Search Results - (Author, Cooperation:R. T. Bailer)
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1Latest Papers from Table of Contents or Articles in PressI. S. Georgiev ; N. A. Doria-Rose ; T. Zhou ; Y. D. Kwon ; R. P. Staupe ; S. Moquin ; G. Y. Chuang ; M. K. Louder ; S. D. Schmidt ; H. R. Altae-Tran ; R. T. Bailer ; K. McKee ; M. Nason ; S. O'Dell ; G. Ofek ; M. Pancera ; S. Srivatsan ; L. Shapiro ; M. Connors ; S. A. Migueles ; L. Morris ; Y. Nishimura ; M. A. Martin ; J. R. Mascola ; P. D. Kwong
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-05-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies, Neutralizing/blood/*immunology ; Epitope Mapping ; HIV Antibodies/blood/*immunology ; HIV Infections/blood/*immunology ; HIV-1/*immunology/isolation & purification ; Humans ; Immunodominant Epitopes/chemistry/immunology ; Macaca ; Neutralization Tests ; Protein Conformation ; Serum/immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressR. Kong ; K. Xu ; T. Zhou ; P. Acharya ; T. Lemmin ; K. Liu ; G. Ozorowski ; C. Soto ; J. D. Taft ; R. T. Bailer ; E. M. Cale ; L. Chen ; C. W. Choi ; G. Y. Chuang ; N. A. Doria-Rose ; A. Druz ; I. S. Georgiev ; J. Gorman ; J. Huang ; M. G. Joyce ; M. K. Louder ; X. Ma ; K. McKee ; S. O'Dell ; M. Pancera ; Y. Yang ; S. C. Blanchard ; W. Mothes ; D. R. Burton ; W. C. Koff ; M. Connors ; A. B. Ward ; P. D. Kwong ; J. R. Mascola
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-05-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressJ. Huang ; G. Ofek ; L. Laub ; M. K. Louder ; N. A. Doria-Rose ; N. S. Longo ; H. Imamichi ; R. T. Bailer ; B. Chakrabarti ; S. K. Sharma ; S. M. Alam ; T. Wang ; Y. Yang ; B. Zhang ; S. A. Migueles ; R. Wyatt ; B. F. Haynes ; P. D. Kwong ; J. R. Mascola ; M. Connors
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-11-16Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Substitution ; Antibodies, Neutralizing/chemistry/*metabolism ; Antibody Specificity ; Cells, Cultured ; HEK293 Cells ; HIV Antibodies/chemistry/isolation & purification/*metabolism ; HIV Envelope Protein gp41/chemistry/*immunology ; HIV-1/*physiology ; Humans ; Models, Molecular ; Molecular Sequence Data ; Protein Binding ; Protein Structure, TertiaryPublished by: -
4Latest Papers from Table of Contents or Articles in PressM. Pancera ; T. Zhou ; A. Druz ; I. S. Georgiev ; C. Soto ; J. Gorman ; J. Huang ; P. Acharya ; G. Y. Chuang ; G. Ofek ; G. B. Stewart-Jones ; J. Stuckey ; R. T. Bailer ; M. G. Joyce ; M. K. Louder ; N. Tumba ; Y. Yang ; B. Zhang ; M. S. Cohen ; B. F. Haynes ; J. R. Mascola ; L. Morris ; J. B. Munro ; S. C. Blanchard ; W. Mothes ; M. Connors ; P. D. Kwong
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-10-09Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/chemistry/immunology ; Amino Acid Sequence ; Antibodies, Neutralizing/immunology ; Cohort Studies ; Crystallography, X-Ray ; Genetic Variation ; Glycosylation ; HIV Antibodies/immunology ; HIV Envelope Protein gp120/*chemistry/genetics/*immunology ; HIV Envelope Protein gp41/*chemistry/genetics/*immunology ; HIV Infections/immunology ; Humans ; Immune Evasion ; Membrane Fusion ; Models, Molecular ; Molecular Sequence Data ; Polysaccharides/chemistry/immunology ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Subunits/chemistry/genetics/immunology ; Structural Homology, Protein ; Virus InternalizationPublished by: -
5Latest Papers from Table of Contents or Articles in PressN. A. Doria-Rose ; C. A. Schramm ; J. Gorman ; P. L. Moore ; J. N. Bhiman ; B. J. DeKosky ; M. J. Ernandes ; I. S. Georgiev ; H. J. Kim ; M. Pancera ; R. P. Staupe ; H. R. Altae-Tran ; R. T. Bailer ; E. T. Crooks ; A. Cupo ; A. Druz ; N. J. Garrett ; K. H. Hoi ; R. Kong ; M. K. Louder ; N. S. Longo ; K. McKee ; M. Nonyane ; S. O'Dell ; R. S. Roark ; R. S. Rudicell ; S. D. Schmidt ; D. J. Sheward ; C. Soto ; C. K. Wibmer ; Y. Yang ; Z. Zhang ; J. C. Mullikin ; J. M. Binley ; R. W. Sanders ; I. A. Wilson ; J. P. Moore ; A. B. Ward ; G. Georgiou ; C. Williamson ; S. S. Abdool Karim ; L. Morris ; P. D. Kwong ; L. Shapiro ; J. R. Mascola
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/chemistry/immunology ; Amino Acid Sequence ; Antibodies, Neutralizing/chemistry/genetics/*immunology/isolation & purification ; Antibody Affinity/genetics/immunology ; Antigens, CD4/immunology/metabolism ; B-Lymphocytes/cytology/immunology/metabolism ; Binding Sites/immunology ; Cell Lineage ; Complementarity Determining Regions/chemistry/genetics/immunology ; Epitope Mapping ; Epitopes, B-Lymphocyte/chemistry/immunology ; Evolution, Molecular ; HIV Antibodies/chemistry/genetics/*immunology/isolation & purification ; HIV Envelope Protein gp160/*chemistry/*immunology ; HIV Infections/immunology ; HIV-1/chemistry/immunology ; Humans ; Models, Molecular ; Molecular Sequence Data ; Neutralization Tests ; Protein Structure, Tertiary ; Somatic Hypermutation, Immunoglobulin/geneticsPublished by: -
6Latest Papers from Table of Contents or Articles in PressM. Roederer ; B. F. Keele ; S. D. Schmidt ; R. D. Mason ; H. C. Welles ; W. Fischer ; C. Labranche ; K. E. Foulds ; M. K. Louder ; Z. Y. Yang ; J. P. Todd ; A. P. Buzby ; L. V. Mach ; L. Shen ; K. E. Seaton ; B. M. Ward ; R. T. Bailer ; R. Gottardo ; W. Gu ; G. Ferrari ; S. M. Alam ; T. N. Denny ; D. C. Montefiori ; G. D. Tomaras ; B. T. Korber ; M. C. Nason ; R. A. Seder ; R. A. Koup ; N. L. Letvin ; S. S. Rao ; G. J. Nabel ; J. R. Mascola
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-12-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/*immunology ; Amino Acid Sequence ; Animals ; Antibodies, Neutralizing/immunology ; Disease Susceptibility/immunology ; Female ; Founder Effect ; HIV Antibodies/immunology ; HIV Infections/immunology/*prevention & control/*virology ; HIV-1/chemistry/*immunology ; Humans ; Immune Evasion/immunology ; Macaca mulatta ; Male ; Molecular Sequence Data ; Phylogeny ; Risk ; SAIDS Vaccines/*immunology ; Simian Acquired Immunodeficiency Syndrome/immunology/prevention & ; control/virology ; Simian Immunodeficiency Virus/chemistry/genetics/*immunology/physiology ; env Gene Products, Human Immunodeficiency Virus/immunologyPublished by: -
7Latest Papers from Table of Contents or Articles in PressJ. Huang ; B. H. Kang ; M. Pancera ; J. H. Lee ; T. Tong ; Y. Feng ; H. Imamichi ; I. S. Georgiev ; G. Y. Chuang ; A. Druz ; N. A. Doria-Rose ; L. Laub ; K. Sliepen ; M. J. van Gils ; A. T. de la Pena ; R. Derking ; P. J. Klasse ; S. A. Migueles ; R. T. Bailer ; M. Alam ; P. Pugach ; B. F. Haynes ; R. T. Wyatt ; R. W. Sanders ; J. M. Binley ; A. B. Ward ; J. R. Mascola ; P. D. Kwong ; M. Connors
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-09-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/chemistry/immunology ; Antibodies, Monoclonal/chemistry/genetics/immunology/pharmacology ; Antibodies, Neutralizing/chemistry/genetics/*immunology/pharmacology ; *Antibody Affinity ; Antibody Specificity ; Antigens, CD4/metabolism ; Cell Line ; Cell Membrane/virology ; Conserved Sequence ; Epitope Mapping ; Epitopes/chemistry/immunology ; HIV Antibodies/chemistry/genetics/*immunology/pharmacology ; HIV Envelope Protein gp120/*chemistry/*immunology ; HIV Envelope Protein gp41/*chemistry/*immunology ; HIV-1/drug effects/immunology ; Humans ; Immunoglobulin Fab Fragments/chemistry/genetics/immunology/ultrastructure ; Inhibitory Concentration 50 ; Leukocytes, Mononuclear ; Models, Molecular ; Molecular Sequence Data ; Receptors, CCR5/metabolism ; Virus Internalization/drug effectsPublished by: -
8Articles: DFG German National LicensesLazo, A. ; Bailer, R. T. ; Blakeslee, J. R. ; Yanagihara, R. ; Stevens, V. C. ; Kramer, L. ; Lairmore, M. D.
Springer
Published 1995Staff ViewISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Nucleotide sequence analysis of selected regions of the gag, pol, env and pX genes of simian T-cell lymphotropic virus type I (STLV-I) strains indicated that African isolates were more closely related to human T-cell lymphotropic virus type I (HTLV-I) than Asian isolates. Despite these recent comparative studies on nucleotide sequence homology between HTLV-I and STLV-I isolates, only limited information is available regarding the influence of genetic differences on antigen-antibody recognition of distinct STLV-I strains. In this study, we demonstrated that sera from STLV-I-infected yellow baboons (Papio cynocephalus) reacted strongly with env gp62/68 from HTLV-I-infected cell lines MT-2 and C10/MJ. In contrast, sera from Japanese macaques (Macaca fuscata) naturally infected with Asian STLV-I had weak reactivity to env gp62/68 of these prototypic HTLV-I strains. Pst-1 restriction enzyme analysis of proviral DNA indicated that the baboon virus isolates were more closely related to HTLV-I than the Japanese isolates. These results indicate that nucleotide sequence diversity, correlates with variations in proviral restriction enzyme sites and antibody recognition of viral envelope proteins. These differences in immunoreactivity may have important implications for serologic diagnosis, as well as epidemiological and vaccine studies of STLV-I infection.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesMallery, S. R. ; Bailer, R. T. ; Hohl, C. M. ; Ng-Bautista, C. L. ; Ness, G. M. ; Livingston, B. E. ; Hout, B. L. ; Stephens, R. E. ; Brierley, G. P.
New York, N.Y. : Wiley-Blackwell
Published 1995Staff ViewISSN: 0730-2312Keywords: reactive oxygen intermediates ; nucleotides ; glutathione ; redox state ; energy charge ; DNA damage ; apoptosis ; Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyChemistry and PharmacologyMedicineNotes: Despite its recognition as the most prevalent HIV associated cancer, speculation still abounds regarding the pathogenesis of AIDS-related Kaposi's sarcoma (AIDS-KS). However, it has been established that both cytokines, e.g. IL-6, and HIV-associated products, e.g., Tat, are integral in AIDS-KS cellular proliferation. Further, both experimental and clinical evidence is accumulating to link reactive oxygen intermediates (ROI) with both cytokine induction (primarily via nuclear factor-κB [NF-κB] dependent routes) as well as the subsequent cytokine, tumor necrosis factor α (TNFα) stimulation of HIV replication. Features of AIDS-KS patients, such as retention of phagocytes, presence of sustained immunostimulation, and a frequent history of KS lesions arising at traumatized sites, make oxidant stress a viable clinical factor in AIDS-KS development. Time course nucleotide profile analyses show that AIDS-KS cells have an inherent, statistically significant, biochemical deficit, even prior to oxidant stress, due to (1) a more glycolytic bioenergetic profile, resulting in lower levels of high energy phosphates (impairing capacity for glutathione [GSH] synthesis and DNA repair); (2) lower levels of NADPH (compromising the activities of GSSG reductase and peroxidase function of catalase); and (3) reduced levels of GSH (impeding both GSH peroxidase and GSH-S-transferases). Following exposure to physiologically relevant levels of H2O2 only the human microvascular endothelial cells (a putative AIDS-KS progenitor cell) responded with bioenergetic adaptations that reflected co-ordination of energy generating and cytoprotective pathways, e.g., retention of the cellular energy charge, increased NAD+, and an accentuation of the ATP, NADPH, and total adenine nucleotide differences relative to AIDS-KS cells. Also, some of the AIDS-KS strains retained intracellular GSSG subsequent to oxidant challenge, inviting the formation of deleterious protein mixed disulfides. While the results of our study address some AIDS-KS issues, they also raise an etiological question, i.e., Does the inability to tolerate oxidant stress arise in conjunction with AIDS-KS neoplastic development, or is it pre-existing in the population at risk? Regardless, use of antioxidant therapy (low risk/potentially high benefit) in both the “at risk” population as well as in those individuals with active disease may prove a useful preventative and/or treatment modality. © 1995 Wiley-Liss, Inc.Additional Material: 2 Ill.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesMallery, S. R. ; Ng-Bautista, C. L. ; Lantry, L. E. ; Ness, G. M. ; Hegtvedt, A. K. ; Lazo, A. ; Bailer, R. T. ; Hout, B. L. ; Stephens, R. E. ; Brierley, G. P.
New York, N.Y. : Wiley-Blackwell
Published 1994Staff ViewISSN: 0730-2312Keywords: oxidant stress ; nucleotides ; glutathione ; catalase ; redox state ; energy charge ; reactive oxygen species ; Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyChemistry and PharmacologyMedicineNotes: Features of AIDS-related Kaposi's sarcoma (AIDS-KS), such as the multifocal presentation at mucosal and epidermal sites subjected to trauma, suggest that AIDS-KS is initially a reactive hyperplasia that subsequently progresses to a neoplasia. It is recognized that there is an association between sustained states and the subsequent development of neoplasia (e.g., ulcerative colitis/colonic adenocarcinoma). Furthermore, patients who develop AIDS-KS experience both a constant immune stimulation due to sustained high levelsof virus-induced cytokines and, because of a sparing effect on their phagoctic cells, retention of the phagocytic inflammatory response. A component of phygocytic activation is the initiation of the oxidative brust, resulting in the generation of reactive oxygen species (ROS), which can be mutagenic to host cells if released beyond the phagolysosome and not inactivated. Our results demonstrate that cultured AIDS-KS cells possess drcreased cytoprotective capabilities. Relativeto either dermal fibroblasts, or human microvascular endothelial cells (HMECs), AIDS-KS cells contained significantly lower levels of glutathione, a tripeptide integral in both cytoprotection and maintenance of cellular thiol status. While HMECs increased catalase activity during culture in the cytokine-rich KS milieu (control medium supplement with conditioned medium from MOT, an TLV II-infected cell line), AIDS-KS cells demonstrated reduced catalase function under these conditions. Furthermore, HMEC cultures showed in inherent biochemical responsiveness, by increasing catalase activity following exposure to exaogenous H2(O2). In contrast, the catalase activity of AIDS-KS cells decreased following (H2O2) challenge. Our results show that an inherent deficiency in cellular cytoprotection is present in AIDS-KS cells and suggest that oxidant stress may function in the development and progression AIDS-KS.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: