Search Results - (Author, Cooperation:S. A. Wilson)
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1Latest Papers from Table of Contents or Articles in PressA. G. Tomkins ; L. Bowlt ; M. Genge ; S. A. Wilson ; H. E. Brand ; J. L. Wykes
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-05-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. P. Grotzinger ; S. Gupta ; M. C. Malin ; D. M. Rubin ; J. Schieber ; K. Siebach ; D. Y. Sumner ; K. M. Stack ; A. R. Vasavada ; R. E. Arvidson ; F. Calef, 3rd ; L. Edgar ; W. F. Fischer ; J. A. Grant ; J. Griffes ; L. C. Kah ; M. P. Lamb ; K. W. Lewis ; N. Mangold ; M. E. Minitti ; M. Palucis ; M. Rice ; R. M. Williams ; R. A. Yingst ; D. Blake ; D. Blaney ; P. Conrad ; J. Crisp ; W. E. Dietrich ; G. Dromart ; K. S. Edgett ; R. C. Ewing ; R. Gellert ; J. A. Hurowitz ; G. Kocurek ; P. Mahaffy ; M. J. McBride ; S. M. McLennan ; M. Mischna ; D. Ming ; R. Milliken ; H. Newsom ; D. Oehler ; T. J. Parker ; D. Vaniman ; R. C. Wiens ; S. A. Wilson
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-10-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Climate ; Exhumation ; *Lakes ; *Mars ; PaleontologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressA. Cruz-Migoni ; G. M. Hautbergue ; P. J. Artymiuk ; P. J. Baker ; M. Bokori-Brown ; C. T. Chang ; M. J. Dickman ; A. Essex-Lopresti ; S. V. Harding ; N. M. Mahadi ; L. E. Marshall ; G. W. Mobbs ; R. Mohamed ; S. Nathan ; S. A. Ngugi ; C. Ong ; W. F. Ooi ; L. J. Partridge ; H. L. Phillips ; M. F. Raih ; S. Ruzheinikov ; M. Sarkar-Tyson ; S. E. Sedelnikova ; S. J. Smither ; P. Tan ; R. W. Titball ; S. A. Wilson ; D. W. Rice
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-11-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Motifs ; Animals ; Bacterial Proteins/*chemistry/genetics/metabolism/*toxicity ; Bacterial Toxins/*chemistry/genetics/metabolism/*toxicity ; Burkholderia pseudomallei/*chemistry/*pathogenicity ; Catalytic Domain ; Cell Line ; Crystallography, X-Ray ; Cytotoxins/chemistry/genetics/metabolism/toxicity ; Escherichia coli Proteins/chemistry ; Eukaryotic Initiation Factor-4A/*antagonists & inhibitors/metabolism ; Glutamine/metabolism ; Humans ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Mutant Proteins/toxicity ; Peptide Chain Initiation, Translational/drug effects ; Protein Binding ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, TertiaryPublished by: -
4Latest Papers from Table of Contents or Articles in PressJ. Cho ; S. Jeon ; S. A. Wilson ; L. V. Liu ; E. A. Kang ; J. J. Braymer ; M. H. Lim ; B. Hedman ; K. O. Hodgson ; J. S. Valentine ; E. I. Solomon ; W. Nam
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-10-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aldehydes/metabolism ; Crystallography, X-Ray ; Enzymes/chemistry/metabolism ; Hydrogen Peroxide/*chemistry/metabolism ; Iron/*chemistry/metabolism ; Ligands ; Models, Molecular ; Nonheme Iron Proteins/chemistry/metabolism ; Oxygen/chemistry/metabolismPublished by: -
5Articles: DFG German National LicensesZheng, L. R. ; Wilson, S. A. ; Lawrence, D. J. ; Rudolph, S. I. ; Chen, S. ; Braunstein, G.
Woodbury, NY : American Institute of Physics (AIP)
Published 1992Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Sequential deposition of Pd/AuGe/Ag/Au and rapid thermal annealing are used to form shallow ohmic contacts to n-GaAs and n-AlxGa1−xAs. Ion backscattering measurements and cross-sectional transmission electron microscopy show limited metal-substrate reaction and uniform interfaces. The metallization on GaAs displays good electrical properties with a contact resistivity of 2.0×10−6 Ω cm2 at a carrier concentration of 2×1017 cm−3. The contacts formed on Al0.55Ga0.45As have a contact resistivity of 2.1×10−5 Ω cm2 at a carrier concentration of 7.5×1017 cm−3.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0309-1740Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-1459Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-1459Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung Chorea und Choreoathetose stellen einen komplexen Typ von unwillkürlicher Bewegung dar, für deren Ausführung motorische Mechanismen kortikalen Sitzes erforderlich sind. Für Läsionen, die ihrer Entwicklung zugrundeliegen, ist die Annahme einer einzelnen, umschriebenen anatomischen Stelle nicht möglich. Chorea und Choreoathetose sind der Ausdruck der Störung eines Systems. Zu ihrem Fortbestehen trägt ein Defekt der afferenten cerebello-cerebralen Regulation bei; die transkortikale („willkürliche“) Kontrolle ihrer Äußerungen ist sehr unvollkommen. Jede Theorie, die ihren Ursprung einzig und allein zerstörenden Läsionen des Corpus striatum zuschreibt, ist völlig unmöglich. Diese Ansichten (für welche ich nicht den Anspruch auf besondere Neuheit erhebe) sind von mir seit 1912 vertreten und haben in den letzten Jahren erhöhte Beachtung gefunden. Die neuen ausgezeichneten Arbeiten von Minkowski, Littmann, Wartenberg, Wenderowic haben weiter dazu beigetragen, die striäre Theorie zu verwerfen. Man kann keine Hypothese über die Ursache der unwillkürlichen Bewegungen diskutieren, die nicht den Prinzipien der semiologischen und pathologischen Interpretation folgt, die wir zum großen Teil dem Genie Hughlings Jacksons verdanken.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The compound was prepared very simply in a helium atmosphere (less than 20 p.p.m. oxygen) in a 'glove-box'. Powdered graphite was heated with about 3 per cent sodium (commercial purity, filtered through sintered glass at about 150 C.) at about 400 G. for 1 hr. with continuous stirring. The ...Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-1424Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNotes: Summary In frog skin (Rana temporaria) acetylcholine applied to the serosal surface produces either a sustained inhibition or sustained stimulation of short-circuit current (SCC). The former effect is accompanied by a reduction and the latter by an increase in total tissue conductance. Both effects of acetylcholine can be accounted for, within experimental error, by changes in net sodium flux across the tissue. By use of selective agonists and antagonists it is concluded that acetylcholine interacts with muscarinic receptors in the serosal membrane. The effects of cholinoceptor agents are also seen with isolated epithelium. The stimulatory effect of acetylcholine is potentiated by theophylline and blocked by inhibitors of prostaglandin synthetase and by mepacrine. It is suggested that acetylcholine stimulates transport by liberating prostaglandins which may then activate adenylcyclase. The inhibitory effect of acetylcholine is correlated with a reduction in cyclic AMP content of the epithelium. Calcium appears to be an important determinant of the type of response seen with acetylcholine, but the mechanism is not known.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesGoller, M. I. ; Barthet, C. ; McCarthy, G. P. ; Corradi, R. ; Newby, B. P. ; Wilson, S. A. ; Armes, S. P. ; Luk, S. Y.
Springer
Published 1998Staff ViewISSN: 1435-1536Keywords: Key words Nanocomposite particle ; homopolypyrrole silica ; polypyrrole silica ; copolymerisingSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Two synthetic routes to surface-aminated polypyrrole–silica nanocomposite particles have been investigated. Route 1 involved the initial synthesis of homopolypyrrole – silica particles as described previously, followed by surface amination using 3-aminopropyltriethoxy-silane. In Route 2 aminated polypyrrole–silica particles were synthesized directly by copolymerising an N-substituted aminopyrrole comonomer with pyrrole in the presence of an ultrafine silica sol. Both types of aminated particles were characterized in terms of their particle size and morphology, long-term colloid stability and degree of amination using transmission electron microscopy, disc centrifuge photosedimentometry and zeta potential measurements, respectively.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1573-5036Keywords: Carbonic anhydrase ; Dry matter ; Eucalyptus maculata ; E. marginata ; E. patens ; Seedlings ; Symptoms ; Triticum aestivum ; ZincSource: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Summary Effects of zinc supply on shoot and root dry weight, root length, zinc concentrations and carbonic anhydrase activity were measured in 52 day old seedlings ofEucalyptus maculata, E. marginata, E. patens and wheat grown in a zinc deficient soil in the glasshouse. Symptoms of zinc deficiency in the eucalyptus and wheat appeared within 20 to 35 days. Eucalypt seedlings had short internodes and small necrotic leaves, reduced dry weight of shoots and roots, root length and zinc concentrations in young leaves; the measurable level of leaf carbonic anhydrase activity decreased to zero. Similar responses also occurred in wheat. The level of zinc fertilizer required for normal growth of Eucalyptus seedlings is therefore likely to be similar to that used for wheat and other agricultural crops.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1573-5036Keywords: Bark ; Calcium phosphate ; Eucalyptus marginata ; Fertilizer ; Leaf ; Lignotuber ; Phosphorus ; Shoot growth ; WoodSource: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Summary Effects of calcium phosphate supply on plant dry matter and phosphorus concentrations of parts of jarrah (Eucalyptus marginata) seedlings grown in a lateritic topsoil from the jarrah forest were examined in two glasshouse trials. Phosphorus deficiency depressed root and shoot dry weights and severely deficient leaves were smal and purple with prominent red major veins. Phosphorus deficiency severely reduced stem phosphorus levels (0.5% to 0.02%, experiment 1). Phosphorus concentrations were higher in bark than wood and the amount of phosphorus in the bark was sensitive to stem age and phosphate supply. Phosphorus adequate plants had bark phosphorus concentrations in the range 0.2–0.9% compared to 〈0.1% in deficient plants (experiment 2). Jarrah leaves accumulated dry matter up to 80 days after expansion and some leaves exported phosphorus during this period. Bark analysis may therefore be preferable to leaf analysis for detecting phosphorus deficiency in this species.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1573-5036Keywords: carbonic anhydrase ; diagnosis ; Eucalyptus maculata ; nutrient deficiency ; Trifolium subterraneum ; zincSource: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Abstract Carbonic anhydrase activity in selected leaves was examined in relation to zinc supply toEucalyptus maculata seedlings andTrifolium subterraneum grown in the glasshouse on a zinc-deficient sand. In both species, carbonic anhydrase activity was closely related to the zinc supply and fell to 0 in severely-deficient plants. Enzyme activity increased linearly as a function of the leaf zinc concentration. InE. maculata plants supplied with adequate zinc, carbonic anhydrase levels were only 3% of those inT. subterraneum. It is concluded that foliar zinc analysis is more sensitive than the carbonic anhydrase assay for determining the zinc status ofE. maculata seedlings. Critical zinc concentration for young fully-expandedE. maculata leaves was between 9 and 10 μg g−1 dry matter.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0006-3592Keywords: Thermus ; proteinase ; enzyme immobilization ; enzyme hermostability ; Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: An extracellular proteinase from Thermus strain Rt41A was immobilized to controlled pore glass (CPG) beads. The properties of the free and CPG-immobilized enzymes were compared using both a large (azocasein) and a small (peptidase) substrate. The specific activity of the immobilized proteinase was 5284 azoU/mg with azocasein and 144 sucU/mg for SucAAPFpNA. The percentage recovery of enzyme activity was unaffected by pore size when it was immobilized at a fixed level of activity/g of beads, whereas it increased with increasing pore size when added at a fixed level/m2 of support. Saturation of the CPG beads was observed at 540 azoU/m2 of 105-nm beads. Lower levels (50 azoU/m2 of 50-nm beads) were used in characterization experiments. The pH optimum of the immobilized Rt41A proteinase was 8.0 for azocasein and 9.5 for SucAAPFpNA, compared with the free proteinase which was 10.5 for both substrates. The immobilized enzyme retained 65% of its maximum activity against azocasein at pH 12, whereas the free proteinase retained less than 10% under the same conditions. Stability at 80°C increased on immobilization at all pH values between 5 and 11, the greatest increase in half-life being approximately 12-fold at pH 7.0. Temperature-activity profiles for both the free and immobilized enzymes were similar for both substrates. The stability of the immobilized proteinase, however, was higher than that of the free enzyme in the absence and presence of CaCl2. Overall, the results show that low levels of calcium (10 μM) protect against thermal denaturation, but that high calcium or immobilization are required to protect against autolysis. © 1994 John Wiley & Sons, Inc.Additional Material: 3 Ill.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0006-3592Keywords: peptide synthesis ; Thermus ; proteinase ; Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: A proteinase isolated from Thermus RT41a was immobilized to controlled pore glass beads and was used in the free and immobilized forms for peptide synthesis. The observed maximum yield was the same in both cases. a number of dipeptides were produced from amino acid esters and amides. The best acyl components, from those tested, were found to be Ac-Phe-OEt and Bz-Ala-OMe. Tur-NH2, Trp-NH2, Leu-pNA, and Val-pNA were all reactive nucleophiles.The kinetically controlled synthesis of Bz-ala-Tyr-NH2 was optimized by studying the effect of pH, temperature, solvent concentration, ionic strength, and nucleophile and acyl donor concentration, ionic strength, and nucleophile and acyl donor concentration on the maximum yield. The initial conditions used were 25 mM Bz-ala-OMe, 25 mM Tyr-NH2, 70°C, pH 8.0, and 10% v/v dimethylformamide (DMF). The optimum conditions were 90% v/v DMF using 80 mM bz-Ala-OMe and 615 mM Tyr-NH2 at 40°C and pH 10. These conditions increased the maximum conversion from 0.75% to 26% (of the original ester concentration). In a number of other cosolvents, the best peptide yields were observed with acetonitrile and ethyl acetate. In 90% acetonitrile similar yields were observed to those in 90% DMF under optimized conditions except that the acyl donor and nucleophile concentrations could be reduced to 25 mM and 100mM, respectively. The effect of the blocking group on the nucleophile was also investigated; -βNA and -pNA as blocking groups improved the yields markedly. The blocking and leaving groups of the acyldonor had no effect on the dipeptide yield. © 1994 John Wiley & Sons, Inc.Additional Material: 5 Ill.Type of Medium: Electronic ResourceURL: