemistry/metabolism ; RNA, Viral/biosynthesis/metabolism ; Ribonucleoproteins/chemistry
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    S. Reich ; D. Guilligay ; A. Pflug ; H. Malet ; I. Berger ; T. Crepin ; D. Hart ; T. Lunardi ; M. Nanao ; R. W. Ruigrok ; S. Cusack
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-11-20
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Catalytic Domain ; Crystallization ; DNA-Directed RNA Polymerases/chemistry/*metabolism ; Gene Expression Regulation, Viral ; Influenza A virus/chemistry/*enzymology ; Influenza B virus/chemistry/*enzymology ; *Models, Molecular ; Promoter Regions, Genetic ; Protein Binding ; Protein Structure, Tertiary ; *RNA Caps/chemistry/metabolism ; RNA, Viral/*biosynthesis/*chemistry ; Virus Replication
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    A. Pflug ; D. Guilligay ; S. Reich ; S. Cusack
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-11-20
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Binding Sites ; Crystallization ; DNA-Directed RNA Polymerases/*chemistry ; Influenza A virus/*enzymology ; Models, Molecular ; Promoter Regions, Genetic ; Protein Binding ; Protein Structure, Tertiary ; Protein Subunits/chemistry ; RNA, Viral/*chemistry
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2012-07-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Aged ; Aged, 80 and over ; Aging/*physiology ; Cohort Studies ; Diet/*statistics & numerical data ; Diet Surveys ; Feces/*microbiology ; Fruit ; Geriatric Assessment ; Health ; *Health Status ; Health Surveys ; Homes for the Aged ; Hospitals, Community ; Humans ; Intestines/*microbiology ; Meat ; Metagenome/*physiology ; Rehabilitation Centers ; Surveys and Questionnaires ; Vegetables
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Kneller, G. R. ; Doster, W. ; Settles, M. ; Cusack, S. ; Smith, J. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1992
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The dynamics of the methyl groups in the crystalline alanine dipeptide is examined over a wide range of temperatures using elastic and inelastic neutron scattering experiments and molecular dynamics (MD) simulations of the full crystal. Neutron scattering spectra are calculated from the simulations and directly compared to the experimental profiles. The N-ter and C-ter methyl groups in the molecule have low rotational barriers, i.e., (approximately-less-than)1 kcal/mol. They undergo rotations that are activated on time scales faster than ≈1 ns at temperatures as low as 50–100 K and are on the picosecond time scale at 150 and 300 K. At 300 K the rotational motion becomes strongly diffusive in the simulation. In contrast, the side-chain methyls possess a significant intramolecular intrinsic torsional barrier, ≈3 kcal/mol. As a result, their dynamics consists of librations and rare jumps between wells. The simulations are further analyzed to characterize in detail the motions giving rise to the calculated scattering. Using a quaternion-based method the simulated methyl dynamics is decomposed into rigid-body rotational and translational components. The decomposed motions and their contributions to the calculated neutron profiles are examined.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.463361

    Articles: DFG German National Licenses
  6. 6
    Leberman, R. ; Hartlein, M. ; Cusack, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0167-4781
    Keywords:
    Aminoacyl-tRNA synthetase ; Evolution ; Nucleotide binding ; Protein structure ; Structural motif
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0167-4781(91)90168-L

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0014-5793
    Keywords:
    Aminoacyl-tRNA synthetase, tRNA ; Protein-RNA complex, Crystallization ; Thermus thermophilus
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)81319-H

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0014-5793
    Keywords:
    Crystallization ; Solubility
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)01060-9

    Articles: DFG German National Licenses
  9. 9
    Oostergetel, G.T. ; Mellema, J.E. ; Cusack, S. ; Klug, A.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-2836
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0022-2836(83)80351-9

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    0022-2836
    Keywords:
    adenovirus fibre ; computer model ; triple helix
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0022-2836(92)91053-R

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    0022-2836
    Keywords:
    Thermus thermophilus ; X ray analysis ; aminoacyl-tRNA synthetase ; crystal structure ; thermostability
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/jmbi.1993.1576

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    0022-2836
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0022-2836(83)80350-7

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    0022-2836
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0022-2836(05)80169-X

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    0014-5793
    Keywords:
    Aminoacyl-tRNA synthetase ; Crystallization ; Serine ; X-ray structure ; tRNA
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(93)81386-E

    Articles: DFG German National Licenses
  15. 15
    Cusack, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0959-440X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0959-440X(93)90199-U

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    0921-4526
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0921-4526(89)90699-6

    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    0378-4363
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0378-4363(86)90422-5

    Articles: DFG German National Licenses
  18. 18
    Cusack, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0300-9084
    Keywords:
    class 2 aminoacyl-tRNA synthetase ; α"2 dimer
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0300-9084(93)90006-E

    Articles: DFG German National Licenses
  19. 19
    Cusack, S. ; Jesior, J.-C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0304-3991
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Natural Sciences in General
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0304-3991(85)90074-9

    Articles: DFG German National Licenses
  20. 20
    Weis, W. ; Brown, J. H. ; Cusack, S. ; Paulson, J. C. ; Skehel, J. J. ; Wiley, D. C.

    [s.l.] : Nature Publishing Group
    Published 1988
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The three-dimensional structures of influenza virus haemagglutinins complexed with cell receptor analogues show sialic acids bound to a pocket of conserved amino acids surrounded by antibody-binding sites. Sialic acid fills the conserved pocket, demonstrating that it is the influenza virus ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/333426a0

    Articles: DFG German National Licenses