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1Latest Papers from Table of Contents or Articles in PressI. Lazaridis ; N. Patterson ; A. Mittnik ; G. Renaud ; S. Mallick ; K. Kirsanow ; P. H. Sudmant ; J. G. Schraiber ; S. Castellano ; M. Lipson ; B. Berger ; C. Economou ; R. Bollongino ; Q. Fu ; K. I. Bos ; S. Nordenfelt ; H. Li ; C. de Filippo ; K. Prufer ; S. Sawyer ; C. Posth ; W. Haak ; F. Hallgren ; E. Fornander ; N. Rohland ; D. Delsate ; M. Francken ; J. M. Guinet ; J. Wahl ; G. Ayodo ; H. A. Babiker ; G. Bailliet ; E. Balanovska ; O. Balanovsky ; R. Barrantes ; G. Bedoya ; H. Ben-Ami ; J. Bene ; F. Berrada ; C. M. Bravi ; F. Brisighelli ; G. B. Busby ; F. Cali ; M. Churnosov ; D. E. Cole ; D. Corach ; L. Damba ; G. van Driem ; S. Dryomov ; J. M. Dugoujon ; S. A. Fedorova ; I. Gallego Romero ; M. Gubina ; M. Hammer ; B. M. Henn ; T. Hervig ; U. Hodoglugil ; A. R. Jha ; S. Karachanak-Yankova ; R. Khusainova ; E. Khusnutdinova ; R. Kittles ; T. Kivisild ; W. Klitz ; V. Kucinskas ; A. Kushniarevich ; L. Laredj ; S. Litvinov ; T. Loukidis ; R. W. Mahley ; B. Melegh ; E. Metspalu ; J. Molina ; J. Mountain ; K. Nakkalajarvi ; D. Nesheva ; T. Nyambo ; L. Osipova ; J. Parik ; F. Platonov ; O. Posukh ; V. Romano ; F. Rothhammer ; I. Rudan ; R. Ruizbakiev ; H. Sahakyan ; A. Sajantila ; A. Salas ; E. B. Starikovskaya ; A. Tarekegn ; D. Toncheva ; S. Turdikulova ; I. Uktveryte ; O. Utevska ; R. Vasquez ; M. Villena ; M. Voevoda ; C. A. Winkler ; L. Yepiskoposyan ; P. Zalloua ; T. Zemunik ; A. Cooper ; C. Capelli ; M. G. Thomas ; A. Ruiz-Linares ; S. A. Tishkoff ; L. Singh ; K. Thangaraj ; R. Villems ; D. Comas ; R. Sukernik ; M. Metspalu ; M. Meyer ; E. E. Eichler ; J. Burger ; M. Slatkin ; S. Paabo ; J. Kelso ; D. Reich ; J. Krause
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-09-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Agriculture/history/manpower ; Asia/ethnology ; Europe ; European Continental Ancestry Group/*classification/*genetics ; Genome, Human/*genetics ; History, Ancient ; Humans ; Population Dynamics ; Principal Component AnalysisPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralNotes: Apolipoprotein (apo) E is associated with the two characteristic neuropathologic lesions of Alzheimer's disease–extracellular neuritic plaques representing deposits of amyloid beta (Aβ) peptide and intracellular neurofibrillary tangles representing filaments of a microtubule-associated protein called tau. Incubation of the apoE4 isoform with the Aβ peptide in vitro results in the formation of a dense, stable network of very long monofibrils, while incubation of apoE3 with the Aβ peptide results in the formation of a less dense, less stable network. The more complex nature of the plaques formed with the Aβ peptide in the presence of apoE4 in vivo may impair the normal clearance process and enhance plaque formation. Alternatively or additionally, apoE may alter the cytoskeletal structure and function and, under certain conditions, may promote the formation of the neurofibrillary tangles. Our studies have demonstrated that apoE3 and apoE4 exert differential effects on neuronal growth (i.e., neurite extension and branching) in vitro. When combined with a source of lipid, apoE3 stimulated neurite extension in peripheral nervous system neurons (dorsal root ganglia), whereas apoE4 inhibited it. Similar results were obtained with central nervous system neurons (murine neuroblastoma Neuro-2a cells). Addition of free apoE3 or apoE4 without β-VLDL had no effect on neurite outgrowth. There was also differential accumulation of apoE3 and apoE4 by the neuroblastoma cells: apoE3 accumulated within cell bodies and neurites to a greater extent than apoE4. Thus, apoE3 may facilitate cytoskeletal activity, whereas apoE4 may inhibit it, which would be detrimental during synaptic remodeling.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Keywords: Apolipoprotein E ; Lipoprotein metabolismSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The role of apo-E in mediating lipoprotein interaction with specific receptors has been established. Through the use of selective chemical modification of specific amino acid residues of certain lipoproteins, we have gained insight into the importance of the lysine and arginine residues in this process. This understanding has been expanded by structure-function studies of mutant forms of apo-E. These studies have revealed important information concerning the genetic heterogeneity of the apo-E isoforms, focusing attention on the importance of a specific region of apo-E in the binding process.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesKnott, T. J. ; Pease, R. J. ; Powell, L. M. ; Wallis, S. C. ; Rall, S. C. ; Innerarity, T. L. ; Blackhart, B. ; Taylor, W. H. ; Marcel, Y. ; Milne, R. ; Johnson, D. ; Fuller, M. ; Lusis, A. J. ; McCarthy, B. J. ; Mahley, R. W. ; Levy-Wilson, B. ; Scott, J.
[s.l.] : Nature Publishing Group
Published 1986Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Fig. 1 a, Restriction map of apo B-100 cDNA. Abbreviations, Sa, Sa/I; H, Hindlll; ß, BamHI; X, Xbal\ S, Sst\\ E, EcoRl. 6, Amino-acid sequence of human apolipoprotein B-100. Vertical arrows, mature protein amino terminus (residue 1) and two thrombin cleavage sites. Solid bars, two stretches of ...Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1439-0973Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Das Hepatitis C Virus (HCV) und das Hepatitis E Virus (HEV) sind weltweit die Haupterreger der Non-A, Non-B-Hepatitis: In der Türkei sind ein Drittel der Fälle von akuter Hepatitis Non-A, Non-B. Eine Seroprävalenzstudie für HCV wurde durchgeführt, um die Epidemiologie des HCV, einschließlich der Assoziation von HCV und HEV in der Türkei zu ermitteln. Seren von Einwohnern von fünf verschiedenen Regionen des Landes wurden auf Antikörper gegen HCV (anti-HCV) und HEV (anti-HEV) getestet. Bei 21 von 1.374 Personen (1,5%) wurde anti-HCV nachgewiesen. Der Test war häufiger positiv bei Einwohnern über 54 Jahre (p=0,02), bei Personen, die unter dem Hauptschul-Bildungsstand waren (p=0,013), bei Familien mit mehr als zwei Kindern (p=0,003) und bei Personen, die in der Region von Ayvalik (p=0,046) oder Trabzon (p=0,038) wohnen — verglichen mit Einwohnern von Istanbul. Zwischen anti-HCV und anti-HEV bestand eine marginale Assoziation, die bei 5,9% der Einwohner aufgedeckt wurde. Die HCV-Infektion tritt in allen Regionen der Türkei auf und ist häufiger bei älteren Personen und bei niedrigem sozio-ökonomischen Status. Für die Einschränkung der HCV-Übertragung in der Türkei sollten — falls Mittel verfügbar sind — Schritte wie das anti-HCV Screening von Blutspenden durchgeführt werden.Notes: Summary Hepatitis C virus (HCV) and hepatitis E virus (HEV) are the principal causes of non-A, non-B hepatitis worldwide, and in Turkey one-third of the cases of acute hepatitis are non-A, non-B. To explore the epidemiology of HCV in Turkey (including the association of HCV with HEV), a seroprevalence study of HCV was conducted. Sera from residents from five distinct regions of the country were tested for antibodies to HCV (anti-HCV) and HEV (anti-HEV). Anti-HCV was detected in 21 (1.5%) of 1,374 persons and was more common in residents over 54 years of age (p=0.02), with less than primary education (p=0.013), more than two children (p=0.003), and who lived in the regions of Ayvalik (p=0.046) or Trabzon (p=0.038) compared to Istanbul. Anti-HCV was marginally associated with anti-HEV, which was found in 5.9% of residents. However, this association was lost after controlling for age and education (p=0.225). HCV infection occurs in all regions of Turkey and is more common in persons who are older and of low socioeconomic status. As resources permit, efforts to reduce the transmission of HCV in Turkey (such as screening blood donations for anti-HCV) are indicated.Type of Medium: Electronic ResourceURL: