Search Results - (Author, Cooperation:S. C. Chen)
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1Latest Papers from Table of Contents or Articles in PressPiekos, S. C., Chen, L., Wang, P., Shi, J., Yaqoob, S., Zhu, H.-J., Ma, X., Zhong, X.-b.
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
Published 2018Staff ViewPublication Date: 2018-07-18Publisher: The American Society for Pharmacology and Experimental Therapeutics (ASPET)Print ISSN: 0090-9556Electronic ISSN: 1521-009XTopics: Chemistry and PharmacologyMedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressQ. Li ; N. Bohin ; T. Wen ; V. Ng ; J. Magee ; S. C. Chen ; K. Shannon ; S. J. Morrison
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bone Marrow Transplantation ; Cell Proliferation ; Gene Expression Profiling ; Genes, ras/*genetics ; Hematopoietic Stem Cells/*cytology/*metabolism ; Mice ; Mice, Inbred C57BL ; Time FactorsPublished by: -
3Latest Papers from Table of Contents or Articles in PressSpilker, J. S., Aravena, M., Bethermin, M., Chapman, S. C., Chen, C.- C., Cunningham, D. J. M., De Breuck, C., Dong, C., Gonzalez, A. H., Hayward, C. C., Hezaveh, Y. D., Litke, K. C., Ma, J., Malkan, M., Marrone, D. P., Miller, T. B., Morningstar, W. R., Narayanan, D., Phadke, K. A., Sreevani, J., Stark, A. A., Vieira, J. D., Weiss, A.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-09-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: AstronomyPublished by: -
4Latest Papers from Table of Contents or Articles in PressM. Dail ; J. Wong ; J. Lawrence ; D. O'Connor ; J. Nakitandwe ; S. C. Chen ; J. Xu ; L. B. Lee ; K. Akagi ; Q. Li ; J. C. Aster ; W. S. Pear ; J. R. Downing ; D. Sampath ; K. Shannon
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Benzamides/pharmacology/therapeutic use ; Clone Cells/drug effects/metabolism/pathology ; Diphenylamine/analogs & derivatives/pharmacology/therapeutic use ; Down-Regulation/drug effects ; *Drug Resistance, Neoplasm/drug effects/genetics ; Drug Synergism ; Genes, ras/genetics ; Indazoles/*pharmacology/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Phosphatidylinositol 3-Kinases/*antagonists & inhibitors ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*drug ; therapy/*genetics/metabolism/pathology ; Protein Kinase Inhibitors/*pharmacology/therapeutic use ; Protein Structure, Tertiary ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Notch1/chemistry/deficiency/genetics/*metabolism ; Signal Transduction/drug effects ; Sulfonamides/*pharmacology/therapeutic usePublished by: -
5Latest Papers from Table of Contents or Articles in PressE. C. de Bruin ; N. McGranahan ; R. Mitter ; M. Salm ; D. C. Wedge ; L. Yates ; M. Jamal-Hanjani ; S. Shafi ; N. Murugaesu ; A. J. Rowan ; E. Gronroos ; M. A. Muhammad ; S. Horswell ; M. Gerlinger ; I. Varela ; D. Jones ; J. Marshall ; T. Voet ; P. Van Loo ; D. M. Rassl ; R. C. Rintoul ; S. M. Janes ; S. M. Lee ; M. Forster ; T. Ahmad ; D. Lawrence ; M. Falzon ; A. Capitanio ; T. T. Harkins ; C. C. Lee ; W. Tom ; E. Teefe ; S. C. Chen ; S. Begum ; A. Rabinowitz ; B. Phillimore ; B. Spencer-Dene ; G. Stamp ; Z. Szallasi ; N. Matthews ; A. Stewart ; P. Campbell ; C. Swanton
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-10-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Carcinogens/toxicity ; Carcinoma, Non-Small-Cell Lung/chemically induced/*diagnosis/*genetics ; Cytidine Deaminase/genetics ; Evolution, Molecular ; Gene Dosage ; *Genetic Heterogeneity ; *Genomic Instability ; Humans ; Lung Neoplasms/chemically induced/*diagnosis/*genetics ; Mutation ; Neoplasm Recurrence, Local/genetics ; Prognosis ; Smoking/adverse effects ; Translocation, Genetic ; Tumor Cells, CulturedPublished by: -
6Latest Papers from Table of Contents or Articles in PressJ. Zhang ; L. Ding ; L. Holmfeldt ; G. Wu ; S. L. Heatley ; D. Payne-Turner ; J. Easton ; X. Chen ; J. Wang ; M. Rusch ; C. Lu ; S. C. Chen ; L. Wei ; J. R. Collins-Underwood ; J. Ma ; K. G. Roberts ; S. B. Pounds ; A. Ulyanov ; J. Becksfort ; P. Gupta ; R. Huether ; R. W. Kriwacki ; M. Parker ; D. J. McGoldrick ; D. Zhao ; D. Alford ; S. Espy ; K. C. Bobba ; G. Song ; D. Pei ; C. Cheng ; S. Roberts ; M. I. Barbato ; D. Campana ; E. Coustan-Smith ; S. A. Shurtleff ; S. C. Raimondi ; M. Kleppe ; J. Cools ; K. A. Shimano ; M. L. Hermiston ; S. Doulatov ; K. Eppert ; E. Laurenti ; F. Notta ; J. E. Dick ; G. Basso ; S. P. Hunger ; M. L. Loh ; M. Devidas ; B. Wood ; S. Winter ; K. P. Dunsmore ; R. S. Fulton ; L. L. Fulton ; X. Hong ; C. C. Harris ; D. J. Dooling ; K. Ochoa ; K. J. Johnson ; J. C. Obenauer ; W. E. Evans ; C. H. Pui ; C. W. Naeve ; T. J. Ley ; E. R. Mardis ; R. K. Wilson ; J. R. Downing ; C. G. Mullighan
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-01-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Age of Onset ; Child ; DNA Copy Number Variations/genetics ; Genes, ras/genetics ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; Genomics ; Hematopoiesis/genetics ; Histones/metabolism ; Humans ; Janus Kinases/genetics/metabolism ; Leukemia, Myeloid, Acute/drug therapy/genetics/pathology ; Molecular Sequence Data ; Mutation/*genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/*genetics/pathology ; Receptors, Interleukin-7/genetics ; Sequence Analysis, DNA ; Signal Transduction/genetics ; Stem Cells/metabolism/pathology ; T-Lymphocytes/metabolism/pathology ; Translocation, Genetic/geneticsPublished by: -
7Latest Papers from Table of Contents or Articles in PressKuo, P.-J., Wu, S.-C., Chien, P.-C., Rau, C.-S., Chen, Y.-C., Hsieh, H.-Y., Hsieh, C.-H.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-01-07Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Public healthPublished by: -
8Latest Papers from Table of Contents or Articles in PressBiron, B. M., Chung, C.-S., Chen, Y., Wilson, Z., Fallon, E. A., Reichner, J. S., Ayala, A.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-02-21Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
9Latest Papers from Table of Contents or Articles in PressM. A. Schwartz ; C. S. Chen
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-01-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Biological Transport ; Cell Communication ; Cell Culture Techniques ; Cell Movement ; *Cell Physiological Phenomena ; Cell Polarity ; Cell Shape ; *Extracellular Matrix ; Spheroids, Cellular/physiologyPublished by: -
10Latest Papers from Table of Contents or Articles in PressJ. T. Hinson ; A. Chopra ; N. Nafissi ; W. J. Polacheck ; C. C. Benson ; S. Swist ; J. Gorham ; L. Yang ; S. Schafer ; C. C. Sheng ; A. Haghighi ; J. Homsy ; N. Hubner ; G. Church ; S. A. Cook ; W. A. Linke ; C. S. Chen ; J. G. Seidman ; C. E. Seidman
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adrenergic beta-Agonists/pharmacology ; Cardiomyopathy, Dilated/*genetics/pathology/*physiopathology ; Cells, Cultured ; Connectin/chemistry/*genetics/*physiology ; Heart Rate ; Humans ; Induced Pluripotent Stem Cells/*physiology ; Isoproterenol/pharmacology ; Mutant Proteins/chemistry/physiology ; *Mutation, Missense ; Myocardial Contraction ; Myocytes, Cardiac/*physiology ; RNA/genetics/metabolism ; Sarcomeres/*physiology/ultrastructure ; Sequence Analysis, RNA ; Signal Transduction ; Stress, PhysiologicalPublished by: -
11Latest Papers from Table of Contents or Articles in PressJ. M. Tas ; L. Mesin ; G. Pasqual ; S. Targ ; J. T. Jacobsen ; Y. M. Mano ; C. S. Chen ; J. C. Weill ; C. A. Reynaud ; E. P. Browne ; M. Meyer-Hermann ; G. D. Victora
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-02-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
12Latest Papers from Table of Contents or Articles in PressTimms, V. J., Rockett, R., Bachmann, N. L., Martinez, E., Wang, Q., Chen, S. C.- A., Jeoffreys, N., Howard, P. J., Smith, A., Adamson, S., Gilmour, R., Sheppeard, V., Sintchenko, V.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-02-15Publisher: The American Society for Microbiology (ASM)Print ISSN: 0099-2240Electronic ISSN: 1098-5336Topics: BiologyPublished by: -
13Articles: DFG German National LicensesHwang, J. S. ; Hwang, W. C. ; Chang, C. C. ; Chen, S. C. ; Lu, Y. T.
[S.l.] : American Institute of Physics (AIP)
Published 2001Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Photoreflectance is used to investigate the band gap, built-in electric field, and surface Fermi level of a series of lattice-matched In0.52Al0.48As surface-intrinsic n+ structures having different undoped layer thicknesses. Experimental results indicate that, although the built-in electric field depends on the undoped layer thickness, there is a range of thickness within which the surface Fermi level is weakly pinned. From the dependence of electric field and surface Fermi level on the undoped layer thickness, we can determine that the surface states distribute over two separate regions within the energy band gap. The densities of the surface states are evaluated as well. Moreover, the dependence of the built-in electric field on undoped layer thickness is converted into the dependence of surface state density on the surface Fermi level in order to theoretically and exactly calculate the energy spectrum of the surface state density using a Guassian distribution function. The center and width of the distribution near the conduction band are obtained from the fitting parameters. © 2001 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesChen, S. C. ; Bekefi, G. ; DiCecca, S. ; Temkin, R.
Woodbury, NY : American Institute of Physics (AIP)
Published 1989Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We present the design, construction, and test results of a novel microwiggler structure with a periodicity of 2.4 mm for free-electron laser applications. The experimentally demonstrated tunability of field amplitude provides versatile means for field tapering, optical klystron configurations, improving field uniformity, and electron beam matching at the wiggler entrance.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesJohnson, J. A. ; Chen, S.-C. ; Johnson, L. E.
[S.l.] : American Institute of Physics (AIP)
Published 1985Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: Flows with coherent structures allow see-free measurements of local velocity and velocity fluctuations. Continuous turbulent velocity histories in ionizing shock waves are obtained at a 10-MHz sampling rate. From this, correlation profiles and frequency spectra are determined which reveal the presence of prominent high-frequency components.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Low carrier concentrations of undoped p-type and Te-doped n-type GaSb epilayers have been grown on (100)-oriented Te-doped GaSb substrates by liquid-phase epitaxy with supersaturation and undersaturation techniques, respectively. The net carrier concentrations of undoped and Te-doped layers obtained by C-V measurement can be as low as NA −ND =8×1015 cm−3 and ND −NA =1016 cm−3 , respectively. These GaSb-grown layers were characterized by photoluminescence (PL) measurement. The native neutral acceptor transitions appear at 778.2 meV for undoped layers and 777.2 meV for Te-doped layers. The ionization energy for the Te donor in GaSb was determined to be 3.6 meV below the bottom of conduction band at 18 K. The relation between the energy gap of GaSb and temperature was obtained by PL measurement at various temperatures. The spin-orbit splitting of the valence band was measured to be 0.798 eV at room temperature.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesCHEN, S. C. ; COLLINS, J. L. ; McCARTY, I. E. ; JOHNSTON, M. R.
Oxford, UK : Blackwell Publishing Ltd
Published 1971Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: SUMMARY —Small white potatoes were heated with microwave energy followed by boiling water to determine the penetration of heat, inactivation of peroxidase and firmness of the potatoes. Treatments consisted of heating potatoes with microwave energy for 0.5, 1, 1.5 and 2 min followed by boiling water for 0, 1, 2, 3, 4 and 5 min. Temperature measurements were made at depths of 0.75 and 1.5 cm using tubers with a mean radius of 1.95 cm. Peroxidase inactivation was measured along the radius of a slice removed from the equatorial region. Firmness was determined by the ALLO-Kramer shear press. Potatoes, when heated by microwave energy, became hot first at the core with a heat gradient developing toward the periphery. Boiling water produced a heat gradient from the periphery toward the core. Consequently, the tissue located about midway of the radius was subjected to the least amount of heat. The minimum time required to completely inactivate peroxidase and the firmness values of the potato tissue at the time of enzymatic inactivation were as follows: 1.5 min microwaves and 3 min boiling water, 119 lb shear force; and 2 min microwaves and 2 min boiling water, 124 lb shear force. Peroxidase was not completely destroyed when the potatoes were subjected to energy for 1 min or less followed by heating in boiling water up to 5 min.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesLai, Y-S ; Chiu, H-C ; Murali, S ; Guo, I-C ; Chen, S-C ; Fang, K ; Chang, C-Y
Oxford UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2761Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Mouse monoclonal antibodies (MAbs) were produced by using yellow grouper nervous necrosis virus (YGNNV) as an immunogen, isolated from infected yellow grouper, Epinephelus awoara (Temminck & Schlegel), and propagated in GB cells. In enzyme linked immunosorbent assay (ELISA), 43 hybridoma clones secreting MAbs strongly reacted with the purified virus. Ten of them showed a higher neutralization index (NI) value between 6.5 and 4.5 (log10 NI) than the other 33 MAbs against YGNNV infection in cell culture. All 10 MAbs belonged to the IgG isotype with a κ light chain and recognized the 42 kDa coat protein of YGNNV by Western blot analysis. Immunohistochemical results demonstrated that the viral signals co-located with pathological lesions observed in retina, brain and spinal cord. These results indicate that the MAbs are useful for confirmative diagnosis of YGNNV infection.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1365-2761Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Mycobacterium spp. isolated from food and ornamental fish in Thailand (TB1, TB40, TB267 and TB268), and the type strains Mycobacterium marinum (NCIMB 1298), M. fortuitum (NCIMB 1294) and M. chelonae (NCIMB 1474) were cultured in Long’s medium, Eagle’s minimum essential medium, Sauton’s medium and modified Sauton’s medium. The latter enabled excellent growth and production of extracellular products (ECP) from TB 40, TB267, TB268 and M. marinum NCIMB 1298 in particular, whereas growth and production of ECP for all strains was limited in Long’s medium. SDS-PAGE protein profiles of ECPs from 14-day culture supernatants showed major bands at 65 and 〈14 kDa. After 2 days culture at the higher temperature of 37°C (heat shock), the production of ECP from all mycobacteria strains except M. marinum averaged approximately four- to 10-fold higher than from strains cultured for 14 days at 28°C. Enzyme testing for the type strains indicated only mucinase activity for M. marinum, while lipase and RNase activities were detected for M. chelonae and M. fortuitum. Protease and DNase activities could not be detected for any of the Mycobacterium spp. tested. The medium lethal dose (LD50) of ECP to rainbow trout and Nile tilapia was greater than 400 μg protein fish–1.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesCHEN, S.-C. ; TUNG, M.-C. ; CHEN, S.-P. ; TSAI, J.-F. ; WANG, P.-C. ; CHEN, R.-S. ; LIN, S.-C. ; ADAMS, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1365-2761Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Abstract. A rickettsia-like organism was observed in diseased Nile tilapia, Oreochronuis niloticus (L.), from southern Taiwan. Most affected fish were pale and lethargic with haemorrhages and ulcers on the skin. The most significant gross pathological changes were varying degrees of ascites, and enlargement of the spleen, kidney and liver. Marked white nodules (as ring-shaped foci), varying in size, were found in these organs. A Gram-negative, rickettsia-like organism (RLO) frequently appeared as inclusions or within host cell intra-cytoplasmic vacuoles. Fibrin thrombi, perivascular necrosis, chronic inflammatory cells with hypertrophy and RLO-laden cells were characteristic of the disease. White nodules induced in experimental fish were similar to naturally infected cases and RLOs were reisolated in tissue culture using a CHSE-214 cell line. This provides evidence that the systemic granulomas in Nile tilapia were caused by RLOs.Type of Medium: Electronic ResourceURL: