Search Results - (Author, Cooperation:S. Andersen)

2018-01-09

The Company of Biologists

0950-1991

1477-9129

Biology

Plant development

2018-01-03

Nature Publishing Group (NPG)

2041-1723

Biology

Chemistry and Pharmacology

Natural Sciences in General

Physics

2015-04-16

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Amino Acid Sequence ; Animals ; Apoptosis/genetics ; Cell Adhesion Molecules/metabolism ; Cell Division/genetics ; *Cell Polarity/genetics ; Cell Transformation, Neoplastic/genetics ; Disease Models, Animal ; Drosophila Proteins/chemistry/deficiency/genetics/*metabolism ; Drosophila melanogaster/*cytology/enzymology/genetics/*metabolism ; Female ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Signaling System ; Male ; Matrix Metalloproteinase 1/metabolism ; Membrane Proteins/chemistry/deficiency/genetics/*metabolism ; Molecular Sequence Data ; Neoplasm Invasiveness/genetics ; Neoplasms/enzymology/genetics/*metabolism/*pathology ; Receptors, Tumor Necrosis Factor/chemistry/genetics/*metabolism ; ras Proteins/genetics/metabolism

2011-07-23

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

2015-11-05

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Anti-Bacterial Agents/*pharmacology/therapeutic use ; *Bacteremia/drug therapy/microbiology ; Carrier State/drug therapy/microbiology ; Drug Design ; Female ; Immunoconjugates/chemistry/*pharmacology/*therapeutic use ; Intracellular Space/drug effects/*microbiology ; Methicillin-Resistant Staphylococcus aureus/drug effects/pathogenicity ; Mice ; Microbial Sensitivity Tests ; Phagosomes/drug effects/metabolism/microbiology ; Staphylococcal Infections/drug therapy/*microbiology/pathology ; Staphylococcus aureus/*drug effects/pathogenicity ; Vancomycin/*pharmacology/therapeutic use

2018-02-10

Nature Publishing Group (NPG)

2041-1723

Biology

Chemistry and Pharmacology

Natural Sciences in General

Physics

2018-04-18

American Chemical Society (ACS)

0006-2960

1520-4995

Biology

Chemistry and Pharmacology

2014-08-16

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

DNA/chemistry/genetics ; DNA-Directed RNA Polymerases/metabolism ; *Nanostructures ; *Nucleic Acid Conformation ; RNA/*chemistry/genetics/*ultrastructure ; Software ; Templates, Genetic ; *Transcription, Genetic ; Viral Proteins/metabolism

2015-05-16

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Caenorhabditis elegans/*genetics/*metabolism ; Caenorhabditis elegans Proteins/chemistry/genetics/*metabolism ; Cell Cycle Proteins/chemistry/genetics/*metabolism ; Centrosome/*metabolism/ultrasonography ; Metabolic Networks and Pathways ; Phosphorylation ; Polymerization ; Protein Binding ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases/*metabolism ; Proto-Oncogene Proteins/*metabolism

2018-12-19

The American Society for Pharmacology and Experimental Therapeutics

0022-3565

1521-0103

Medicine

2018-09-08

Nature Publishing Group (NPG)

2044-4052

Medicine

2012-05-05

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Brain/metabolism ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster/genetics/*growth & development/*metabolism ; Ecdysone/biosynthesis ; Gene Expression Regulation, Developmental ; Genes, Insect ; Imaginal Discs/*growth & development ; Intercellular Signaling Peptides and Proteins/genetics/*metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Larva/genetics/growth & development/metabolism ; MAP Kinase Signaling System ; *Metamorphosis, Biological ; RNA Interference ; Sequence Deletion ; Time Factors ; Wings, Animal/growth & development

2012-06-05

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

DNA, Single-Stranded/*chemical synthesis/*chemistry ; Nanostructures/*chemistry ; *Nucleic Acid Conformation

2018-02-09

BMJ Publishing Group

0017-5749

1468-3288

Medicine

Gut

2018-04-14

BMJ Publishing

2044-6055

Medicine

Open access, General practice / Family practice

1524-4741

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: Tubular carcinoma of the breast (TCB) is a recognized histologic variant of infiltrating ductal carcinoma (IDC) and has been considered to have a comparatively favorable prognosis. However, previous studies have been based on small numbers of cases, some pure TCB and some mixed histology, or have not employed an appropriate comparison group. In this study 171 pure TCB cases and a comparison group of 386 cases with grade I (well differentiated) IDC were identified in a population-based database maintained by the British Columbia Cancer Agency (BCCA). The proportion of cases with axillary nodal involvement at presentation was lower in TCB cases than in the grade I IDC comparison group (12.9% and 23.9%, respectively; p 〈 0.05). Low-risk tumors (T1 and without vascular lymphatic or perineural invasion) were more prevalent in the TCB patients than in the grade I IDC patients (66.7% and 60.0%; p 〈 0.05). Low-risk TCB cases had a significantly lower rate of nodal metastases at presentation than low-risk grade I IDC cases (7.0% and 13.2%; p 〈 0.05). Kaplan–Meier and log-rank analyses indicated a statistically significantly lower rate of local recurrence in TCB cases than among IDC cases (p 〈 0.05) and a trend toward a lower rate of systemic relapse in TCB cases (p = 0.07). However, no difference in disease-specific survival was observed between TCB cases and grade I IDC comparisons. We conclude that the biologic behavior of TCB was more favorable than that of a comparison group of IDC cases. In view of the low incidence of axillary node metastases at presentation in the low-risk TCB subset (7%), axillary dissection may be omitted as part of the initial surgical management in these patients.

Electronic Resource

1468-2397

Blackwell Publishing Journal Backfiles 1879-2005

Sociology

Drug addict rehabilitation programs receive a small proportion of the funds made available through the social welfare system. Emphasis has traditionally been placed on the pathological rather than the salutogenic elements of an addicted lifestyle. A new test of a person's sense of coherence in life (Antonovsky's 9-item Sense of Coherence scale) may be of interest in rehabilitation work with drug addicts, and in focusing more attention on this aspect of addiction treatment. Thirty drug addicts in treatment and rehabilitation and 10 former drug addicts were interviewed using the 9-item Sense of Coherence scale. The results obtained were compared to a well known test of distress, the 24-item Symptom Checklist. Drug addicts in treatment facilities had significantly lower mean scores on the 9-item Sense of Coherence scale (2.3) and higher scores on the 24-item Symptom Checklist (2.3) than both drug addicts in rehabilitatively oriented institutions (3.3 and 1.6) and the long-term rehabilitated non-using former drug addicts (4.2 and 1.5 respectively). The differences between the group in rehabilitation and the former drug addicts were also statistically significant. The levels of the two psychometric tests suggested a gradual movement towards normal values and an increased sense of meaning in life among the former drug addicts, contrary to findings by other researchers. The length of time before these tests return to normal values may exceed the observation period often used in follow-up at treatment facilities. Increased social welfare may follow if a disclosure of salutogenic possibilities in drug addicts is obtained. Further prospective research is, however, necessary to confirm our findings.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

A fast, arc-driven hydrogen gas source and its application as a module in a scheme for multiple downstream propellant supply to a light-gas gun is described. The potential of this scheme for high-speed acceleration of hydrogen fuel-pellets for fusion plasma fueling is considered. In experiments with a single module in which 200 J of electrical energy were dissipated with a power level approaching 5 MW within 30 μs, the velocity of a 23-mg plastic dummy pellet was increased from 1.7 to 2.4 km/s. Barrel pressure transients and arc characteristics are described.

Electronic Resource

1439-0523

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Twenty doubled haploid broccoli lines from breeding material were evaluated for resistance to Peronospora parasitica at the seedling stage. All lines supported sporulation of the pathogen but to varying extents and intensities. Partial resistance of the more resistant lines,‘br8’and ‘br9′, reduced conidia production on cotyledons by 50-70% compared with the most susceptible lines. Inoculation of the two most resistant lines with 13 isolates of different geographical origins revealed that ‘br9′, showed a rather uniform level of resistance to all isolates while ‘br8’showed some isolate specificity Partial resistance was evaluated in six of the broccoli lines in a half diallel set of crosses. Disease assessment of seedlings showed that additive genetic effects explained 45.8% and 31.8% of the total variation of sporulation score and conidia production, respectively This suggests that recurrent selection for partial resistance to P. parasitica in early generation in breds or in populations of broccoli will be efficient to obtain cotyledon resistance.

Electronic Resource

1439-0523

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Colchicine uptake into ovules of sugar beet after 7 days of culture and its chromosome-doubling effect on ovule-derived plants were studied with high colchicine concentrations (0.4–6.0%) and short treatment duration (0–5 h). The best result of 4.2 diploid plants per 100 ovules was produced by treatment with 0.4% colchicine for 2.5 h. Both colchicine concentration and treatment time of ovules showed toxic effects on embryo formation, but it was stabilized at a low level with short exposure. The chromosome-doubling effect, by contrast, was unchanged with the colchicine concentrations used, but highly affected by the duration of exposure studied. A maximum percentage of 60% diploid plants was obtained after 3–5 h of uptake, which corresponds to only 31–39% of the total capacity for colchicine uptake in the ovules. Further uptake of the drug produced mainly toxic effects. Flow-cytometric measurements of the ploidy level in plantlets in vitro and of the same plants before flowering in soil were similar in about 80% of cases. Thus, flow-cytometric selection of diploid plants in vitro may be an efficient tool.

Electronic Resource