Search Results - (Author, Cooperation:S. C. Gough)
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1Latest Papers from Table of Contents or Articles in PressK. A. Hunt ; V. Mistry ; N. A. Bockett ; T. Ahmad ; M. Ban ; J. N. Barker ; J. C. Barrett ; H. Blackburn ; O. Brand ; O. Burren ; F. Capon ; A. Compston ; S. C. Gough ; L. Jostins ; Y. Kong ; J. C. Lee ; M. Lek ; D. G. MacArthur ; J. C. Mansfield ; C. G. Mathew ; C. A. Mein ; M. Mirza ; S. Nutland ; S. Onengut-Gumuscu ; E. Papouli ; M. Parkes ; S. S. Rich ; S. Sawcer ; J. Satsangi ; M. J. Simmonds ; R. C. Trembath ; N. M. Walker ; E. Wozniak ; J. A. Todd ; M. A. Simpson ; V. Plagnol ; D. A. van Heel
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-05-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Autoimmune Diseases/*genetics ; European Continental Ancestry Group/genetics ; Exons/genetics ; Gene Frequency ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Genome-Wide Association Study ; Great Britain ; Humans ; Models, Genetic ; Mutation/genetics ; Open Reading Frames/*genetics ; Phenotype ; Sample SizePublished by: -
2Articles: DFG German National LicensesReed, P. W. ; Davies, J. L. ; Copeman, J. B. ; Bennett, S. T. ; Palmer, S. M. ; Pritchard, L. E. ; Gough, S. C. L. ; Kawaguchi, Y. ; Cordell, H. J. ; Balfour, K. M. ; Jenkins, S. C. ; Powell, E. E. ; Vignal, A. ; Todd, J. A.
[s.l.] : Nature Publishing Group
Published 1994Staff ViewISSN: 1546-1718Source: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] To facilitate large–scale genetic mapping of the human genome, we have developed chromosome–specific sets of microsatellite marker loci suitable for use with a fluorescence–based automated DNA fragment analyser. We present 254 dinucleotide repeat marker loci (80% from the ...Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesGough, S. C. L. ; Smyllie, J. ; Barker, M. ; Berkin, K. E. ; Rice, P. J. S. ; Grant, P. J.
Springer
Published 1995Staff ViewISSN: 1432-5233Keywords: Cardiac function ; Glycaemic control ; Diabetes type 2Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Diastolic dysfunction may be the earliest marker of a diabetes-induced heart muscle disease which leads to the progressive development of cardiac failure. Left ventricular diastolic function was indirectly assessed using pulsed wave Doppler ultrasound mitral-flow velocities in 20 normotensive patients with a new diagnosis of type 2 diabetes mellitus, normal cardiac function and no evidence of coronary artery disease and in 16 age-matched normal subjects. Peak velocities of early (E) and late (A) left ventricular filling were measured. The median (interquartile ranges) peak E/A ratio was significantly reduced in the diabetic group 0.96 (0.8–1.2) vs 1.2 (1.1–1.3),P〈0.01. Despite improvements in glycaemic control over 3 months, HbA1c 9.9% (7.6%–10.5%) to 7.4% (6.5%–7.9%),P〈0.001, maintained at 6 months, HbA1c 7.0% (6.4%–7.3%), there were no changes in the E/A ratio, 0.96 (0.83–1.15) and 0.95 (0.83–1.17), respectively. Furthermore, there was no correlation between percentage change in HbA1c and E/A ratio over 6 months. The results of this study suggest that in patients with type 2 diabetes mellitus and normal systolic function, diastolic function was impaired at diagnosis and was not affected by an improvement in the glycaemic control.Type of Medium: Electronic ResourceURL: