Search Results - (Author, Cooperation:S. A. Moore)

2012-10-12

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Apoptosis/drug effects ; Calcium/*metabolism/pharmacology ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/antagonists & ; inhibitors/chemistry/*metabolism ; Cyclosporine/pharmacology ; Female ; Heart/drug effects/physiopathology ; Heart Failure/drug therapy/prevention & control ; Membrane Potential, Mitochondrial/drug effects/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mitochondria, Heart/enzymology/*metabolism/*pathology ; Mitochondrial Membrane Transport Proteins/metabolism ; Myocardial Infarction/drug therapy/prevention & control ; Myocardium/*enzymology/metabolism/*pathology ; Reperfusion Injury/enzymology/metabolism/pathology/prevention & control ; Serine/metabolism ; *Stress, Physiological/drug effects

2014-09-26

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Calcium/*metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism ; Female ; Mitochondria, Heart/*metabolism/*pathology ; Myocardium/*enzymology/*pathology ; *Stress, Physiological

2013-10-18

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Basement Membrane/metabolism/pathology ; Cell Differentiation ; Cell Line ; Dystroglycans/*chemistry/*metabolism ; Extracellular Matrix/chemistry/*metabolism ; Female ; Humans ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Weight ; Muscle Development ; Muscles/metabolism/pathology ; Muscular Dystrophies/metabolism/pathology/*prevention & control ; Myoblasts ; N-Acetylglucosaminyltransferases/deficiency/genetics/*metabolism ; Neuromuscular Junction/metabolism/pathology ; Phenotype ; Polysaccharides/chemistry/*metabolism

1432-0533

Key words Spinal cord neoplasm ; Germinoma

Springer Online Journal Archives 1860-2000

Medicine

Abstract Germ cell neoplasms occur in extra-gonadal midline locations of the retroperitoneum, mediastinum, pineal gland, areas of the suprasellar cistern, and rarely in the spinal cord. We recently reviewed a case of an unresectable lumbar spinal cord tumor in a 16-year-old female previously diagnosed as "metastatic poorly differentiated carcinoma." An extensive evaluation for a primary neoplasm at that time was unsuccessful and the patient was treated with local radiation therapy. Recently, additional histochemical and immunocytochemical studies were performed on the archival formalin-fixed paraffin-embedded material and the clinical history was reviewed. These ancillary studies (including positive immunohistochemical staining for placental alkaline phosphatase) support a diagnosis of intramedullary germinoma of the conus medullaris. This patient has enjoyed 28 years of disease free survival which reflects the radiosensitive nature of this neoplasm. These data lend support to the existence of a primary germinoma in the spinal cord and illustrate the utility of using histochemical stains and immunohistochemistry to assist in diagnosing this treatable neoplasm.

Electronic Resource

1420-9071

Springer Online Journal Archives 1860-2000

Biology

Medicine

Summary High resolution glass capillary gas chromatography and GC/MS were utilized to examine qualitative and quantitative variations from normal of urinary volatile metabolites of long-term alloxan and streptozotocin diabetic rats. Volatile metabolites were structurally compared with known neurotoxins to examine any possible relationship between these metabolites and the development of the diabetic polyneuropathy.

Electronic Resource

1432-136X

Springer Online Journal Archives 1860-2000

Biology

Medicine

Summary The effects of water restriction on nitrogen metabolism were compared in the semi-arid adapted tammar wallaby (Macropus eugenii) and a wallaby from a moist forest environment, the red-necked pademelon (Thylogale thetis). On a medium (9 to 13%) protein diet water restriction depressed dry matter and nitrogen intakes in both species. Nitrogen balance remained positive, but fell further in the pademelons. Urea excretion decreased in the tammars, but increased in the pademelons. Urea recycling as a proportion of urea entry rate tended to increase in the tammars but not in the pademelons. These findings suggest thatT. thetis is not as well adapted asM. eugenii to coping with water shortages. In a second experiment water restriction depressed nitrogen balance in tammars on both high (15%) and low (5%) protein diets, but only on the latter diet did nitrogen balance become negative. Urea recycling was greater on the low than on the high protein diet, but was unaffected by water restriction. Although better able to withstand water stress,M. eugenii was unable to cope with both water stress and a low protein diet together. The reported ability ofM. eugenii to maintain water intake by drinking sea water during the dry season when fresh water is unavailable and vegetation is of low protein content is thus of great ecological significance.

Electronic Resource