Search Results - (Author, Cooperation:R. Y. Yang)

2018-02-09

BMJ Publishing Group

0017-5749

1468-3288

Medicine

Gut

2011-06-04

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

*Agriculture/economics/standards ; Conservation of Natural Resources ; *Developing Countries/economics ; Food Handling ; *Food Industry/economics/standards ; Food Safety ; *Food Supply/economics/standards ; Marketing ; Policy Making ; Private Sector

2018-05-16

BMJ Publishing

2044-6055

Medicine

Open access, Respiratory medicine

0922-338X

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Process Engineering, Biotechnology, Nutrition Technology

Electronic Resource

1749-6632

Blackwell Publishing Journal Backfiles 1879-2005

Natural Sciences in General

Electronic Resource

1432-0797

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Abstract A novel operation strategy employing self-generated oscillation to imrpove the performances of bioreactors is proposed and applied to a model system consisting of two continuous stirredtank bioreators (CSTBs) connected in series. It is demonstrated via computation that the performance of the system (in terms of timeaveraged cell concentration) can be greatly enhanced by adopting the proposed strategy. The process concept presented and the results obtained in this paper are expected to have significant implications beyond the bioprocessing industry.

Electronic Resource

1573-6776

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Summary An iontophoretic device with a configuration similar to that of a single hollow fiber reactor was found to enhance the release and transport of intracellular alkaloids fromCatharanthus roseus cells. As the applied current increased from 1 to 2 milliamperes, the rate of release and transport of alkaloids almost doubled. Pretreatment of the cells with DMSO further enhanced the production.

Electronic Resource

0029-5981

Engineering ; Engineering General

Wiley InterScience Backfile Collection 1832-2000

Mathematics

Technology

Methods for comparing the accuracy of numerical methods for the solution of parabolic partial differential equations are briefly surveyed. Criteria for a more systematic comparison are proposed and applied to an accuracy comparison of the classical and the modified Saul'yev methods and the Crank-Nicholson method on a simple linear problem. The results obtained, which include observation of the existence of optimal spatial mesh size for the two Saul'yev methods, are discussed.

9 Ill.

Electronic Resource

0006-3592

Chemistry ; Biochemistry and Biotechnology

Wiley InterScience Backfile Collection 1832-2000

Biology

Process Engineering, Biotechnology, Nutrition Technology

The diffusion characteristics of sucrose, a nutrient, and yohimbine, a secondary metabolite, in alginate gel beads, with or without entrapped periwinkle (Catharanthus roseus) or apple (Malus domestica) cells, were investigated. Effective diffusivities of both solutes in the gel beads were determined by two different methods from transient concentration changes in well-stirred solutions where the beads were suspended. The linear plot method developed in this work is easy to use and requires no data from the initial periods of diffusion experiments. It was found that while the cell-free beads provided only minor diffusional resistance to both solutes, the effective diffusivities of both solutes decreased significantly with the presence of cells in the beads and the amount of reduction was proportional to the amount of cell loading. Further, the effective diffusivity of sucrose appeared to be slightly larger than that of yohimbine under identical conditions. It was also observed that permeabilization of apple cells with dimethyl sulfoxide (DMSO) led to an increase in effective diffusivity with the effect being more significant for yohimbine.

6 Ill.

Electronic Resource

0001-1541

Chemistry ; Chemical Engineering

Wiley InterScience Backfile Collection 1832-2000

Chemistry and Pharmacology

Process Engineering, Biotechnology, Nutrition Technology

Experimental and theoretical studies on a backflush hollow-fiber enzymatic reactor (HFER) were conducted in this work for a lactose/lactase system. An A. niger lactase was chosen, from the four lactases tested, for reversible immobilization in the sponge layers of the fibers. An enzyme loading procedure was developed that allowed reliable and reproducible operation of the hollow-fiber reactor and produced industrially significant conversions without apparent change in the activity or stability of the lactase used. This reversible immobilization scheme also permitted easy replacement of the enzyme used. The performance of the backflush HFER was investigated and a large number of data concerning its operation were obtained and interpreted. Momentum and mass transports in such a HFER were analyzed, and mathematical models that took the experimental findings into consideration were also developed and solved analytically and/or numerically. Predictions from the computer model developed in this work were found to be in excellent agreement with the experimental data collected, suggesting the possibility of a priori design of a process-scale backflush HFER. With minor modifications, the models developed are expected to be applicable to hollow-fiber reactors with a wide selection of immobilized cells, organelles, and other enzymes.

5 Ill.

Electronic Resource