Search Results - (Author, Cooperation:S. Chia)

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  1. 1
    Staff View
    Publication Date:
    2014-12-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Breast Neoplasms/*genetics/*pathology/secondary ; Clone Cells/*metabolism/*pathology ; DNA Mutational Analysis ; Genome, Human/*genetics ; Genomics ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Mice ; Neoplasm Transplantation ; *Single-Cell Analysis ; Time Factors ; Transplantation, Heterologous ; *Xenograft Model Antitumor Assays/methods
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
  3. 3
    Staff View
    Publication Date:
    2012-04-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Breast Neoplasms/diagnosis/*genetics/*pathology ; Clone Cells/metabolism/pathology ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; Disease Progression ; *Evolution, Molecular ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; INDEL Mutation/genetics ; Mutation/*genetics ; Point Mutation/genetics ; Precision Medicine ; Reproducibility of Results ; Sequence Analysis, RNA
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
  5. 5
    Chia, S. E. ; Goh, J. ; Lee, G. ; Foo, S. C. ; Gan, S. L. ; Bose, K. ; Jeyaratnam, J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. Computerized postural sway measurement systems have been used recently in human physiology and pharmacology for determining postural stability, but their applicability for the assessment of the effects of exposure to neurotoxic agents is lacking.2. We have examined the feasibility of using a computerized postural sway measurement system to assess the postural sway parameters of manganese exposed workers compared with a control group.3. Sway parameter data were collected using a kislter multicomponent measuring platform (Type 9281B) connected to vicon motion analysis system for 13 exposed and 16 control subjects.4. Significant differences in several of the sway parameters (Px, Py—mean distance (mm), from the centre of the platform along the X-axis [anterior-posterior movement] and Y-axis [lateral movement], respectively) between the exposed and control groups were observed even after adjustment for possible confounders. Computerized postural sway measurement system may be a useful method of assessing workers exposed to neurotoxic agents affecting posture.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    Chia, S.-P.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0370-2693
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Chia, S.-P. ; Chiu, C.B. ; Chou, K.-C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0370-2693
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Chia, S.-P.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0370-2693
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Chia, S.-P.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0370-2693
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Chia, S.-P. ; Rajagopal, G.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0370-2693
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    CHIA, S. S. ; BAKER, R. C. ; HOTCHKISS, J. H.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1983
    Staff View
    ISSN:
    1750-3841
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Process Engineering, Biotechnology, Nutrition Technology
    Notes:
    The physical, chemical and sensory properties of rainbow trout, pollock and shrimp processed at equal lethalities in cans and retortable pouches were compared at certain storage periods. Pouched rainbow trout, pollock and shrimp required respectively 34%, 32% and 37% less thermal processing time than the canned product. The pouched products had lower amounts of ammonia, trimethylamine and total carbonyl compounds than the canned products. The pouched products retained 17%, 9% and 15% more Vitamin B1 than the canned products for rainbow trout, pollock and shrimp, respectively. Pouched products had a firmer texture and lighter color than the canned products. In sensory evaluations, the pouched products were scored higher, in most cases, for color, flavor and overall acceptability.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Ong, C. N. ; Chia, S. E. ; Foo, S. C. ; Ong, H. Y. ; Tsakok, M. ; Liouw, P.
    Springer
    Published 1993
    Staff View
    ISSN:
    1572-8773
    Keywords:
    heavy metals ; maternal blood ; umbilical cord blood
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Chemistry and Pharmacology
    Notes:
    Abstract Concentrations of lead, cadmium, methylmercury and total mercury were measured in maternal and umbilical cord blood using graphite atomic absorption spectrometry. Two essential metals, copper and zinc, were also determined using ion chromatography. Lead, copper and zinc were found to be lower in the cord blood, whereas methylmercury and total mercury were higher in cord blood than in maternal blood. Little differences were noted for cadmium in maternal and cord blood. Significant positive correlations were observed between the concentrations in maternal and cord blood with regard to lead (correlation coefficient, r = 0.44), copper (r = 0.34), zinc (r = 0.29), methylmercury (r = 0.44) and total mercury (r = 0.58). These results suggest that, like essential metals, most heavy metals can move rather freely across the human placenta. The potential health effects of heavy metal transfer from mothers to young infants cannot be discounted.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1432-1246
    Keywords:
    Hair metals ; Lead ; Manganese ; Mercury
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Hair samples from three groups of occupationally exposed subjects were analyzed for their lead (Pb), manganese (Mn) and mercury (Hg) contents. For lead (number of subjects, n=209), the hair Pb ranged from 0.93 to 3527 μg/g (geometric mean, GM=641) and blood Pb from 33.3 to 774 μg/l (GM=341); for manganese (n=38), the hair Mn ranged from 0.20 to 52.97 μg/g (GM=2.66) and urine Mn ranged from 1.70 to 17.9 μg/l (GM=5.56); and for mercury (n=85), the hair Hg from 1.79 to 12.8 μg/g (GM=5.09) and the blood Hg from 0.63 to 57.3 μg/l (GM=10.9). The hair Pb was significantly (P〈0.0001) correlated to blood Pb (r=0.85); the hair Mn to urinary Mn (r=0.45); and the hair Hg to blood Hg (r=0.53). The average metal content at the distal end was not significantly (P〉0.05) different from that of proximal end. The GM levels for the distal end were 223 μg/g (95% CI 152–347) and 2.26 (95% CI 0.97–5.29); and those for the proximal end were 186 (95% CI 97–261) and 1.18 (95% CI 0.54–2.58) for Pb and Mn respectively. However, linear regression analysis of hair metal levels in the proximal end with respect to those in the distal end after logarithmic transformation showed that hair Pb in the proximal end was related to hair Pb in the distal end with a slope of 0.95 (95% Cl 0.89–1.01) whereas hair Mn in the proximal end was related to that of the distal end with a slope of only 0.52 (95% CI 0.13–0.91), reflecting the relatively constant Pb exposure as compared to the dropping Mn exposure in recent years. Metals in hair are suitable biological indicators for exposure and the distribution along the different segments of hair strands reflects the time history of exposure.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1573-2959
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Energy, Environment Protection, Nuclear Power Engineering
    Notes:
    Abstract This study was conducted to evaluate the usefulness of various biological parameters for monitoring of workers exposed to methyl ethyl ketone (MEK). Fifty male workers from a large magnetic videotape factory participated in this study. Personal air samples were collected using 3M organic vapor monitors and analysed for MEK by gas chromatography with flame ionisation detector (FID). 10 mL of urine; blood (1 mL) and exhaled air were also collected at the end of an 8-hour workshift. The headspace GC method was applied for measurement of urinary and blood MEK. MEK in expired air was analysed directly by using a GC/FID. The correlation coefficients (r) between environmental MEK and all other biological parameters measured show significant positive relationships. The r for environmental MEK and urine MEK was 0.84; for blood 0.73 and for breath 0.64. The correlation coefficients between blood and urine was 0.72; blood and breath was 0.88 and urine and breath 0.60. These findings suggest that measurements of unmetabolised MEK in blood, exhaled air and urine can be used for biological monitoring of MEK exposure. Nevertheless, laboratory methodological assessment is in favour of measuring urinary MEK as it is non-invasive and does not have to be analysed immediately after collection.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses