Search Results - (Author, Cooperation:S. Aparicio)

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  1. 1
    Staff View
    Publication Date:
    2012-04-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Breast Neoplasms/diagnosis/*genetics/*pathology ; Clone Cells/metabolism/pathology ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; Disease Progression ; *Evolution, Molecular ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; INDEL Mutation/genetics ; Mutation/*genetics ; Point Mutation/genetics ; Precision Medicine ; Reproducibility of Results ; Sequence Analysis, RNA
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2012-04-24
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Breast Neoplasms/classification/diagnosis/*genetics/*pathology ; DNA Copy Number Variations/*genetics ; Female ; *Gene Expression Profiling ; *Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks/genetics ; Genes, Neoplasm/genetics ; Genome, Human/*genetics ; Genomics ; Humans ; Kaplan-Meier Estimate ; MAP Kinase Kinase 4/genetics ; Polymorphism, Single Nucleotide/genetics ; Prognosis ; Protein Phosphatase 2/genetics ; Treatment Outcome
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2013-05-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Algorithms ; Breast Neoplasms/*genetics/pathology ; DNA Copy Number Variations ; Female ; Follow-Up Studies ; Gene Expression Profiling ; *Gene Expression Regulation, Neoplastic ; Genome, Human/genetics ; Humans ; Kaplan-Meier Estimate ; MicroRNAs/*genetics/metabolism ; Prognosis ; Proportional Hazards Models ; RNA, Messenger/genetics/metabolism ; RNA, Neoplasm/genetics/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    J. M. Tubio ; Y. Li ; Y. S. Ju ; I. Martincorena ; S. L. Cooke ; M. Tojo ; G. Gundem ; C. P. Pipinikas ; J. Zamora ; K. Raine ; A. Menzies ; P. Roman-Garcia ; A. Fullam ; M. Gerstung ; A. Shlien ; P. S. Tarpey ; E. Papaemmanuil ; S. Knappskog ; P. Van Loo ; M. Ramakrishna ; H. R. Davies ; J. Marshall ; D. C. Wedge ; J. W. Teague ; A. P. Butler ; S. Nik-Zainal ; L. Alexandrov ; S. Behjati ; L. R. Yates ; N. Bolli ; L. Mudie ; C. Hardy ; S. Martin ; S. McLaren ; S. O'Meara ; E. Anderson ; M. Maddison ; S. Gamble ; C. Foster ; A. Y. Warren ; H. Whitaker ; D. Brewer ; R. Eeles ; C. Cooper ; D. Neal ; A. G. Lynch ; T. Visakorpi ; W. B. Isaacs ; L. van't Veer ; C. Caldas ; C. Desmedt ; C. Sotiriou ; S. Aparicio ; J. A. Foekens ; J. E. Eyfjord ; S. R. Lakhani ; G. Thomas ; O. Myklebost ; P. N. Span ; A. L. Borresen-Dale ; A. L. Richardson ; M. Van de Vijver ; A. Vincent-Salomon ; G. G. Van den Eynden ; A. M. Flanagan ; P. A. Futreal ; S. M. Janes ; G. S. Bova ; M. R. Stratton ; U. McDermott ; P. J. Campbell
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-08-02
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Carcinogenesis/genetics ; Chromatin/chemistry ; *DNA Transposable Elements ; Exons ; Genome, Human ; Humans ; *Long Interspersed Nucleotide Elements ; Mutagenesis, Insertional ; Neoplasms/*genetics ; *Transduction, Genetic ; Translocation, Genetic
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2015-12-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Breast Neoplasms/genetics/*physiopathology ; Carcinoma, Ductal, Breast/genetics/*physiopathology ; Cell Lineage/genetics ; *Cell Transformation, Neoplastic ; Cells, Cultured ; DNA Barcoding, Taxonomic ; Female ; Gene Expression Profiling ; Heterografts ; Humans ; Lentivirus/genetics ; Mammary Glands, Human/cytology/*physiopathology ; Mice ; Mice, Inbred Strains ; Mice, SCID ; Proto-Oncogene Proteins/genetics ; Time Factors ; Transduction, Genetic ; ras Proteins/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2014-12-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Breast Neoplasms/*genetics/*pathology/secondary ; Clone Cells/*metabolism/*pathology ; DNA Mutational Analysis ; Genome, Human/*genetics ; Genomics ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Mice ; Neoplasm Transplantation ; *Single-Cell Analysis ; Time Factors ; Transplantation, Heterologous ; *Xenograft Model Antitumor Assays/methods
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Aparicio, S. R. ; Bradbury, K. ; Bird, C. C. ; Foley, M. E. ; Jenkins, D. M. ; Clayton, J. K. ; Scott, J. S. ; Rajah, S. M. ; Mcnicol, G. P.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1979
    Staff View
    ISSN:
    1471-0528
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The effect of the intrauterine contraceptive device (IUCD) on uterine haemostasis was studied at various stages of the menstrual cycle in a series of 46 patients by light- and electron-microscopy and by following the distribution of an infusion of 51Cr-labelled autologous platelets. The endometrium in contact with the IUCD in the majority of cases showed grooving with atrophy and mild chronic inflammation in the surrounding tissues. The adjacent stroma also showed increased vascularity and occasional foci of haemorrhage but the increased blood loss associated with the presence of the IUCD could not be attributed to mechanical erosion or disruption of stromal blood vessels by the device. During menstruation the presence of an IUCD does not appear to inhibit the formation of fibrin/platelet thrombi although both in control and IUCD patients there was a striking paucity of platelet/fibrin thrombi in circumstances where their formation should be enhanced. In contrast to other workers we have not observed that gaps or breaks in the endothelial lining of endometrial blood vessels occur with any greater frequency in patients fitted with an IUCD. The principal mechanism by which uterine haemostasis is achieved remains to be established.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-0528.1979.tb11262.x

    Articles: DFG German National Licenses
  8. 8
    Brenner, S. ; Elgar, G. ; Sanford, R. ; Macrae, A. ; Venkatesh, B. ; Aparicio, S.

