Search Results - (Author, Cooperation:S. Alonso)

2013-08-03

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Adult ; Chromosomes, Human, Y/*classification/*genetics ; European Continental Ancestry Group/*genetics ; *Evolution, Molecular ; Haplotypes ; Humans ; Italy ; Male ; Phylogeny ; Polymorphism, Single Nucleotide

2018-10-30

The Company of Biologists

0950-1991

1477-9129

Biology

1468-3083

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Cysticercosis is infestation of human tissues by Cysticercus cellulosae, the encysted larva of Taenia solium. An endemic disease in tropical countries, especially in Latin America, an increase is expected in its frequency in Europe because of increasing shifts in population. We report the case of a Spanish woman who had lived for some time in Bolivia and Peru who presented at our Department with a tumoral growth on the mucosa of her lower lip. Clinically, this was interpreted as a mucocele (salivary mucoid ‘cyst’); but histological study of the excised piece revealed, surprisingly, that it was a single–element cysticercosis.

Electronic Resource

1600-0536

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1600-0536

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1365-3083

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The development of safe and potent mucosal adjuvants remains a major objective in vaccinology. The potential usefulness of filamentous haemagglutinin (FHA) of Bordetella pertussis as an adjuvant was assessed in a mouse model. The glutathione-S-transferase of Schistosoma mansoni (Sm28GST) was used for intranasal administration, while the gut-resistant keyhole limpet haemocyanin (KLH) was administrated by the oral route. For both antigens, coadministration with FHA increased antigen-specific immunoglobulin titres. This adjuvant effect did not require chemical cross-linking or direct interaction between FHA and the antigen tested. FHA also behaved as an adjuvant by the subcutaneous route, indicating that its adjuvanticity is not restricted to binding to mucosal surfaces. The FHA-induced adjuvanticity was also observed in mice with high anti-FHA antibody titres as a result of antipertussis vaccination, indicating that pre-existing anti-FHA antibodies do not impair FHA adjuvanticity. No mRNA coding for proinflammatory cytokines was induced in the lungs after intranasal FHA administration. However, an increase in the levels of mRNAs coding for B7-1, transforming growth factor (TGF)-β and major histocompatibility complex (MHC)-II was detected in the lungs after FHA administration. Although the molecular mechanisms of the FHA-induced adjuvanticity remain to be elucidated, the data presented here indicate that this adhesin, already assessed for human use as a pertussis vaccine constituent, represents a promising adjuvant to improve the humoral immune response when given by mucosal routes.

Electronic Resource

1600-0560

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Visceral leishmaniasis is a protozoan infection that may complicate the course of patients with human immunodeficiency virus (HIV). Dermatofibroma is a cutaneous fibrohistiocytic lesion considered neoplastic by some authors and inflammatory by others. Eruptive dermatofibromas have been described in patients with HIV infection or with other altered immunity situations. We present the case of a 32-year-old, HIV-positive man with visceral leishmaniasis who complained of the appearance of a cutaneous lesion in the leg formed by the coexistence of dermatofibroma and Leishmania parasitic colonization. As far as we know, this type of association has not been reported previously. We consider that the dermatofibroma could have developed as an unusual form of fibrohistiocytic reaction to leishmania. From a practical approach, we recommend the search of leishmaniasis in dermatofibroma in immunosupressed patients.

Electronic Resource

1365-3059

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

‘Meleira’, or ‘sticky disease’, is currently the most damaging papaya disease in the mid-eastern Brazilian growing regions. Consistent disease transmission via latex injection, presence of similar isometric particles in the laticiferous vessels of diseased plants, and detection of double-stranded DNA in naturally and experimentally infected papaya trees suggest that a virus is the causal agent. Conclusive evidence for viral aetiology was previously lacking, mostly because every attempt to purify the putative virus from infected papayas had failed. Following the successful purification and partial characterization of the meleira virus, healthy papaya seedlings injected with purified virus particles later developed typical symptoms of the disease. Negatively stained, isometric, full and ‘empty’ purified virus particles measured 42 and 38 nm, respectively. The viral genome was a single dsRNA molecule of about 12 kbp. Several capsid proteins, ranging in size from 14·4 to 45 kDa, were consistently revealed by PAGE. Papaya meleira virus (PMeV) appears to represent a novel group of viruses, with no known similar counterpart among known plant-, vertebrate-, invertebrate- or prokaryote-infecting viruses.

Electronic Resource

0020-1693

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

0304-3924

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Architecture, Civil Engineering, Surveying

Geography

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Electronic Resource

0924-2244

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Process Engineering, Biotechnology, Nutrition Technology

Electronic Resource

0022-1902

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Energy, Environment Protection, Nuclear Power Engineering

Electronic Resource

0022-2836

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Electronic Resource

0012-1606

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Electronic Resource

0300-9084

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource

1569-8041

chemotherapy ; mitomycin ; recurrent ; undifferentiated carcinoma of nasopharyngeal type

Springer Online Journal Archives 1860-2000

Medicine

Abstract Background: This phase-II study was conducted to investigate the potential benefit from the addition of mitomycin to a conventional anthracycline-cisplatin- and 5-fluorouracil-based chemotherapy for recurrent and metastatic undifferentiated carcinoma of nasopharyngeal type (UCNT). Patients and methods: Between July 1989 and December 1991, 44 consecutive patients (M/F 36/8; median age: 45, range 20–72; performance status (PS) 0: 20 patients, PS 1: 14 patients, PS 2: 10 patients) with recurrent or metastatic UCNT were entered in this study after complete clinical, biological, and radiological pre-therapeutic work-ups. Chemotherapy (FMEP regimen) consisted of 800 mg/m2/day 5-fluorouracil in continuous infusion from day 1 to day 4 combined with 70 mg/m2 epirubicin, 10 mg/m2 mitomycin, and 100 mg/m2 cisplatin on day 1, every four weeks for six cycles. Mitomycin was delivered in cycles 1, 3, and 5 only. Eleven patients had isolated loco-regional recurrences, 12 patients had local recurrences associated with distant metastasis, and 21 patients had metastasis only. Toxicity and response were evaluated according to WHO criteria. Toxicity: Grade 3–4 neutropenia was observed in 122 of 212 evaluable cycles (57%) and 39 of 44 patients (89%); febrile neutropenia occurred in 16 patients (36%) and 24 cycles (11.3%). Grade 3–4 thrombocytopenia was observed in 27 patients (61%) and 45 cycles (21%), including 27 of 45 cycles (60%) with mitomycin. Grade 3 anemia was noted in 18 patients (40%) and 23 cycles (11%), including 18 of 23 cycles (78%) with mitomycin. Grade 3–4 mucositis occurred in 25 cycles (11%) and 14 patients (32%), mainly in those previously treated with radiation therapy in the head and neck area. There were four treatment-related deaths (9%); three of them neutropenia-related, and one of cardiac toxicity. Response: Forty-four patients were evaluable for response: There were 23 of 44 objective responses (52%), including six complete responses (13%), and 17 partial responses (38%). Additional radiotherapy was given to 13 patients after documentation of response: Nasopharyngeal tumor + cervical nodes (eight patients) and/or on bone metastasis sites (five patients); mediastinal lymph nodes (one patient). At a median follow-up of 87 months (range 71–100), five patients are alive and in continuous complete remission. The median survival time was 14 months and the median time to progression nine months. Conclusion: The regimen under study is active in recurrent/metastatic UCNT, but associated with excessive toxicity.

Electronic Resource

0992-7689

Springer Online Journal Archives 1860-2000

Geosciences

Physics

Abstract During the summer a thermal low-pressure system is locked over the Iberian Peninsula. We present a first analysis of such a system using the potential vorticity approach. Our results show that its main characteristic is the existence of a negative potential vorticity (PV) dome and a funnel-like structure for potential temperature, both located at the centre of the low. The build-up and evolution of this PV dome can be understood in terms of the dot products of the absolute vorticity and the gradient of diabetic heating vectors and the curl of the friction forces and the gradient of potential temperature vectors. The inhibition of the Algerian Mediterranean cyclogenesis during the summer seems to bear some relation to the existence of this kind of low-pressure disturbance over the Iberian Peninsula.

Electronic Resource

1432-1904

Springer Online Journal Archives 1860-2000

Biology

Chemistry and Pharmacology

Natural Sciences in General

Electronic Resource

1436-5065

Springer Online Journal Archives 1860-2000

Geography

Physics

Summary The Spanish island of Mallorca is located almost in the centre of the western Mediterranean. Very often from April to October, and almost every day during the summer, the sea breeze circulation develops. The shape and the topography of the island determine that the main characteristic feature of the sea breeze is the existence of a convergence line in the centre of the island. In this paper we describe the sea breeze circulation. A very simple non-eulerian numerical model allows us to simulate the evolution of the circulation during 24 hours.

Electronic Resource

1436-5065

Springer Online Journal Archives 1860-2000

Geography

Physics

Summary Several cases of lee cyclogenesis that occurred during ALPEX-SOP have been analyzed, with the aim of separating the large scale structures from the subsynoptic/meso-a scale features that are characteristic of this meteorological phenomenon. The results presented here are mainly based on composites of the analyzed cases. We assume that the deformation caused by the orography can be, at least to a reasonable extent, isolated from the “undisturbed” state using scale separation. The analysis technique we employ provides the scale separation as built-in in the interpolation algorithm. The scale separation error due to the large inhomogeneities of the data density distribution is partly corrected using a method described in the text. The orographic disturbance appears in different mesoscale fields as a quasiantisymmetric dipolar structure. For example, high/low pressure, cold/warm temperature and anticyclonic/cyclonic couplets characterize the mesoscale fields near the Alps. A qualitative agreement is found with the structure of the orographically induced perturbations predicted by the normal mode theory of lee cyclogenesis.

Electronic Resource