Search Results - (Author, Cooperation:S. A. Darroch)

2015-12-18

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Biodiversity ; Biological Evolution ; Classification ; Conservation of Natural Resources ; Ecology/methods ; *Ecosystem ; *Extinction, Biological ; Fossils ; Population Density

1432-1912

Prejunctional muscarine receptors ; Sympathetic nerves ; Rabbit ear artery

Springer Online Journal Archives 1860-2000

Medicine

Summary The ability of several selective muscarine receptor antagonists to inhibit the effect of carbachol on prejunctional muscarine receptors on sympathetic nerve endings in the rabbit isolated ear artery was investigated to characterise the receptor subtype involved. Carbachol did not reduce responses to exogenous noradrenaline and the inhibitory effect of carbachol on responses to nerve stimulation was unaffected by hexamethonium (10 μM) indicating that the effect of the muscarine agonist was exerted prejunctionally and was not modulated by nicotine receptor stimulation. The dissociation constants or apparent dissociation constants obtained using (±)-benzhexol (pKB; 6.63), (R)-benzhexol methiodide (8.11), dicyclomine (5.86), (±)-telenzepine (7.34), AF-DX 116 (6.95), himbacine (7.60), (±)-hexahydrosiladiphenidol (5.39) and a bisquaternary ammonium compound, heptane-1,7-bis(dimethyl-3′-phthalimidopropyl ammonium bromide) (5.84), indicate that the muscarine receptor subtype involved is not of the M1, M2 or M3 subtype.

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