    [s.l.] : Nature Publishing Group
    Published 1993
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] It has been known for some time that the genomes of tetra-odontoid fish are particularly small. Hinegardner found haploid DNA contents ranging from 0.4 pg (380 Mb) in Tetraodon flu-viatilis to 0.5 pg (480 Mb) in Spheroides (Arothron) maculatus6, about one-eighth to one-sixth of the size of ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/366265a0

    Articles: DFG German National Licenses
  9. 9
    DICKINSON, J. P. ; JONES, K. M. ; APARICIO, S. R. ; LUMSDEN, C. E.

    [s.l.] : Nature Publishing Group
    Published 1970
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The myelin was prepared from bovine cerebral white matter by an ultracentrifugation method modified from that of Autilio et al.*. The equilibrium density centrifugal distribution of water-washed, crude myelin product in preformed continuous sucrose density gradients varied according to the time ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/2271133a0

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Anionic site ; cationic gold ; heparan sulphate proteoglycans ; chondroitin sulphate proteoglycans ; collagen IV
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary We examined glomerular basement membrane anionic site distribution identified by cationic gold in seven patients with insulin-dependent and four patients with non-insulin-dependent diabetes mellitus, presenting a spectrum of clinical and glomerular changes. Anionic sites were investigated by pretreatment of tissue with glycosaminoglycan-degrading enzymes prior to cationic gold staining. The distribution of chondroitin sulphate proteoglycans — a previously unrecognized glomerular basement membrane component — and type IV collagen was examined by immunoelectron microscopy to identify structural changes in the basement membrane. Findings were compared with those of non-diabetic patients showing minor proteinuria and morphologically normal glomerular basement membranes. Two patients, originally diagnosed as having diabetic nephropathy were also examined at 19 weeks and 5 years after renal transplantation. Characteristic redistribution of type IV collagen and chondroitin sulphate proteoglycans was noted in thickened glomerular basement membrane segments (〉400 nm) of diabetic patients and those with renal transplants. Extension of anionic sites deep into the glomerular basement membrane at pH 2.5, together with loss of interna sites at pH 5.8 is unique to diabetic nephropathy. Reduced charge density was apparent in some patients due to thickening of the glomerular basement membrane, although the number of anionic sites per unit length of membrane was actually increased. Thus, charge aberration in diabetic nephropathy is due to displacement rather than loss of anionic sites. Removal of more than 90% of these sites by heparitinase, confirms their association with heparan sulphate proteoglycans. Similar derangement of anionic sites in all patients with diabetic nephropathy irrespective of the degree of proteinuria, suggests that a heparan sulphate proteoglycan-related charge barrier plays a minor role in controlling permeability of the diabetic glomerular basement membrane.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00400607

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-119X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary The present study shows that aniline blue can be used as a fluorescent stain for glycogen. The dye is also helpful in tracing pathological and autolytic changes in lysosomes, mitochondria, erythrocytes and nuclei, and it can also be used for demonstrating bacteria in tissue sections and smears. The techniques used are simple, rapid and inexpensive. Spectrophotometric studies on aniline blue solutions have shown that aniline blue fluorescence was enhanced by the addition of certain proteins, or of glycogen to the dye solution. In case of albumen which has the maximum effect, enhancement is dependent upon the albumen-dye ratio. The mechanism of staining is mainly due to self quenching, but there is also an evidence of the presence of hydrophobic reaction.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00495407

    Articles: DFG German National Licenses
  12. 12
    Goode, N. P. ; Shires, M. ; Aparicio, S. R. ; Davison, A. M.
    Springer
    Published 1993
    Staff View
    ISSN:
    1573-6865
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary Glomerular capillary wall anionic sites have been demonstrated by cationic gold staining of archived renal biopsy tissue (up to 10 years old), obtained from six patients, originally embedded in paraffin wax, and subsequently reprocessed into LR gold resin. The staining patterns at pH 2.5 and pH 7.0, demonstrating different glomerular basement membrane (GBM) anionic constituents, were compared in three patients from whom tissue directly processed into LR gold and reprocessed tissue was available. Ultrastructural preservation was poorer and shrinkage artefact greater in paraformaldehyde-lysine periodate (PLP) as opposed to formol saline-fixed reprocessed tissue. However, GBM anionic site expression was well preserved, or even enhanced (lamina rara externa, pH 7.0) in reprocessed tissue, using either fixative. Although it may not be possible to compare subtle changes in anionic site distribution in variously fixed and processed tissues, due to these artefacts, the technique enables retrospective study of charge status in archived material from disease groups in which there are distinct anionic site aberrations.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00159505

    Articles: DFG German National Licenses